Physician-scientist Paul Noble, MD, chair of the Department of Medicine at Cedars-Sinai, was named president-elect of the Association of American Physicians (AAP) at the group's annual meeting in Chicago on April 22.
Researchers at the Department of Biology, University of Copenhagen, have now contributed to solving this problem for a specific gene called GCK. The study has just been published in Genome Biology.
New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS. The University of Bristol-led study, published in Arthritis & Rheumatology, analysed genetic data on nearly 34,000 people.
In a novel study in The American Journal of Pathology, published by Elsevier, researchers found that when fragile-X related protein-1 (FXR1) is absent, VSMC proliferate more slowly, become senescent, and scar tissue (neointima) development is reduced. Therefore, drugs targeting FXR1 may treat vascular proliferative diseases.
The National Academy of Sciences elected two more UT Southwestern Medical Center scientists in the fields of molecular genetics and physiology into its membership, one of the highest honors for American scientists. Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics, and Duojia Pan, Ph.D., Chair of Physiology and a Howard Hughes Medical Institute Investigator, were elected by their peers in recognition of the importance of their scientific discoveries.
For millions of Americans that suffer from seasonal allergies (pollen and mold), climate change is exacerbating an earlier, longer, and overall worse allergy season.
UC San Diego researchers describe how exposure to ambient air pollution, such as car exhaust and power plant emissions — is associated with a measurably greater risk of developing dementia over time.
The prestigious J. Roger Porter Award has been awarded to Kevin McCluskey in recognition of his outstanding work in support of microbial culture collections when he was curator of the Fungal Genetic Stock Center (FGSC)
Gene-editing therapy aimed at two targets – HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells – can effectively eliminate HIV infection. The study is the first to combine a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
For years, Maggie was questioning why she didn’t have the same stamina as her peers. A new diagnosis gave her peace of mind.
John Hibbing has long been a venerable voice in the world of politics, often fielding interviews for local and national media, parsing the data and making sense of things where it seems there’s little.
A scientific project that compares the genomes of 240 living species of mammals has identified transposable elements (TEs) – genes that can change their position within a genome, creating or reversing mutations and thus altering a cell’s genetic identity – as a crucial area of study to help uncover the evolutionary process of mammals and to better understand biodiversity.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach could also power the development of advanced cell therapies for cancers and other diseases, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
In the cell nucleus, numerous proteins bind to the DNA molecule in order to regulate the activity of certain genes. One such is the TATA-box binding protein (TBP), which binds to a specific DNA sequence and constitutes an initial signal for the reading of DNA.
Lecturers of the Faculty of Allied Health Sciences, Chulalongkorn University have developed MTB Strip Test Kit for Tuberculosis (TB) diagnosis that’s accurate and easy to use, guaranteed by the 2023 Invention Award from the National Research Council of Thailand (NRCT) — Another hope to reduce the spread of tuberculosis in Thailand.
Research shows which regions have important functions in mammals, which genetic changes have led to specific characteristics in different species and which mutations can cause
The atmosphere is a large-scale dissemination route for bacteria carrying antibiotic-resistance genes. A research team from Université Laval and Université Clermont Auvergne has shown that these genes can be transported by clouds.
A Cornell University-led project has added a new chapter to the story of Balto – the most famous sled dog in history – by using ancient DNA extraction and analysis to reconstruct his phenotype and identify his genetic connections to modern dog breeds.
More than a dozen scientists from multiple disciplines across the university collaborated on the Zoonomia Project.
Researchers have developed a biosynthetic “clock” that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Researchers from Japan have reported the use of an advanced DNA sequencing technique, whole-exome sequencing (WES), to determine why a young child died after a relatively mild infection.
Illinois researchers identified cells in the hippocampus that could be chemogenetically turned off to make young mice show signs of cognitive decline associated with aging. They are using this new mouse model to search for ways to prevent or reverse age-related learning and memory problems.
Researchers led by Sanford Burnham Prebys assistant professor Lukas Chavez, Ph.D., are leveraging the latest technology to take a never-before-seen look at ependymoma, one of the deadliest pediatric brain tumors. By visualizing how the genome is organized and arranged within tumor cells, they were able to reveal genes in tumors that may be future targets for therapy. The results appear in Nature Communications.
