Research conducted at the Stony Brook University that enhances the time a drug remains bound to its target, or residence time, may prove to be an important step in developing better diagnostic and therapeutic agents.
A study led by Mayo Clinic suggests remission from Crohn’s disease may be more likely if patients get biologic therapy combined with immune-suppressing drugs first instead of immune-suppressing drugs alone.
Sleep. Humans need it in order to perform well on the job, in space and on the ground. Space researchers have developed software that uses mathematical models to help astronauts better adjust to shifting work and sleep schedules. On Earth, the software could help people who do shift or night work or who experience jet lag due to travel across time zones.
A new study reviews the currently published scientific literature to determine what evidence exists to support the use of vitamins in skin care products to slow or reverse the effects of sun damage.
The American Society of Anesthesiologists today released results from the inaugural Vital Health Report, which demonstrate that Americans associate good health with lifestyle behaviors and habits, but overlook their key Vital Health measures, some of the true indicators of overall health.
Investigators from Hospital for Special Surgery have identified a pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis.
Multiple myeloma researchers at the University of Arkansas for Medical Sciences (UAMS) recently discovered that widespread activity of a specific class of genes can identify aggressive, or high-risk, cases of the disease.
Most women scheduled for gynecologic surgery to address noncancerous symptoms said in a recently published survey that they were not worried about the effects of the procedure on their sex lives.
Telling stories of patients and families harmed by medical errors—and of healthcare professionals who have the courage to speak out about errors—is a powerful "secret weapon" in the fight to improve patient safety, according to an article co-authored by actor-turned-patient-safety-crusader Dennis Quaid in the current issue of the Journal of Patient Safety.
Study finds people without migraines can filter out more visual noise.
Findings by a Saint Louis University researcher published in the New England Journal of Medicine bode well for hard-to-treat patients.
A study of nearly 13,000 rescue workers from the Fire Department of the City of New York (FDNY) shows that the significant proportion who suffered acute lung damage after exposure to World Trade Center (WTC) dust have not recovered normal lung function in the years since the September 11, 2001 terrorist attacks.
Underscoring what researchers call a serious global public health concern, results from a new study of more than 60,000 women, led by Columbia University Medical Center reveal that many women at an elevated level of risk for osteoporosis-associated fractures fail to perceive the implications of the risk factors. Highlights need for public education about osteoporosis risk factors and treatment.
A systematic review of nursing handoff literature found that minimal research has been done to identify best practices, despite well-known negative consequences of inadequate nursing handoffs. The article was published in the April issue of the American Journal of Nursing (AJN).
Kidney damage associated with chronic reflux is the fourth leading cause of chronic kidney disease and is the most common cause of severe hypertension in children. Doctors and researchers at Nationwide Children’s Hospital have developed a new mouse model of vesicoureteral reflux (VUR), a common childhood condition that can lead to chronic kidney disease in children.
Among kidney transplant donors, variation of a gene that is an inhibitor of the development of fibrous connective tissue is significantly associated with an increased risk of graft failure, according to a study in the April 7 issue of JAMA.
For patients with juvenile idiopathic arthritis in remission, withdrawal of treatment with the drug methotrexate over 12 months vs. 6 months did not reduce the rate of relapse, according to a study in the April 7 issue of JAMA.
Patients with sickle cell disease average about 2.5 hospital visits per year, with 18- to 30-year old patients more likely to require acute care or rehospitalization, according to a study in the April 7 issue of JAMA.
Dr. Christie Ballantyne is one of the world’s foremost experts on lipids, cholesterol and statins. His research has contributed to FDA approval for many of the stains on the market today, including Crestor.
New clinical algorithms give physicians a practical, efficient and cost-effective aid to diagnose frequent GI symptoms that patients commonly bring to their primary care doctors and gastroenterologists--symptoms of functional GI disorders that are often difficult to diagnose. The tool has the potential to improve patient experience and provide opportunities to reduce excessive testing and office visits.
A drug whose clinical benefit in treating multiple sclerosis was discovered at Rush University Medical Center was approved by the Food and Drug Administration on January 22 and is now available in the U.S.
New guidelines that outline best practices for measuring the economic burden of visual impairment will make it easier for the policy, science and medical communities to draw conclusions and compare results across studies.
Jay Yim, 21-year-old student, collapsed at mile 18 of the LA Marathon in full cardiac arrest, and was saved by joint efforts of LAPD and UCLA doctors.
More than half of donor kidneys in the United State infected with hepatitis C are thrown away, despite the need among hepatitis C patients who may die waiting for an infection-free organ, Johns Hopkins research suggests.
A paper scheduled to be published March 31 in the journal Nature questions much of what had been believed about the kinetics of T cell receptors. The new study is based on two techniques that mechanically study receptors as they operate on T cell membranes.
Congenital stationary night blindness, an inherited condition that affects one’s ability to see in the dark, is caused by a mutation in a calcium channel protein that shuttles calcium into and out of cells. Now, researchers at the Johns Hopkins University School of Medicine have teased apart the molecular mechanism behind this mutation, uncovering a more general principle of how cells control calcium levels.
A small study of children with cancer enrolled in therapeutic clinical research trials shows that they don’t fully understand what physicians and parents tell them about their participation, nor do they feel they are genuinely involved in the choice to take part.
A two-drug combination destroys precancerous colon polyps with no effect on normal tissue, opening a new potential avenue for chemoprevention of colon cancer, a team of scientists at The University of Texas M. D. Anderson Cancer Center reports in the advance online edition of the journal Nature.
