Feature Channels: Clinical Trials

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A newly updated clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer. The guideline also considers the role of surgical staging and molecular profiling techniques in determining whether a patient should receive post-operative therapy. The guideline is published in the January/February 2023 issue of Practical Radiation Oncology.

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Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news.

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Researchers from the Desai Sethi Urology Institute, part of the University of Miami Miller School of Medicine, have launched a study to determine if wearing virtual reality headsets during in-office vasectomy helps relieve patients of procedure-related pain and anxiety.

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SEATTLE — Dec. 1, 2022 — The 64th Annual Meeting and Exposition of the American Society of Hematology (ASH) will take place virtually and in person Dec. 10-13 in New Orleans, Louisiana.

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A new study have identified which blood tests are best at detecting Alzheimer’s disease during the earliest stages, and another blood test that is optimal for detecting relevant treatment effects.

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The 2023 American Urological Association Gold Cystoscope Award has been awarded to Ranjith Ramasamy, M.D., associate professor and director of the University of Miami Miller School of Medicine Reproductive Urology Program and urologist within the Desai Sethi Urology Institute. Dr. Ramasamy has earned the honor for his commitment to education and mentorship.

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A Phase 2 clinical trial has started of DS-1211 in individuals with Pseudoxanthoma Elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity. DS-1211 is a potential first-in-class small molecule developed through a research collaboration between Daiichi Sankyo and Sanford Burnham Prebys.

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A roundup of the latest research discoveries and faculty news at Cedars-Sinai.

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A pilot, “look-back” study of information about 106 patients with “wet” age-related macular degeneration (AMD) treated at the Wilmer Eye Institute at Johns Hopkins Medicine has revealed that nearly half of patients treated with aflibercept could safely stop eye injection therapy after one year without further vision loss.

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Irvine, Calif., Nov. 29, 2022 — When the U.S. Food and Drug Administration gave controversial accelerated approval to the first Alzheimer’s drug in nearly 20 years, it had a surprising impact on attitudes about research into the disease. A survey by University of California, Irvine neuroscientists has found news coverage of the FDA’s decision made the public less willing to volunteer for Alzheimer’s pharmaceutical trials.

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Findings from a Johns Hopkins Medicine research study published today in JAMA Network Open provide strong evidence that people who are pregnant and have been infected with SARS-CoV-2 (the virus that causes COVID-19) can safely take the antiviral drug Paxlovid to reduce the possibility of severe disease.

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La regeneración del músculo esquelético y los síntomas de la incontinencia urinaria por esfuerzo en una investigación preclínica indican una mejora tras el uso de una sustancia acelular descubierta en Mayo Clinic. Los equipos del Dr. en Ciencias Atta Behfar y del Dr. Emanuel Trabuco encabezaron esta investigación en una colaboración entre los Departamentos de Medicina Cardiovascular y de Obstetricia y Ginecología de Mayo Clinic. El artículo se ha publicado en NPJ Regenerative Medicine.

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临床前研究中的再生骨骼肌和压力性尿失禁的症状表明，在使用妙佑医疗国际(Mayo Clinic) 发现的无细胞物质后，症状有所改善。Atta Behfar医学博士/博士和Emanuel Trabuco医学博士的团队在妙佑医疗国际心血管医学部和妇产科之间开展合作，领导了这项研究。这篇论文发表在NPJ Regenerative Medicine上。

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Músculo esquelético regenerado e sintomas de incontinência urinária por esforço em pesquisa pré-clínica sugerem melhora após o uso de uma substância livre de células descoberta na Mayo Clinic. As esquipes do Dr. Atta Behfar, Ph.D. e do Dr. Emanuel Trabuco lideram a pesquisa em uma colaboração entre os Departamentos de Medicina Cardiovascular e de Obstetrícia e Ginecologia da Mayo Clinic. O artigo foi publicado na revista NPJ Regenerative Medicine.

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Researchers at Washington University School of Medicine in St. Louis have found a biomarker that identifies, with up to 89% accuracy, people with a rare, deadly, untreatable brain disease called corticobasal degeneration (CBD). The biomarker could accelerate efforts to develop treatments for CBD.

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Patients who take statins to lower high cholesterol levels often complain of muscle pains, which can lead them to stop taking the highly effective medication and put them at greater risk of heart attack or stroke.

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The Cardiovascular Research Foundation (CRF) announced today that Alexandra Popma, MD, has joined the organization as Executive Director of the CRF Clinical Trials Center.

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UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.

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Findings from a recent prospective study show promising safety and patient outcomes data for locally advanced and borderline resectable pancreatic cancer treatment using ablative Stereotactic MRI-Guided On-table Adaptive Radiation Therapy, also known as SMART.

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Experts from the Jona Goldrich Center for Alzheimer’s and Memory Disorders at Cedars-Sinai are available for interviews and to comment on research being presented at the conference.

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PCORI funding will support trial to see if early transition to oral antibiotic therapy from intravenous administration improves outcomes for patients with gram-negative bloodstream infections

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Preclinical study suggests that a class of new drugs already in clinical trials might work especially well in breast cancer patients who have acquired the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy

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A polymer-based microshunt is safe and effective in pediatric patients with refractory childhood glaucoma, according to a small, single-center case series at the UC Davis Health Eye Center. The children in the study needed trabeculectomy or implantation of a glaucoma drainage device.

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Research finds low-certainty evidence that programs such as emergency rent assistance, legal assistance with waitlist priority for public housing, long-term rent subsidies and homeownership assistance lead to positive health outcomes.

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The recovery of Jesus Torres, a patient at Loyola Medicine with acute myeloid leukemia, highlights the importance of access to innovative, experimental treatments for blood cancers for all communities. As a world-class research institute, Loyola Medicine provides unique, life-saving therapies through its participation in clinical trials, such as a phase 3 clinical trial that uses umbilical cord blood transplantation to treat patients with acute myeloid leukemia.

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AI-based approach could make it easier to incorporate metabolic tumor volume into clinical trials and possibly patient care

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Baylor Scott & White The Heart Hospital, Plano, Texas, changed its treatment paradigm for its COVID-19 patients receiving ECMO during the pandemic, finding that progressive mobility and a more aggressive application of rehabilitation therapies contributed to significantly higher survival rates.

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A scalpel-free, high-tech form of brain surgery pioneered at UVA Health offers long-term relief for patients with essential tremor, a common movement disorder, a five-year review shows.

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Here are some of the latest articles that have been added to the Arthritis channel on Newswise.

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A guided mindfulness-based stress reduction program was as effective as use of the gold-standard drug -- the common antidepressant drug escitalopram -- for patients with anxiety disorders, according to results of a first-of-its-kind, randomized clinical trial led by researchers at Georgetown University Medical Center.

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A national study led by UBC researchers at the Centre for Cardiovascular Innovation is shedding light on how to more effectively treat atrial fibrillation (AF) – a common heart rhythm problem associated with increased risk of stroke and heart failure.

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estoring blood flow to the legs, whether through bypass surgery or a less invasive artery-opening procedure with a stent, reduced pain and improved quality of life for people with peripheral artery disease (PAD), according to preliminary, late-breaking research presented today at the American Heart Association’s Scientific Sessions 2022.

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Suggests a more proactive, innate immune response among females

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After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant effect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Penn Medicine scientists.

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In clinical trials of patients with chronic kidney disease, combining information from the treatment effects on two markers of kidney disease progression—urinary albumin:creatinine ratio change and glomerular filtration rate slope—improves predictions of treatment effects on clinical endpoints.