The National Institutes of Health (NIH) have awarded $6.5 million to a consortium that includes the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai
A Johns Hopkins expert panel of health care providers and patients have announced what is, to their knowledge, the nation’s first set of operation-specific opioid prescribing guidelines. The guidelines are based on the premise that opioid prescribing limits should be based on the operation performed rather than a blanket approach. The ranges offered for each of 20 common operations generally call for reductions from the current rates of opioid prescription, and the researchers say that patients themselves favor using less of the drugs than physicians often prescribe.
A valuable cache of brain cancer biomedical data, one of only two such large collections in the country, has been made freely available worldwide by researchers at Georgetown Lombardi Comprehensive Cancer Center.
It’s a longstanding mystery why salamanders can perfectly regenerate their tails whereas lizard tails grow back all wrong. By transplanting neural stem cells between species, Pitt researchers have discovered that the lizard’s native stem cells are the primary factor hampering tail regeneration.
Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
Johns Hopkins Medicine researchers say a study designed to see if reducing the amount of anesthesia reduces the risk of postoperative delirium in older patients surprisingly found that lighter sedation failed to do so in severely ill people undergoing hip fracture repair.
Researchers at University of Utah Health have developed high-tech tools to uncover the genetic cause of the most difficult to diagnose cases.
Newborn granule cells show high excitability that disappears as the cells mature. Now University of Alabama at Birmingham researchers have described key roles for G protein-mediated signaling and the late maturation of an ion channel during the differentiation of granule cells.
An international team of researchers has identified which brain proteins might be most influential in controlling neural activity associated with epilepsy and anxiety, paving the way for better prevention and treatments someday.
As marine mammals evolved to make water their primary habitat, they lost the ability to make a protein that defends humans and other land-dwelling mammals from the neurotoxic effects of a popular man-made pesticide.
Lamont R. Jones, M.D., MBA, vice chair for the Department of Otolaryngology - Head and Neck Surgery at Henry Ford Health System, received a five-year, $895,814 grant from the National Institutes of Health to fund a research project titled, "Characterization of Keloid Specific Exosomes and Determination of Exosomal Critical Signaling Pathways in the Keloid Microenvironment."
Study constrains the history of volatile transport from the atmosphere into the deep Earth
A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including ALS (Lou Gehrig’s disease) and some forms of frontotemporal degeneration, by halting the misplacement of specific proteins that affect nerve cells.
Cybersecurity researchers at the Georgia Institute of Technology have helped close a security vulnerability that could have allowed hackers to steal encryption keys from a popular security package by briefly listening in on unintended “side channel” signals from smartphones.
Saint Louis University research finds post-traumatic stress disorder does not directly lead to type 2 diabetes mellitus (T2DM), instead, obesity in PTSD patients accounts for the increased risk.
Investigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator. The team, led by researchers at the Cancer Center at Beth Israel Deaconess Medical Center, is hopeful that the discovery could lead to new treatment strategies for diverse types of cancer.
Checkpoint inhibitor therapies have made metastatic melanoma and other cancers a survivable condition for 20 to 30 percent of treated patients, but clinicians have had very limited ways of knowing which patients will respond. Researchers have uncovered a novel mechanism by which tumors suppress the immune system. Their findings also usher in the possibility that a straightforward blood test could predict and monitor cancer patients’ response to immunotherapy.
In a new study, Johns Hopkins researchers found that fewer than half of interviewed caregivers for Baltimore preschool children with asthma were prepared to administer medication for routine management or emergency response to a child's chronic condition.
University of Colorado Cancer Center study shows that common laboratory tests used to determine ROS1 status may return false-negative results, meaning that some patients who could benefit from ROS1-directed therapy may be slipping through the cracks.
Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the tumor necrosis factor (TNF) superfamily, is necessary for ILCs to mount an anti-bacterial response.
A new study at Texas Biomedical Research Institute is shedding light on the role of specific proteins that trigger a mechanism allowing Ebola virus to enter cells to establish replication.
Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications.
Ask most people to identify the fastest animal on Earth and they’ll suggest a cheetah, falcon or even a sailfish. To that list of speedy animals, Georgia Institute of Technology assistant professor Saad Bhamla would like to add the Spirostomum ambiguum, a tiny single-celled protozoan that achieves blazing-fast acceleration while contracting its worm-like body.
"In humans, being able to tweak levels of TTR degradation could act as a means of stopping TTR toxicity."
Using genetic sequencing to understand the evolutionary relationships among pathogens, an international team of researchers—including several from the Center for Drug Use and HIV/HCV Research (CDUHR) at New York University—has developed a new method to determine how effective interventions are against the spread of infectious diseases like HIV.
Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV—the virus that causes AIDS—and the hepatitis C virus. The study revealed that two genes—CMPK2 and BCLG, are selectively activated in the presence of type 1 interferon, a drug once used as the first line of treatment against hepatitis C.
Sulfur isotopes can serve as tracers of atmospheric oxygen, and new data collected from the present-day atmosphere in China by an international team of researchers, led by the University of California San Diego, indicate remarkable similarity to the isotopic footprint found in ancient rocks. This opens up new interpretations of the Archean Period’s sulfur isotope sedimentary signature—a proxy for the origins and evolution of atmospheric oxygen and early life on Earth.
Researchers have found an important contributor to heart pathology caused by the cancer drug doxorubicin — disruption of metabolism that controls immune responses in the spleen and heart. This allows chronic, non-resolving inflammation that leads to advanced heart failure.
By analyzing thousands of flies, scientists at University of Utah Health found that variation in a background gene, called Baldspot, can make a difference in severity of the disease.
The process, discovered in the axons of neurons, is implicated in Alzheimer’s, amyotrophic lateral sclerosis, traumatic brain injury and other diseases or injuries to the nervous system.
A $1.5 million grant from the National Institutes of Health will advance work by Indiana University researchers that seeks to identify Americans at risk for diabetes and other metabolic disorders based on their exposure to trace minerals in the environment.
By looking into the brains of locusts, researchers in the School of Engineering & Applied Science at Washington University in St. Louis have determined how one smell can affect another, and how a locust can recognize a smell even though its brain activity looks different depending on the context.
Using 100-year-old minerals processing methods, chemical engineering students have found a solution to a looming 21st-century problem: how to economically recycle lithium ion batteries.
Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer’s disease may be a simple imbalance in acid-alkaline—or pH—chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.
Professor William Yeoh is designing algorithms to run the smart homes of the future – and he's making sure they won't bother us too much.
A new study using machine learning has identified brain-based dimensions of mental health disorders, an advance towards much-needed biomarkers to more accurately diagnose and treat patients.
Elijah Patino is a happy, healthy seven-year-old now, but it took a while to get there. For much of his life, he had a mysterious disease that made it painful to eat and painful to play. A pediatric immunologist resolved this "diagnostic odyssey" by identifying the molecular cause of this autoimmune condition, then crafted a low-dose immunosuppressive regimen to provide a precise treatment.
A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.
More than 60 years after the drug thalidomide caused birth defects in thousands of children whose mothers took the drug while pregnant, scientists at Dana-Farber Cancer Institute have solved a mystery that has lingered ever since the dangers of the drug first became apparent: how did the drug produce such severe fetal harm?
The Second Annual University of Utah Translational Hypertension Symposium assembles national experts in hypertension treatment and research. This year's meeting will focus on implementation strategies for the 2017 American College of Cardiology/American Heart Association guidelines, the future of hypertension research, and a mentored workshop for early-stage investigators.
The National Science Foundation (NSF) has awarded the San Diego Supercomputer Center (SDSC) at UC San Diego a supplemental grant valued at almost $2.4 million to extend operations of its Comet supercomputer by an additional year, through March 2021. The extension brings the value of the total Comet program to more than $27 million.
Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy in the Johns Hopkins Kimmel Cancer Center discovered inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness of immunotherapy treatments.
Women’s brains are much more vulnerable than men’s to injury from repeated soccer heading, according to a new study by researchers at Albert Einstein College of Medicine, part of Montefiore. The study found that regions of damaged brain tissue were five times more extensive in female soccer players than in males, suggesting that sex-specific guidelines may be warranted for preventing soccer-related head injuries. The results were published online today in Radiology.
New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations from errors during cellular replication is significantly elevated. The results are significant since DNA errors play a significant role in many types of cancer.
The National Cancer Institute has awarded the University of Michigan Rogel Cancer Center a grant worth $33.4 million over five years. At the same time, the center’s designation as a “comprehensive cancer center” was renewed.
Communication breakdown among nurses and doctors is one of the primary reasons for patient care mistakes in the hospital.
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), has awarded the University of California, Irvine School of Medicine, a 4-year, $9 million grant aimed at determining the long-term impact of cannabis exposure on the adolescent brain.
A common class of drugs used to treat diabetes exerts a powerful check on macrophages by controlling the metabolic fuel they use to generate energy. Keeping macrophages from going overboard on the job may inhibit the onset of obesity and diabetes following tissue inflammation.
In a series of experiments with mice, Johns Hopkins investigators have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation linked by previous studies to human diets heavy in fat and cholesterol.
Cindy Blair, PhD, was recently awarded a five-year $750,000 grant that will allow her to explore ways to help older cancer survivors in New Mexico become more active and study how being more active affects their health.
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