An artificial intelligence technique that combs electronic medical records can identify trauma patients who misuse alcohol, a study has found. In 78 percent of cases, the technique was able to differentiate between patients who misused alcohol and those who did not.
The research, by the Genetic Investigation of ANthropometric Traits (GIANT) consortium, identifies genetic variants associated with obesity that are central to developing targeted interventions that can reduce the risks of chronic illnesses to which obesity contributes in significant ways.
The Next Generation Precision Oncology Symposium, a novel meeting of industry and academic leaders in cancer science and medicine, will be held February 21, 2019 at UC San Diego Moores Cancer Center.
Researchers have successfully identified two genetic markers for potentially effective treatment of Mesothelioma, an orphan disease most commonly associated with asbestos exposure, and for which few treatments exist.
Leading health care companies and organizations representing patients, providers, academic medical centers, laboratories, and diagnostic manufacturers urged the Centers for Medicare and Medicaid Services to revise its interpretation of the National Coverage Determination for Next Generation Sequencing.
Researchers from the George Washington University , the U.S. Food and Drug Administration, and industry leaders published in PLOS Biology, describing a standardized communication method for researchers performing high-throughput sequencing called BioCompute.
The first U.S. patient to participate in a global study of a stem cell therapy injected directly into the brain to treat stroke disability was enrolled in the clinical trial this week at The University of Texas Health Science Center at Houston (UTHealth).
UT Southwestern Medical Center is helping the Duff family organize a gene therapy clinical trial to treat Talia’s condition, called Charcot Marie Tooth disease, type 4J (CMT4J).
For children—whose tiny bodies are still growing—chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications.
George Mias, Michigan State University biochemistry and molecular biology researcher, believes precision medicine -- a personalized approach using technology to analyze an individual's wellness to predict and possibly prevent illnesses -- can keep astronauts healthy during deep space missions.
ONEVoice, a landmark survey funded by the Muscular Dystrophy Association (MDA) and conducted by Edge Research, has identified key areas of concern among more than 3,000 respondents – 2,430 adults with neuromuscular disease and 932 caregivers/family members – as well as ways in which many of these concerns can be addressed.
Manish Kohli, M.D., has joined Moffitt Cancer Center as the vice chair of the Department of Genitourinary Oncology. He also has an extensive research background, focusing on creating new ways to bring individualized care to patients.
By pairing a novel personalized cancer vaccine with a more established immunotherapy drug that is administered to patients in an innovative fashion, scientists at Dana-Farber Cancer Institute are testing a first-of-its-kind strategy aimed at improving outcomes for kidney cancer patients who are at high risk of recurrence following surgery.
Professor Dean Ho, Director of the Singapore Institute for Neurotechnology at the National University of Singapore, has been elected as a Fellow of the United States National Academy of Inventors, the highest professional accolade for academic inventors.
Bethesda, MD, December 4, 2018 – Human organoids are being hailed as a major development in biomedicine in a report issued by the American Society for Cell Biology (ASCB) to be released Monday, Dec. 10 at a session at the 2018 ASCB|EMBO Meeting in San Diego, CA.
Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular threat to young children.
Precision medicine will extend beyond prediction, diagnosis and treatment of disease to also include broader health initiatives, including prevention, nutrition and wellness. These new procedures raise novel legal, policy and ethical issues.
The PhRMA Foundation and the Personalized Medicine Coalition (PMC) partnered earlier this year for the 2018 Value Assessment Challenge Awards — designed to encourage innovative approaches in defining and measuring value in health care.
New team-based care guided by a personalized risk score for heart failure patients reduced the mortality rate of high-risk heart failure patients by nearly 50 percent, according to new research from the Intermountain Medical Center Heart Institute in Salt Lake City.
The $200-million commitment will fund:
o Fundamental curiosity-driven research and a therapeutics initiative to catalyze the development of new treatments
o Integrated data science and artificial intelligence capabilities and applications
o Cross-disciplinary research across the Harvard life sciences ecosystem
o LifeLab Longwood, an incubator for early-stage, high-potential biotech start-ups
In honor of the gift—the largest in Harvard Medical School history—the School will name a research institute for the donor to recognize the pioneering work of its basic science and social science departments.
New agreement between National Comprehensive Cancer Network and Syapse will augment health information technology around precision medicine and biomarkers in cancer care
A subset of patients with low-risk breast cancer is highly unlikely to see cancer return following breast conservation surgery but can lower that risk even further with radiation therapy, finds a new long-term clinical trial report. These 12-year follow-up data from the only prospective, randomized trial to compare recurrence outcomes after treatment for low-risk ductal carcinoma in situ (DCIS) were presented last week at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Research scientists find that a gene involved in the immune system called IDO2 plays a significant role in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer. The discovery may help physicians provide better treatment options for patients.
