McMaster Scientists Uncover New Way to Grow Rare Life-Saving Blood Stem Cells
McMaster UniversityDiscovery provides a serious advantage in determining how to maximize blood stem cells in therapeutics and could help ease current stem cell shortages.
Discovery provides a serious advantage in determining how to maximize blood stem cells in therapeutics and could help ease current stem cell shortages.
It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell “commitment.”
Drug-carrying “nanoghosts” that battle melanoma and new treatments for malignant mesothelioma will be the focus of the first joint research projects led by NYU Langone Medical Center and the Technion-Israel Institute of Technology under a groundbreaking research initiative.
Dr. Kevin Francis’ research appears in Nature Medicine
A noted designer of artistic ties has turned scientific images into a striking design that can be worn by men and women - and the proceeds will aid bipolar disorder research.
An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.
While stem cells have shown promise for treating brain regions damaged by cancer radiation treatments, University of California, Irvine researchers have found that microscopic vesicles isolated from these cells provide similar benefits without some of the risks associated with stem cells.
An investigational stem cell therapy derived from patients’ own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute.
End-stage heart failure patients treated with stem cells harvested from their own bone marrow experienced 37 percent fewer cardiac events - including deaths and heart failure hospital admissions - than a placebo-controlled group, according to a new study. Results from ixCELL-DCM, the largest cell therapy clinical trial for treating heart failure to date, will be presented at the 2016 American College of Cardiology annual meeting and published online in The Lancet on April 4.
Linda Carli's "Stereotypes About Gender and Science: Women ≠ Science” shows that despite significant progress made, women are still thought to lack the qualities needed to be successful scientists, and the findings suggest this may contribute to discrimination and prejudice against women in those fields.
Writing in Nature Medicine, researchers at University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, with colleagues in Japan and Wisconsin, report that they have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats, resulting in functional benefit.
Working with human breast cancer cells and mice, scientists say new experiments explain how certain cancer stem cells thrive in low oxygen conditions. Proliferation of such cells, which tend to resist chemotherapy and help tumors spread, are considered a major roadblock to successful cancer treatment.
Dr. Pradeep "Max" Dass, director of the NAU Center of Science Teaching and Learning at NAU, is helping guide STEM teaching methods on the other side of the globe in a small school in India. The CSTL continues its mission to lead the way in global STEM education.
Neuroscientists document some of the first steps in the process by which a stem cell transforms into different cell types.
Dr. Mansoor Husain named first executive director of Ted Rogers Centre for Heart Research
The Princeton Plasma Physics Laboratory hosted a Young Women's Conference in Science, Technology, Engineering and Mathematics for 575 girls. The conference is aimed at sparking young women's interest in STEM and encouraging them to consider STEM careers. Women still lag behind men in STEM careers, especially in certain fields such as computer science, physics, and engineering.
Emma and Molly White and Ru-Shyan and Ru-Huey Yen, a pair of twin sisters and close friends who met in high school 16 years ago, went on to careers in STEM
An overwhelming number of researchers still struggle within the black hole of the effectiveness and safety of stem cell therapy for neurological diseases. While the complexity of understanding how neurons grow, connect and function has long been studied, it remains a mystery, one that Forrest Goodfellow is helping to unravel.
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine approved yesterday a $6.3 million grant to a research team from the University of California, San Diego School of Medicine and University of California, Davis to pursue a novel human embryonic stem cell-based therapy to rescue and restore neurons devastated by amyotrophic lateral sclerosis or ALS.
Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.
If you want to harness the full power of stem cells, all you might need is an eraser – in the form of a drug that can erase the tiny labels that tell cells where to start reading their DNA. In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an ‘embryonic’ state.
In one of the first studies to "read" the genetic activity inside individual brain cells, University of Wisconsin-Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell.
Stem cells may have the potential to protect the optic nerve from further damage and slow the progression of vision loss due to glaucoma. Stem cells may also have the potential to replace ocular tissues that have degenerated in eyes with glaucoma.
Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.
Scientists from The Hebrew University of Jerusalem, Columbia University Medical Center (CUMC) and The New York Stem Cell Foundation Research Institute (NYSCF) have succeeded in generating a new type of embryonic stem cell that carries a single copy of the human genome, instead of the two copies typically found in normal stem cells. The scientists reported their findings today in the journal Nature.
Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses.
