Curated News: National Institute of General Medical Sciences (NIGMS)

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Newswise: Two new papers demonstrate use of Outbreak.info as one-stop online source for COVID data
Released: 23-Feb-2023 5:45 PM EST
Two new papers demonstrate use of Outbreak.info as one-stop online source for COVID data
Scripps Research Institute

While COVID-19 may be transitioning from a “pandemic” to an “endemic” phase, it remains critically important to continue tracking the virus in real-time.

Released: 14-Feb-2023 2:50 PM EST
Multiplication on, multiplication off: Targeting an enzymatic switch to develop oncology drugs
University of Illinois Urbana-Champaign

Interdisciplinary research highlighted lipid-protein interaction as a new avenue for oncology drug development, demonstrating its functionality by designing small molecule-based inhibitors to target acute myeloid leukemia.

Newswise:Video Embedded computer-model-ids-roles-of-individual-genes-in-early-embryonic-development
VIDEO
Released: 10-Feb-2023 4:35 PM EST
Computer model IDs roles of individual genes in early embryonic development
Washington University in St. Louis

Computer software developed at Washington University School of Medicine in St. Louis can predict what happens to complex gene networks when individual genes are missing or dialed up more than usual. Mapping the roles of single genes in these networks is key to understanding healthy development and finding ways to regrow damaged cells and tissues. Likewise, understanding genetic errors could provide insight into birth defects, miscarriage or even cancer.

Newswise: LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
Released: 30-Jan-2023 4:30 PM EST
LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
La Jolla Institute for Immunology

Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.

   
27-Jan-2023 9:45 AM EST
Clemson scientists identify enzyme that reduces diet-induced obesity in humans
Clemson University

Clemson University researchers have identified an enzyme and its products in humans that reduce diet-induced obesity.

Newswise: Study reveals obesity-related trigger that can lead to diabetes
10-Jan-2023 2:00 PM EST
Study reveals obesity-related trigger that can lead to diabetes
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese.

Released: 5-Jan-2023 1:40 PM EST
Electrochemistry converts carbon to useful molecules
Cornell University

A chemistry collaboration led to a creative way to put carbon dioxide to good – and even healthy – use: by incorporating it, via electrosynthesis, into a series of organic molecules that are vital to pharmaceutical development.

Newswise: Dry eye disease alters how the eye’s cornea heals itself after injury
29-Dec-2022 3:15 PM EST
Dry eye disease alters how the eye’s cornea heals itself after injury
Washington University in St. Louis

Studying mice, researchers at Washington University School of Medicine in St. Louis have found that proteins made by stem cells to help regenerate the cornea may become new targets for treating and preventing injuries to the cornea related to dry eye disease. When eyes are dry, the cornea is more susceptible to injury.

Released: 22-Dec-2022 7:40 PM EST
In some US zip codes, young men face more risk of firearm death than those deployed in recent wars
Brown University

The risk of firearm death in the U.S. is on the rise: in 2020, firearms became the leading cause of death for children, adolescents and young adults. Yet the risk is far from even — young men in some U.S. zip codes face disproportionately higher risks of firearm-related injuries and deaths.

Newswise: Digital Marker for Coronary Artery Disease Built by Researchers at Mount Sinai
19-Dec-2022 7:00 PM EST
Digital Marker for Coronary Artery Disease Built by Researchers at Mount Sinai
Mount Sinai Health System

Using machine learning and clinical data from electronic health records, researchers at the Icahn School of Medicine at Mount Sinai in New York constructed an in silico, or computer-derived, marker for coronary artery disease (CAD) to better measure clinically important characterizations of the disease.

Newswise: Space and time influence G-protein coupled receptor interactions
Released: 5-Dec-2022 3:55 PM EST
Space and time influence G-protein coupled receptor interactions
St. Jude Children's Research Hospital

By simulating molecular dynamics, scientists from St. Jude Children’s Research Hospital revealed how the selectivity or promiscuity of GPCR coupling relies on the location and duration of intermolecular interactions.

Released: 1-Nov-2022 9:05 AM EDT
Light of Transformation: Research Explores the Inner Workings of Chemical Change
Binghamton University, State University of New York

Binghamton University Assistant Professor of Chemistry Jennifer Hirschi recently received a Maximizing Investigators’ Research Award for $1.93 million from the National Institute of General Medical Sciences to study the mechanisms involved in catalytic reactions.

Released: 27-Oct-2022 4:20 PM EDT
UAlbany Researchers Awarded $1.4M to Identify RNAs Linked to Cancer and Bacterial Infections
University at Albany, State University of New York

Researchers from The RNA Institute at the University at Albany have been awarded $1.4 million to investigate stress-induced RNA modifications and associated cell response. The focus of the study — “wobble uridines” in tRNA — could hold important clues for treating bacterial infections and detecting cancer.

Released: 17-Oct-2022 10:05 AM EDT
Protein IDs, drug candidates, show promise for COVID science
Cornell University

A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.

   
Newswise: Jianhua Zhao awarded $2.4M to reveal cancer targets through atomic-resolution imaging
Released: 2-Aug-2022 6:05 PM EDT
Jianhua Zhao awarded $2.4M to reveal cancer targets through atomic-resolution imaging
Sanford Burnham Prebys

Assistant Professor Jianhua Zhao, Ph.D., has been awarded a unique and competitive grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH). The five-year, $2.4 million grant aims to give researchers greater research flexibility to work on fundamental questions in biology.

Newswise: Protein Parts Must Indeed Wiggle and Jiggle to Work Right, New Research Suggests
14-Jul-2022 11:00 AM EDT
Protein Parts Must Indeed Wiggle and Jiggle to Work Right, New Research Suggests
Johns Hopkins Medicine

Johns Hopkins Medicine scientists report they have probed the atomic structure of proteins to add to evidence that the wobbles, shakes and quivers of proteins play a critical role in their ability to function. The findings of the research may help scientists design new drugs that can modify or disrupt the intricate “dances” of proteins to alter their functions.

Newswise: Research Centered on Single Cells May Open Doors to New Discoveries on Disease Processes
Released: 22-Jun-2022 2:15 PM EDT
Research Centered on Single Cells May Open Doors to New Discoveries on Disease Processes
Stony Brook University

Gábor Balázsi, PhD, and his research team in the Laufer Center and the Department of Biomedical Engineering at Stony Brook University are embarking upon a new way to research cells, the building blocks of life and often triggers to disease when their behavior changes.

   
Newswise: Johns Hopkins Medicine Researchers Link Sugar-Studded Protein to Alzheimer’s Disease
Released: 25-May-2022 12:40 PM EDT
Johns Hopkins Medicine Researchers Link Sugar-Studded Protein to Alzheimer’s Disease
Johns Hopkins Medicine

Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.

Newswise:Video Embedded university-of-kentucky-receives-renewed-11-4-million-grant-to-further-cancer-research
VIDEO
Released: 25-May-2022 9:55 AM EDT
University of Kentucky Receives Renewed $11.4 Million Grant to Further Cancer Research
University of Kentucky

The University of Kentucky’s Center for Cancer and Metabolism (CCM) will continue its critical mission to research the metabolism of cancer with a renewed Centers of Biomedical Research Excellence (COBRE) grant award from the National Institutes of General Medical Sciences, part of the National Institutes of Health. The prestigious grant — totaling $11.4 million — will continue to fund UK’s CCM over the next five years.

Released: 19-May-2022 2:45 PM EDT
Without ‘work-life balance,’ this protein may promote disease
Ohio State University

A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests.



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