Feature Channels: Genetics

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Released: 22-Sep-2014 3:30 AM EDT
Singapore Researchers Discover a Gene That Increases Incidence of Acute Myelogenous Leukaemia
National University of Singapore (NUS)

A novel study by the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) found that an increase in a gene known as Leo1 affects other genes that are directly implicated in acute myelogenous leukaemia (AML), increasing the incidence of cancer.

Released: 19-Sep-2014 11:40 AM EDT
Using Genetic Screening to Improve Korean White Wheat
South Dakota State University

Korean white winter wheat is particularly susceptible to preharvest sprouting, according to Dae Wook Kim, a scientist at National Institute of Crop Science in Suwaon, South Korea. Working with molecular biologist Jai Rohila at South Dakota State University, Kim has identified proteins which are differentially expressed in tolerant cultivars, with the goal of breeding more resistant varieties that can help increase wheat production in Korea.

Released: 18-Sep-2014 2:00 PM EDT
Down Syndrome Helps Researchers Understand Alzheimer’s Disease
University of Wisconsin–Madison

The link between a protein typically associated with Alzheimer’s disease and its impact on memory and cognition may not be as clear as once thought, according to a new study from the University of Wisconsin-Madison’s Waisman Center. The researchers looked at the role of the brain protein amyloid-β in adults living with Down syndrome, a genetic condition that leaves people more susceptible to developing Alzheimer’s.

Released: 18-Sep-2014 11:00 AM EDT
UNC Researchers Link Gene to Increased Dendritic Spines – a Signpost of Autism
University of North Carolina Health Care System

UNC scientists discover that knocking out the gene NrCAM increases the number of dendritic spines on excitatory pyramidal neurons. Other studies have confirmed that the overabundance of dendritic spines allows for too many synaptic connections – a phenomenon strongly linked to autism.

Released: 18-Sep-2014 10:00 AM EDT
Melanoma Risk Found to Have Genetic Determinant
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, an international research consortium, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma.

Released: 17-Sep-2014 5:40 PM EDT
University of Kentucky Research Explores STXBP5 Gene and its Role in Blood Clotting
University of Kentucky

Two independent groups of researchers led by Sidney (Wally) Whiteheart, PhD, of the University of Kentucky, and Charles Lowenstein, MD, of the University of Rochester, have published important studies exploring the role that a gene called STXBP5 plays in the development of cardiovascular disease.

16-Sep-2014 12:40 PM EDT
Modern Europeans Descended from Three Groups of Ancestors
Howard Hughes Medical Institute (HHMI)

New studies of ancient DNA are shifting scientists' ideas of how groups of people migrated across the globe and interacted with one another thousands of years ago. By comparing nine ancient genomes to those of modern humans, Howard Hughes Medical Institute (HHMI) scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.

Released: 17-Sep-2014 12:50 PM EDT
Large Study Reveals New Genetic Variants That Raise Risk for Prostate Cancer
Johns Hopkins Medicine

In an analysis of genetic information among more than 87,000 men, a global team of scientists says it has found 23 new genetic variants – common differences in the genetic code -- that increase a man’s risk for prostate cancer. The so-called “meta-analysis,” believed to be the largest of its kind, has revealed once hidden mutations among men in a broad array of ethnic groups comprising men of European, African, Japanese and Latino ancestry.

Released: 17-Sep-2014 10:00 AM EDT
Moffitt Cancer Center Researchers Help Lead International Efforts to Find New Genetic Links to Prostate Cancer
Moffitt Cancer Center

Researchers at Moffitt Cancer Center, including Center Director Thomas A. Sellers, Ph.D., M.P.H., Jong Park, Ph.D. and Hui-Yi Lin, Ph.D., have discovered 23 new regions of the genome that influence the risk for developing prostate cancer, according to a study published Sept. 14 in Nature Genetics.

