Researchers from the McKelvey School of Engineering and Washington University School of Medicine in St. Louis are one step closer to delivering precise amounts of medication to exact location, repurposing an existing imaging "painting" method.
Medically high-risk patients and communication breakdowns between providers contribute to the difficulty of medication management for older adults receiving home health care, finds a study led by researchers at NYU Rory Meyers College of Nursing.
The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.
New research shows that fluctuation and severity of depressive symptoms are much better at predicting risk of suicidal behavior in at-risk young adults.
By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic changeone in a gene involved in muscle formationin five of the tumors.
For nanomedicine to achieve the envisioned breakthroughs in disease treatment, scientists must learn why the immune system often responds inhospitably to these therapies. An NIH-funded team at the University of Colorado (UC) has assembled a clearer picture of the molecular activity that occurs when nanoparticles injected into the body are marked for immune system attack.
Scientists at the University of Southern California (USC), Queen’s University (Ontario) and Duke University have developed a new tool that can screen children for fetal alcohol spectrum disorder (FASD) quickly and affordably, making it accessible to more children in remote locations worldwide.
A team led by José Bauermeister, PhD, MPH, Presidential Professor of Nursing and Director of the Program on Sexuality, Technology, & Action Research (PSTAR), at the University of Pennsylvania School of Nursing (Penn Nursing) designed the My Desires & Expectations (myDEx) tool to address cognitive and emotional factors that influence YGBMSM sexual decision-making when seeking partners online.
New preclinical findings from extensive cell and animal studies suggest that cysteamine bitartrate, a drug already used for a rare kidney disease, could benefit patients with some mitochondrial disorders. No proven effective treatments yet exist for these complex conditions with severe energy deficiency
New research from Washington University in St. Louis shows that when cells divide rapidly, their mitochondria are fused together. In this configuration, the cell is able to more efficiently use oxygen for energy.
The University of Virginia Health System is expanding its telehealth capacity to help patients across Virginia better prevent or manage chronic conditions that include diabetes, prediabetes and heart disease. Through the UVA Center for Telehealth, UVA will expand or pilot several initiatives to battle chronic diseases, including remote monitoring for patients with diabetes, screenings for patients with diabetic eye disease, cardiac rehabilitation programs for heart failure patients and streamlined access to specialists.
Desert snakes slithering across the sand at night can encounter obstacles such as plants or twigs that alter the direction of their travel -- and cause them to mimic aspects of light or subatomic particles when they encounter a diffraction grating.
A powerful tool is available to investigate brain development, memory and learning, and brain dysregulation in neuropsychiatric diseases like addiction, depression, schizophrenia and Alzheimer’s. This molecular biology tool can selectively and robustly turn on genes in brain neurons of living rats.
A team of engineers in the McKelvey School of Engineering has developed a high-powered fuel cell that operates at double the voltage of today’s commercial fuel cells. It could power underwater vehicles, drones and eventually electric aircraft at a significantly lower cost.
A single dose of a PD-1 inhibitor before surgery for melanoma can put patients in remission.
A new ultrasensitive diagnostic device invented by researchers at the University of Kansas, The University of Kansas Cancer Center and KU Medical Center could allow doctors to detect cancer quickly from a droplet of blood or plasma, leading to timelier interventions and better outcomes for patients.
A small, retrospective study has found that, in patients with particular pancreatic duct lesions, the presence of an inherited mutation in a pancreatic cancer susceptibility gene may increase the patients’ risk of developing pancreatic cancer. To verify these results and learn more about the development of this deadly cancer, the researchers recommend more genetic studies. Their hope—in line with the goals of precision medicine—is to eventually find a better way to guide patient care, dividing patients, for example, into those who need regular screening versus immediate surgery or other early interventions.
Scientists have discovered a defect in immune cells known as “killer T cells” that explains their inability to destroy cancer tumors. The researchers believe that repairing this defect could make the cells much better cancer killers.
In a study of older people with no clinical diagnosis or signs of dementia when hospitalized to repair hip fractures, Johns Hopkins researchers say they found biomarkers of Alzheimer’s disease in most of the patients’ spinal fluid samples. The researchers say results of their study add to evidence that brain alterations that lead to poor balance in older people may underpin both increased risk of hip-fracturing falls and Alzheimer’s disease, and that hip fracture itself may therefore serve as a first sign of undiagnosed disease.
The number of low-income patients screened for colorectal cancer more than tripled after Medicaid expansion in 2014, according to study findings in the Journal of the American College of Surgeons.
Biologic age, a DNA-based estimate of a person’s age, is associated with future development of breast cancer, according to scientists at the National Institutes of Health. If a woman’s biologic age was older than her chronologic age, she had a 15 percent increased risk of developing breast cancer.
Research published in the American Journal of Public Health shows CommunityRx helps patients gain confidence finding health resources in their own neighborhoods.
A pair of Affordable Care Act clauses had a sizable effect on the ability of people with diabetes to get health insurance, a new study suggests. Before the requirements took effect, the percentage of people with private health insurance who had diabetes had declined, but it began to increase again after the ACA required insurers to accept people with pre-existing conditions, and limited their ability to charge higher rates to older people.
