Using new sequencing technologies, UCLA and University of Pennsylvania researchers uncovered 214,516 unique isoforms in the developing neocortex — over 70% of which have not been previously studied.
Volume 29, Issue 2 of SLAS Discovery features two review articles, six original research articles covering phenotypic screening perspectives, medulloblastoma therapies and interventions for neurodegenerative diseases.
Announcement of next JNSPG Editor in Chief
Even slight cognitive changes can affect an older person’s decision to stop driving, according to a new study by researchers at Washington University School of Medicine in St. Louis. The findings suggest that routine cognitive testing — in particular, the kind of screening designed to pick up the earliest, most subtle decline — could help older adults and their physicians make decisions about driving that maximizes safety while preserving independence as long as possible.
What factors lead older adults to stop driving? A new study followed older adults who had no memory or thinking problems to examine this question. The study is published in the May 22, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
People who eat more ultra-processed foods like soft drinks, chips and cookies may have a higher risk of having memory and thinking problems and having a stroke than those who eat fewer processed foods, according to a new study published in the May 22, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that eating ultra-processed foods causes memory and thinking problems and stroke. It only shows an association.
Engineers at the University of California San Diego have developed a wearable ultrasound patch that can offer continuous, non-invasive monitoring of blood flow in the brain. The soft and stretchy patch can be comfortably worn on the temple to provide three-dimensional data on cerebral blood flow—a first in wearable technology.
Scientists have long been studying the brain with a goal of aiding healthier aging. While much is known about risk factors for accelerated brain aging, less has been uncovered to identify ways to reduce cognitive decline.
Lucy, with her boundless puppy-like energy even at 12 years old, is more than just a pet to Susan Ketcham. She's now part of a research project that could transform the way we treat brain cancer – in both dogs and humans. This study at Virginia Tech's Virginia-Maryland College of Veterinary Medicine explores an innovative therapy called histotripsy.
An increase in nightmares and hallucinations could signal the onset of autoimmune diseases such as lupus, according to a new study.
Current methods to model or correct mutations in live cells are inefficient, especially when multiplexing — installing multiple point mutations simultaneously across the genome. Researchers from the UC San Diego have developed new, efficient genome editing tools called multiplexed orthogonal base editors (MOBEs) to install multiple point mutations at once.
MIRA Pharmaceuticals, Inc. (NASDAQ: MIRA) ("MIRA" or the "Company"), a pre-clinical-stage pharmaceutical company focused on the treatment of neurologic and neuropsychiatric disorders, announced it is in advanced discussions with Memorial Sloan Kettering Cancer Center (MSK) to initiate a preclinical study evaluating MIRA's novel oral ketamine analog, Ketamir-2, for the treatment of cancer-related pain and depression.
Australian scientists are exploring how harmful gut bacteria from a poor diet can access the brain and trigger early onset Alzheimer's disease.
Dr. Cook realized, when his father was diagnosed with epilepsy, that a system to identify and predict seizures could improve care and change people's lives. In this episode, Dr. Cook talks about entrepreneurship in epilepsy and advancing the field through innovation.
MIRA Pharmaceuticals, Inc. (NASDAQ: MIRA) ("MIRA" or the "Company"), a pre-clinical-stage pharmaceutical company focused on the treatment of neurologic and neuropsychiatric disorders, announced that it has advanced new preclinical studies using Ketamir-2, its differentiated oral ketamine analog, towards clinical development for the treatment of severe post-traumatic stress disorder (PTSD) and other leading mental health disorders and neuropathic pain indications.
May is both Brain Tumor Awareness Month and National Cancer Research Month. Virginia Tech’s Fralin Biomedical Research Institute at VTC is dedicated to advancing health through a better understanding of cancer and brain tumors and developing new ways to treat and prevent them.
Researchers at the UNC School of Medicine, UCSF, Stanford, and Harvard determined that a protein prediction technology can yield accurate results in the hunt to efficiently find the best possible drug candidates for many conditions.
Learning a simple acronym could help you save a life. A Penn State Health expert explains why “time is brain.”
A new guideline has been issued to help neurologists and other clinicians determine the best antiseizure medications for people with epilepsy who may become pregnant.
Hackensack Meridian Jersey Shore University Medical Center celebrates a significant milestone: the attainment of Global Healthcare Accreditation (GHA) for Medical Travel Services for its Center for Treatment of Paralysis and Reconstructive Nerve Surgery. The Center is the first GHA accredited facility in New Jersey.
A new study led by UCLA Health has shown that repetitive practice not only is helpful in improving skills but also leads to profound changes in the brain’s memory pathways.
Nasal chemosensation is considered the evolutionarily oldest mammalian sense and, together with somatosensation, is crucial for neonatal well-being before auditory and visual pathways start engaging the brain.
New research led by Children’s Hospital Los Angeles has found that racial and socioeconomic disparities contribute to delayed care for craniosynostosis—a rare birth defect that occurs when a baby’s skull bones close too early.In the study, being Black/African American, having public insurance and living in an economically disadvantaged area were all risk factors for presenting for a first consultation at older ages.
