Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers.
Yu-Ki Lee, Yue Hao, Zhonghua Xi, Woongbae Kim, Youngmin Park, Kyu-Jin Cho, Jyh-Ming Lien, In-Suk Choi
Wenjing Wan, Yuyang Miao, Yuwei Niu, Kunyuan Zhu, Yingwan Ma, Menghao Pan, Baohua Ma, Qiang Wei
Yulong Qiao, Qiang Sun, Xiaona Chen, Di Wang, Ruibao Su, Yuanchao Xue, Hao Sun, Huating Wang
Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y. Kwon, Fen-Biao Gao, Raymond Roos, Paschalis Kratsios
Katsuhiro Tomofuji, Jumpei Kondo, Kunishige Onuma, Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii, Etsuro Hatano, Masahiro Inoue
Charlotte Jaloux, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Julie Veran, Laurent Giraudo, Florence Sabatier, Justin Michel, Romaric Lacroix, Corinne Chareyre, Regis Legre, Gaelle Guiraudie Capraz, Francois Feron
The four-year award, part of the NIH’s BRAIN Initiative, will support the design, manufacturing and distribution of two types of new "miniscopes" that will allow scientists to peer much deeper into the brain than before.
Fenghua Qian, Brooke E Arner, Shaneice K Nettleford, Robert F Paulson, K. Sandeep Prabhu
Catherine Thieblemont, Bettina Altmann, Fabian Frontzek, Loïc Renaud, Loic Chartier, Nicolas Ketterer, Christian Recher, Viola Poeschel, Olivier Fitoussi, Gerhard Held, René-Olivier Casasnovas, Corinne Haioun, Franck Morschhauser, Be
Qiang Feng, Yushang Wang, Lihua Wang, Tianyong Sun, Song Shen, Zixuan Li, Xiaomei Ma, Xiufeng Gu, Xiumei Zhang, Ai Peng, Xin Xu
Xiang Xu, Shidan Li, Wei Xing, Shaochuan Wang, Youbin Li, Hao Jiang, Hanxuan Zheng, XiaoMing Li, Jing Yang, Debin Guo, Xiaoyu Xie, Renqing Jiang, Chao Fan, Lei Li, Jun Fei
Lola Reid, Wencheng Zhang, Giacomo Lanzoni, Eliane Wauthier, Sean Simpson, Amanda Allen, Carolyn Suitt, Juan Dominguez-Bendala, Vincenzo Cardinale, Domenico Alvaro, Diletta Overi, Eugenio Gaudio, Guido Carpino, Kyle Mathews,
Jian Zhang, Xiao Hu, Qiao Wu, Shangqin Guo
Haruka Miyata, Masakazu Ishii, Fumio Suehiro, Naohiro Komabashiri, Nao Ikeda, Tomoaki Sakurai, Masahiro Nishimura
Ana Gutierrez-Franco, Mohamed N. Hassan, Loris Mularoni, Mireya Plass
Inflammation and infection acutely suppress HSC function. However, the long-term ramifications of such challenges are unclear. This study demonstrates that murine HSCs fail to recover functional potency up to 1 year post-inflammatory/infection challe
Palikuqi et al. employ imaging of cleared intestinal tissue, transcriptional analyses, and genetic mouse models to investigate the role of lymphatic endothelial cells in the intestinal stem cell niche. The authors demonstrate that lymphatic endothel
Goto and colleagues identify lymphatic endothelial cells (LECs) and RSPO3+GREM1+ fibroblasts (RGFs) as stromal niche components of intestinal stem cells (ISCs). LECs and RGFs sustain ISCs through the production of RSPO3 and GREM1 in homeostasis. In i
A small-molecule cocktail reprograms human cord blood erythroblasts into induced megakaryocytes with ex vivo functionality. The four small molecules extensively remodel the chromatin and induce the dynamic network transition from erythroid master ge
Tsai and colleagues explored the impact of the Alzheimer’s disease-associated risk gene APOE4 onto the cellular communication of neurons and microglia. Through combinatorial experiments with cells derived from CRISPR-edited APOE isogenic lines, thi
Jing et al. combine a stroma-free differentiation system with EZH1-repression-mediated epigenetic reprogramming to generate developmentally mature iPSC-derived CAR T cells with enhanced antitumor activities.
Talbott et al. discuss the current state of knowledge in fibroblast biology and heterogeneity, primarily focusing on fibroblasts in skin wound repair. They also consider emerging techniques in the field and evaluate limitations of existing methodolo
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importan
In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes
In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.
