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14-Mar-2019 8:05 AM EDT
Epigenetic protein could be new therapeutic target in acute myeloid leukemia, study suggests
The Rockefeller University Press

British researchers have discovered that an epigenetic protein called EZH2 delays the development of acute myeloid leukemia (AML) but then switches sides once the disease is established to help maintain tumor growth. The study, which will be published March 19 in the Journal of Experimental Medicine, suggests that targeting EZH2 could therefore be an effective treatment for AML, an aggressive blood cancer expected to kill over 10,000 people in the US alone this year.

Released: 19-Mar-2019 7:30 AM EDT
Health Insurance Associated with Lower Risk of Cardiovascular Disease Among Aging Immigrants
New York University

Aging immigrants’ risk for cardiovascular disease may be heightened by their lack of health insurance, particularly among those who recently arrived in the United States, finds a study led by researchers at NYU Rory Meyers College of Nursing.

Released: 18-Mar-2019 9:05 PM EDT
Seeing through a Robot’s Eyes Helps Those with Profound Motor Impairments
Georgia Institute of Technology

An interface system that uses augmented reality technology could help individuals with profound motor impairments operate a humanoid robot to feed themselves and perform routine personal care tasks such as scratching an itch and applying skin lotion. The web-based interface displays a “robot’s eye view” of surroundings to help users interact with the world through the machine.

Released: 18-Mar-2019 3:05 PM EDT
Robot-guided video game gets older adults out of comfort zone, learning and working together
Vanderbilt University

The game isn’t about talking robots or colorful books. It’s about getting seniors in the early stages of dementia out of their rooms, moving their bodies and, most importantly, working together.

14-Mar-2019 3:00 AM EDT
Fertility App “Dot” Found to be As Effective As Other Family Planning Methods
Georgetown University Medical Center

Results of a first-of-its-kind prospective study with a family planning app find it to be as effective as other modern methods for avoiding an unplanned pregnancy, according to Georgetown researchers.

Released: 18-Mar-2019 12:00 PM EDT
Fast-Acting Psychedelic Can Improve Depression, Anxiety
Johns Hopkins Medicine

Johns Hopkins researchers have discovered that use of the synthetic psychedelic 5-methocy-N,-N-dimethyltryptamine (5-MeO-DMT) appears to be associated with unintended improvements in self-reported depression and anxiety when given in a ceremonial group setting. 5-MeO-DMT is a psychedelic that is found in the venom of Bufo Alvarius toads, in a variety of plants species, and can be produced synthetically.

Released: 18-Mar-2019 10:05 AM EDT
Study Aims to Predict Treatment Response in Epilepsy Patients
Vanderbilt University Medical Center

With the aid of $2.5 million in funding from the National Institutes of Health (NIH), Vanderbilt researchers are on a quest to develop early biomarkers of treatment outcomes for patients with temporal lobe epilepsy based on their individual brain networks.

Released: 18-Mar-2019 3:05 AM EDT
Scientists discover how Proteins interact along Metabolic Pathway
University of California San Diego

New research from scientists at the University of California San Diego and the University of Michigan has opened a new chapter in the story about what happens between two key metabolic enzymes, setting chemical biologists on their own path to a new understanding of fatty acid biosynthesis.

   
Released: 15-Mar-2019 1:05 PM EDT
Nursing Work Environment Shapes Relationship Between EHR & Quality of Care
University of Pennsylvania School of Nursing

In a first-of-its-kind study, Penn Nursing’s Center for Health Outcomes & Policy Research (CHOPR) has examined nurse satisfaction with EHR systems and the concurrent effects of EHR adoption level and the hospital work environment on usability and quality outcomes. Data from more than 12,000 nurses at 353 hospitals in four states show that the work environment is associated with all EHR usability outcomes, with nurses in hospitals with better environments being less likely than nurses in less favorable environments to report dissatisfaction with EHR systems.

Released: 14-Mar-2019 12:05 PM EDT
Engineering Treatments for the Opioid Epidemic
Washington University in St. Louis

A biomedical engineer at Washington University in St. Louis is developing a therapeutic option that would prevent opiates from crossing the blood-brain barrier, preventing the high abusers seek.

Released: 14-Mar-2019 8:05 AM EDT
NSF CAREER award to advance nanomanufacturing research
Missouri University of Science and Technology

Dr. Heng Pan, assistant professor of mechanical and aerospace engineering at Missouri University of Science and Technology, has received a big boost from the National Science Foundation (NSF) to support his efforts to create large-scale nanostructures from very small nanocrystals. Pan received the NSF Faculty Early Career Development (CAREER) Award for his project, “Laser Direct Writing of Three-Dimensional Functional Nanostructures."