Researchers at the University of Alabama at Birmingham (UAB) have found the first bio-marker for multiple sclerosis (MS) that might predict which patients will respond to a standard therapy and which will not. In findings published online March 28 in Nature Medicine, the UAB team, in a joint effort with researchers at Stanford University, discovered that patients with a particular type of T helper immune cells responded well to interferon-ß, the usual first-line therapy for the disease, while those with a different T helper immune-cell type either did not respond or experienced worsening symptoms.
A medical student and faculty directors from the Johns Hopkins Berman Institute of Bioethics analyzed depictions of bioethical issues and professionalism over a full season of two popular medical dramas—“Grey’s Anatomy” and “House, M.D.”—and found that the shows were “rife” with ethical dilemmas and actions that often ran afoul of professional codes of conduct.
Most kidney transplant candidates are willing to receive a kidney from a donor at increased risk of viral infection, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that kidney disease patients can make rational tradeoffs between the virtues and risks conferred by donated kidneys.
A protein discovered in fruit fly eyes has brought a Johns Hopkins team closer to understanding how the human heart and other organs automatically “right size” themselves, a piece of information that may hold clues to controlling cancer.
Physician-scientists at the Cedars-Sinai Heart Institute have found that a genetic variation is associated with lower risk of sudden cardiac arrest, a disorder that gives little warning and is fatal in about 95 percent of cases. Findings will be published tomorrow by the Public Library of Science (PloS One).
By enhancing the activity of immune cells that protect against runaway inflammation, researchers at NYU Langone Medical Center may have found a novel therapy for rheumatoid arthritis and other autoimmune diseases. In a new study published in the March 25, 2010 online edition of Science, the researchers reveal how treating these immune cells with an investigational drug wards off inflammation by holding a particular enzyme at bay.
The Internet has had a profound effect on clinical practice by providing both physicians and patients with a wealth of information. But with those rewards come risks of incorrect or poorly interpreted information that require that a doctor “never be optional.”
A team of cardiologists, materials scientists, and bioengineers have created and tested a new type of implantable device for measuring the heart’s electrical output that they say is a vast improvement over current devices. The new device represents the first use of flexible silicon technology for a medical application. The technology may herald the next generation of active, flexible, implantable devices for applications in cardiology and neurology.
MDA-Funded Researcher Begins Clinical Trials to Test Efficacy of Cialis (tadalafil) to increase blood flow to muscles of men with Becker muscular dystrophy.
The ATS has released an official policy statement of pay-for-performance (P4P) in pulmonary, critical care and sleep medicine. In the statement, the Society encourages clinicians in these fields to participate in P4P programs and views them as an opportunity to partner with healthcare payers, accrediting organizations, governmental oversight groups and others to improve quality, rather than as a threat to autonomy and independence.
Bony fish like the tiny zebrafish have a remarkable ability that mammals can only dream of: if you lop off a chunk of their heart they swim sluggishly for a few days but within a month appear perfectly normal. How they accomplish this - or, more importantly, why we can't - is one of the significant questions in regenerative medicine today.
Dolphins, whales and porpoises have extraordinarily small balance organs, and scientists have long wondered why. Now a study at Washington University School of Medicine in St. Louis has contradicted a leading theory, which held that the animals moved their heads so vigorously that they had to have smaller, less responsive balance organs to avoid overwhelming their senses.
Flip-flops and sneakers with flexible soles are easier on the knees than clogs or even special walking shoes, a study by Rush University Medical Center has found. And that's important, because loading on the knee joints is a key factor in the development of osteoarthritis.
Many egg donation agencies and private couples routinely exceed compensation recommendation limits for potential donors, a new study finds.
A Cedars-Sinai Heart Institute cardiologist has been awarded a three-year, nearly $1 million grant from the Muscular Dystrophy Association (MDA) to study whether drugs used to treat erectile dysfunction could also be used to improve muscle blood flow and reduce fatigue in muscular dystrophy patients.
An international study of nearly 100 clinical trials that were stopped early due to positive treatment effects has found that many of those effects were exaggerated.
With a concern that the automatic reporting of estimated glomerular filtration rate (GFR; the flow rate of filtered fluid through the kidney, which is used to define the stage and severity of chronic kidney disease) may result in unnecessary referrals by physicians, new research indicates that automated laboratory reporting was associated with a significant increase in first-time visits to a kidney specialist, particularly among those at increased risk of late detection of kidney disease (such as older or female patients), according to a study in the March 24/31 issue of JAMA.
Increasing interest in health care has lead reporters to seek more sources for health news than ever before. And, as more and more consumers use the web to research health information, the growing demand for health news has an increasing influence on the health industry. In response to these trends, Newswise has developed a new category for medical news called Health Marketplace.
Scientists have determined that chronic wounds might have trouble healing because of the actions of a tiny piece of a molecular structure in cells known as RNA. Targeting this RNA segment may offer new strategies for treating chronic wounds.
For more than 30 years, scientists have known that multiple sclerosis (MS) is much more common in higher latitudes than in the tropics. Because sunlight is more abundant near the equator, many researchers have wondered if the high levels of vitamin D engendered by sunlight could explain this unusual pattern of prevalence.
The number of living donor organs available for transplant has progressively declined over the past five years, according to a new study. In addition, the study showed that for the first time, organs from deceased donors decreased in 2008.
In honor of the designation of March as National Autoimmune Disease Awareness Month by the U.S. Senate on March 4, 2010, the American Autoimmune Related Diseases Association (AARDA) wants to help you learn your family’s AQ. AQ is a play on IQ that stands for Autoimmune Quotient. It’s about knowing how likely you or a loved one is to develop an autoimmune disease, based on the prevalence of these diseases and your family history.
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