Bioengineers and physicians at the University of California, San Diego have developed a potential new therapy for critical limb ischemia, a condition that causes extremely poor circulation in the limbs and leads to an estimated 230,000 amputations every year in North America and Europe alone to prevent the spread of infection and tissue death. The new therapy could prevent or limit amputations for a condition that affects more than 27 million people and is a manifestation of advanced peripheral arterial disease.
The American Pain Society (APS), www.americanpainsociety.org, will host its 35th annual scientific meeting May 11-14 at the Austin Convention Center. APS is the leading multidisciplinary professional society in the United States dedicated to advancing pain-related research, education, treatment and team-oriented professional practice.
Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai have identified a precursor cell in the placenta and embryo of mice that can be matured in the lab to make hematopoietic stem/progenitor cells
Kejin Hu, Ph.D., has found a robust reprogramming factor that increases the efficiency of creating human induced pluripotent stem cells (HiPSCs) from skin fibroblasts more than 20-fold, speeds the reprogramming time by several days and enhances the quality of reprogramming.
Florida State University researchers have made a major breakthrough in the quest to learn whether the Zika virus is linked to birth defects with the discovery that the virus is directly targeting brain development cells and stunting their growth. This is the first major finding by scientists that shows that these critical cells are a target of the virus and also negatively affected by it.
Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study, UNC researchers report significant progress toward a novel approach that could shrink the amount of heart scar tissue while replenishing the supply of healthy heart muscle.
A new study led by scientists at The Scripps Research Institute (TSRI) and the J. Craig Venter Institute (JCVI) shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.
SBP researchers have identified specific ways in which fetal muscle stem cells remodel their environment to support their enhanced capacity for regeneration, which could lead to targets for therapies to improve adult stem cells’ ability to replace injured or degenerated muscle.
Findings clear path to devise new treatments for muscular injuries and dystrophies
The Coriell Institute for Medical Research today announces the in-licensing of PluriTest, a cost-effective, accurate, animal-free bioinformatics assay for determining the pluripotency of human induced pluripotent stem cells (hiPSC).
Scientists have used a new gene-editing technology called CRISPR, to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide.
Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.
New research by UC San Francisco stem cell biologists has revealed that a DNA-binding protein called Foxd3 acts like a genetic traffic signal, holding that ball of undifferentiated cells in a state of readiness for its great transformation in the third week of development.
Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease, including diabetes. The researchers discovered methods for reducing these conditions in naturally aged mice.
Su-Chun Zhang, a pioneer in developing neurons from stem cells at the University of Wisconsin-Madison, has created a specialized nerve cell that makes serotonin, a signaling chemical with a broad role in the brain.
Ghosts are not your typical cell biology research subjects but scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human Development (NICHD) who developed a technique to observe muscle stem/progenitor cells migrating within injury sites in live mice, report that “ghost fibers,” remnants of the old extracellular matrix left by dying muscle fibers, guide the cells into position for healing to begin.
In a study published in this week’s edition of NATURE, scientists from the Research Institutes of Molecular Biotechnology (IMBA) and Molecular Pathology (IMP) in Vienna and from the Harvard Medical School in Boston have identified a long-sought “roadblock factor” in stem cell engineering that prevents the conversion of adult cells into induced pluripotent stem cells. By suppressing this factor, the team discovered a way to
An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs). The findings are published in the November 30 online issue of Proceedings of the National Academy of Sciences.
Researchers at the University of Louisville have identified the role of TNF receptor-associated factor 6 (TRAF6), an adaptor protein and E3 ubiquitin ligase, in ensuring the vitality of stem cells that regenerate muscle tissue.
Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain.
A particular location in DNA, called the Dlk1-Gtl2 locus, plays a critical role in protecting hematopoietic, or blood-forming, stem cells—a discovery revealing a critical role of metabolic control in adult stem cells, and providing insight for potentially diagnosing and treating cancer, according to researchers from the Stowers Institute for Medical Research.
Scientists at Case Western Reserve University School of Medicine have demonstrated in lab animals that a family of therapeutic stem cells lessen consequences of a damaging immune response and preserve function that would otherwise be lost. Their findings appear in the Nov. 19 Scientific Reports.
• After researchers transplanted kidney tissue generated from human induced pluripotent stem cells into a mouse kidney, the animal’s blood vessels readily connected to the human tissue.