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Less Satisfaction in Breast Cancer Patients Who Have Radiation and Implants, Personalized Cancer Vaccine for AML, Model to Predict if Chemotherapy Will Work for Aggressive Breast Cancer, and More in the Cancer News Source

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Science

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Antibiotic Resistance, scientist profile, Profile, Microbiome, Drug Resistant Bacteria, Gut commensal microbiota

The Irresistible Resistome: How Infant Diapers Might Help Combat Antibiotic Resistance (Sort of)

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Biochemist Gautam Dantas inspects what’s deposited on infant diapers for clues about antibiotic resistance.

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Last-Line Antibiotics Are Failing

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On the occasion of the 9th European Antibiotic Awareness Day, the European Centre for Disease Prevention and Control (ECDC) is releasing its latest EU-wide data on antibiotic resistance and antibiotic consumption.

Science

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antibiotic resisistance, Antibiotics, E. Coli, Bacteria, supercomputering, Drug Discovery, efflux pumps, Proteins, Modeling And Simulation, High Performace Computing

Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance

Supercomputer simulations at the Department of Energy’s Oak Ridge National Laboratory have played a key role in discovering a new class of drug candidates that hold promise to combat antibiotic resistance. In a study led by the University of Oklahoma with ORNL, the University of Tennessee and Saint Louis University, lab experiments were combined with supercomputer modeling to identify molecules that boost antibiotics’ effect on disease-causing bacteria.

Medicine

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Infection, Critical Care, ICU, Public Health, Patient Care

Candida auris Emerging Form of Serious Infections.

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Medicine

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Medicine, Drugs, Public Health

Gene Mutations May Increase Adverse Event Risk in Older Adults Taking Multiple Meds

Gene mutations that affect drug metabolism may explain higher hospitalization rates for some older adults taking multiple medications, according to researchers from Columbia University.

Medicine

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Ribosome, catalytic center, chloramphenicol, Linezolid

Two Antibiotics Fight Bacteria Differently Than Thought

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Two widely prescribed antibiotics — chloramphenicol and linezolid — may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found. Instead of indiscriminately stopping protein synthesis, the drugs put the brakes on the protein synthesis machinery only at specific locations in the gene.

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New Insight on Cytomegalovirus Infection, Breakthrough Therapy for Patients with Giant Cell Arteritis, Zika Infection May Affect Adult Brain Cells and More in the Cell Biology News Source

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Antibiotic Resistance, Superbug, H

Prevalence of Drug-Resistant Staph Bacteria Higher in Young Children Living with Hog Workers, Study Suggests

Young children who reside with adults who work on large industrial hog operations in rural North Carolina had a higher prevalence of antibiotic-resistant Staphylococcus aureus bacteria in their nasal passages than children who live with adults who live in the same community but do not work on such operations, a new study suggests.

Medicine

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Cardiology, Heart Disease, drug side effects, Drug Safety, data science

Dangerous Drug Interactions Uncovered with Data Science

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Researchers at Columbia University Medical Center and the Data Science Institute at Columbia University have uncovered a potentially dangerous drug interaction using data science.

Medicine

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Tuburculosis, Supplement, supplement risks , supplemental nutrition, Botancal, Treatment, Drug Treatment, Botanical Products, Botanical Research, Herbal, Herbal Medicine, Herbal Remedies, Medical Treatment, Tuberculosis, tuberculosis resistance, Tuberculosis treatment

Anti-Tuberculosis Drug Disrupted by Botanical Supplement, Can Lead to Development of Disease

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A new study from the University of Missouri in partnership with scientists in Africa has uncovered evidence that these supplements and their antioxidants may reduce the effectiveness of prescription medications. The researchers examined the effects of a widely used African botanical supplement, called Sutherlandia, and found that it may disrupt the effectiveness of a common anti-tuberculosis drug. This could lead to the development of active tuberculosis and perhaps drug resistant forms of the pathogen in some patients.

