The researchers discovered injecting potato virus particles into melanoma tumor sites activates an anti-tumor immune system response. And simultaneously injecting the nanoscale plant virus particles and a chemotherapy drug—doxorubicin—into tumor sites further helps halt tumor progression in mice.
Researchers at the University of Michigan will lead one of five nationally funded centers dedicated to accelerating research into understanding the molecular basis of cancer and sharing resources with the scientific community.
In a first, UW researchers have delivered targeted treatment for essential tremor - the world's most common neurological movement disorder - by decoding brain signals to sense when patients limbs are shaking.
Wayne State University received a four-year, $533,151 award from the National Institute of Mental Health of the National Institutes of Health to develop a technology-based parent-training program for addressing young children’s challenging behaviors.
Acute and chronic infections in a person’s upper gastrointestinal tract appear to be linked to Parkinson’s disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions.
In the fruit fly, social isolation leads to sleep loss, which in turn leads to cellular stress and the activation of a defense mechanism called the unfolded protein response.
This research found that light makes migraine headaches more painful and induces negative emotions and unpleasant physical sensations. Laboratory studies identify previously unknown connections between nerve cells in the eye and neurons in the brain that regulate physiological, autonomic, endocrine and emotional responses. These findings offer promising path forward for researchers in treatment of migraines.
Your cancer has metastasized. No one wants to ever hear that. Now researchers have found a way to virtually halt cell migration, a key component in metastasis, in vitro, in human cells. In past in vivo studies in mice, treated cancer did not appear to recur. No significant side effects were observed.
Just as people endlessly calculate how to upsize or downsize, bacteria continually adjust their volume (their stuff) to fit inside their membrane (their space). But what limits their expansion? The answer will surprise you.
Mount Sinai researchers find this network central to Alzheimer’s disease susceptibility
Findings could transform treatment worldwide and enhance patient care
Researchers at the University of Pittsburgh and the University of Toronto have uncovered the first molecular steps that lead to immune system activation and eventual rejection of a transplanted organ.
Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.
Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation.
USC Norris Comprehensive Cancer Center is actively recruiting for a clinical trial that seeks to eliminate unnecessary testing for breast cancer with a simple breath test.
A microscopic fungus called Candida tropicalis triggered gut inflammation and exacerbated symptoms of Crohn’s disease, in a recent study conducted at Case Western Reserve University School of Medicine.
Three geography faculty members have received a National Science Foundation (NSF) Research in Undergraduate Institutions (RUI) award of $232,099 for a collaborative research project to assess the environmental and human drivers and the cultural dimension of changes in oak forests in the eastern United States.
A new drug shows promise in its ability to target one of the most common and sinister mutations of acute myeloid leukemia (AML), according to researchers at the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center. The Fms-like tyrosine kinase 3 (FLT3) gene mutation is a known predictor of AML relapse and is associated with short survival. In a first-in-human study, researchers treated relapsed patients with gilteritinib, an FLT3 inhibitor, and found it was a well-tolerated drug that led to frequent and more-sustained-than-expected clinical responses, almost exclusively in patients with this mutation.
A study led by computer scientists at Indiana University has found that people with the most connections on social media are also happier. This may cause most social media users to not only regard themselves as less popular than their friends but also less happy.
The National Institutes of Health has renewed a major grant that funds a University of Washington-led research center to understand malaria in India.
For decades, HIV has successfully evaded all efforts to create an effective vaccine but researchers at The Scripps Research Institute (TSRI) and the La Jolla Institute for Allergy and Immunology (LJI) are steadily inching closer. Their latest study, published in the current issue of Immunity, demonstrates that optimizing the mode and timing of vaccine delivery is crucial to inducing a protective immune response in a preclinical model.
The use of topical antibiotics can dramatically alter communities of bacteria that live on the skin, while the use of antiseptics has a much smaller, less durable impact. The study, conducted in mice in the laboratory of Elizabeth Grice, PhD, an assistant professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania, is the first to show the long-term effects of antimicrobial drugs on the skin microbiome.
A new study from Roswell Park Cancer Institute reporting the findings of the first clinical trial to evaluate the immune effects of high-dose radiation therapy followed by surgery in patients with advanced kidney cancer may also set the stage for combination treatments with immunotherapy.
There hasn’t been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.
Diabetes brings a wide array of complications that can harm the cardiovascular system and other organs, and it has been found to affect some groups, such as racial and ethnic minorities and people with low incomes, at a disproportionate rate.
One in three people has a potentially nasty parasite hiding inside their body -- tucked away in tiny cysts that the immune system can’t eliminate and antibiotics can’t touch. But new research reveals clues about how to stop it: Interfere with its digestion during this stubborn dormant phase.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases.
