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Drug Resistance

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Medicine

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MRSA, Superbugs, Food Pathogens, Antibiotic Resistance, Public Health, Food Safety

Superbug MRSA May Be Spreading Through Contaminated Poultry

A new study offers compelling evidence that a novel form of the dangerous superbug Methicillin-Resistant Staphylococcus aureus (MRSA) can spread to humans through consumption or handling of contaminated poultry. The research, published online today in the journal Clinical Infectious Diseases, shows that poultry may be an important source of human exposure to MRSA, a superbug which can cause serious infections and even death.

Medicine

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C. Difficile, , Clostridium Difficile, Intestinal Infection, Drug Resistant, salicylanilides, BI/NAP1/027, Drug Discovery,

SRI Study Suggests Repurposed Deworming Drugs Could Combat C. difficile Epidemic

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Scientists at The Scripps Research Institute have discovered a potential new weapon against Clostridium difficile, a bacterium that causes hundreds of thousands of severe intestinal infections in the U.S. every year and is frequently fatal.

Science

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How to Fight Drug-Resistant Bacteria

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This year, the U.S. reported for the first time that a patient had been infected by bacteria resistant to colistin, an antibiotic of last resort. The announcement followed several years of warnings that current antibiotics aren't diverse enough to fight pathogens as drug resistance spreads. The cover story of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, sums up how researchers are trying to stay ahead of the bugs.

Medicine

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Chronic Pain, Anxiety, anxiety disorder, Stress, Neuroscience, Neurotransmitter, Amygdala, Psychiatric Treatment, Drug Development

New Study Finds Connection Between Chronic Pain and Anxiety Disorders

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New study results provide insight into a long-observed, but little-understood connection between chronic pain and anxiety and offer a potential target for treatment. Researchers found that increased expression of PACAP -- a peptide neurotransmitter the body releases in response to stress -- is also increased in response to neuropathic pain and contributes to these symptoms.

Medicine

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Nanoparticle That Mimics Salmonella Counteracts Chemotherapy Resistance, Protein’s Role in Cell Division, A Novel MRI Method, and MORE in the Cancer News Source

Click here to go directly to the Cancer News Source

Science

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meth methamphetamine , Wound Healing, wound healing complications, Microbiology, Microbiology And Immunology, METH

Methamphetamine and Skin Wounds: NYIT Researcher Wins $431,000 NIH Grant to Study Immune Response Problems with Drug Use

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The National Institutes of Health has awarded Dr. Luis Martinez of New York Institute of Technology a $431,700 three-year grant to investigate, in mice, methamphetamine's effects on the underlying biological mechanisms that cause inflammation and impair wound healing. Martinez hopes his findings can form the foundation for new studies on human subjects that might lead to targeted prevention and wound management.

Medicine

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Whitehead Institute, Susan Lindquist, Drug Resistance, Antifungal, mitochondrial function, cytochrome b, Fluconazole, Fungal Infections

Disrupting Mitochondrial Function Could Improve Treatment of Fungal Infections

Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50% and cause an estimated 1.5 million deaths worldwide annually.

Medicine

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Leukemia, Leukaemia, Cancer, Cancer Treatment, Drug Resistance

Early Detection of Leukemia Patients' Resistance to Therapy

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Australian researchers have made a world-first breakthrough in the early detection of patients' resistance to a common treatment for chronic myeloid leukemia.

Medicine

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Uniformed Services University Of The Health Sciences, Uniformed Services University, USU, Usuhs, H.Pylori, Helicobacter Pylori, Biofilm, Biofilm formation, Journal of Bacteriology, regulatory system, stomach cancer-causing bacteria, ulcer-causing bacteria, antibiotic resisistance, Formation of Bacterial Communities, Military Health System, Military Healt

Researchers Identify Regulatory System in Ulcer-Causing Bacteria That Controls Formation of Bacterial Communities

Researchers have discovered a regulatory system in the ulcer- and stomach cancer-causing bacteria, Helicobacter pylori, that can control the formation of biofilm – a “fortress-like” cluster of cells that can become resistant to antibiotics and cause major medical problems.

Medicine

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hospital acquired infection, Yeast Infection, Gene Therapy, Candida Albicans, Immunity

Genetic Target Could Help Fight Deadly Drug-Resistant Infections

Fungal infections pose a major threat to hospital patients and have proven difficult to combat, but scientists have unlocked evidence that could lead to more effective treatment.

