New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 – the presence of which is used in the lab to detect and stage various types of cancers – is not just a biomarker for the disease, but may play a critical role in tumor growth.
Multiple myeloma uses a trick akin to a wolf in sheep’s clothing to grow in and spread to new bone sites. By overexpressing Runx2, a gene that normally is a master regulator of bone formation, the cells of this largely incurable cancer produce proteins that mimic the normal bone-resident cells.
A new study in the Journal of Immunotherapy finds that T cells from patients with melanoma can trigger a protective immune response against the disease.
It’s the season for backyard grilling, campfires, fireworks – and burn injuries. Over the next few months, U.S. burn centers will see thousands of severe burns requiring painful skin grafts and lengthy treatment. Researchers are developing new ways to use already approved therapies to help alleviate the anxiety and pain of burn treatments – as well as improve outcomes.
Monte Shaheen, MD, and colleagues from around the country recently published a paper in the New England Journal of Medicine about a promising new treatment for melanoma.
A rigorous analysis of more than 20,000 medical records concludes that erectile dysfunction drugs, such as Viagra, are not a cause of melanoma, an often deadly form of skin cancer, despite the higher risk for the disease among users of these drugs.
Topics include: women's health, cancer care, research at the Large Hadron Collider, dementia drug treatment, dermatology, skin cancer, breast cancer, smoking risks, and genetics.
Boni Elewski, M.D., and Wendy Cantrell, DNP, pursue research and therapies that bring new drugs to market and change patients’ lives.
The development of targeted therapies has significantly improved the survival of melanoma patients over the last decade; however, patients often relapse because many therapies do not kill all of the tumor cells, and the remaining cells adapt to treatment and become resistant. Moffitt Cancer Center researchers have discovered a novel mechanism that can lead melanoma cells to develop resistance to drugs that target the protein BRAF.
PHOENIX, Ariz. — Mayo Clinic and the Translational Genomics Research Institute (TGen) are helping launch a national clinical trial that will apply the latest in precision medicine to treat advanced melanoma skin cancer.
Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a new study.
As many begin to spend long summer days outside, it’s crucial to have the right information about skin protection and the dangers of sun exposure. Today, Montefiore dermatologist Dr. Holly Kanavy debunks many widely-shared myths regarding skin care and offers accurate information to help people enjoy the outdoors this summer while preserving their skin.
A University of Manchester led trial of a new psoriasis drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement.
Whenever your skin is injured, a scar may form, but there are things you can do at home to help care for these types of minor injuries and reduce the appearance of scars.
Trending news releases with the most views in a single day. Topics include: neurology, cancer, immunotherapy, Alan Alda present science award, genetics, vision, lung cancer, prostate cancer, environmental health.
A Phase 3, multicenter clinical trial led by Ludwig Cancer Research investigators Jedd Wolchok and Stephen Hodi shows that the combination of two immunotherapies—ipilimumab and nivolumab—induces more frequent responses and considerably longer progression-free survival in patients with advanced melanoma than the administration of either of them alone. The results of the trial, which confirm those of a smaller study similarly conducted in previously untreated patients by the same Ludwig scientists, were presented today at the 2015 American Society for Clinical Oncology Annual Meeting and published online later today in the New England Journal of Medicine.
Treating advanced melanoma patients with either a combination of the immunotherapy drugs nivolumab and ipilimumab or nivolumab alone significantly increases progression-free survival over using ipilimumab alone, according to Memorial Sloan Kettering researchers.
The incidence of melanoma, a deadly form of skin cancer, has increased by more than 250% among children, adolescents and young adults since 1973, according to award-winning research to be presented by Roswell Park Cancer Institute (RPCI) at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting in Chicago.
Scientists have found that stage IIIb to IV melanoma patients treated with a modified cold sore (herpes) virus had improved survival. The results of the findings were published recently in the Journal of Clinical Oncology.
Study explains why some melanoma tumors are resistant to BRAF inhibitor treatment
Trending news releases with the most views in a single day. Topics include: income inequality, climate change, genetics, cancer, precision medicine, medical imaging, schizophrenia, research funding, molecular biology and skin cancer.
In what they believe to be the first survey of its kind in the United States, researchers at NYU Langone Medical Center have found that as many as 6 percent of adult New Yorkers who get “inked” — in other words, those who get a tattoo — have experienced some form of tattoo-related rash, severe itching or swelling that lasted longer than four months and, in some cases, for many years.
