Deciphering the Functions Encoded in Phage Genomes
Department of Energy, Office of ScienceBacteriophages are the most common biological entities in microbial communities, but it has been challenging to study their biology. As a result, the genomes of most phages contain many genes of unknown function. In this study, researchers developed a new CRISPR-based technology to reduce the activity of genes in phages to determine if those genes are essential.