Released: 14-Mar-2019 8:00 AM EDT
Blood Diseases Cured With Bone Marrow Transplant
Johns Hopkins Medicine

Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only “half-matched” increased the rate of engraftment from only about 50 percent to nearly 100 percent, according to a new study by Johns Hopkins researchers. The findings, published online Mar. 13 in The Lancet Haematology, could offer a significantly higher chance of a cure for patients with severe and deadly inherited blood disorders including sickle cell anemia and beta thalassemia.

Released: 13-Mar-2019 4:25 PM EDT
Found: The Missing Ingredient to Grow Blood Vessels
University of Virginia Health System

Researchers have discovered an ingredient vital for proper blood vessel formation that explains why numerous promising treatments have failed. The discovery offers important direction for efforts to better treat a host of serious conditions ranging from diabetes to heart attacks and strokes.

Released: 13-Mar-2019 12:05 PM EDT
NYU College of Dentistry Awarded $2 Million NIH Grant to Study HIV Latency
New York University

The National Institute of Allergy and Infectious Diseases awarded a grant to researchers at New York University College of Dentistry to study HIV latency. The grant provides nearly $2 million over five years to support research led by David N. Levy, PhD, associate professor of basic science and craniofacial biology at NYU Dentistry.

Released: 13-Mar-2019 11:05 AM EDT
How the heart sends an SOS signal to bone marrow cells after a heart attack
University of Alabama at Birmingham

After a heart attack, exosomes in the bloodstream carry greatly increased amounts of heart-specific microRNAs. The exosomes go to bone marrow progenitor cells, where the microRNAs turn off a gene that allows progenitor cells to leave the bone marrow and travel to the heart to attempt repairs.

Released: 12-Mar-2019 11:05 AM EDT
Detroit Cardiovascular Training Program Receives Big Boost From NIH
Wayne State University Division of Research

The Detroit Cardiovascular Training Program at Wayne State University received notice that funding from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) will continue for the next five years with additional funding of $1.29 million. In addition, NIH has approved raising the trainee slots from four to six, strengthening the university’s ability to attract the most talented candidates searching for a cardiovascular graduate program.

26-Feb-2019 11:00 AM EST
Targeting Stem-Like Cells Could Prevent Ovarian Cancer Recurrence
Health Sciences at the University of Pittsburgh

A new drug takes out the "seeds" that cause ovarian cancer to come back after chemo

Released: 12-Mar-2019 9:05 AM EDT
New Contributor to Age-Related Hearing Loss Identified
University of Virginia Health System

Researchers have discovered a new potential contributor to age-related hearing loss, a finding that could eventually help doctors identify people at risk and better manage the condition.

6-Mar-2019 3:35 PM EST
Few Pathways to an Acceptable Climate Future Without Immediate Action, According to Study
Tufts University

A new comprehensive study of climate change has painted over 5 million pictures of humanity’s potential future, and few foretell an Earth that has not severely warmed. But with immediate action and some luck, there are pathways to a tolerable climate future, according to a research team led by Tufts University

Released: 11-Mar-2019 9:00 AM EDT
Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms?
Duke Health

A study of more than 200 people at the Duke Eye Center suggests the loss of blood vessels in the retina could signal Alzheimer’s disease.

Released: 11-Mar-2019 8:00 AM EDT
Potential Way to Improve Cancer Surgery Outcomes by Managing Nontraditional Risk Factors
Johns Hopkins Medicine

In a study of 142 patients preparing for cancer surgery, Johns Hopkins Medicine researchers say they have evidence that psychological or social risk factors such as depression, limited resilience and lack of emergency resources along with standard medical risk factors such as high blood pressure or diabetes are linked with higher risks of surgical complications.

Released: 8-Mar-2019 11:05 AM EST
Study: Urban African-Americans More Likely to Live in Trauma Deserts
University of Chicago Medical Center

A new study from the University of Chicago Medicine shows African-American communities were the only racial/ethnic group to have consistent disparities in geographic access to trauma centers. A new Level 1 trauma center at UChicago Medicine, which opened in 2018, reduced those racial disparities in the city 7 fold.

Released: 8-Mar-2019 10:05 AM EST
Vitamin D may protect against pollution-associated asthma symptoms in obese children
National Institute of Environmental Health Sciences (NIEHS)

A new study finds vitamin D may be protective among asthmatic obese children living in urban environments with high indoor air pollution. The study out of John Hopkins University School of Medicine, funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, was published in The Journal of Allergy and Clinical Immunology: In Practice.

Released: 7-Mar-2019 2:05 PM EST
The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers
University of Colorado Cancer Center

University of Colorado Cancer Center study published in the journal Oncogene shows that while estrogen doesn’t directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness.

