A new study at Washington University School of Medicine in St. Louis finds disparities between African-Americans and Caucasians in a key biomarker for Alzheimer’s disease – suggesting that tools to diagnose the disease in Caucasian populations may not work as well in African-Americans.
High-energy X-ray beams and a clever experimental setup allowed researchers to watch a high-pressure, high-temperature chemical reaction to determine for the first time what controls formation of two different nanoscale crystalline structures in the metal cobalt.
As genetic testing for breast cancer has become more complex, evaluating a panel of multiple genes, it introduces more uncertainty about the results. But a new study finds that newer, more extensive tests are not causing patients to worry more about their cancer risk.
Using discarded foreskins from circumcisions, researchers were able to identify a potential cellular mechanism that connects a mother's smoking while pregnant with an increased risk of offspring obesity later in life
The healing of wounded skin in diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows.
Johns Hopkins researchers have shown how to best identify nonadherent patients, combining technology with the perceptions of health care providers.
New research led by Washington University School of Medicine in St. Louis suggests that tailoring treatments to men and women with glioblastoma based on the molecular subtypes of their tumors may improve survival for all patients.
See news and research from participating DOE National Labs in the DOE Science Channel
Newly described mechanism called 'neuritosis' could play an important role in normal brain development, aging and neurodegenerative disease
A community-based, pilot study shows a high-tech app is as effective as low-tech picture card intervention at improving social and communication skills in children with autism.
A team of researchers led by UC San Diego's Michael Burkart describes a new method for creating peptides that could produce biomaterials, like nanostructures and microstructures, to modify proteins.
New research from scientists at the Coriell Institute for Medical Research shows that some individuals whose bodies metabolize ibuprofen more slowly – causing the drug to be present at higher levels than intended – intuitively self-correct their dose without knowing their genetic makeup.
About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs.
Researchers from the George Washington University received more than $3.1 million from the National Institutes of Health to investigate the causes of cardiovascular disease in HIV-infected patients
A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries.
Engineers have developed a neuroinspired hardware-software co-design approach that could make neural network training more energy-efficient and faster. Their work could one day make it possible to train neural networks on low-power devices such as smartphones, laptops and embedded devices.
A team of researchers led by Noa Ofen, Ph.D. at Wayne State University and Lisa Johnson, Ph.D., at the University of California-Berkeley, are addressing the critical gap in our understanding of how maturation of the prefrontal cortex drives memory development through the use of electrocorticographic (ECoG) data.
Researchers used 3D computer modeling to simulate heat exchange in dinosaurs
Biomedical engineer Jon Silva led an international team that determined which patients would benefit the most from a commonly used drug treatment.
The American College of Surgeons today issued a national call for interested hospitals to join the third cohort of the AHRQ ISCR program.
Researchers at the University of Arizona have discovered that metformin, a drug commonly used to treat type 2 diabetes, might also be used to treat heart failure with preserved ejection fraction (HFpEF), a condition that is predicted to affect over 8% of people ages 65 or older by the year 2020. The study, which was published December 19 in the Journal of General Physiology, shows that metformin relaxes a key heart muscle protein called titin, allowing the heart to properly fill with blood before pumping it around the body.
Research completed at Johns Hopkins and the Greater Baltimore Medical Center has demonstrated that vaginal childbirth substantially increases the probability a woman will develop a pelvic floor disorder later in life.
Researchers used NMR to detail how the matrix domain of the Avian Sarcoma Virus Gag protein binds to certain phospholipids. These phospholipids are vital for Gag protein binding to the plasma membrane of a cell, as the virus replicates and takes its first step toward virus formation and budding.
Researcher shows the two most common means of resistance to BRAF and MEK inhibitors are actually connected processes and can be targeted by other therapies.
A study from researchers at Indiana University has found that CBD -- a major chemical component in marijuana -- appears to increase pressure inside the eye of mice, suggesting the use of the substance in the treatment of glaucoma may actually worsen the condition.
A new study from the University of Pennsylvania School of Nursing’s Center for Health Outcomes and Policy Research (CHOPR) describes the quality of end of life care in nearly 500 U.S. hospitals, utilizing nearly 13,000 bedside nurses as informants of quality. The study has been published online first. It will also be in a future issue of the Journal of the American Geriatrics Society.
Results of a medical records study of more than 7,000 patients awaiting a lung transplant in the United States affirm the basis of a court filing in 2017 that called the organ allocation system geographically “rigged” in some regions of the nation.
In a study of adolescent mice with a version of a gene linked to serious human mental illnesses, Johns Hopkins Medicine researchers say they have uncovered a possible explanation for how marijuana may damage the brains of some human teens.
Lab simulations nix common wisdom that atmospheric oxygen and organic compounds are good evidence that a planet harbors life.
Results of a medical records study of children with Crohn’s disease by Johns Hopkins researchers have added substantial evidence for a strong and direct link between malnutrition and increased risk of surgical complications and poor outcomes.
In September 2018, the Centers for Disease Control and Prevention (CDC) awarded funds to 28 state and local health departments across the United States to design, test and evaluate new, innovative approaches to address these significant health problems. The Michigan Department of Health and Human Services (MDHHS) was one of 21 state health departments to receive this funding. As part of this, a new partnership has been forged with Wayne State University researchers who will directly work with MDHHS in their efforts to prevent and manage cardiovascular health and diabetes.
