Feature Channels: Pharmaceuticals

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Certified Registered Nurse Anesthetists (CRNAs) and other healthcare professionals will gather and discuss issues and solutions for enhanced recovery after surgery, access to quality anesthesia care, and technology’s role in healthcare, among other topics during the Nurse Anesthesia Annual Congress of the American Association of Nurse Anesthetists (AANA), Sept. 21-25, 2018, in Boston, Mass.

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The inaugural lecture on diversity and inclusion is named after the American Association of Nurse Anesthetists’ 1973-1974 President, Goldie D. Brangman, MEd, MBA, CRNA. Brangman is the first and only African-American President of the AANA and will celebrate her 101st birthday in October.

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This first randomized clinical study of a polymer-coated zotarolimus-eluting stent (Resolute Onyx) that utilizes a novel thin-strutted metallic platform allowing for better x-ray visibility was shown to be non-inferior to an ultrathin-strutted bioresorbable polymer-coated sirolimus-eluting stent (Orsiro) that uses a cobalt-chromium strut platform.

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The University of Texas MD Anderson Cancer Center today joined with more than 450 communities and institutions across the country in hosting a Biden Cancer Community Summit, organized under the charge of the Biden Cancer Initiative. The Summit aims to encourage an ongoing dialogue about opportunities to make significant advances in cancer research, prevention, diagnosis and care.

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A University of Arkansas at Little Rock spin-off company, NuShores Biosciences, LLC, has received a $1.7 million grant to study how NuShores’ bone regeneration technology can be applied in craniofacial tissues. The National Institute of Dental and Craniofacial Research, a component of the National Institutes of Health, has awarded the company a 2.

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A small study shows that business managers and staff—such as those running coffee shops and fast-food restaurants—can be trained to reverse opioid overdoses, which are known to occur in public bathrooms.

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Hurricane Florence made landfall in North and South Carolina days ago, but Penn Medicine Hospitals and other facilities nationwide have planned for weeks to adapt to expected drug shortages associated with its path of destruction.

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Enthusiasm for an emerging digital health tool, the smart pill, is on the rise but researchers at the University of Illinois at Chicago have published a paper in the American Journal of Bioethics that cautions health care providers and policymakers to slow down when it comes to allowing this technology in patient care settings.

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Death rates from drug overdoses in the U.S. have been on an exponential growth curve that began at least 15 years before the mid-1990s surge in opioid prescribing, suggesting that overdose death rates may continue along this same historical growth trajectory for years to come.

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Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell’s binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.

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A new study published in the Journal of the American Heart Association shows disparities between the care given to black and white patients seeking treatment for a type of heart attack called NSTEMI (Non-ST-elevation myocardial infarction).

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The medical community has long known that patients on long-term opioid therapy often have significantly more health care visits. But adhering to a standardized care process model for opioid prescriptions appears to reduce the overall number of health care visits for these patients while maintaining safety, shows new research published in Mayo Clinic Proceedings.

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Under the three-year program, minority physicians will be recruited to conduct clinical trials—research studies that prospectively assign human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. The goal is to encourage more minority patients to participate in clinical trials by taking trials directly to minority patient populations.

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Physician-scientists at The University of Kansas Cancer center are designing and initiating their own clinical trials.

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By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or “ecstasy,” scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree.

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MyoKardia, a clinical-stage biopharmaceutical company pioneering precision medicine for the treatment of cardiovascular diseases, today announced the launch of the MyoSeeds™ Research Grants Program, a new initiative to support original, independent research in the biology and underlying mechanisms of cardiomyopathies and precision heart disease treatment with the goal of improving the lives of patients.

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Effective management of neonatal abstinence syndrome (NAS) – withdrawal symptoms occurring in infants exposed to opioids in utero – requires a coordinated "cascade of care" from prevention through long-term follow-up, reports a study in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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On September 20, a coalition of health care leaders will host a summit, “Drug Shortages as a Matter of National Security: Improving the Resilience of the Nation’s Health Care Critical Infrastructure.” The meeting will examine vulnerabilities in the supply chain, U.S. dependence on foreign-sourced pharmaceutical ingredients, disaster planning and response efforts, and risk factors associated with pharmaceutical manufacturing and distribution.

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Researchers at University of California San Diego School of Medicine have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings, published September 18 in Cell Reports, suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis.

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Researchers at University of California School of Medicine are preparing to launch a novel clinical trial to examine the safety, efficacy and pharmacological properties of cannabis as a potential treatment for adults with essential tremor (ET). Currently, ET is treated using repurposed medications originally developed for high blood pressure or seizures.

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The PhRMA Foundation announced today the launch of a new online educational series for medical, nursing and pharmacy schools on safe and effective prescribing, featuring instruction from national experts.

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he University of Pennsylvania Health System and Grand View Health have announced a new alliance focused on the development of joint clinical care programs to improve health care for people in Bucks and Montgomery counties and the surrounding areas.

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Value in Health, the official journal of ISPOR (the professional society for health economics and outcomes research), announced the publication of a series of articles that tackle the challenges associated with assessing the value of next-generation sequencing technologies in clinical care.

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The American Society of Anesthesiologists (ASA) applauds the Senate for the passage of the Opioid Crisis Response Act (“OCRA”), a bill that includes several bipartisan provisions supported by ASA that will help address the nation’s ongoing opioid abuse epidemic. In particular, ASA commends the Senate for the inclusion of the provision that would provide technical assistance and grants to hospitals and other acute care settings on alternatives to opioids for pain management. This will support the development of best practices on the use of alternatives to opioids; technologies or techniques to identify patients at risk for opioid use disorder; disseminating information on the use of alternatives to opioids; and collecting data and reporting on health outcomes associated with the use of alternatives to opioids. ASA was pleased to coordinate with policymakers on this concept.

