Prospective Trial Evaluating Transanal Endoscopic Total Mesorectal Excision for Rectal Cancer
Diseases of the Colon and Rectum JournalSeveral groups have championed standardization of this approach in order to optimize outcomes.
Several groups have championed standardization of this approach in order to optimize outcomes.
Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify all patients who may respond to certain therapies. Other molecular information from patients may reveal these so-called “hidden responders."
Articles on personal care product chemicals; PBPK modeling; 2D vs 3D for drug-induced liver injury; zebrafish and drug discovery; glutathione restoration and acetaminophen; high-throughput screening for thyroid hormone T4; and genetically engineered food crops featured in new Toxicological Sciences.
More people are receiving coronary revascularization under Michigan's Medicaid expansion (the Healthy Michigan Plan). A new analysis finds that the expansion hasn’t caused significant problems for patients.
Researchers at the University of Notre Dame focused on an enzyme in gram-negative bacterium Pseudomonas aeruginosa, a pathogen that causes pneumonia and sepsis.
Many of the “forensic science” methods commonly used in criminal cases and portrayed in popular police TV dramas have never been scientifically validated and may lead to unjust verdicts, according to an editorial in this week’s Proceedings of the National Academy of Sciences.
Columbia Engineering researchers have invented a new Robotic Spine Exoskeleton, a dynamic spine brace that enabled them to conduct the first study that looks at in vivo measurements of torso stiffness and characterizes the three-dimensional stiffness of the human torso. This device may solve current bracing limitations and lead to new treatments for children with spine deformities such as idiopathic scoliosis and kyphosis.
New Yorkers love apples. The Empire State is the second-largest apple grower in the U.S. and is the No. 1 producer of processedapple products, such as cider, juice and canned apples. Given this appreciation for apples, consumers might be concerned by reports from food scientists of a fungus, Paecilomyces niveus, that spoilsapple products even after heat pasteurization. The fungus also produces an FDA-regulated toxin called patulin that is found in these spoiled processed foods.
This week, the Axion Dark Matter Experiment (ADMX) unveiled a new result, published in Physical Review Letters, that places it in a category of one: It is the world’s first and only experiment to have achieved the necessary sensitivity to “hear” the telltale signs of dark matter axions. This technological breakthrough is the result of more than 30 years of research and development, with the latest piece of the puzzle coming in the form of a quantum-enabled device that allows ADMX to listen for axions more closely than any experiment ever built.
“As researchers, they take risks without knowing the answers...I really admire it.”
UIC researchers have confirmed for the first time the association of a chromosomal genetic variant with increased risk of AFib in Latinos. Latino patients were found to be at a 2.3-fold increased risk for developing AFib if they carried this common genetic variant, which is labeled rs10033464 SNP at chromosome 4q25.
A promising class of drugs known as CD40 monoclonal antibodies could be the spark needed to light the fire in the immune system of patients who don’t respond to the newer cancer immunotherapies. Robert H. Vonderheide, MD, DPhil, director of the Abramson Cancer Center at the University of Pennsylvania and an internationally renowned cancer immunotherapy expert, makes the case for the drugs in a new perspective piece published this week in Cancer Cell, as part of a series in the issue focusing on the next phase of the evolving field of cancer immunotherapy.
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered that that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice. The findings suggest that mTOR inhibitors currently used to treat a wide range of cancers may have the unintended consequence of shutting down fat tissue metabolism and fueling tumor growth.
New research from Florida State University scientists has found that urban areas throughout the Florida peninsula are experiencing shorter, increasingly intense wet seasons relative to underdeveloped or rural areas.
UPTON, NY—Scientists studying plant biochemistry at the U.S. Department of Energy’s Brookhaven National Laboratory have discovered new details about biomolecules that put the brakes on oil production. The findings suggest that disabling these biomolecular brakes could push oil production into high gear—a possible pathway toward generating abundant biofuels and plant-derived bioproducts.
The term “superfluid quasicrystal” sounds like something a comic-book villain might use to carry out his dastardly plans. In reality, it’s a new form of matter proposed by theoretical physicists at The University of Texas at Dallas in a recent study published in the journal Physical Review Letters.
UCLA researchers have tweaked CRISPR technology, enabling them to monitor the outcome of tens of thousands of gene edits in the time it currently takes to analyze a few. The advance will improve scientists’ ability to identify the genetic changes most likely to harm cells and contribute to disease.
EMBARGOED - A team of Cedars-Sinai investigators has developed a new technique for conducting cardiac magnetic resonance imaging (MRI) tests that improves patient comfort, shortens testing time and has the potential to increase diagnostic accuracy and reliability.
Studying data from more than 125,000 individuals, an international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified genetic links between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The link between the seemingly unrelated disorders suggests that some drugs developed to treat ALS also may work against frontotemporal dementia and vice versa.
Examining 44,000 brief text samples collected over 25 years, a study of ego level and language sheds light on ego development, its relationship with other models of personality and individual differences, and its utility in characterizing people, texts and cultural contexts. If ego development can be scored from everyday language, then text from Twitter feeds to political speeches, and from children’s stories to strategic plans, may provide new insights into the state of moral, social and cognitive development.
Compared to physicians who didn’t receive any payments, those who received general payments for meals and lodging from a drug manufacturer had higher odds of prescribing that company’s particular drug for metastatic renal cell carcinoma and for chronic myeloid leukemia.
By April, nearly one-third of the U.S. is already experiencing high pollen levels while the weather and temperatures continue to fluctuate, aggravating sinus symptoms. A patient’s mucus may predict the type of his or her chronic sinusitis, which could help doctors determine whether surgery or medical treatments can produce the best outcomes, according to a recently published Vanderbilt study.
