A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position and flips out when it encounters the right target. The new findings give scientists a clearer picture of the process through which cells eliminate proteins that promote diseases such as cancer and Alzheimer’s.
Treatment of multiple sclerosis (MS) and other inflammatory diseases may benefit by new findings from a study that identified potential therapeutic targets for a devastating disease striking some 2.3 million people worldwide.
Marine microorganisms play a critical role in capturing atmospheric carbon, but a new study finds much less certainty than previously believed about the populations of the viruses that infect these important organisms.
Pavithra Prabhakar, Kansas State University assistant professor of computing and information sciences, has received a five-year $446,000 CAREER award for her research on cyber-physical systems.
Workers at New York City hookah bars are inhaling hazardous levels of carbon monoxide and nicotine while at work, signaling yet another breach by their employers of New York City’s anti-smoking bylaws.
Having the wrong coat color during shorter winters is deadly for snowshoe hares and could lead to a steep population decline by mid-century. However, wide variance in molting times could enable natural selection to work.
As countries around the world seek to craft policy frameworks governing the powerful new genetic editing tool, policy makers need to determine 'thresholds of acceptability' for using the technology, according to three researchers from the Centre of Genomics and Policy at McGill University.
A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system’s effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.
Immunotherapy is one of the hottest emerging areas of cancer research. After all, using the body’s own cells to fight cancer can be more effective and less invasive than flooding the entire system with toxic chemicals. Yubin Zhou, Ph.D., assistant professor at the Center for Translational Cancer Research at the Texas A&M Health Science Center Institute of Biosciences & Technology, is studying how to use light to control the immune system and induce it to fight cancer.
Researchers, led by Ilir Agalliu, M.D., and Robert Burk, M.D., at Albert Einstein College of Medicine have found that when human papillomavirus (HPV)-16 is detected in peoples’ mouths, they are 22 times more likely than those without HPV-16 to develop a common type of head and neck cancer.
Gregory Gan, MD, PhD, doesn’t just study cancer cells to find out why they regrow and spread; he also studies their surroundings. Called the tumor microenvironment, he thinks it may help head and neck tumors regrow after radiation therapy or chemotherapy. Gan is using a two-year $150,000 grant from the Radiological Society of North America Research and Education Foundation to study the tumor microenvironment of head and neck cancers.
Researchers at University of California, San Diego School of Medicine and collaborators developed GenomeSpace, a cloud-based, biologist-friendly platform that connects more than 20 bioinformatics software packages and resources for genomic data analysis. The team is now developing and crowdsourcing “recipes” — step-by-step workflows — to better enable non-programming researchers to interpret their genomic data. The work is described in a paper published January 18, 2016 in Nature Methods.
The scars of childhood abuse and neglect affect adults’ brains for decades to come – including their ability to process and act on information both quickly and accurately, new research suggests.
Researchers at Duke Health are fine-tuning a test that can determine whether a respiratory illness is caused by infection from a virus or bacteria so that antibiotics can be more precisely prescribed.
Search for new inflammatory disease drugs may be aided by detailed structure of distinct ubiquitin ligase complex
Building on a 30-year, three-generation study of depressed individuals, their children and offspring, a study provides a better understanding of the familial risk for depression and the role neuroplasticity might have in increasing the risk of developing depression.
A Johns Hopkins Bloomberg School of Public Health analysis of registered medical marijuana users found that a hodgepodge of law and policy changes since 2001 had varying effects on the number of people consuming what in many states remains an otherwise illegal drug for its purported health benefits.
University of Nebraska-Lincoln receives $6.5 million grant to shape state policies; will lead a $26 million national research initiative.
Patients are often unaware that choosing the right hospital is very important to having a good outcome. A novel study published today in the prominent surgery journal JAMA Surgery showed that patients undergoing surgery at Magnet hospitals recognized for nursing excellence, and good nurse staffing, have better outcomes at the same or lower costs as other hospitals.
A Mayo Clinic study of people who received anesthesia for surgery after age 40 found no association between the anesthesia and development of mild cognitive impairment later in life.
According to a new study led by researchers at Tufts University, 92 percent of both large-chain and non-chain restaurants serve meals exceeding recommended calorie requirements for a single serving. The researchers suggest offering consumers smaller portions at lower prices.
Scientists have identified a gene that appears to play a significant role in raising a person’s risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the chromosomal disorder 22q11.2 deletion syndrome. Variations in this gene, RANBP1, may disrupt brain signaling in different neuropsychiatric conditions.
A new study led by scientists at The Scripps Research Institute shows how dangerous autoimmune responses, seen in diseases such as lupus and multiple sclerosis, might be “dialed down” without compromising the immune system’s ability to fight viruses and bacteria.
After developing a novel investigational technology called PathoChip that can rapidly identify elusive microorganisms, researchers succeeded for the first time in identifying a pathogen in a patient sample, demonstrating the proof of principle that this technology can be used to identify pathogens in human disease.
Despite widespread perception, the United States does not provide the worst end-of-life care in the world. In the first international comparison of end-of-life care practices, researchers from the Perelman School of Medicine at the University of Pennsylvania and colleagues from seven countries found that the United States actually has the lowest proportion of deaths in the hospital and the lowest number of days in the hospital in the last six months of life among the those countries, according to a new study published today in JAMA.
