Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body’s immune system, an effect that is difficult to deliver with currently available pharmaceuticals, a new Yale study finds.
In a rare but serious complication of cancer, the immune system can start attacking the brain, causing rapid memory loss. What triggers this was largely unknown. Now, researchers at University of Utah Health have found that some tumors can release a virus-like protein, kickstarting an out-of-control autoimmune reaction.
The latest research and expertise on the flue can be found in the Influenza channel on Newswise.
Sergio E. Baranzini, PhD, a geneticist, neuroimmunologist, and data scientist at the University of California, San Francisco, is the winner of this year’s Barancik Prize for Innovation in MS Research.
Tomato juice can kill Salmonella Typhi and other bacteria that can harm people's digestive and urinary tract health, according to research published this week in Microbiology Spectrum, a journal of the American Society for Microbiology.
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.
It is with great pleasure that we announce the appointment of Lydia Lynch as a full member of the Princeton Branch of the Ludwig Institute for Cancer Research.
Storb was a Professor in the Department of Molecular Genetics and Cell Biology for more than 29 years.
One major hurdle in the development of safe and effective immunotherapies has been the risk of depleting healthy T cells during CAR-T treatment that seeks out and kills cancerous T-cells. In a new study published in Nature Communications, Yale Cancer Center researchers have developed a novel CAR-T cell therapy designed to efficiently kill cancerous T cells while leaving most healthy cells intact.
Over 700 million people were infected and almost seven million died, making SARS-CoV-2 the most devastating pandemic of the 21st century.
Researchers from IRB Barcelona describe a mechanism by which senescent cells generated by chemotherapy survive inside tumours.
RUDN University doctors have studied how anti-inflammatory immune cells can help mitigate an excessive immune response. The authors discovered both positive and negative aspects of the new approach, but overall they proved its promise.
Molecular defense system protects bacteria from viruses and at the same time makes them susceptible to antibiotics.
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Researchers with McMaster University have created the instruction manual that will help scientists across the globe find hard to detect B cells.
Six physician-scientists from the University of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia have been elected to the American Society of Clinical Investigation, joining one of the nation’s oldest and most respected medical honor societies composed of more than 3,000 physician-scientists representing all medical specialties.
Most people infected with the SARS-CoV-2 virus recover after the acute illness.
“We found sort of a special ‘flavor’ of CD4+ T cells critical for clearing this chronic virus replication,”
"These patients may be candidates in whom immunotherapy has the potential to show clinical benefit."
A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.
Kelly Kersten, Ph.D., who joined Sanford Burnham Prebys this month as an assistant professor in the Cancer Metabolism and Microenvironment program, studies the interactions between immune cells and their microenvironment to better understand how they contribute to anti-tumor immune responses.
Axi-cel CAR T targets the CD19 molecule on large B-cell lymphoma cells. The ZUMA-7 trial demonstrated that axi-cel reduced the risk of disease progression, the need for new therapy, or death by 60% compared to standard therapy. Despite these positive outcomes in event-free survival and overall survival, some patients did not respond well to therapy or relapsed quickly after treatment. Researchers wanted to assess if there were specific tumor characteristics associated with improved outcomes that could better inform treatment selection. Their findings were published today in Nature Medicine.
The award recognizes Dr. Chacon’s role as co-inventor of a licensed patent involving cancer immunotherapy.
By taking advantage of mechanisms that allow cancer cells to evade immune attack, UT Southwestern Medical Center researchers have developed a new strategy in animal models that has potential for treating ulcerative colitis.
Recent SARS-CoV-2 variants such as BA.4 and BA.5 developed abilities missing from the first Omicron variants that allowed them to overcome humans’ innate immunity, according to research from UCL.
Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in five incident TB cases were attributable to malnutrition, more than double the number attributed to HIV/AIDS.
Two studies led by a researcher at UT Southwestern Medical Center show the effects of different SARS-CoV-2 variants on lung tissue, revealing what may cause some COVID-19 infections to be more severe than others.