Among families with children diagnosed with autism spectrum disorder, Johns Hopkins University researchers say they have found a link between chemical “marks” on DNA in the sperm of fathers and autistic traits in their 3-year-old children.
Researchers at the Francis Crick Institute, King’s College London and University College London have shed light on the genetics behind changes in the structure and shape of the face and head in a mouse model of Down Syndrome.
Researchers have discovered a novel genetic disorder associated with neurodevelopmental differences. The discovery identified the disorder in 21 families from all over the world.
Researchers design “mini gene” therapy for severe syndrome that causes blindness and deafness
A gene in the brain driving anxiety symptoms has been identified by an international team of scientists. Critically, modification of the gene is shown to reduce anxiety levels, offering an exciting novel drug target for anxiety disorders. The discovery, led by researchers at the Universities of Bristol and Exeter, is published online today [25 April] in Nature Communications.
Researchers have identified new genetic mutations linked to a subset of canine bladder cancers. Their findings have implications both for early cancer detection and for targeted treatments in dogs and humans.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
The genomes of two hornet species, the European hornet and the Asian hornet (or yellow-legged hornet) have been sequenced for the first time by a team led by UCL (University College London) scientists.
Cedars-Sinai investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.
We finally know why our DNA has an X shape. This finding by researchers at the Netherlands Cancer Institute may have much broader implications for how our cells behave.
An extra copy of a gene that controls synapse formation in the cortex causes excessive inhibitory signaling and may contribute to Down syndrome, according to a new study publishing April 20th in the open access journal PLOS Biology by Bing Ye of the University of Michigan, US, and colleagues.
Cedars-Sinai investigators have identified a genetic variant that increases people’s risk of developing perianal Crohn’s disease, the most debilitating manifestation of Crohn’s disease.
Obesity and its associated cardiometabolic issues are a major health concern in the U.S. and internationally. According to a study published in 2017, 12% of the world's adult population was affected by obesity in 2016, double the percentage from 30 years earlier.
Details of the mechanisms at the cellular level remain hidden from view. Now, special reporter proteins developed by a research team led by the Technical University of Munich (TUM) may help unveil these mechanisms.
University of School of Medicine researchers have identified a gene that plays a crucial role in determining our risk for heart attacks, deadly aneurysms, coronary artery disease and other dangerous vascular conditions.
Vitamin D deficiency could be the reason African American men experience more aggressive prostate cancer at a younger age compared with European American men, new research from Cedars-Sinai Cancer suggests.
Vestibular schwannomas related to neurofibromatosis type 2 (NF2) are difficult to manage and are sometimes treated with a noninvasive option, stereotactic radiosurgery. A retrospective study conducted by an international, multicenter team found that stereotactic radiosurgery is effective for patients with these tumors while preserving serviceable hearing and not causing radiation-related tumor development or malignant transformation.
Tisch Cancer Center scientists have developed unique models of the deadliest blood cancer, acute myeloid leukemia (AML), creating a transformative resource to study this cancer and eventually its drug response and drug resistance. The models were described in a late-breaking abstract at the annual meeting of the American Association of Cancer Research and simultaneously published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.
A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered that co-occurring mutations in three tumor suppressor genes – KEAP1, SMARCA4 and CDKN2A – are linked with poor clinical outcomes in patients with KRAS G12C-mutant non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitors adagrasib or sotorasib.
Long obscured in the shadows of history, the world’s first nomadic empire - the Xiongnu - is at last coming into view thanks to painstaking archaeological excavations and new ancient DNA evidence.
Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.
The Association for Research in Vision and Ophthalmology (ARVO) announced today that Patrick Yu-Wai-Man, MD, PhD (University of Cambridge, U.K.), is the 2023 recipient of the Ludwig von Sallmann Clinician-Scientist Award.
To better understand the inner workings of the seemingly enigmatic Xiongnu empire, an international team of researchers at the Max Planck Institutes for Evolutionary Anthropology (MPI-EVA) and Geoanthropology (MPI-GEO), Seoul National University, the University of Michigan, and Harvard University conducted an in-depth genetic investigation of two imperial elite Xiongnu cemeteries along the western frontier of the empire: an aristocratic elite cemetery at Takhiltyn Khotgor and a local elite cemetery at Shombuuzyn Belchir.
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