1-Mar-2019 11:35 AM EST
Permitting First-Year Doctors to Work Longer Shifts Does Not Create Chronic Sleep Loss or Reduce Patient Safety
Perelman School of Medicine at the University of Pennsylvania

Two large national studies show that patient safety was unaffected and residents showed no signs of chronic sleep loss regardless of shift length.

4-Mar-2019 3:55 PM EST
Potential New Therapy for Crohn’s, Colitis Identified
Washington University in St. Louis

researchers at Washington University School of Medicine in St. Louis have found a compound that may treat IBD without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice.

4-Mar-2019 11:05 AM EST
Cancer Most Frequently Spreads to the Liver. Here’s Why.
Perelman School of Medicine at the University of Pennsylvania

When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why.

Released: 5-Mar-2019 1:05 PM EST
NIH Provides $23 Million for Statewide Translational Research Institute
University of Virginia Health System

The integrated Translational Health Research Institute of Virginia (iTHRIV) has been awarded a five-year grant of nearly $23 million from the National Institutes of Health (NIH) to advance innovative ideas from the point of discovery to implementation in clinical practice and population health. I

Released: 5-Mar-2019 10:50 AM EST
Researchers Use Machine Learning To More Quickly Analyze Key Capacitor Materials
Georgia Institute of Technology

Researchers at Georgia Institute of Technology are using machine learning to ultimately find ways to build more capable capacitors.

28-Feb-2019 1:00 PM EST
Disclosing Bed Bug Infestation to Potential Tenants Improves Public Health and Leads to Savings for Landlords
Perelman School of Medicine at the University of Pennsylvania

Laws that require landlords to disclose bed bug infestations help combat the spread of the insects and protect the health of potential tenants. According to a new study, these laws also lead to cost savings, on average, for landlords within five years. Researchers in the Perelman School of Medicine at the University of Pennsylvania published their findings today in Proceedings of the National Academy of Sciences (PNAS).

Released: 4-Mar-2019 2:05 PM EST
Texas Biomed Scientists Developing New Vaccine Strategy for Tuberculosis
Texas Biomedical Research Institute

For years, scientists have been trying to come up with a better way to protect people against tuberculosis, the disease caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Texas Biomedical Research Institute Professor Jordi Torrelles, Ph.D., says new hope is on the horizon after a recent experiment performed in mice showed great promise. The study was published in the journal Mucosal Immunology.

   
Released: 4-Mar-2019 11:05 AM EST
Firearm Homicide Rate for Young Black Men in Chicago Drops, but Still Shockingly High
Ann and Robert H. Lurie Children's Hospital of Chicago

The firearm homicide rate for black male adolescents in Chicago declined by 25 percent from 2016 to 2017. The lower 2017 rate for black male adolescents is still 35 times higher than that for U.S. adolescents and 13 times that of all other adolescents in Chicago.

3-Mar-2019 11:00 AM EST
Novel Treatments Offer New Hope for Patients with Autoimmune Disease
University of Utah Health

Researchers at University of Utah Health have developed a new approach that targets the misfunctioning immune cells while leaving normal immune cells in place.

Released: 4-Mar-2019 8:00 AM EST
Breaking Up is Hard to Do: Asteroids are Stronger, Harder to Destroy Than Previously Thought
 Johns Hopkins University

A popular theme in the movies is that of an incoming asteroid that could extinguish life on the planet, and our heroes are launched into space to blow it up. But incoming asteroids may be harder to break than scientists previously thought, finds a Johns Hopkins study that used a new understanding of rock fracture and a new computer modeling method to simulate asteroid collisions.

28-Feb-2019 10:00 AM EST
Recommending the Pneumococcal Vaccine at Age 50 Reduces Disease-Related Racial Disparities; But is it Cost-Effective?
Health Sciences at the University of Pittsburgh

If mitigating racial disparities in those who contract pneumococcal diseases, such as meningitis and pneumonia, is a top public health priority, then recommending that all adults get a pneumococcal vaccine at age 50 would likely be effective guidance.

Released: 1-Mar-2019 2:05 PM EST
New chemical probes advance search for new antibiotics
Indiana University

Researchers at Indiana University have invented a new method to observe bacterial build cell walls in real time that could contribute to the search for new antibacterial drugs.

   
Released: 1-Mar-2019 11:05 AM EST
High-fat diet and age alter gut microbes and immune response, causing inflamed state in heart failure
University of Alabama at Birmingham

A calorie-dense, obesity-generating diet in aging mice disrupts the composition of the gut microbiome. This correlates with development of a system-wide nonresolving inflammation in acute heart failure, with a notable disruption of the immune cell profile, primarily the neutrophil-leukocyte ratio.