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Case Western Reserve University School of Medicine has received a three-year, $1,118,556 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to investigate a new imaging approach for diagnosing peripheral arterial disease, a common and potentially serious circulatory problem. More than 200 million people worldwide suffer from the condition.

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Taking a low-dose aspirin daily does not prolong healthy living in older adults, according to findings from the ASPirin in Reducing Events in the Elderly (ASPREE) trial published online Sept. 16 in three papers in The New England Journal of Medicine.

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The use of probiotics is linked to reduced need for antibiotic treatment in infants and children, according to a review of studies that probed the benefits of probiotics, co-led by a Georgetown investigator.

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Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now identified three new molecular drug targets in Naegleria fowleri and a number of drugs that are able to inhibit the amoeba’s growth in a laboratory dish. Several of these drugs are already approved by the U.S. Food and Drug Administration for other uses, such as antifungal agents, the breast cancer drug tamoxifen and antidepressant Prozac.

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National Comprehensive Cancer Network convenes Policy Summit to address changing care paradigms, and the impact across the cancer care continuum

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Medicaid expansion under the Affordable Care Act does not appear to reduce disparities in use of regionalized surgical care among vulnerable persons.

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New discoveries and innovations in obstetric pharmacology will be highlighted November 1-2, 2018 during “Obstetric-Fetal Pharmacology: Practical Prescribing and Research Methods Update,” a conference for researchers and clinicians to be held at Northwestern University in Chicago.

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Among older Americans, the poorest are the most likely to have used prescription opioids, according to a University at Buffalo study providing new insights into unexplored contours of the opioid crisis. The study also raises important questions about access to pain management options for the disadvantaged in the current climate of the opioid epidemic.

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A new $3 million, five-year grant from the National Heart, Lung and Blood Institute will allow researchers to determine whether a unique program designed to educate people with uncontrolled hypertension — also known as high blood pressure — about the importance of getting their blood pressure under control can help reduce the risk of developing chronic and expensive-to-treat secondary cardiovascular conditions among this high-risk group.

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Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, wet age-related macular degeneration (AMD) and other conditions. Because the drug has been approved to treat malaria for decades, it could move relatively quickly through the pipeline to help patients. The study was published in the journal PLOS ONE.

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Using new bioinformatics tools to analyze thousands of human tissue samples, researchers created a new database of daily rhythms in human gene activity—including many genes that regulate how drugs work. Reporting in Science Translational Medicine, scientists say their results could have significant implications for a growing field of study called circadian medicine.

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A team of scientists has uncovered the neural processes mice use to ignore their own footsteps, a discovery that offers new insights into how we learn to speak and play music.

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The American Society of Anesthesiologists (ASA) will be one of nearly 350 organizations participating in the sixth annual Rally for Medical Research Hill Day, urging our nation’s policymakers to make lifesaving medical research funding a national priority by supporting robust, sustained, and predictable annual increases in funding for the National Institutes of Health (NIH).

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In a proof of concept study, scientists at Johns Hopkins report they have successfully performed 3D personalized virtual simulations of the heart to accurately identify where cardiac specialists should electrically destroy cardiac tissue to stop potentially fatal irregular and rapid heartbeats in patients with scarring in the heart. The retrospective analysis of 21 patients and prospective study of five patients with ventricular tachycardia, the researchers say, demonstrate that 3D simulation-guided procedures are worthy of expanded clinical trials.

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Potential to speed vaccine response to emerging infectious diseases

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The University of Chicago Medicine and Almoosa Specialist Hospital, a private hospital in the Al-Ahsa region of Saudi Arabia offering comprehensive medical care, have signed a collaboration agreement.

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Los Alamos National Laboratory Fellow Bruce Carlsten will explore the ways particle accelerators can improve our lives in three Frontiers in Science public lectures beginning September 17 in Albuquerque.

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A Mayo Clinic se juntou a uma coligação de sete hospitais para lançar a Civica Rx, uma empresa de medicamentos genéricos sem fins lucrativos que irá ajudar os pacientes, solucionando a escassez de medicamentos e os preços elevados dos medicamentos essenciais. A empresa, que é organizada como uma corporação Delaware não estocável, sem fins lucrativos, será sediada em Utah.

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ANESTHESIOLOGY® 2018, the annual meeting of the American Society of Anesthesiologists (ASA), Oct. 13-17, in San Francisco, will bring together more than 14,000 global thought leaders driving the innovation behind the latest scientific and technological advances in anesthesiology.

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Revolutionary Noninvasive Therapy Shows Promise for Immunotherapy and Opening Blood-Brain Barrier to Enable Treatment of Neurological Disease and Cancer

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Mayo Clinic加入了一个七家医院的联盟来成立了一家非盈利的仿制药公司Civica Rx，该公司将致力于解决药物短缺和挽救生命药物的高价等问题来帮助患者。 该公司是一家特拉华州注册的非股份非营利性公司，其总部位于犹他州。

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For couples hoping for a baby via in vitro fertilization, chances have improved. A process that once took hours now takes minutes: Cornell University scientists have created a microfluidic device that quickly corrals strong and speedy sperm viable for fertilization.