Released: 16-Sep-2014 10:35 AM EDT
Researchers Develop Improved Means Of Detecting Mismatched DNA
Johns Hopkins Medicine

Researchers at Johns Hopkins have identified a highly sensitive means of analyzing very tiny amounts of DNA. The discovery, they say, could increase the ability of forensic scientists to match genetic material in some criminal investigations. It could also prevent the need for a painful, invasive test given to transplant patients at risk of rejecting their donor organs and replace it with a blood test that reveals traces of donor DNA.

Released: 16-Sep-2014 10:00 AM EDT
Endocrine-Related Protein Found to Be Master Regulator in Other Important Diseases
Children's Hospital of Philadelphia

Investigating a protein known to influence human glucose levels, scientists found that this factor has a broader reach than first thought, acting on key gene pathways involved in cardiovascular, neuropsychiatric, and cancer-related diseases.

11-Sep-2014 6:00 PM EDT
Schizophrenia Not a Single Disease but Multiple Genetically Distinct Disorders
Washington University in St. Louis

New research shows that schizophrenia isn’t a single disease but a group of eight genetically distinct disorders, each with its own set of symptoms. The finding could be a first step toward improved diagnosis and treatment for the debilitating psychiatric illness. The research at Washington University School of Medicine in St. Louis is reported online Sept. 15 in The American Journal of Psychiatry.

10-Sep-2014 11:30 AM EDT
Muscular Dystrophy: Repair the Muscles, Not the Genetic Defect
University of Michigan

A potential way to treat muscular dystrophy directly targets muscle repair instead of the underlying genetic defect that usually leads to the disease.

11-Sep-2014 1:00 PM EDT
How an Ancient Vertebrate Uses Familiar Tools to Build a Strange-Looking Head
Stowers Institute for Medical Research

Investigator and Scientific Director Robb Krumlauf, Ph.D. and colleagues show that the sea lamprey Petromyzon marinus, a survivor of ancient jawless vertebrates, exhibits a pattern of gene expression that is reminiscent of its jawed cousins, who evolved much, much later.

Released: 12-Sep-2014 4:00 PM EDT
Zebrafish Model of a Learning and Memory Disorder Shows Better Way to Target Treatment
Perelman School of Medicine at the University of Pennsylvania

Using a zebrafish model of a human genetic disease called neurofibromatosis, researchers have found that the learning and memory components of the disorder are distinct features that will likely need different treatment approaches.

Released: 12-Sep-2014 11:15 AM EDT
Worldwide Study Demonstrates Accuracy of Genetic Analyses
Mayo Clinic

Physicians envision a future in which genomic data from patients is heavily used to manage care — but experts have questioned the accuracy and reliability of these analyses. Now, a study by 150 researchers in 12 countries finds real strength and agreement across RNA genomic sequencing techniques and laboratories — as well as ways to improve what little variability exists to set a new high standard.

Released: 11-Sep-2014 2:00 PM EDT
Primary Care Doctors Reluctant to Provide Genetics Assessment in Routine Care
Michigan Medicine - University of Michigan

Physicians report many barriers keep them from giving patients guidance on genetic risks, disease, according to new research

10-Sep-2014 12:00 PM EDT
Genomic Analysis Reveals That a High-Risk Leukemia Subtype Becomes More Common with Age
St. Jude Children's Research Hospital

More than one-quarter of young adults with the most common form of acute lymphoblastic leukemia (ALL) have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children’s Research Hospital investigators.

Released: 10-Sep-2014 8:25 AM EDT
Penn Researcher and CVS Health Physician Urge New Payment Model for Costly Gene Therapy Treatments
Perelman School of Medicine at the University of Pennsylvania

Hoping to encourage sufficient investments by pharmaceutical companies in expensive gene therapies, which often consist of a single treatment, a Penn researcher and the chief medical officer of CVS Health outline an alternative payment model.

Released: 9-Sep-2014 11:15 AM EDT
Genetic Modifier Impacts Colon Tumor Formation
University of Kansas Cancer Center

Unexpected results from an ongoing experiment in the lab of Kristi Neufeld, Ph.D., co-leader of the Cancer Biology Program, led to a potentially important discovery that could have an impact on how cancer researchers test anti-cancer therapies in mice, and possibly prevent colon cancer in people.



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