A $2.24 million competing renewal grant from the National Cancer Institute will support the work of investigators at Rutgers Cancer Institute of New Jersey and Princeton University to learn more about the fuel required for tumor growth. The collaborative research will focus on melanomas and lung cancers caused by mutations in genes known as K-ras and Braf.
Experimenting with mice, neuroscientists at Johns Hopkins Medicine report new evidence that the eye's iris in many lower mammals directly senses light and causes the pupil to constrict without involving the brain.
Frequent measurement of a quantum system's state can either speed or delay its collapse, effects called the quantum Zeno and quantum anti-Zeno effect. But so too can "quasimeasurements" that only poke the system and garner no information about its state.
Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) — a newly recognized level of gene expression regulation — in bacterial keratitis – an infection of the cornea caused by bacteria — as well as to identify new therapeutic targets and alternative treatment strategies.
Indiana University researchers discovered a key biological mechanism that could explain why mosquitoes infected Wolbachia bacteria are unable to transmit diseases such as dengue fever, West Nile virus and Zika.
Engineers at the University of California San Diego have developed new electrolytes that enable lithium batteries to run at temperatures as low as -60 degrees Celsius with excellent performance -- in comparison, today's lithium-ion batteries stop working at -20 degrees Celsius. The new electrolytes also enable electrochemical capacitors to run as cold as -80 degrees Celsius -- their current limit is -40 degrees Celsius.
A new, high-resolution view of the structure of Hsp104 (heat shock protein 104), a natural yeast protein nanomachine with six subunits, may show news ways to dismantle harmful protein clumps in disease.
Physical activity among children and teens is lower than previously thought, and, in another surprise finding, young adults after the age of 20 show the only increases in activity over the lifespan.
Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors. The findings open possibilities for new clinical approaches.
Duke University researchers have identified a potential new mechanism for Parkinson's disease in both mice and human endocrine cells that populate the small intestines.
The West Antarctic Ice Sheet, a landbound mass of ice larger than Mexico, experienced substantial surface melt through the austral summer of 2015-2016 during one of the largest El Niño events of the past 50 years
By acting out scenarios commonly seen in the clinic, real-life transgender actors can help residents learn to provide more sensitive care. This is the main finding of a study published online June 15 in the Journal of Graduate Medical Education.
Scientists at The Scripps Research Institute (TSRI) have shown that for the virus that causes the flu, two wrongs can sometimes make a right.
Scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation. The study demonstrates targeting these cells could lead to novel treatments for PGD, a complication that currently impacts more than half of transplant patients.
Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract. A new study from Washington University School of Medicine in St. Louis has found that a molecular decoy can reduce the numbers of UTI-causing bacteria in the gut, potentially reducing the risk of recurrent UTI.
By developing a new approach to imaging and manipulating particular groups of neurons in the mouse brain, scientists at Beth Israel Deaconess Medical Center (BIDMC) have identified a pathway by which neurons governing feelings of hunger influence distant neurons involved in the decision of whether or not to react to food-related cues. Their findings could open the door to targeted therapies that dampen food cue-evoked cravings in people with obesity. The research was published online today in the journal Nature.
Researchers detail a molecule that acts as a molecular pilot light required to turn on the brown fat furnace. Brown fat burns sugar and fat to produce radiant heat in the body. These cells are of interest because some of the sugar and fat they burn is stored in the body and might otherwise lead to increases in white fat, the form that increases in obesity.
A North Dakota State University assistant professor has received a national award that will bring more than $500,000 to the geosciences department at NDSU and provide research opportunities for students.
Wildfires are major polluters. Their plumes are three times as dense with aerosol-forming fine particles as previously believed. For the first time, researchers have flown an orchestra of modern instruments through brutishly turbulent wildfire plumes to measure emissions in real time. They have also exposed other never before measured toxins.
A team led by New York University researchers has identified and described how a major player in the repair process, called nucleotide excision repair or NER, works to recognize certain lesions for subsequent removal by the NER machinery.
In a study of predominantly African-American women — who have a much higher rate of delivering babies early compared with other racial groups — researchers at Washington University School of Medicine in St. Louis showed that a decrease in the diversity of vaginal microbes of pregnant women between the first and second trimesters is associated with preterm birth.
A team of Wayne State University and Barbara Ann Karmanos Cancer Institute researchers recently received funding from the National Cancer Institute of the National Institutes of Health to expand the use of Positron Emission Tomography (PET) in cancer therapy.
APS is sponsoring summer research fellowships for 49 undergraduate students in labs throughout the U.S. The fellowships aim to give students a firsthand look at what it's like to pursue a career in science and encourage them to stay involved in STEM fields.
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