Study Differentiating Function of Two Immune Cells Could Improve Vaccine Design
Rutgers University-New BrunswickRutgers researchers find that one type of tissue-resident memory cell fights reinfection better than another.
Rutgers researchers find that one type of tissue-resident memory cell fights reinfection better than another.
• In a population-level study of 1,105 adults with stable glomerular disease (a type of autoimmune kidney disease), a first dose of a COVID-19 vaccine was not associated with relapse risk; however, receiving a subsequent vaccine dose was associated with a 2-fold higher relative risk of relapse. • Importantly, the increase in absolute risk associated with vaccination was low (1–5% depending on type of glomerular disease), and most vaccine-associated disease flares were mild.
Patients with cancer and a weakened immune system who are treated with immunotherapies tend to fare far worse from COVID-19 than those who haven't received such therapies in the three months before their COVID diagnosis, show findings in a new study by researchers at Dana-Farber Cancer Institute, and across the U.S., Canada, and Mexico. Researchers found worse outcomes in both the disease itself as well as the fierce immune response that sometimes accompanies it.
A comprehensive review and meta-analysis of published research confirm that young adults (40 years old and younger) have a slightly elevated risk for myocarditis or pericarditis after mRNA COVID-19 vaccination.
A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) blocked infection when tested in human cells in a laboratory setting.
A 5-year-old with “brain on fire” autoimmune disorder improves with blood plasma exchanges
Cecilia Lindestam Arlehamn, Ph.D., aims to shed light on how sex-based immune system differences may affect the development and progression of these neurodegenerative diseases in men versus women.
Researchers have found a small molecule enzyme inhibitor capable of manipulating an immune process that plays an important role in cancers and autoimmune diseases.
COUR Pharmaceuticals, a clinical-stage biotechnology company developing novel immune-modifying nanoparticles designed to reprogram the immune system for the treatment of autoimmune disorders (COUR NanoParticles or CNPs), today announced that the U.S. Food and Drug Administration has cleared an Investigational New Drug (IND) application to initiate a Phase 1b/2a proof-of-concept study of COUR's investigational therapy, CNP-106.
This model can be used by researchers to discover targets for treatments that improve walking, cognitive, coordination and visual disabilities in MS.
An international team of scientists who analyzed centuries-old DNA from victims and survivors of the Black Death pandemic has identified key genetic differences that determined who lived and who died, and how those aspects of our immune systems have continued to evolve since that time.
Receiving a medical diagnosis can be difficult. You may only hear parts of the conversation as you start to think about what treatment will be needed and how this will affect your daily life. It can be especially challenging when different diseases have names that sound similar, such as inflammatory bowel disease, or IBD, and irritable bowel syndrome, or IBS. Daisy Batista, M.D., a gastroenterologist at Mayo Clinic Health System-La Crosse, explains the difference between the two diseases.
医疗诊断可能是困难重重的。当您开始考虑需要哪种治疗以及您的日常生活将受到怎样的影响时,得到的信息往往很片面。如果不同疾病的名称听起来十分相似,这种困难将尤为明显,例如炎性肠病(IBD)和肠易激综合征(IBS)。拉克罗斯市妙佑区域医疗系统的胃肠科医生Daisy Batista(医学博士)解释了这两种疾病之间的差异。
Receber um diagnóstico médico pode ser difícil. Você pode ouvir apenas partes da conversa quando começa a pensar sobre qual tratamento será necessário e como isso afetará a sua rotina diária. E pode ser especialmente desafiador quando doenças diferentes têm nomes parecidos, como a doença inflamatória intestinal (ou DII) e a síndrome do intestino irritável (ou SII). A Dra. Daisy Batista, M.D., gastroenterologista do Sistema de Saúde da Mayo Clinic em La Crosse, explica a diferença entre as duas doenças.
لاكروس، ولاية ويسكنسن- قد يكون الحصول على تشخيص طبي أمرًا صعبًا. فبمجرد أن تسمع جزءًا من المحادثة، تبدأ في التفكير في العلاج الذي ستحتاجه وكيف سيؤثر ذلك على حياتك اليومية. قد يكون الأمر صعبًا خاصةً عندما يكون للأمراض المختلفة أسماءٌ تبدو متشابه، مثل مرض الأمعاء الالتهابي (IBD)، ومتلازمة القولون المتهيج (IBS). ديزي باتيستا، دكتورة الطب، وطبيبة الجهاز الهضمي في نظام مايو كلينك الصحي في لاكروس، تشرح الفرق بين المرضين.
ecibir un diagnóstico médico puede ser difícil, porque el paciente escucha solo partes de la conversación mientras empieza a pensar en el tratamiento que será necesario y cómo este afectará su vida diaria. Esto puede ser aún más complejo en el caso de enfermedades que tienen nombres muy similares, como es el caso de la enfermedad inflamatoria intestinal y el síndrome de colon irritable. La Dra.Daisy Batista, gastroenteróloga del Sistema de Salud de Mayo Clinic en La Crosse, explica la diferencia entre estas dos enfermedades.
The Endocrine Society and the European Society of Endocrinology (ESE) have jointly awarded the 2023 Transatlantic Alliance Award—to Prof. George P. Chrousos, M.D., Sc.D.
Gigi Robinson will deliver a lunch keynote session at the Autoimmune Association’s annual Autoimmune Community Summit.
What is autoimmune-associated epilepsy, and how is it different from acute seizures with an autoimmune cause? How can clinicians best diagnose and treat these conditions? Sharp Waves reporter Dr. Maryam Nabavi-Nouri spoke with Dr. Claude Steriade.
A new study focused on the immune system’s Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.