Restoring motor control and sensation from an artificial hand in a natural way remains a scientific “holy grail.” Researchers have developed a novel biohybrid neuro-prosthetic research platform comprised of a dexterous artificial hand electrically interfaced with biological neural networks. Ultimately, this could lead to a better understanding of the complex sensation of touch, which is necessary for refined control of the hand.
Results from an Iowa State University pilot study indicate three months of exercise benefits vascular health, but improving brain blood flow may require more time.
A research team led by the University of California, Irvine has revealed the link between the frequency of sleep apnea events during the rapid-eye-movement stage and the severity of verbal memory impairment in older adults at risk for Alzheimer’s disease. Verbal memory refers to the cognitive ability to retain and recall information presented through spoken words or written text and is particularly vulnerable to Alzheimer’s.
Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease. Additionally, researchers observed sex-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of “old” oligodendrocytes to “old” neurons compared to the male cortex.
Xylazine, often found in street-drug combo with fentanyl, was thought to only bind to the α2-adrenergic receptor, but UNC-Chapel Hill scientists discovered it also binds to opioid receptors, which could have profound impacts on fentanyl overdose treatment.
Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson’s disease (PD). Published in Genome Medicine on May 13, their study highlights the potential for joint therapeutic strategies to target these two challenging disorders.
A night spent dreaming can help you forget the mundane and better process the extreme, according to a new University of California, Irvine study. Novel work by researchers in the UC Irvine Sleep and Cognition Lab examined how dream recall and mood affected next-day memory consolidation and emotion regulation.
Duaa Jabari, MD, a neuromuscular medicine specialist with a particular interest in autoimmune neuromuscular disorders and neuromuscular pathology, has joined the Cedars-Sinai Department of Neurology as director of Electromyography.
Les recommandations de la Commission des thérapies chirurgicales de l'ILAE suggèrent de référer chaque patient de moins de 70 ans souffrant d'épilepsie résistante aux médicaments pour une évaluation plus approfondie dès qu'ils ont échoué à deux médicaments anticonvulsivants. Et bien que la chirurgie puisse être une option pour jusqu'à 40 % d'entre eux, moins de 1 % sont référés aux centres d'épilepsie chaque année.
The designation means OMC-Baton Rouge meets The Joint Commission's designation for readiness to treat patients who experience severe stroke.
Randomized controlled trials have long been the gold standard for evaluating new therapies. But for pediatric brain tumors, it can be difficult—if not impossible—to enroll the large numbers of patients needed for these studies.
The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) is excited to announce Marcos V. Oliveira Marques, MD, as the 2024 Surinderjit Singh Young Lectureship Award recipient.
Measuring heart rate or body temperature may sound easy, but retrieving the data from small animals with bulky traditional tech is difficult, especially during behavioral tests, which are critical for understanding brain disorders. Thanks to a recent study, the animal data is now in reach.
Dr. Morcos assumes the role of president of the American Association of Neurological Surgeons (AANS) for 2024-25. His term will culminate with the prestigious 2025 AANS Annual Scientific Meeting scheduled to convene in Boston on April 25-28, 2025.
Attention Deficit Hyperactivity Disorder can impact many common childhood milestones and cognitive processes, such as decision-making, inhibitory control, language development, and goal-setting.
The Faculty of Psychology at Chulalongkorn University cordially invites everyone to join a Research Sharing Session on “Neural Sensitivity and Facilitation in Visual Word Processing of Typical and Dyslexic Readers” presented by Prof. Dr. Urs Maurer from the Department of Psychology, The Chinese University of Hong Kong.
The American Macular Degeneration Foundation supports a diverse portfolio of research investigations to advance the development of treatments, tools and usable information that improve the lives of those affected by AMD.
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.
Sylvester Comprehensive Cancer Center today announced establishment of the Sylvester Brain Tumor Institute. It will focus on personalized medicine approaches for treating all patients with brain tumors.
Neuropathy, the nerve damage that causes pain and numbness in the feet and hands and can eventually lead to falls, infection and even amputation, is very common and underdiagnosed, according to a study published in the May 8, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
How a non-invasive technique temporarily opened the blood-brain barrier to deliver an immunotherapy drug to the brain in a large animal study.
In a groundbreaking study published May 2, 2024 in Neuron, researchers have identified four new genetic risk factors for multiple system atrophy (MSA), shedding light on this poorly understood disorder.
Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to produce potential therapeutic effects in patients with neuropsychiatric disorders such as depression and anxiety.
Researchers from the University of California, Irvine have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly. These findings point to the potential of developing precise prognostic and therapeutic interventions.
With this funding, FAU researchers will shed light on the biological functions of Alzheimer’s disease (AD) by taking advantage of synthetic chemistry strategies; provide an innovative online screening tool for older drivers with cognitive decline; and gain a deeper understanding of the role of brain cholesterol in AD.
UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep. This efficient memory occurs in a part of the brain that is crucial for learning and memory, and where Alzheimer’s disease begins.
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