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Slaying Bacteria with Their Own Weapons

A novel antibiotic delivery system would exploit small molecules called siderophores that bacteria secrete to scavenge for iron in their environments. Each bacterium has its own system of siderophores, which it pumps across its cell membrane before releasing the iron the siderophores hold. If an antibiotic were linked to one of these scavenger molecules, it would be converted into a tiny Trojan horse that would smuggle antibiotics inside a bacterium’s cell membrane.

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Kryptonite for Superbugs: Scientists Unearth What May Be a Secret Weapon in the Urgent Battle Against Antibiotic-Resistance

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A fungus living in the soils of Nova Scotia could offer new hope in the pressing battle against drug-resistant germs that kill tens of thousands of people every year, including one considered a serious global threat.

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Antibiotic Developed 50 Years Ago May Be the Key to Fighting ‘Superbugs’

The aim of the project is to evaluate novel dosing regimens for polymyxin combinations to maximize antibacterial activity and to minimize the emergence of resistance and toxicity, says Tsuji, principal investigator on the grant.

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Why Transatlantic Trade Must Play a Role in Addressing Antibiotic Resistance

Leading public health researchers and trade experts will convene in Washington to address the spread of antibiotic resistance, the role of food animal production and the consequences of using the Transatlantic Trade and Investment Partnership to weaken existing standards to facilitate trade.

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E-cigarettes May Boost Resistance of Drug-Resistant Pathogens

Despite being touted by their manufacturers as a healthy alternative to cigarettes, e-cigarettes appear in a laboratory study to increase the virulence of drug- resistant and potentially life-threatening bacteria, while decreasing the ability of human cells to kill these bacteria

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University of Iowa Virologist Developed First MERS Mouse Model. Says SARS Experience Has Helped with Rapid MERS Response

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The Rise and Threat of Antibiotic-Resistant Bacteria, and the Research Into Fighting Them

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New MRSA Superbug Emerges in Brazil

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An international research team led by Cesar A. Arias, M.D., Ph.D., at The University of Texas Health Science Center at Houston (UTHealth) has identified a new superbug that caused a bloodstream infection in a Brazilian patient. The report appeared in the April 17 issue of The New England Journal of Medicine.

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Antibiotic-Resistant Bacteria Among Children in the United States on the Rise

Infections caused by a specific type of antibiotic-resistant bacteria are on the rise in U.S. children, according to new study published in the Journal of the Pediatric Infectious Diseases Society. While still rare, the bacteria are increasingly found in children of all ages, especially those 1-5 years old, raising concerns about dwindling treatment options.

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Fighting Antibiotic Resistance with ‘Molecular Drill Bits’

In response to drug-resistant “superbugs” that send millions of people to hospitals around the world, scientists are building tiny, “molecular drill bits” that kill bacteria by bursting through their protective cell walls. They presented some of the latest developments on these drill bits, better known to scientists as antimicrobial peptides (AMPs), at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.

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