Clinical trial to test potential for blood-based biopsies to identify cancer patients more likely to response to treatment with immunotherapy
Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. They caution in the journal Pediatric Blood & Cancer that expediting HLH treatment may miss underlying malignancies that could end up being fatal to the patient.
In a new study published in the Journal of Biological Chemistry, researchers at Imperial College London and the Francis Crick Institute report some of the details of how Salmonella shuts down an immune pathway after infection.
Wistar scientists have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.
Houston Methodist Cancer Center has expanded its basic cancer research program, cancer prevention and control efforts, and surgical oncology services with the addition of two national recruits.
UCI School of Medicine researchers have been awarded a $3.4 million grant by the National Cancer Institute (NCI) as part of the Beau Biden Cancer Moonshot initiative. The funding will support efforts to provide proof of principal data for an entirely new class of cancer killing immunotherapeutics with the potential to treat highly diverse types of cancer, from leukemia to breast cancer.
Scientists have known that bacteria produce small spherical versions of themselves. Lacking basic materials to function like normal cells, the role of minicells has remained a mystery. Now, researchers at UC San Diego have demonstrated for the first time that minicells play a key function in the survival of bacteria.
Diabetes makes it harder for the immune system to fight off some infections, leaving people with the condition at a higher risk for serious complications from vaccine-preventable diseases, like the flu, pneumonia, hepatitis B, tetanus and shingles.
Governor Andrew M. Cuomo today announced Buffalo-based Roswell Park Comprehensive Cancer Center has formed the Innovative Immunotherapy Alliance S.A., the first-ever biotech venture between the U.S. and Cuba.
Scientists in the UK have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to the study “Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment,” by Wong et al., published today in the Journal of Experimental Medicine.
CU Boulder researchers have identified a family of small molecules that turn off defense mechanisms inside bacteria that enable them to resist antibiotics. The compounds could ultimately be given alongside existing medications to rejuvenate them.
Researchers at the Case Western Reserve University School of Dental Medicine found that smoking also weakens the ability for pulp in teeth to fight illness and disease.
Restricting protein from a cancer patient’s diet may enhance the response to immunotherapy, according to an Indiana University cancer physician researcher.
Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers say their studies demonstrate that use of an experimental drug called CASIN in laboratory mice results in higher efficiency when harvesting blood stem cells from donors and less toxicity in transplant recipients.
Researchers at Mount Sinai have discovered that an antimicrobial protein found in the gut can stave off a common and highly lethal side effect of bone marrow transplants, according to a study published in the Journal of Clinical Investigation in September.
Harnessing the immune system to treat cancer shows great promise in some patients, but for many, the response does not last long-term. In an effort to find out why, Fred Hutchinson Cancer Research Center scientists are using a new technology to look at how cancer cells change under the pressure of immunotherapy treatments.
With fall just around the corner, the Centers for Disease Control (CDC) expects flu season to begin ramping up within the next few months.
Providers in states that expanded Medicaid were more likely to believe that the law would improve HIV outcomes, the study found. However, providers in all states agreed that the law would improve healthcare outcomes in general for their HIV patients.
A therapeutic vaccine can boost antibodies and T cells, helping them infiltrate tumors and fight off human papillomavirus (HPV)-related head and neck cancer. Researchers from the Abramson Cancer Center of the University of Pennsylvania tested the immunotherapy approach in two groups of patients with advanced head and neck squamous cell carcinoma (HNSCCa) and found 86 percent showed elevated T cell activity.
Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell’s binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.
Attention has focused on how NSAIDs may cause dysfunction of the immune system. Researchers now have found that sub-acute pretreatment with the NSAID carprofen before experimental heart attack in mice impaired resolution of acute inflammation following cardiac injury.
A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought.
Fibromyalgia patients who regularly visit their physicians are much less likely to attempt suicide than those who do not, according to a new Vanderbilt University Medical Center study published in Arthritis Care & Research.
The discovery made by Notre Dame researchers and their collaborators tosses a new wrench into the process of building better molecules to develop immunotherapies
Researchers at University of California San Diego School of Medicine have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings, published September 18 in Cell Reports, suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis.