I Gde Rurus Suryawan, Andrianto Andrianto, Arisya Agita, Anudya Kartika Ratri, Ricardo Adrian Nugraha
The entire virus detection process is executed inside a uniquely designed, portable, inexpensive, disposable, and self-driven microfluidic chip. The fully automated sample-in–answer-out molecular diagnostic set-up rapidly detects Hepatitis C virus in about 45 minutes and uses relatively inexpensive and reusable equipment costing about $50 for sample processing and disease detection. The disposable microfluidic chip also offers shorter times for a reliable diagnosis and costs about $2.
During the annual ACA meeting, David Goodsell, of Scripps Research and RCSB Protein Data Bank, will discuss his use of artistic methods to visualize biological data. His presentation, "Art as a Tool for Structural Biology," takes place Tuesday. Traditional artistic mediums, like painting, provide the freedom necessary to illustrate cells, and Goodsell is using illustrations to lay the foundation for computational modeling of whole cells. He also creates brightly colored, cartoonlike graphics with nonphotorealistic computer graphics methods to highlight the overall shape of molecules and how they assemble and interact.
For the first time, plant biologists have defined the high-efficiency “hacks” that cannabis cells use to make cannabinoids (THC/CBD).
Mayo Clinic is using 3D printing as a new option to heal the larynx after cancer or traumatic injury.
Researchers report that a gene therapy approach, developed at UC San Diego measurably delayed disease onset in humanized mouse and rat models of familial ALS, an inherited form of the disease that runs in families.
By creating a new framework for using mechanical energetics as a measurement for stability, Georgia Tech researchers have gained deeper insights into how and why we fall.
Researchers at the McKelvey School of Engineering at Washington University in St. Louis have developed a synthetic chemistry approach to polymerize proteins inside of engineered microbes.
Yoshimitsu Shimomura, Masashi Nishikubo, Hayato Maruoka, Seiko Nasu, Tomomi Nishioka, Kenji Sakizono, Satoshi Mitsuyuki, Tomoyo Kubo, Naoki Okada, Daishi Nakagawa, Kimimori Kamijo, Hiroharu Imoto, Ryusuke Yamamoto, Yuya Nagai,
JMIR Publications recently published "Nonfungible Tokens as a Blockchain Solution to Ethical Challenges for the Secondary Use of Biospecimens: Viewpoint" in JMIR Bioinformatics and Biotechnology in which the authors discuss how current practices of de-identifying human samples for research is reminiscent of the treatment of Henrietta Lacks’s tissue in 1951. They highlight how current standards continue to release researchers and health systems from obligations to promote respect, beneficence, and justice for patients.
Michael Herriges, Maria Yampolskaya, Bibek R Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Cheng-Lun Na, Liang Ma, McKenna M Montminy, Jessie Huang, Carlos Villacorta-Martin, Pankaj Mehta, Darrell N. Kotton
Raly James Custodio, Hee Jin Kim, Jiyeon Kim, Darlene Mae Ortiz, Mikyung Kim, Danilo Buctot, Leandro Val Sayson, Hyun Jun Lee, Bung-Nyun Kim, Eugene Yi, Jae Hoon Cheong
Adam Stabell, Shuxiong Wang, Grace Lee, Ji Ling, Sandrine Nguyen, George Sen, Qing Nie, Scott Atwood
Helena G Asenjo, Maria Alcazar-Fabra, Mencia Espinosa, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugan, Pedro Carmona-Saez, Antonio Sanchez-Pozo, Alvaro Rada-Iglesias, Robert J Klose, David
Chunbo Li, Luopei Guo, Keqin Hua
Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda
CHICAGO, July 26, 2022 /PRNewswire/ -- AACC 2022 Open Lab Solutions, Inc., is announcing the formation of a new division, AMCAR Scientific, that will focus on an expanding product line of plastic consumables used in the medical industry. OLS is exhibiting within booth #3257 at the 74th American Association for Clinical Chemistry Annual Scientific Meeting and Clinical Laboratory Exposition (AACC 2022) at the McCormick Place Convention Center in Chicago, July 24 – 28th.
In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,
BACKGROUNDDermal papillae (DP) and outer root sheath (ORS) cells play important roles in hair growth and regeneration by regulating the activity of hair follicle (HF) cells. AIMTo investigate the effects of human mesenchymal stem cell-derived
Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cor
For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (M
BACKGROUNDBronchopulmonary dysplasia (BPD) is not merely a chronic lung disease, but a systemic condition with multiple organs implications predominantly associated with hyperoxia exposure. Despite advances in current management strategies, lim
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