Released: 1-Mar-2019 10:05 AM EST
Researchers search for solutions to ‘invisible threat’ that affects cancer care workers
Michigan Medicine - University of Michigan

A study from the University of Michigan Rogel Cancer Center sought to improve nurses’ handling of chemotherapy by delivering an educational intervention with quarterly reminders and tailored messages. But despite the strong study design and quality intervention, it did not increase use of protective gear.

27-Feb-2019 8:05 AM EST
Gene transcription machinery constrains DNA movements, study suggests
The Rockefeller University Press

Researchers in Japan have discovered that the DNA inside human cells moves around less when its genes are active. The study, which will be published March 1 in the Journal of Cell Biology, suggests that RNA polymerase II—the key enzyme required to produce messenger RNA molecules from active genes—restricts the movement of DNA by organizing it into a network of interconnected domains.

Released: 28-Feb-2019 3:05 PM EST
Study first to show processes determining fate of new RNA pesticides in soils
Washington University in St. Louis

Researchers at the McKelvey School of Engineering at Washington University in St. Louis develop a method to learn more about how a new type of pesticide degrades in the environment.

27-Feb-2019 2:30 PM EST
How Prostate Cancer Becomes Treatment Resistant
Sanford Burnham Prebys

Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified how prostate cancer transforms into a deadly treatment-resistant subtype following treatment with anti-androgen therapy. Their findings—which include the metabolic rewiring and the epigenetic alteration that drives this switch— reveal that an FDA-approved drug holds potential as a NEPC treatment. The research also uncovers new therapeutic avenues that could prevent this transformation from occurring. The study was published in Cancer Cell.

27-Feb-2019 4:15 PM EST
Shedding Light—Literally—on Resistance to Radiation Therapy
 Johns Hopkins University

A new Johns Hopkins study offers promise towards someday being able to non-invasively examine changes in cancerous tumors to determine whether they’ll respond to radiation treatment, before treatment even begins.

Released: 27-Feb-2019 2:05 PM EST
A New Method for Precision Drug Delivery: Painting
Washington University in St. Louis

Researchers from the McKelvey School of Engineering and Washington University School of Medicine in St. Louis are one step closer to delivering precise amounts of medication to exact location, repurposing an existing imaging "painting" method.

   
Released: 27-Feb-2019 1:05 PM EST
Complex Medication Regimens Create Challenges for Home Health Care
New York University

Medically high-risk patients and communication breakdowns between providers contribute to the difficulty of medication management for older adults receiving home health care, finds a study led by researchers at NYU Rory Meyers College of Nursing.

25-Feb-2019 8:50 AM EST
Researchers ‘Bait’ Pathological Proteins Underlying Many Neurodegenerative Disorders
Health Sciences at the University of Pittsburgh

The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.

26-Feb-2019 1:00 PM EST
Researchers Develop Model to Predict Suicide Risk in At-Risk Young Adults
Health Sciences at the University of Pittsburgh

New research shows that fluctuation and severity of depressive symptoms are much better at predicting risk of suicidal behavior in at-risk young adults.

Released: 27-Feb-2019 9:00 AM EST
Muscle Gene Mutations Implicated in Human Nasal/Sinus Cancer
Johns Hopkins Medicine

By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic changeone in a gene involved in muscle formationin five of the tumors.

Released: 26-Feb-2019 5:05 PM EST
Antibodies on nanoparticle surfaces may foster or fluster therapies
National Institute of Biomedical Imaging and Bioengineering

For nanomedicine to achieve the envisioned breakthroughs in disease treatment, scientists must learn why the immune system often responds inhospitably to these therapies. An NIH-funded team at the University of Colorado (UC) has assembled a clearer picture of the molecular activity that occurs when nanoparticles injected into the body are marked for immune system attack.

   
Released: 26-Feb-2019 2:35 PM EST
New Method Uses AI to Screen for Fetal Alcohol Spectrum Disorder
University of Southern California Viterbi School of Engineering

Scientists at the University of Southern California (USC), Queen’s University (Ontario) and Duke University have developed a new tool that can screen children for fetal alcohol spectrum disorder (FASD) quickly and affordably, making it accessible to more children in remote locations worldwide.

Released: 26-Feb-2019 12:20 PM EST
Online Intervention Shows Promise in HIV Prevention
University of Pennsylvania School of Nursing

A team led by José Bauermeister, PhD, MPH, Presidential Professor of Nursing and Director of the Program on Sexuality, Technology, & Action Research (PSTAR), at the University of Pennsylvania School of Nursing (Penn Nursing) designed the My Desires & Expectations (myDEx) tool to address cognitive and emotional factors that influence YGBMSM sexual decision-making when seeking partners online.



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