A $50 million gift from Stewart and Judy Colton will accelerate the existing Colton Center for Autoimmunity at the University of Pennsylvania’s Perelman School of Medicine into an internationally leading center of autoimmune research and treatment with a dedicated space, powerful recruitment capabilities, scientific resources, and more. This gift builds on a $10 million gift from the Coltons, which established the Colton Center for Autoimmunity at Penn in the fall of 2021.
A McMaster University-led has found that most people infected with the SARS-CoV2 virus recover within 12 months, irrespective of the severity.
Early intervention with rituximab, a drug used in the treatment of rheumatoid arthritis (RA), can reduce the risk of deterioration in myasthenia gravis, an autoimmune disease that causes loss of muscle control.
LMU molecular biologist Gunnar Schotta has investigated which mechanisms prevent endogenous retroviruses from becoming overly active.
In a large study led by researchers at the American Cancer Society, men and women who drank two or more servings of sugar-sweetened beverages (SSB) per day, compared to people who never drank, had a five percent increased risk of death from an obesity-related cancer, including gastrointestinal, postmenopausal breast, endometrial and kidney cancer.
“Dr. Welford works closely with both basic science and clinical investigators to understand the biology of cancer and develop new therapies that will lead to better clinical outcomes. His excellence in translational research is founded on strong basic science discoveries,” Dr. El-Rifai said.
The American College of Rheumatology (ACR) released a summary of its updated guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. New osteoporosis medications and new literature have become available since the last ACR treatment guideline was published in 2017.
Popping a pill may bring short-term relief for arthritis-related joint pain, but many older adults may not realize that what they swallow could raise their risk of other health problems, or that other non-drug options could help them, a new poll suggests.
The latest research and expert commentary on pain management.
A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai
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The latest research and expert commentary on the monkeypox outbreak.
There’s no cure for lupus, an autoimmune disease that attacks organs. But today, scientists report they have begun phase 2 clinical trials with a pill containing a compound that, in mice, reverses organ damage and prevents death. They will present their results at ACS Fall 2022.
Nunzio Bottini, MD, PhD, whose groundbreaking research focuses on the role of a group of proteins in the development of rheumatic diseases, has joined Cedars-Sinai as the inaugural director of the Kao Autoimmunity Institute.
Researchers at Michigan Medicine have uncovered the enigmatic mechanism that genetically predisposes people to the worst effects of the most typical form of lupus, a study suggests. Researchers say the findings could potentially facilitate the discovery of safe, simple and effective treatments.
The Vasculitis Foundation applauds Ashton Kutcher for publicly sharing his diagnosis of vasculitis.
The Phase I clinical trial will test umbilical cord-derived stem cells to treat two rare autoimmune conditions.
Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
KSL Beutner Laboratories (Beutner), a global leader in immunologic testing for the diagnosis of bullous, vascular, connective tissue and inherited skin diseases, has launched a first-to-market indirect immunofluorescence (IIF) serum blood test in the U.S. that positively identifies laminin 332, an antigen associated with the chronic, debilitating autoimmune disease mucous membrane pemphigoid (MMP).
Neutrophils are a type of white blood cell that helps fight illness and disease by traveling to the body’s infected site to seek and destroy harmful pathogens.
Tufts University School of Medicine immunologist Pilar Alcaide explains what autoimmune diseases are, what causes them, who gets them the most, and what can be done about them.
People with systemic lupus erythematosus, or SLE, who received a “booster” dose of SARS-CoV-2 vaccine after full vaccination are roughly half as likely to have a subsequent “breakthrough” COVID-19 infection, a new study shows.
Using UT Southwestern’s Cryo-Electron Microscopy Facility, researchers for the first time have captured images of an autoantibody bound to a nerve cell surface receptor, revealing the physical mechanism behind a neurological autoimmune disease. The findings, published in Cell, could lead to new ways to diagnose and treat autoimmune conditions, the study authors said.
Stiff person syndrome spectrum disorders are rare autoimmune and neurological disorders that most often cause muscle stiffness and spasms in the torso and limbs. According to a small, preliminary study released today, a blood treatment called plasmapheresis, also known as therapeutic plasma exchange, may be a safe way to treat stiff person syndrome spectrum disorders. The research will be presented at the new American Academy of Neurology Summer Conference: Autoimmune Neurology and Neurology Year in Review in San Francisco, July 15 to 16, 2022. Researchers also found that many study participants also experienced an improvement in symptoms or function, or both, while being treated with this therapy.
Along with the central nervous system, the immune system may play a fundamental role in Amyotrophic Lateral Sclerosis (ALS), suggesting that bone marrow transplants may be an effective novel treatment for the neurodegenerative disease, according to findings from a research team that included Albert LaSpada, MD, PhD, distinguished professor of pathology, neurology and biological chemistry at the University of California, Irvine School of Medicine.
Interstitial pneumonia with autoimmune features (IPAF) is a disease with many possible causes and no standard of care, making it particularly difficult to treat. While immunosuppressant drugs are primarily prescribed, they don’t work for all patients.
Researchers identify new mechanism that teaches immune cells-in-training to spare the body’s own tissues while attacking pathogens.
The Autoimmune Association supports a recommendation that the National Institutes of Health (NIH) should create an Office of Autoimmune Disease/Autoimmunity Research within the Office of the Director, a key finding from a new report from the National Academies of Sciences, Engineering, and Medicine.
Here are some of the latest articles that have been added to the Aging channel on Newswise, a free source for journalists.
New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system’s ability to protect against infection. The findings, published in Science Immunology, explain why patients with rare mutations in a gene that codes for this machinery are often immunodeficient and could offer new approaches to treat autoimmune diseases.