The PhRMA Foundation and the Personalized Medicine Coalition (PMC) have announced the recipients of the 2018 Value Assessment Challenge Awards – designed to encourage innovative approaches in defining and measuring value in health care.
A team led by Dr. Adam Friedman from the GW School of Medicine and Health Sciences found nanoparticle technology shows promise in therapy for triple-negative breast cancer.
Mayo Clinic released a new DNA product with Helix, a personal genomics company, called "Mayo Clinic GeneGuide." The DNA-powered product provides healthy individuals with genetic testing and insights with a focus on education. This product is backed by Mayo medical science and expertise.
A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.
The international summit will convene leaders in reproductive biology, precision medicine, public health and global health advocacy. The experts will share groundbreaking research and will culminate with crowdsourcing ideas on how to move women’s health to the forefront of medical research.
UC Davis Comprehensive Cancer Center has received a $6.3 million grant from the National Cancer Institute’s (NCI) Center to Reduce Cancer Health Disparities for a 5-year study to tease out why some ethnic and racial minority groups fare worse than whites when they get cancer and to find more precise treatments to improve their chances of survival.
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. The newly published research in the journal Cell Stem Cell is the first time scientists have been able to grow human esophageal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body.
Value in Health, the official journal of ISPOR (the professional society for health economics and outcomes research), announced the publication of a series of articles that tackle the challenges associated with assessing the value of next-generation sequencing technologies in clinical care.
The Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) today announced the opening of the Randi and Brian Schwartz Family Cancer Immunotherapy and Cell Manipulation Facility. The state-of-the-art laboratory expands BIDMC’s research capacity with the ultimate goal of accelerating the delivery of new immunotherapies to patients with cancer.
A new grant to University of Michigan Rogel Cancer Center member Arul Chinnaiyan, M.D., Ph.D., will provide long-term support to increase understanding of genetic markers to leverage targeted treatments for cancer.
For the 2018 annual meeting of the AANEM, more than 200 research abstracts were submitted on various topics related to neuromuscular and electrodiagnostic medicine. However, each year, special recognition is awarded to the authors of the best research abstracts (up to 10 abstracts) submitted on the AANEM President’s chosen topic.
Asthma patients, with a specific genetic profile, exhibit more intense symptoms following exposure to traffic pollution, according to researchers at the National Institutes of Health and collaborators. The study appeared online in Scientific Reports.
Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society (ACS), is today unveiling its annual “Talented 12” list. This award program, now in its fourth year, and for the first time sponsored by Thermo Fisher Scientific, recognizes young global stars in the chemical sciences that are working to solve some of the world’s most challenging problems. These up-and-coming innovators in chemistry will be debuted at an event today at ACS’ 256th National Meeting & Exposition. They are also featured in this week’s issue of C&EN.
University Hospitals Seidman Cancer Center in Cleveland has a new clinical trail to study the safety of CAR-T therapy for Non-Hodgkin's lymphoma. In addition, UH is manufacturing on-site the cells used in the trial.
In 1993, neurologist Camilo Gomez, MD, coined a phrase that became a fundamental rule of stroke care: "Time is brain!" The longer therapy is delayed, the less chance it will succeed. But the "time is brain" rule is not as simple as it once seemed, Dr. Gomez now reports in the Journal of Stroke & Cerebrovascular Diseases.
By analyzing thousands of flies, scientists at University of Utah Health found that variation in a background gene, called Baldspot, can make a difference in severity of the disease.
Elijah Patino is a happy, healthy seven-year-old now, but it took a while to get there. For much of his life, he had a mysterious disease that made it painful to eat and painful to play. A pediatric immunologist resolved this "diagnostic odyssey" by identifying the molecular cause of this autoimmune condition, then crafted a low-dose immunosuppressive regimen to provide a precise treatment.
Scientists at the Innovative Genomics Institute have concocted a transformative new way to harness the power of evolution. Today in Nature, researchers at UC Berkeley describe yet another creative application for CRISPR: a platform to spur evolution of specific genes inside cells. Their inventive new system, “EvolvR,” lets scientists shake up the DNA letters in their gene of choice until they find the variation that’s just right. The technology opens up countless possibilities, like engineering yeast that efficiently turn waste into biofuels, or developing new human therapeutics.
Designing a new pharmaceutical drug takes years of research, and now chemists and computational and computer scientists have developed a software framework that could help expedite this process by supporting accurate and rapid calculations of how strongly drug compounds bind to target molecules.
Fitness trackers can be valuable tools for assessing the quality of life and daily functioning of cancer patients during treatment, a new study has found. The trackers, also known as wearable activity monitors, include commercial devices worn on the wrist that log a wearer's step counts, stairs climbed, calories, heart rate and sleep.
University Hospitals has selected the 2bPrecise platform to make genomic data points more accessible to physicians allowing for the data to be part of the medical record and subsequently shape and tailor the best treatment or therapy options for patients.