Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.
Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
Dr. Song Soo-chang's research team at the Center for Biomaterials, Korea Institute of Science and Technology (KIST, President Yoon Seok-jin), revealed the first development of poly(organophosphazene) hydrogel-based temperature-sensitive bioink that stably maintained its physical structure only by temperature control without photocuring, induced tissue regeneration, and then biodegraded in the body after a certain period of time.
New AI tool accurately predicts both overall survival and disease-free survival after colorectal cancer diagnosis. The model uses visual markers on pathology images to glean insights into a tumor’s genomic profile and predicts tumor behavior, disease progression, treatment response. The new model could help augment clinical decision-making. Because the AI tool relies on images alone, it could be particularly valuable for hospitals lacking the technology or expertise to perform sophisticated genomic profiling of tumor tissues.
Mayo Clinic has made significant strides biomanufacturing early-stage therapeutics. The focus is on new medicines derived from the human body, called biotherapeutics, which are shaping the future of medicine.
Accure Acne, Inc.™ (www.accureacne.com), a pioneer in the development of innovative solutions for the treatment of acne, announced today that Alfred (Al) Intintoli has joined the company as Chief Technology Officer.
Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the unveiling of its technology platform NULISA™, a novel automated ultrasensitive and highly multiplexed proteomics technology for liquid biopsy.
A new twist on a drug used to treat alcohol use disorder could double up as a treatment for stroke. Called “Carb” for short, this new formulation is designed to treat ischemic stroke, protect brain tissue against injury and minimize the size of a brain infarct.
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Some polymers can expand and contract — acting like artificial muscles — but only when stimulated by high voltages. Researchers in ACS Applied Materials & Interfaces report a series of thin, elastic films that respond to lower electrical charges, representing a step toward artificial muscles.
Wireless or leadless pacemakers, commonly implanted in adults, may be a safe and effective short-term option for children with slow heartbeats, according to new research published today in Circulation: Arrhythmia and Electrophysiology, a peer-reviewed journal of the American Heart Association.
Global pharmaceutical company Takeda has agreed to exclusively license a group of small molecules that target tau – a protein in which misfolding and aggregation are believed to be a cause of Alzheimer’s disease.
An implantable device that stimulates the vagus nerve, paired with traditional rehabilitation therapy, is being used to restore hand and arm function in stroke survivors treated in New Jersey.
A team of scientists from the Universities of Sheffield, Reading and University College London (UCL) and US-based biopharmaceutical company Neuresta have created a new, elongated botulinum neurotoxin which can alleviate chronic pain without risk of paralysis or addiction.
Imagine if you could ask a machine to “smell” something for you with just a click of a button. That’s what electronic noses, or e-noses, are for. They are systems that combine chemical gas sensors, signal processing and machine learning algorithms to mimic the sense of smell.
Did you know recycled human hair has many industry uses? As you might expect, beauty trends have fueled growth in the global hair business. But could those clippings — the ones often found on the floor of a hair salon — help repair dilapidated bridges and buildings across Kentucky and beyond? A research team in the College of Engineering at the University of Kentucky is leading the charge to answer that very question.
Ribonucleic acid (RNA) molecules are present in all living cells, with different types of RNA having different jobs. For example, messenger RNA is copied from DNA and carries instructions on how to make a protein. Transfer RNA (tRNA) links the mRNA sequence with its corresponding amino acid, ensuring that proteins are stitched together correctly as instructed by DNA.
