UC San Diego clinical trial suggests ivabradine may be effective in treating postural orthostatic tachycardia syndrome, a potential COVID-19 long-hauler symptom.
According to some estimates, chronic pain affects up to 40% of Americans, and treating it frustrates both clinicians and patients––a frustration that's often compounded by a hesitation to prescribe opioids for pain.
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.
In a new study led by researchers at Yale Cancer Center, the drug enfortumab vedotin significantly prolonged survival as compared with standard chemotherapy in patients with locally advanced or metastatic urothelial carcinoma or bladder cancer, who had previously received platinum-based treatment and a PD-1–PD-L1 inhibitor.
Cleveland: Cleveland Clinic researchers have found that zinc or ascorbic acid (vitamin C) - or a combination of the two - do not significantly decrease the severity or duration of symptoms in COVID-19-positive patients, when compared to standard care. The study was published today in JAMA Open Network.
The AIDS Clinical Trials Group has added rapid infusion, intramuscular injection, an inhalant, and an oral agent to its ACTIV-2 phase 2 and 3 evaluations of multiple investigational agents for treating early, symptomatic COVID-19 in a single trial for outpatient treatment.
An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells.
Despite a Mexican government initiative launched in 2015 to improve access to prescription opioids among palliative care patients, the country has seen only a marginal increase in dispensing levels, and inequities in dispensing have left many of the nation’s poorest residents without comfort in their final days
In the early days of the COVID-19 pandemic, it was established that SARS-CoV-2 infects cells by binding to the human protein ACE2, which plays a role in regulating blood pressure.
Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of COVID-19, revealing vital clues for the discovery of antiviral drugs.
Aileen Starnbach, MD, has been named Chair of Anesthesia at Mount Auburn Hospital.
On the 18th and 19th of February, Sbarro Health Research Organization (SHRO) Founder and Director, Antonio Giordano, M.D., Ph.D., will host an online medical conference titled, “Why do we need independent research in oncology?”
Ten organizations have created a pipeline of artificial intelligence and simulation tools to narrow the search for drug candidates that can inhibit SARS-CoV-2.
In a new study, scientists have discovered the cellular pathway that leads to osteoarthritis and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
Animal venoms as natural resource for new drugs. Currently, there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.
Researchers at the University of Illinois Chicago have been awarded a five-year, $10.15 million grant to develop a broad-spectrum immunomodulatory eye drop.
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma.
The McMaster research team is partnering with research clinic Cardresearch and the Pontifical Catholic University of Minas Gerais in Brazil as well as the University of Stellenbosch in South Africa on an ongoing clinical trial established to answer multiple questions of drug effectiveness over time.
A new study describes how cellular survival after radiation exposure depends on behavior of the protein p53 over time. In vulnerable tissues, p53 levels go up and remain high, leading to cell death. In tissues that tend to survive radiation damage, p53 levels oscillate up and down.
Researchers have identified a previously unknown site on the filovirus glycoprotein to which small drug molecules can bind and prevent infection -- blocking both sites may be more a more effective treatment with reduced risk of side effects.
DALLAS – Feb. 8, 2021 – A new nanoparticle-based drug can boost the body’s innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment.
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020.
A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy bacteria — may be key to the development of a new class of antibiotics for human health.
Wayne State University researchers have reported that zinc supplements for men and women attempting to conceive either naturally or through assisted reproduction during the COVID-19 pandemic may prevent mitochondrial damage in young egg and sperm cells.
In a new perspective piece published in the Feb. 5 issue of Science, pharmacologist Namandje Bumpus, Ph.D. — who recently became the first African American woman to head a Johns Hopkins University School of Medicine department, and is the only African American woman leading a pharmacology department in the country — outlines the molecular origins for differences in how well certain drugs work among distinct populations. She also lays out a four-part plan to improve the equity of drug development.
Shortages of many essential drugs amid the COVID-19 crisis reveal serious vulnerabilities in the systems for supplying and distributing pharmaceuticals in the United States.
UVA Health is offering monoclonal antibody drugs for appropriate patients with COVID-19 who are at highest risk for developing severe symptoms and requiring hospitalization.
Although an expert FDA panel voted ten to one to withhold approval for a Biogen anti-Alzheimer's drug candidate, the Alzheimer's Association endorsed the compound. Serious questions have been raised about why, including conflict of interest.