Researchers from Osaka University find characteristic changes in CD4+ T cell categories and gene programs associated with autoimmune disease.
A new paper in Molecular Biology and Evolution, published by Oxford University Press, finds that HIV populations in people with higher viral loads also have higher rates of viral recombination.
Cedars-Sinai Cancer investigators have analyzed the cells within triple-negative breast cancer tumors before and after radiation therapy with immunotherapy, identifying three patient groups with different responses to the treatment.
The body’s immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by UTHealth Houston.
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency.
Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment, also finding a way to deliver immunotherapy’s cancer-killing impact without the unwelcome side effect.
In a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind IKAROS, an essential protein for immune cell development and protection against pathogens and cancer.
A type of immune cell can help predict which patients may benefit most from cancer immunotherapies, researchers from King’s College London, Guy’s and St Thomas’ Hospital Trust, and the Francis Crick Institute have found.
Novel insights from the pandemic may be propelling the field of immunology into a new golden age.
حدد الباحثون والمتعاونون في مايو كلينك بروتينًا تفرزه الخلايا المناعية والذي قد يقوم بدورٍ رئيسيٍ في ظهور مرضالتصلُّب الجانبي الضموري، المعروف أيضًا باسم مرض لو غيريغ. ووجد الفريق أيضًا أن العلاج التعديلي المناعي الذي يقوم بعملية إِحْصار للبروتين يمكنه استعادة الوظيفة الحركية في النماذج قبل السريرية. وتشير النتائج إلى أن البروتين، المعروف باسم أ5 إنتغرين (الذي يُنطق ألفا 5 إنتغرين)، هو مستهدف علاجي محتمل لعلاج مرض التصلُّب الجانبي الضموري.
Los investigadores y colaboradores de Mayo Clinic han identificado una proteína expresada en células inmunitarias que podría desempeñar un rol clave en el desarrollo de la esclerosis lateral amiotrófica (ELA), también conocida como enfermedad de Lou Gehrig. El equipo también descubrió que un tratamiento inmunomodulatorio que bloquea la proteína era capaz de restaurar la función motriz en modelos preclínicos. Los hallazgos indican que la proteína, conocida como integrina α5 (pronunciado integrina alfa 5), es un posible blanco terapéutico para la ELA.
Pesquisadores e colaboradores da Mayo Clinic identificaram uma proteína que é expressa por células imunológicas que pode desempenhar uma função importante no desenvolvimento daesclerose lateral amiotrófica (ELA), também conhecida como doença de Lou Gehrig. A equipe também descobriu que um tratamento imunomodulador que bloqueia a proteína conseguiu restaurar a função motora em modelos pré-clínicos. As descobertas sugerem que a proteína, conhecida como integrina α5 (pronunciada como integrina alfa 5), é um possível alvo terapêutico para ELA.
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Cedars-Sinai Cancer investigators have discovered a new way to predict whether a cancer of the immune system will recur in patients treated with a bone marrow transplant.
With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.
The Cancer Research Institute and Lance Kawaguchi with the #SouthPoleTrek4Cancer ring in the Nasdaq Stock Market Closing Bell.
Researchers have found an inexpensive tool that may help reduce rates of pneumonia for hospitalized patients—and it comes with bristles on one end.
Researchers from the National University of Singapore (NUS) devise a simple and innovative way to directly identify and sort the immune cells involved in cell-mediated cytotoxicity.
Immune cells play an active and intimate role in directing the growth of human lung tissue during development, researchers find, revolutionising our understanding of early lung development and the role of immune cells outside of immunity.
UChicago Medicine researchers discover that restoring BAMBI to normal levels in immune suppressive cells can overcome resistance to radiation therapy.
Using lab-made cells, Harvard Med researchers identify how the immune system neutralizes herpesvirus. Study maps, for the first time, the maneuvers used by virus and host in the cell nucleus. Findings could inform design of new treatments for herpes and other viruses that replicate in the same way.
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