When a child comes home from preschool with a stomach bug that threatens to sideline the whole family for days, why do some members of the family get sick while others are unscathed? According to a Duke Health study published January 19 in the Journal of Infectious Diseases, a person’s resistance to certain germs, specifically E. coli bacteria, could come down to their very DNA.
Two consecutive nights of extended sleep, a typical weekend occurrence, appears to counteract the increased risk of diabetes associated with short-term sleep restriction during the work week, at least in lean, healthy, young men eating a controlled diet.
Working with mice, researchers have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their own insides. Their results, moreover, bring with them a possible antidote.
Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings also suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant.
Using strands of nucleic acid, scientists have demonstrated basic computing operations inside a living mammalian cell. The research could lead to an artificial sensing system that could control a cell’s behavior in response to such stimuli as the presence of toxins or the development of cancer.
For a team of Vanderbilt investigators trying to generate heart muscle cells from stem cells, a piece of broken equipment turned out to be a good thing.
Infections caused by vancomycin-resistant Enterococcus faecium (VREfm) bacteria can often be serious and life threatening. These drug-resistant bacterial pathogens are one of the most problematic in the hospital setting. A researcher from Wayne State recently received a $1.9 M grant to explore treatment of these bacteria.
New research from scientists at The Wistar Institute shows that p53 is able to suppress accumulated DNA damage at telomeres. This is the first time this particular function of p53 has ever been described and shows yet another benefit of this vital gene.
While scientists have known for years that African trypanosomes cause sleeping sickness, they’ve been left scratching their heads as to how these tiny single-celled organisms communicate. A University of Georgia study, published Jan. 14 in the journal Cell, helps solve this mystery.
Using optogenetics and other technology, researchers have for the first time precisely manipulated the bursting activity of cells in the brain's thalamus, tying the alerting behavior to the sense of touch.
Radiation-induced breast cancer risk from digital mammography is low for the majority of women, but risk is higher in women with large breasts, who received 2.3 times more radiation and required more views per examination to image as much of the breast as possible compared to those with small or average-sized breasts.
The Georgia Institute of Technology is building a new lab that will allow roboticists from around the country to conduct experiments remotely. Researchers from other universities, as well as middle and high school students, will schedule experiments, upload their own programming code, watch the robots in real-time via streamed video feeds and receive scientific data demonstrating the results.
Do students think best when on their feet? A new study by the Texas A&M Health Science Center School of Public Health indicates they do. Findings published recently in the International Journal of Environmental Research and Public Health provide the first evidence of neurocognitive benefits of stand-height desks in classrooms, where students are given the choice to stand or sit based on their preferences.
Scientists at The Scripps Research Institute have discovered that a lipid (fat molecule) in brain cells may act as a “switch” to increase or decrease the motivation to consume nicotine.
Research will focus on enhancing nitrogen use efficiency.
Researchers at Albert Einstein College of Medicine and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have engineered the first antibodies that can potently neutralize the two deadliest strains of the virus that causes Ebola hemorrhagic fever. The findings, made in mice, are a significant step toward immunotherapies that are effective against all strains of Ebola virus that cause human disease. The study was published online today in Scientific Reports.
University of Utah lab experiments found that when temperatures get warmer, woodrats suffer a reduced ability to live on their normal diet of toxic creosote – suggesting that global warming may hurt plant-eating animals.
Scientists at The Scripps Research Institute have received a grant of more than $2.1 million from the National Institutes of Health’s National Institute of General Medical Sciences to create and screen a new library of drug candidates, using a branch of click chemistry.
When a child has a food allergy, it’s critical for pediatricians and allergists to show parents when and how to use an epinephrine auto-injector and to provide a written emergency food allergy action plan for home and school. But many parents say doctors don’t give them this potentially lifesaving information about their children’s emergency care, a new study reports. This communication gap needs to be fixed, researchers said.
A large new study reveals previously unknown risk factors associated with an eye condition that causes serious progressive nearsightedness at a relatively young age. The findings, made through the largest-ever clinical study of the condition called keratoconus, could help more people receive newer treatments that can slow the problem and protect their vision.
In a first-of-its-kind study of veterans and civilians, researchers from Vanderbilt University Medical Center found that one in 10 patients is at risk of having a new post-traumatic stress disorder (PTSD) following their time in the intensive care unit (ICU). The study, published in the American Journal of Respiratory and Critical Care Medicine, found that the cumulative incidence of PTSD following a critical illness and ICU experience was 6-12 percent and could occur up to one year after hospitalization.
Opioids may cause short-term improvement in mood, but long-term use imposes risk of new-onset depression, a Saint Louis University study shows.
The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice.
New and comprehensive analyses from six independent research teams examining breast cancer screening intervals have produced a unanimous finding — that mammography screening every two years for average risk women ages 50 to 74 offers a favorable balance of benefits to harm.
Researchers from Massachusetts Eye and Ear/Harvard Medical School and Case Western Reserve University School of Medicine have led an international effort to identify three genetic associations that influence susceptibility to primary open angle glaucoma — the most common form of adult onset glaucoma and the leading cause of irreversible blindness in the world.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right