A three-dimensional imaging technique often used in the automotive and aerospace industries for accurate measurement may be useful to measure the efficacy of injectable wrinkle reducers such as Botox and Dysport, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Researchers have uncovered a new molecular mechanism - a function of the NONO protein - whereby cells protect their genome from the detrimental effect of UV radiation and govern DNA replication in cellular mitosis. A recent study investigates what happens when this molecular mechanism malfunctions.
A national regulatory framework designed to prevent and limit indoor tanning is needed to alleviate the cancer burden and reduce the billions in financial costs from preventable skin cancer, say two Georgetown University public health experts.
Collagen is the most abundant protein in the human body, and investigators are uncertain how its presence affects the behavior of melanoma cells.
Trending news releases with the most views in a single day. Topics include: genetics, cancer, nanotech, elderly care, marketing research, energy, children's health, and immunology.
Research by Howard L. Kaufman, MD, FACS, associate director for clinical science and chief surgical officer at Rutgers Cancer Institute of New Jersey and colleagues shows advanced-stage melanoma patients have significant improvement in durable response rate when treated with a genetically-modified form of a herpes virus, whose native form causes the common cold sore.
Exposure to ultraviolet radiation is the most preventable risk factor for all types of skin cancer. But according to new research published in the Journal of the American Academy of Dermatology, the majority of Americans are not regularly using sunscreen to protect themselves from the sun’s harmful UV rays.
Three million cases of skin cancer could be prevented annually by avoiding ultraviolet light. UAB experts share how to pick out the proper UV-protection and use it effectively.
Although most bug bites and stings are harmless, some can be dangerous. This is especially true if you are allergic to the bug’s venom, or if the bug is carrying a disease. In the United States, it’s common to experience a bite or sting from mosquitoes; fleas; spiders; bees, wasps and hornets; biting flies; mites; ticks; fire ants; and bedbugs.
Mississippi State University Extension Service agent Shelaine Pennington and MSU Extension health specialist Dr. David Buys discuss Pennington's skin cancer scare and tips for lifestyle changes for Skin Cancer Awareness Month.
In findings reported in Cell Death and Differentiation, the researchers demonstrate that the enzyme GMPS drives melanoma growth, and propose a new strategy for targeting that protein.
In recognition of Melanoma/Skin Cancer Detection and Prevention Month® in May and Melanoma Monday®, observed on May 4 this year, the American Academy of Dermatology (Academy) asks the public to consider “Who’s Got Your Back?” when it comes to applying sunscreen and examining skin for suspicious spots.
A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published in the journal Clinical Cancer Research, the authors report that they found high levels of an enzyme in melanoma samples that they believe is a potential drug target.
Young women may be up on the latest fashions and trends as they prepare for prom season. But what many don’t know is that the tan that looks oh-so-good with their dress may be the first step toward skin cancer.
A http:team of international scientists has identified hundreds of possible new genes in mice that could transform benign skin growths into deadly melanomas.
In the first major study to examine the use of a computer-assisted, photo-driven differential diagnosis generator for skin conditions, researchers at the Perelman School of Medicine at the University of Pennsylvania found physicians routinely used the tool, without an increase in calling for inpatient dermatology consultations.
Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives.
Research from Rutgers Cancer Institute of New Jersey and Rutgers School of Public Health shows more than a third of New Jersey high school students who engage in indoor tanning do so frequently and many would find it hard to stop the practice. Investigators also found that frequent indoor tanners were more likely to smoke and to engage in social media activities related to indoor tanning.
Once again, researchers at Penn’s Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.
If you have a cold sore – small blisters on the lip or around the mouth – you’re not alone. More than half of Americans ages 14 to 49 carry the virus that causes cold sores. The virus stays in the body even after the cold sores clear. If the virus reactivates, or wakes up, you could get cold sores.
A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.
A new study finds that the incidence of pediatric melanoma in the United States decreased from 2004 to 2010.
"Tanning beds cause skin cancer. It is time to now more openly announce this causality," says Robert P. Dellavalle, MD, PhD, MSPH, investigator at the CU Cancer Center, in the American Journal of Preventive Medicine.
The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations.
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