A new study led by University of Michigan Health Rogel Cancer Center researchers identifies novel biomarkers in renal cell carcinomas.
• Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles. • The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism. • Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.
Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions.
By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.
Fungal disease Fusarium head blight (FHB) is on the rise due to increasingly humid conditions induced by climate change during the wheat growing season, but a fundamental discovery by University of Adelaide researchers could help reduce its economic harm.
Scientists from the University of California San Diego discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis.
Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.
Using state-of-the-art microscopy techniques developed on campus, researchers at UC San Diego School of Medicine have shed new light on the underlying mechanisms driving Alzheimer’s disease.
A new study offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson’s disease and some dementias.
The Martinot Lab at Cummings School of Veterinary Medicine at Tufts University, where faculty and students have been researching the mpox virus in endometrial tissues to raise awareness of the potential increased risk of mpox virus for women.
Biologist B. Duygu Özpolat at Washington University in St. Louis and colleagues published a single-cell atlas for a highly regenerative annelid worm. This research may help inform stem cell technologies and regenerative medicine down the line.
The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That’s still the case, for the most part, but, Johns Hopkins Medicine researchers, studying nerve cells grown in the lab and mice, say that the proteasome’s role may go well beyond that.
A research team from the National University of Singapore (NUS) has unearthed new findings which may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet.
In findings published in Cell Reports, senior author Jerold Chun, M.D., Ph.D., and team also discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from Alzheimer’s disease.
A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington’s disease and multiple cancers.
New research from the University of Wisconsin–Madison decodes the evolutionary pathway of regulatory proteins, the molecules that help control gene expression.The findings from the Raman Lab in the Department of Biochemistry recently published their findings in the journal Cell Systems.
A team of scientists led an experimental study to determine the relationships between subpopulations of cells within the biofilm of a model microbe, revealing new insights regarding their potential.
The results of a UCLA study suggest that using CXCL9 and CXCL10-producing dendritic cells alongside immunotherapy can be a promising strategy to overcome treatment resistance and improve clinical outcomes for patients with non-small cell lung cancer.
A new study conducted in cell cultures showed that cholesterol-lowering drugs help to dampen the inflammation associated with periodontal disease by altering the behavior of macrophages, a type of immune cell.
Scientists at St. Jude Children’s Research Hospital and Dana-Farber Cancer Institute found a small set of proteins that maintain anaplastic large cell lymphoma (ALCL) identity, representing potential future therapeutic targets.
In a first for the condensate field, researchers from the McKelvey School of Engineering at Washington University in St. Louis, figured out how nucleolar sub-structures are assembled.
Researchers at the UNC School of Medicine have found that a metabolic enzyme called Acetyl-CoA Carboxylase causes T cells to store fat when they are in solid tumors, rather than burning fat for energy.
“We are hoping to use this competition not just as a way to examine the capacity of people to predict vaccination outcomes, but also as a way to address an important public health question,” says Peters.
Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.
Researchers from Skaggs School of Pharmacy and Pharmaceutical Science at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.
As we age, our hematopoietic (blood-forming) stem cells (HSCs) become less able to produce new red and white blood cells and other vital blood components—contributing to chronic inflammation and accelerating the onset of blood cancers and degenerative diseases.
Individuals with Williams syndrome have a gregarious “cocktail party” personality, while those with the opposite genetic alteration, in contrast, tend to have autistic traits and are prone to struggle socially. Research from UC San Diego sheds new light on the gene responsible.
A drug in clinical trials as a treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) works with a one-two punch that shuts down triglyceride production and fatty acid synthesis in liver cells, UT Southwestern Medical Center researchers show in a new study.
The biochemist of RUDN University and Institute of Biomedical Chemistry was the first to study how variants of the protein that controls T-lymphocytes affect the development of autoimmune diseases using the example of multiple sclerosis. This will help find new approaches to the treatment of autoimmune diseases.
People living in ancient Eastern Arabia appear to have developed resistance to malaria following the appearance of agriculture in the region around five thousand years ago, a new study reveals.
A subpopulation of gut bacteria given a commonly used antibiotic became "persisters" that were able to survive without developing true resistance, UT Southwestern Medical Center scientists discovered. Their findings, published in Cell Host & Microbe, could lead to better ways to fight bacterial infections.
A preclinical study led by a team of researchers at Roswell Park Comprehensive Cancer Center highlights the potential of a novel two-drug treatment strategy targeting p53-mutant cancers.
Treating complex bacterial infections with customized therapies tailored to the infection and the patient is closer to reality, thanks to researchers at UT Southwestern Medical Center.
A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
Scientists at the University of Southampton have discovered that bacteria can pair up their defense systems to create a formidable force, greater than the sum of its parts, to fight off attack from phage viruses.
"Trans masculine people are people born female but do not identify as such, for example they feel male, gender fluid or non-binary. Our examination of their ovarian tissue shows that 33% of them show signs of recent ovulation, despite being on testosterone and no longer menstruating," says Joyce Asseler, PhD candidate at Amsterdam UMC.
Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples. Findings reveal how toxicant levels relate to their sex, breed, age and other demographic factors.
A team of scientists at the U.S. Department of Energy’s Argonne National Laboratory have discovered an intriguing “cooperative” behavior among components in batteries that points to an exciting new approach to designing next-generation technologies. The team found that combining two different types of anions, negatively charged ions, with cations, positively charged ions, can significantly improve the overall battery’s performance.
Researchers report in the journal Cell that ancient viruses may be to thank for myelin—and, by extension, our large, complex brains.
Scientists at the UC Davis School of Medicine may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.
Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.
University of Queensland-led research has shown there is more coral reef area across the globe than previously thought, with detailed satellite mapping helping to conserve these vital ecosystems.
In the treatment of aggressive lymphomas and blood cancer (leukaemia), so-called chimeric antigen receptor T cells (CAR T cells) are increasingly being used.
In a win for chemistry, inventors at the Department of Energy’s Oak Ridge National Laboratory have designed a closed-loop path for synthesizing an exceptionally tough carbon-fiber-reinforced polymer and later recovering all of its starting materials.
A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).
A team of researchers from the University of Massachusetts Amherst recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change—either internally or in the external environment—to thrive in good times or survive the bad times? The research, focused on plants and published in Cell, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.
A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth. Targeting PHGDH to modulate the cancer-fighting immune system could be a new starting point in cancer treatment and improve the effectiveness of clinical immunotherapies.
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