NIBIB-funded researchers are literally breaking barriers using ultrasound waves emitted from a flexible patch to accurately measure central blood pressure and help detect cardiovascular problems earlier. For a while now, smart, wearable devices have had the ability to capture how many steps we take in a day or measure our heart rate, but researchers are starting to take it a step further.
In general, women who have had children have a lower risk of breast cancer compared to women who have never given birth. However, new research has found that moms don’t experience this breast cancer protection until many years later and may face elevated risk for more than 20 years.
When infants are playing with objects, their early attempts to pay attention to things are accompanied by bursts of high-frequency activity in their brain. But what happens when parents play together with them? New research, publishing December 13 in the open-access journal PLOS Biology, by Dr Sam Wass of the University of East London in collaboration with Dr Victoria Leong (Cambridge University and Nanyang Technological University, Singapore) and colleagues, shows for the first time that when adults are engaged in joint play together with their infant, their own brains show similar bursts of high-frequency activity. Intriguingly, these bursts of activity are linked to their baby’s attention patterns and not their own.
Researchers have developed genetically modified pigs that are protected from classical swine fever virus (CSFV), according to a study published December 13 in the open-access journal PLOS Pathogens by Hongsheng Ouyang of Jilin University, and colleagues. As noted by the authors, these pigs offer potential benefits over commercial vaccination and could reduce economic losses related to classical swine fever.
Ebola virus (green) infects human cells much more easily when you remove the protective RBBP6 protein (compare left to right). Researchers have discovered a human protein that helps fight the Ebola virus and could one day lead to an effective therapy against the deadly disease, according to a new study from Northwestern University, Georgia State University, University of California, San Francisco (UCSF) and the Gladstone Institutes published today, Dec.
Patients with arthritis in their knees experienced significant improvement in pain and mobility after undergoing a weekly, whole-body massage for two months, according to a study led by researchers at Duke Health.
A new brain imaging study shows that when we imagine something we fear, it stimulates similar neural pathways as when we experience it. The findings suggest imagination can be a powerful therapeutic tool for helping people get over phobias or post traumatic stress.
Conventional math cannot adequately model the interaction of multiple genes over multiple time frames – a necessary foundation for any cancer-fighting drugs. The study, published in “Frontiers in Physiology” by Mahboobeh Ghorbani, Edmond Jonckheere and Paul Bogdan of the Ming Hsieh Department of Electrical Engineering, is the first study that accounts for the memory, cross-dependence and fractality of gene expression
Anticipation is often viewed as an emotional experience, an eager wait for something to happen.
Researchers from the University of Texas MD Anderson Cancer Center have discovered that ovarian cancer cells spread, or metastasize, to new tissue after being caught in DNA "webs" extruded by immune cells. The study, which will be published December 19 in the Journal of Experimental Medicine, reveals that preventing immune cells from forming these webs reduces metastasis in mice, suggesting that similar treatments could be used to limit the spread of ovarian cancer in humans.
A team led by Duke Human Vaccine Institute researchers, publishing online Dec. 11 in the journal Immunity, reported that they have filled in a portion of the roadmap toward effective neutralization of HIV, identifying the steps that a critical HIV antibody takes to develop and maintain its ability to neutralize the virus.
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with clinicians from Scripps Clinic, have identified that the loss of two genes drives the formation of serrated colorectal cancer—yielding potential biomarkers. The research has also identified a combination treatment that has treated the cancer in mice. The study published today in Immunity.
A molecular pathway that’s frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, Johns Hopkins researchers report in a new study. The finding, published Nov. 7 in Nature Communications, could eventually lead to new targets for cancer-fighting therapeutics.
If you are wondering how long you personally are willing to stand in line to buy that hot new holiday gift, scientists at Johns Hopkins Medicine say the answer may be found in the biological rules governing how animals typically forage for food and other rewards.
Neurons in the brain and spinal cord don’t grow back after injury, unlike those in the rest of the body. Now, researchers at Washington University School of Medicine in St. Louis have identified some of the key steps taken by nerves in the legs as they regenerate. The findings lay out a path that spinal cord neurons might be able to follow – potentially leading to improved recovery for people paralyzed by spinal cord injuries.
Researchers at the Georgia Institute of Technology have devised a method for using an origami-based structure to create radio frequency filters that have adjustable dimensions, enabling the devices to change which signals they block throughout a large range of frequencies.
More and more, through sequencing done for medical reasons or done by direct-to-consumer companies, people learn they have variants of disease genes with uncertain significance to their health. With a new assay, researchers have a way to determine the potential impact of these cardiomyopathy variants on the health of patients and their family members.
Researchers use a data set of more than 100,000 individuals to identify genetic regions intolerant to change that may underlie developmental disorders.
A team of Missouri University of Science and Technology researchers has received a National Science Foundation research grant of nearly $1 million to develop stronger safeguards for a wide array of complex systems that rely on computers – from public water supply systems and electric grids to chemical plants and self-driving vehicles.
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