Bioengineers are designing aortic heart valve replacements made of polymers rather than animal tissues. The goal is to optimize valve performance and enable increased use of a minimally-invasive method for valve replacement over the current practice of open heart surgery.
A new method of increasing the reactivity of ultrathin nanosheets, just a few atoms thick, can someday make fuel cells for hydrogen cars cheaper, finds a new Johns Hopkins study.
Scientists at Scripps Research, inspired by electric car batteries, have developed a battery-like system that allows them to make potential advancements for the manufacturing of medicines.
Over-testing for urinary tract infections (UTIs) leads to unnecessary antibiotic use, which spreads antibiotic resistance. Infectious disease specialists at Washington University School of Medicine in St. Louis made changes to hospital procedures that cut urine tests by nearly half without compromising doctors’ abilities to detect UTIs.
When a honey bee turns 21 days old, she leaves the nest to look for pollen and nectar. For her, this is a moment of great risk, and great reward. It’s also the moment at which she becomes recognizable to other bees.
A multi-institutional, international team of researchers has developed a method that identifies individuals recently infected with Vibrio cholerae O1. The results of the study are available online in the February 20 issue of the journal Science Translational Medicine.
Through a recent five-year, $2.3 million grant from the National Institutes of Health (NIH), University of Kentucky faculty Don Frazier and Brett Spear will partner with faculty from qualified minority-serving institutions across the U.S. and Puerto Rico to help improve diversity in science and health care.
Research led by Johns Hopkins investigators has uncovered the roles of two types of cells found in the vessel walls of fat tissue and described how these cells may help speed bone repair.
Patients were found to often be willing to share their Google search histories with medical researchers, revealing that many do searches on their health concerns long before deciding to go to the hospital.
Needle biopsies detect rejection after a transplanted organ is already in trouble and sometimes miss the mark. And the needle damages tissue. This biocompatible nanoparticle goes to work at the first sign of trouble and could give clinicians much more information with a simple urine test.
In the quest to design more efficient solar cells and light-emitting diodes (LEDs), a team of engineers has analyzed different types of defects in the semiconductor material that enables such devices to determine if and how they affect performance.
Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system’s ability to fight melanoma in mice. The agents, dubbed s-DAB-IL-2 and s-DAB-IL-2(V6A), comprise a regulatory protein called human interleukin-2 fused to chemically modified portions of diphtheria toxin.
Patients taking diuretics are often at risk for low potassium levels, which can put patients at an increased risk of death from cardiac arrhythmias or other causes. But researchers from the Perelman School of Medicine at the University of Pennsylvania found that taking prescription potassium supplements can reduce these patients’ risk by nearly 10 percent as daily outdoor temperatures increase—a time when patients may be at highest risk due to loss of potassium while sweating. These findings are detailed in a study published today in BMJ Open.
A new animal study describes how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life. Investigating the fetal signaling pathways active in this biological event may offer future opportunities to treat lung damage caused by prematurity and other lung injuries.
A new map of newborn babies’ brains offers details of structure that will provide a new reference for researchers studying both typical brain development and neurological disorders. Using noninvasive, 20-minute MRI scans, researchers have revealed some of the complex and precisely organized brain architecture that emerges as the brain reshapes itself during the third trimester of pregnancy.
Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. Investigating the fetal signaling pathways active in the biological events by which alveoli form may offer future opportunities to treat lung damage caused by prematurity and other lung injuries.
Artificial Intelligence is helping to guide and support some 50 breast cancer patients in rural Georgia through a novel mobile application that gives them personalized recommendations on everything from side effects to insurance.
Keck School of Medicine of USC scientists have developed the first standardized framework for clinicians to document physical findings on older patients for better evidence in abuse cases
Project CLEAR clinical trial finds that the application of antiseptic soap, mouthwash, and nose ointments prevent post-discharge MRSA infections and hospitalizations. Patients
Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen in about half of all brain tumors produces a response that prevents radiation treatment from working. Altering that response using FDA-approved drugs restores tumors’ sensitivity to radiation therapy, extending survival in mice.
A high proportion of multidrug-resistant tuberculosis (TB) cases can be cured in conflict-affected communities with molecular diagnostics, shorter treatment periods and socioeconomic incentives, according to the results of a large, long-term study in the Democratic Republic of Congo.
A new tool from the Keck School of Medicine of USC can improve development and effectiveness of leading-edge cancer therapies derived from patients’ immune systems.
By examining how mammary cells respond in a stiffness-changing hydrogel, researchers discovered that several pathways work together to signal breast cells to turn cancerous. The work could inspire new approaches to treating patients and inhibiting tumor growth.
Once deemed nothing more than signal-transmitters, the axons of nerve cells now emerge as far more complex and autonomous than thought, according to new research
When normal cells grow, divide or do any job in the body, they do so in response to a whole slew of internal sensors that measure nutrients and energy supply, and environmental cues that inform what happens outside the cell.
Research has shown patients are discussing initial cancer treatment options with their primary care doctors. And now a new study finds that a significant number of these physicians report notable gaps in their knowledge of cancer treatment options.
Researchers at University of Utah Health detailed the function of cone snail insulins, bringing them one step closer to developing a faster-acting insulin to treat diabetes.
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