A new drug candidate has been discovered by the University of South Australia (UniSA) to treat the most lethal form of brain cancer – glioblastoma – which kills 95 per cent of patients within five years. Clinical trials will begin this year.
Researchers identified spinal cord neurons responsible for an itchy sensation after an epidural morphine injection and found a drug that may fix the problem without reducing morphine’s pain-killing effects.
DALLAS – Feb. 3, 2021 – Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery – but two new studies from UT Southwestern provide answers on the way this process works.
World-first 3D printed oesophageal stents developed by the University of South Australia could revolutionise the delivery of chemotherapy drugs to provide more accurate, effective and personalised treatment for patients with oesophageal cancer.
Experts discuss key insights in clinical treatment of COVID-19 from Year One of the pandemic.
Interim analysis from phase 3 trial of nearly 20,000 participants suggests efficacy of two-dose regimen of the adenovirus-based vaccine is 91.6% against symptomatic COVID-19 - trial reports 16 COVID-19 cases in the vaccine group (0.1% [16/14,964) and 62 cases (1.3% [62/4,902]) in the placebo group.
A study published today in the New England Journal of Medicine provides the most definitive evidence to date that, of the two drugs recommended for light sedation of patients receiving mechanical ventilation in the ICU, one is as effective and safe as the other.
Using neutron experiments and computer simulations, researchers from Oak Ridge National Laboratory delved into how some of the proposed COVID-19 drug candidates behave at the molecular scale when exposed to water.
The February edition of SLAS Technology is a special collection of articles focused on “Artificial Intelligence in Process Automation” by Guest Editor Cenk Ündey, Ph.D. (Amgen, Thousand Oaks, CA, USA).
The February edition of SLAS Discovery is a Special Issue on Hit Discovery Methodologies edited by Mark Wigglesworth, Ph.D., (Medicines Discovery Catapult, Stockport, EN, UK) and Peter Hodder, Ph.D. (Amgen, Thousand Oaks, CA, USA).
When it comes to developing drugs for mental illnesses, three confounding challenges exist:
A new deep-learning model that can predict how human genes and medicines will interact has identified at least 10 compounds that may hold promise as treatments for COVID-19.
Researchers from Mayo Clinic and AliveCor Inc. have been using artificial intelligence (AI) to develop a mobile device that can identify certain patients at risk of sudden cardiac death. This research has yielded a breakthrough in determining the health of the electrical recharging system in a patient's heart. The researchers determined that a smartphone-enabled mobile EKG device can rapidly and accurately determine a patient's QTc, thereby identifying patients at risk of sudden cardiac death from congenital long QT syndrome (LQTS) or drug-induced QT prolongation.
With more than 65 Featured and Scientific Sessions and 1,000+ presentations showcasing advances in fundamental and translational sciences and emerging disciplines and technologies, the Virtual 2021 Annual Meeting and ToxExpo of the Society of Toxicology (SOT) is the largest forum for toxicological research in the world.
An international team of researchers led by the Universities of Liverpool and Keele, working with Public Health England, has found that the common anticoagulant drug heparin inhibits the SARS-Cov2 virus spike protein, by reducing the virus' ability to attach to human cells and infect them.
A new modelling study has estimated that from 2000 to 2030 vaccination against 10 major pathogens - including measles, rotavirus, HPV and hepatitis B - will have prevented 69 million deaths in low-income and middle-income countries (LMICs).
A remarkable number of pharmaceutical company leaders and chief scientists will come together at a two-day symposium to present efficacy data and updates on twelve vaccines and vaccines candidates. This includes the Moderna and Pfizer mRNA vaccines that have been approved in the US for emergency use. Other topics will include: the clinical epidemiology of COVID-19; the virology, immunology, and genetics of SARS-CoV-2; and research on COVID-19 vaccines in in the elderly.
A team of researchers at UND’s School of Medicine & Health Sciences might just have revolutionized the treatment of solid tumor cancers. As reported in the prestigious Journal for Immunotherapy of Cancer, a team led by Department of Biomedical Sciences professors David S. Bradley, Ph.D., and David S. Terman, M.D., identified two new members of the “superantigen” family that, when combined with a common “helper” molecule, showed significantly higher cure rates in and long-term survival of animals with solid tumors compared to other immunotherapeutic agents now deployed clinically.
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