An international team of researchers is laying the foundation for more widespread use of lithium metal batteries. They developed a method to mitigate the formation of dendrites - crystal-like masses - that damage the batteries' performance.
The findings of two recently published studies on the emergence of hookah use indicate that public health officials may need to consider broadening their tobacco prevention efforts beyond traditional cigarettes.
Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified that RUNX3, a tumour suppressor gene absent in many cancer types, acts as a barrier against oxidative stress in cancer cells.
This one simple mathematical trick can accurately predict the shape and melting effects of ponds on Arctic sea ice, according to new research by UChicago scientists. The study, published April 4 in Physical Review Letters by researchers with UChicago and MIT, should help climate scientists improve models of climate change and perhaps plug a gap between scientific predictions and observations over the past decade, they said.
The mirror-like physics of the superconductor-insulator transition operates exactly as expected. Scientists know this to be true following the observation of a remarkable phenomenon, the existence of which was predicted three decades ago but that had eluded experimental detection until now. The observation confirms that two fundamental quantum states, superconductivity and superinsulation, both arise in mirror-like images of each other.
A new smartphone app allows Parkinson's disease patients and their doctors to better track the progression of symptoms, such as tremors and walking difficulties, that can vary dramatically over days, or even hours.
Researchers at Harvard Medical School, the University of California, San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and packaged. The research, which could facilitate the development of new antibiotics, will appear in the April 6 issue of the Journal of Biological Chemistry.
A University of Kentucky faculty member is looking into explanations for why prices for consumers don't always come back down the way we may think they should.
PHILADELPHIA – Jeffrey S. Berns, MD, associate chief of the division of Renal-Electrolyte and Hypertension in the Perelman School of Medicine at the University of Pennsylvania, received the 2018 Donald W. Seldin Distinguished Award from the National Kidney Foundation (NKF), an award given to clinicians who display excellence in clinical nephrology.
Researchers from the University of Illinois at Chicago and Nosopharm report on the discovery of a new class of antibiotics that may be effective at treating drug-resistant infections.
A new Michigan State University study is the first to find that a particular type of lipid, or fat, thought to only exist in the skin, now lives in your eye and might play a major role in deterring diabetic retinopathy.
New research shines a light on specific cell types that drive normal or diseased kidney function at the molecular level.
Most of us don’t think about our teeth and bones until one aches or breaks. A team of engineers at Washington University in St. Louis looked deep within collagen fibers to see how the body forms new bone and teeth, seeking insights into faster bone healing and new biomaterials.
One third of children who have autism spectrum disorder also have epilepsy. It’s related to a major autism risk gene, which is mutated in patients with autism. But scientists didn’t now why the mutation, catnap2, caused seizures.Now Northwestern Medicine scientists have discovered the mutation acts like a bad gardener in the brain.
New research suggests that species that live on green roofs arrived by hitching lifts on birds or by riding air currents.
McMaster researchers have developed a test to bring certainty to the delicate but critical question of whether meat and other foods are safe to eat or need to be thrown out.
A new blood test has been found to more accurately predict the development of tuberculosis up to two years before its onset in people living with someone with active TB, according to research published online in the American Journal of Respiratory and Critical Care Medicine, an American Thoracic Society journal.
University of Adelaide research has discovered that drugs used in the treatment of certain brain disorders, including epilepsy, also alter the signalling process in plants under stress.
While school lunches in the UK are subject to food standards, the contents of packed lunches are not as closely scrutinized, and studies have raised concern regarding the nutritional quality of packed lunches. A new study published in the Journal of Nutrition Education and Behavior found that children, not their parents, are often the primary decision maker of whether they will eat a school lunch or what is packed for their lunch.
A research team led by Associate Professor He Jianzhong from the Department of Civil and Environmental Engineering at NUS Faculty of Engineering has found that a natural bacterium isolated from mushroom crop residue can directly convert cellulose to biobutanol, a biofuel.
All children have moments of moodiness, but family medicine doctors and pediatricians may doubt their abilities to tell the difference between normal irritability and possibly bigger issues, according to Penn State researchers.
• The risk of death due to infectious causes after kidney transplantation in Finland has dropped by half since the 1990s. • Common bacterial infections remain the most frequent cause of infection-related deaths among transplant recipients.
We are the first to demonstrate that pTregs are important in autoimmune diabetes, and we hypothesize that microbes in the gut, where most of this pTreg cell population is switched on, may be responsible for generating these protective cells and thus protecting against the autoimmune attack on pancreatic beta cells that cause type 1 diabetes.
Lucia Leone and her team will expand their successful Veggie Van project by helping organizations across the Northeast and Southeast start mobile produce markets using the Veggie Van model.
The results of his MRI shocked Tracy Clifford, 58. The images showed a baseball-sized tumor on the base of his spine. Back then, he was unaware of the 2,400 mile journey he’d be undertaking – traveling to Beaumont Health in Michigan to seek leading-edge proton therapy for his tumor. Tracy hadn’t heard of Beaumont’s Proton Therapy Center, Dr. Kabolizadeh, his research or their team of cancer experts. That was all about to change.
Researchers from Case Western Reserve University School of Medicine and colleagues have discovered how two brain regions work together to maintain attention, and how discordance between the regions could lead to attention deficit disorders, including schizophrenia, bipolar disorder, and major depression.
Van Andel Research Institute (VARI) announced today that the work of its scientists is featured in 27 papers focused on the output of The Cancer Genome Atlas (TCGA). The papers were published across the Cell Press family of journals.
Cancer Research Institute iAtlas now online -- a comprehensive web-based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.