– Primary care clinics experienced a significant decline in influenza vaccinations as the day progressed, researchers from Penn Medicine report in a new study published in JAMA Open Network. However, “nudging” clinical staff to order vaccines using a behavioral economics technique known as “active choice” may help curb some of that drop off, the study suggests. The study is the first to show how clinic appointment times can influence influenza vaccination rates.
A new study published in Annals of Allergy, Asthma and Immunology suggests African Americans have greater treatment challenges with AD than European Americans and require higher doses of some medications to get relief.
In a paper published in the journal Science, researchers have detailed a mechanism that sets the stage for the fate decision that gives rise to two major subsets of effector cells: T follicular helper cells and non-T follicular helper cells, known as Tfh and non-Tfh cells.
Rush is testing whether a vaccine can help people’s own immune system slow the spread of glioblastomas, a deadly form of brain cancer.
Vanderbilt-Ingram Cancer Center researchers have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies.
A team led by Marc Ernstoff, MD, of Roswell Park Comprehensive Cancer Center found that a drug complex containing IL-15 is both safe and well tolerated in patients with advanced solid tumors.
Using new bioinformatics tools to analyze thousands of human tissue samples, researchers created a new database of daily rhythms in human gene activity—including many genes that regulate how drugs work. Reporting in Science Translational Medicine, scientists say their results could have significant implications for a growing field of study called circadian medicine.
Researchers at the University of Maryland School of Medicine have made a surprising discovery: during fetal development, a particular immune cell seems to play a key role in determining the male or female characteristics of the brain.
Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at The University of Texas MD Anderson Cancer Center, has been recognized for her innovative work understanding factors that enhance and hinder cancer immunotherapy. Sharma will receive the William B. Coley Award for Distinguished Research in Tumor Immunology, awarded annually by the Cancer Research Institute (CRI), at an annual meeting co-sponsored by CRI in New York Sept. 30 to Oct. 3.
The Cancer Research Institute will bestow its highest honors on three scientists who have made fundamental contributions to the fields of immunology and cancer immunotherapy at its annual taking place on Thursday, October 25, 2018, at The Metropolitan Club in New York City.
he Cancer Research Institute will honor biotechnology company Regeneron, and journalist and filmmaker Perri Peltz with the 2018 Oliver R. Grace Award for Distinguished Service in Advancing Cancer Research at its annual gala taking place on Thursday, October 25, 2018, at The Metropolitan Club in New York City.
Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.
In mouse experiments, scientists have shown a way to hit an immunological “reset button” that ends inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure.
A new article published in Annals of Allergy, Asthma and Immunology, walks allergists and other health care providers through the steps involved in shared decision-making (SDM). It also details what is, and what is not, SDM.
Mayo Clinic physicians Matthew Block, M.D., Ph.D. and Tina Hieken, M.D., have received a Stand up to Cancer (SU2C) Catalyst Award to fund melanoma research and a neoadjuvant clinical trial.
There’s promise in specific immune system peptides – amino acid compounds that signal cells how to function – affecting brain activity.
Paul Brindley, PhD, at the GW School of Medicine and Health Sciences, has received more than $1.7 million from the National Cancer Institute at the National Institutes of Health to investigate the cellular and molecular links between liver fluke infection and bile duct cancer.
A combination of a novel inhibitor of the protein CK2 (Casein kinase 2) and an immune checkpoint inhibitor has dramatically greater antitumor activity than either inhibitor alone, according to research from The Wistar Institute that was published online in Cancer Research.
The August tip sheet from Fred Hutch includes story ideas about next-gen CAR T-cell immunotherapies, cancer care disparities in rural and urban settings, organizing chromosomes in egg and sperm cells, decoding our immune system's memories and more.
Recently published results of a phase 2 clinical trial have shown the best outcomes to date for newly diagnosed older Hodgkin lymphoma patients treated with brentuximab vedotin given before and after doxorubicin, vinblastine and dacarbazine (AVD) chemotherapy, which is the standard of care.
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