Medicine

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Antifungal, Resistance, Antibiotics, perlin

Rutgers Team Awarded Contract by CDC to Better Understand, Combat Multidrug Resistant Fungal Infections

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A team at the Rutgers has won a $300,000 contract with the CDC to investigate emergence of antifungal drug resistance by the common fungal pathogen Candida glabrata. Fungal infections are a leading cause of morbidity and mortality among individuals with compromised immune systems. Treatment options are already highly limited.

Medicine

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MRSA, Superbugs, Food Pathogens, Antibiotic Resistance, Public Health, Food Safety

Superbug MRSA May Be Spreading Through Contaminated Poultry

A new study offers compelling evidence that a novel form of the dangerous superbug Methicillin-Resistant Staphylococcus aureus (MRSA) can spread to humans through consumption or handling of contaminated poultry. The research, published online today in the journal Clinical Infectious Diseases, shows that poultry may be an important source of human exposure to MRSA, a superbug which can cause serious infections and even death.

Medicine

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C. Difficile, , Clostridium Difficile, Intestinal Infection, Drug Resistant, salicylanilides, BI/NAP1/027, Drug Discovery,

SRI Study Suggests Repurposed Deworming Drugs Could Combat C. difficile Epidemic

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Scientists at The Scripps Research Institute have discovered a potential new weapon against Clostridium difficile, a bacterium that causes hundreds of thousands of severe intestinal infections in the U.S. every year and is frequently fatal.

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How to Fight Drug-Resistant Bacteria

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This year, the U.S. reported for the first time that a patient had been infected by bacteria resistant to colistin, an antibiotic of last resort. The announcement followed several years of warnings that current antibiotics aren't diverse enough to fight pathogens as drug resistance spreads. The cover story of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, sums up how researchers are trying to stay ahead of the bugs.

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Chronic Pain, Anxiety, anxiety disorder, Stress, Neuroscience, Neurotransmitter, Amygdala, Psychiatric Treatment, Drug Development

New Study Finds Connection Between Chronic Pain and Anxiety Disorders

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New study results provide insight into a long-observed, but little-understood connection between chronic pain and anxiety and offer a potential target for treatment. Researchers found that increased expression of PACAP -- a peptide neurotransmitter the body releases in response to stress -- is also increased in response to neuropathic pain and contributes to these symptoms.

Science

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meth methamphetamine , Wound Healing, wound healing complications, Microbiology, Microbiology And Immunology, METH

Methamphetamine and Skin Wounds: NYIT Researcher Wins $431,000 NIH Grant to Study Immune Response Problems with Drug Use

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The National Institutes of Health has awarded Dr. Luis Martinez of New York Institute of Technology a $431,700 three-year grant to investigate, in mice, methamphetamine's effects on the underlying biological mechanisms that cause inflammation and impair wound healing. Martinez hopes his findings can form the foundation for new studies on human subjects that might lead to targeted prevention and wound management.

Medicine

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Whitehead Institute, Susan Lindquist, Drug Resistance, Antifungal, mitochondrial function, cytochrome b, Fluconazole, Fungal Infections

Disrupting Mitochondrial Function Could Improve Treatment of Fungal Infections

Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50% and cause an estimated 1.5 million deaths worldwide annually.

Medicine

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Leukemia, Leukaemia, Cancer, Cancer Treatment, Drug Resistance

Early Detection of Leukemia Patients' Resistance to Therapy

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Australian researchers have made a world-first breakthrough in the early detection of patients' resistance to a common treatment for chronic myeloid leukemia.

Medicine

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Uniformed Services University Of The Health Sciences, Uniformed Services University, USU, Usuhs, H.Pylori, Helicobacter Pylori, Biofilm, Biofilm formation, Journal of Bacteriology, regulatory system, stomach cancer-causing bacteria, ulcer-causing bacteria, antibiotic resisistance, Formation of Bacterial Communities, Military Health System, Military Healt

Researchers Identify Regulatory System in Ulcer-Causing Bacteria That Controls Formation of Bacterial Communities

Researchers have discovered a regulatory system in the ulcer- and stomach cancer-causing bacteria, Helicobacter pylori, that can control the formation of biofilm – a “fortress-like” cluster of cells that can become resistant to antibiotics and cause major medical problems.







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