Medicine

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Bacterial Infections, Infections, Microbiology, Clinical Microbiology, Drug Resistant Bacteria, Pathology, microdilution susceptibility test, antimicrobial drugs, Bacteria, Antibiotics

Simple Method Quickly Tests Hard-to-Treat Bacteria’s Susceptibility to Different Antibiotics

The recent emergence of bacterial infections that are resistant to many existing antibiotics is driving an urgent need for tools to quickly identify the small number of therapies that are still effective for individual patients. Currently, multi-drug resistant bacteria often must be sent to specialized laboratories for analysis, leading to several days of delay before results can guide therapy. Now investigators at Beth Israel Deaconess Medical Center (BIDMC) have developed a simple and versatile method using inkjet printing technology to test such bacteria for susceptibility to antibiotics in a clinical setting. The method, already available online, is described in the September issue of the Journal of Clinical Microbiology.

Medicine

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Microbes, antibiotic resisistance

Boston Subway System Covered in Microbes, but They're Not Harmful

Boston’s subway system, known as the T, might be just as bacteria-laden as you’d expect but organisms found there are largely from normal human skin and incapable of causing disease, according to a study published June 28 in mSystems, an open access journal of the American Society for Microbiology.

Medicine

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Schizophrenia, anti-psychotic drugs, Dopamine Receptors

Dopamine Receptor Blockade Seen as Cause for Antipsychotic Drug Side-Effects

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University of California, Irvine scientists led by Emiliana Borrelli and colleagues have discovered the key cellular mechanism that underlies the antipsychotic-induced parkinsonism – which includes involuntary movements, tremors and other severe physical conditions. These studies present evidence that will stimulate a targeted approach for the design of novel antipsychotics without side-effects.

Medicine

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antibacterial resistance, Drug Resistance, Centers for Disease Control & Prevention, CRE carbapenem-resistant Enterobacteriaceae , Superbug, antibacterical

CDC Awards Rush and Cook County $9.45 Million to Combat 'Superbugs'

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A collaboration between Rush University Medical Center and Cook County Health and Hospitals System, considered a national model for developing strategies to combat drug resistant bacteria, was awarded nearly $10 million by the CDC

Medicine

Science

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Zika Mosquitoes Differ From West Nile Mosquitoes; First Zika Vaccine to Be Tested in Human Clinical Trial; Potential Drug Target Identified for Zika, and MORE in the Zika Virus News Source

Go here for the latest research, experts and features on Zika in the Zika Virus News Source

Medicine

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Bacteriology, Biochemistry and Cell Biology, microbioloby, Pharmaceutical Scieince, Plant Sciences

Plant Kingdom Provides 2 New Candidates for the War on Antibiotic Resistance

New research has discovered peptides from two crop species that have antimicrobial effects on bacteria implicated in food spoilage and food poisoning They are similar in structure to a human peptide used to guard against beer-spoiling bacteria

Medicine

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Drug Discovery, Drug Discovery And Development, Drug Discovery And Development Research Grant

UNM Health Sciences Center Wins Award to Expand Drug Development

The University of New Mexico Health Sciences Center has joined a national network of scientists on the leading edge of drug discovery and development in the fight against cancer, centered at the Frederick National Laboratory for Cancer Research.

Medicine

Science

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Switched-on Salmonella: Fluid Forces Guide Disease Traits of Multidrug-Resistant Bacteria

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Once inside the human body, infectious microbes like Salmonella face a fluid situation. They live in a watery world, surrounded by liquid continually flowing over and abrading their cell surfaces--a property known as fluid shear.

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Narrow Wavelength of UV Light Safely Kills Drug-Resistant Bacteria, Finds Columbia’s Center for Radiological Research

Scientists from Columbia University’s Center for Radiological Research have shown that a narrow wavelength of ultraviolet light safely killed drug-resistant MRSA bacteria in mice, suggesting its potential to reduce surgical site infections.

Medicine

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Schistosomiasis, Drug Resistance, schistosomas

Scientists Receive $3.5 Million From NIH to Study Drug Resistance in a Global Parasitic Disease

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Dr. Tim Anderson at Texas Biomedical Research Institute and Dr. Phil LoVerde at the University of Texas Health Science Center at San Antonio have been awarded a $3.5 million grant over the next five years by the National Institutes of Health to understand the genetic changes in the schistosome parasite that lead to drug resistance.







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