Zhang et al. show that the mechanical properties of a three-dimensional (3D) hydrogel can enhance the secretion of niche factors from bone marrow stromal cells, which in turn promotes the maintenance of hematopoietic stem cells (HSCs) and reverses a
Li et al. report on the generation of cynomolgus monkey models of blastocyst-stage embryos (called “blastoids”) using naive cynomolgus embryonic stem cells. These blastoids recapitulate gastrulation in vitro and induce early pregnancy responses
Shivdasani et al. assign niche functions to specific mesenchymal cell types near stem cells at the base of intestinal crypts. They identify PDGFRAlo fibroblasts as a substantial source of requisite Wnt ligands and show that BMP signaling from crypt
Stem cell-based embryo models provide a useful system for studying early embryonic development. Li and colleagues reported the generation of cynomolgus monkey blastoids with similar characteristics to natural blastocysts. These blastoids possess the
The existence of adult beta cell neogenesis has been controversial, with numerous papers published arguing for and against over the years, and many conclusions in the field are thus based on studies that were performed years and sometimes decades ago
Marchiano and colleagues interrogate the underlying causes of ventricular arrhythmias occurring after human pluripotent stem cell-cardiomyocyte transplantation. Through stepwise analysis and gene editing of ion channel expression, they mitigate pace-
Alzheimer’s disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al. report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral s
Engraftment arrhythmia (EA) compromises the safety of hPSC-CM cell therapy. We hypothesized that spontaneous graft depolarizations are the source of EAs. We used a CRISPR screen to demonstrate that targeting excitatory channels HCN4, CACNA1H, and SLC
The process of generating adult-born neurons (ABNs) in the hippocampus is impaired in AD. Song and colleagues report a circuit-based strategy by stimulating SuM to enhance hippocampal neurogenesis in AD mice. Activation of SuM-modified ABNs restores
The paucity of hematopoietic stem cells (HSCs) presents a challenge for both transplantation and the study of HSCs.1 Sakurai et al.2 now present a cytokine-free culture system for robust ex vivo expansion of functional human HSCs that may lead to e
Magenheim et al. challenge a recent study claiming that pancreatic beta cells are generated at a physiologically important rate from progenitor cells within ducts. They show that the lineage-tracing systems used in that study do in fact pulse label
Yue and colleagues demonstrate that matrix stiffness negatively regulates the HSC niche factor expression by BMSCs. They successfully engineer a soft bone marrow niche that not only promotes HSC maintenance and lymphopoiesis but also rejuvenates midd
Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exc
Banjac et al. review the mechanisms behind homeostasis and regeneration in the epidermis, hematopoietic system, and intestinal epithelium with an emphasis on tissue stem cells. They highlight key challenges facing the field with reference to underst
Chemical reprogramming provides a robust approach for cell fate manipulation. Here, Deng and colleagues developed a highly reproducible and efficient chemical reprogramming method for the induction of human pluripotent stem cells and revealed increas
Announcement that NeuRx ® Diaphragm Pacing System, pioneered by University Hospitals and Case Western Reserve University in Cleveland, received FDA premarket approval. The system helps spinal cord injured patients breathe without a mechanical ventilator. Co-inventor Raymond Onders, MD, has implanted the system more than anyone else, and he travels the world teaching other doctors how to do it.
A pre-market regulatory status review conducted by the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service has concluded that teff modified by genome editing to have a semi-dwarf stature is not subject to biotechnology regulation under USDA’s SECURE Rule.
As Earth’s population grows, the demands of modern lifestyles place mounting strain on the global environment. Proposed solutions to preserve and promote planetary sustainability can sometimes prove more harmful than helpful. However, technologies that harness natural processes could be more successful.
Missing crucial doses of medicines and vaccines could become a thing of the past thanks to Rice University bioengineers’ next-level technology for making time-released drugs.
The financial terms of biotechnology licenses from academic institutions are significantly less favorable than those of comparable licenses between commercial firms according to a new study from Bentley University’s Center for Integration of Science and Industry.
The kidney plays a vital role in maintaining homeostasis within the body by eliminating toxic and superfluous substances in the bloodstream, including waste generated during metabolic processes, through urine.
Researchers at the University of Washington have developed GlucoScreen, a system that could enable people to self-screen for prediabetes.
New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.
The Sbarro Health Research Organization (SHRO), led by Prof. Antonio Giordano, in collaboration with the Texas Scientific Italian Community (TSIC), led by Prof. Andrea Giuffrida, will present the XVII Conference of Italian Researchers in the World on Saturday April 1st from 9:30 AM to 3:00 PM at Temple University of Philadelphia.
Bioactive compounds present mostly in fruit and vegetables perform different bodily functions relating to health and well-being. Their effects are considered antioxidant, antidiabetic, antiaging and anticancer, among others.
From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.
In Biophysics Reviews, researchers identify the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts. The team describes the components required to construct synthetic mitochondria and chloroplasts and identifies proteins as the most important aspects for molecular rotary machinery, proton transport, and ATP production. The authors believe it is important to create artificial cells with biologically realistic energy-generation methods that mimic natural processes; replicating the entire cell could lead to future biomaterials.
Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to myocardial dysfunction and the major cause of advanced heart failure requiring heart transplantation. Although optimized medical therapies have been develop
Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there is still a lack of ideal prevention and treatment measures in clinical practice. Notably, the transplan
Osteoporosis is a systemic bone disease, which leads to decreased bone mass and an increased risk of fragility fractures. Currently, there are many anti-resorption drugs and osteosynthesis drugs, which are effective in the treatment of osteopor
BACKGROUNDThe low survival rate of mesenchymal stem cells (MSCs) caused by anoikis, a form of apoptosis, limits the therapeutic efficacy of MSCs. As a proapoptotic molecule, mammalian Ste20-like kinase 1 (Mst1) can increase the production of re
For nearly 20 years, dental stem cells (DSCs) have been successfully isolated from mature/immature teeth and surrounding tissue, including dental pulp of permanent teeth and exfoliated deciduous teeth, periodontal ligaments, dental follicles, a
Most of the time, when someone gets a cut, scrape, burn, or other wound, the body takes care of itself and heals on its own. But this is not always the case. Diabetes can interfere with the healing process and create wounds that will not go away and that could become infected and fester.
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