The number of Americans suffering from kidney stones between 2007 and 2010 nearly doubled since 1994, according to a study by researchers at the University of California, Los Angeles (UCLA) and RAND.
The severity of sleep disordered breathing and nocturnal hypoxemia independently predict both glycosylated hemoglobin (HbA1c) levels and type 2 diabetes mellitus (T2DM), according to a new study.
University of Michigan Health System study shows Bcl10 protein helps the free fatty acids found in high fat foods impair insulin action and raise blood sugar.
For the first time, scientists at the Toronto General Hospital Research Institute have shown that an experimental bariatric surgery can lower blood sugar levels in rats with type 1 diabetes.
Extended daily fasting overrides harmful effects of a high-fat diet.
A new UCLA study is the first to show how a diet steadily high in fructose slows the brain, hampering memory and learning--and how omega-3 fatty acids can minimize the damage.
A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.
The University of Virginia School of Medicine has launched the first U.S. outpatient trial of a UVA-developed artificial pancreas that could make it easier for type 1 diabetes patients to manage their condition.
Diabetes affects nearly 24 million people in the United States, most with Type 2 diabetes, a disease which is often coupled with obesity. Concerned by the increasing number of overweight Americans, nutrition experts with the UC San Diego School of Medicine are launching Take Charge, a research study analyzing the effectiveness of a commercial weight-loss program on participants with Type 2 diabetes who have a BMI of 25 – 45.
Many of the standard ways to detect diabetes fail in people of Asian descent. This research identified alternate methods of diagnosis and treatment.
A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.
Researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with Nurses’ Health Study investigators have shown that levels of certain related proteins found in blood are associated with a greatly reduced risk for developing type 2 diabetes up to a decade or more later. The findings, published today in the online edition of Diabetes, could open a new front in the war against diabetes.
The epidemic of Type 2 diabetes in children is harder to treat than researchers had thought.
Pregnant women may have added incentive to bulk up on broccoli and eggs now that a Cornell University study has found increased maternal intake of the nutrient choline could decrease their children’s chances of developing hypertension and diabetes later in life.
Survival rates strong even for patients who reside in nursing homes or who have multiple health issues that make self-management difficult.
• A technique that removes additional toxins during dialysis does not improve kidney failure patients’ survival or heart health, but intense treatments may provide a benefit. • The technique, called hemodiafiltration, deserves more study. Kidney failure is on the rise and currently afflicts 2 million people worldwide.
A new Spanish-language videonovela, Aprende a vivir, features messages to help diabetes patients compare their treatment options to find a regimen that works best for them. It's entertaining and can be used as an education tool.
Salk scientists find that a long-overlooked protein may be the gateway to the storage and burning of fat.
One of the ultimate ways of understanding what impact any particular gene has in human health or disease is to disrupt it—knocking it down or wiping it out in a worm, fly or mouse and gauging what happens next.
Maintaining the right level of sugar in the blood is the responsibility not only of insulin, which removes glucose, but also of a hormone called glucagon, which adds glucose. For decades, treatments for type II diabetes have taken aim at insulin, but a new study suggests that a better approach may be to target glucagon’s sweetening effect. The findings were published today in the online edition of Cell Metabolism.
A new study found that for advanced heart failure patients with diabetes, having higher blood glucose levels may actually help improve survival rates.
Salk researchers find molecular switch that controls liver glucose production and may represent a new avenue for treating insulin-resistant type II diabetes.
Scientists from the Monell Center report that blood glucose levels following starch ingestion are influenced by genetically-determined differences in the oral enzyme salivary amylase. Specifically, higher salivary amylase activity is related to lower blood glucose. The findings suggest that salivary amylase may contribute significantly to overall metabolic status.
Babies who are born small have a tendency to put on weight during childhood and adolescence if allowed free access to calories. However, a new animal model study at UCLA found when small babies were placed on a diet of moderately regulated calories during infancy, the propensity of becoming obese decreased.
• Patients with pancreatic cancer often have a high prevalence of diabetes. • Metformin was linked with a nearly twofold higher two-year survival rate. • Patients prescribed metformin had a 32 percent reduced risk for death.
Eating foods at breakfast that have a low glycemic index may help prevent a spike in blood sugar throughout the morning and after the next meal of the day, researchers said at the Institute of Food Technologists’ Wellness 12 meeting.
A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively. The study suggests that molecules that specifically inhibit mTORC1 may combat age-related diseases without the insulin-resistance side effect, which can predispose people to diabetes.
The drug rapamycin extends lifespan in lab animals, yet it's linked to two hallmarks of diabetes. By teasing apart its activity, researchers at Whitehead Institute and the University of Pennsylvania have determined that inhibiting only the protein cluster known as mTORC1 prolongs life in mice without adversely affecting glucose tolerance or insulin sensitivity.
Daily intake of vitamin D-fortified doogh (Persian yogurt drink) improved inflammatory markers in type 2 diabetics and extra calcium conferred additional anti-inflammatory benefits, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology and Metabolism (JCEM).
Caroline Apovian, MD, a leading obesity medicine specialist specializing in medical treatments for obesity and monitoring type 2 diabetes, can provide insight into recent research suggesting that weight loss surgery may reverse type 2 diabetes.
Weight loss and increased physical fitness nearly halved the decline in mobility in overweight or obese adults with type 2 diabetes, according to four-year results of the Look AHEAD (Action for Health in Diabetes) trial funded by the National Institutes of Health. The research could lead to lower health care costs for people with type 2 diabetes.
A study from Joslin Diabetes Center finds that hyperinsulinemia is itself not a cause of atherosclerosis, as previously thought.
In the first published study of its kind, researchers from the Catholic University/Policlinico Gemelli in Rome, Italy, and NewYork-Presbyterian/Weill Cornell Medical Center found that bariatric surgery dramatically outperforms standard medical treatment of severe type 2 diabetes.
Researchers surprised by second effect of established drug.
Intervention by peer mentors has a statistically significant effect on improving glucose control in African American veterans with diabetes, according to a study by researchers at the Perelman School of Medicine at the University of Pennsylvania and the Philadelphia VA Center for Health Equity Research and Promotion (CHERP). Full results of the study were published in the March 20th issue of the Annals of Internal Medicine.
A University of Virginia-developed artificial pancreas that could potentially automate care for millions of Type 1 diabetes patients has received U.S. Food and Drug Administration (FDA) approval for a key testing phase. The FDA recently approved the first U.S. outpatient clinical trials for the device, created by a UVA School of Medicine research team led by Patrick Keith-Hynes, PhD, and Boris Kovatchev, PhD.
A new study by researchers at NYU Langone Medical Center reveals that the presence of Helicobacter pylori (H. pylori) bacteria is associated with elevated levels of glycosylated hemoglobin (HbA1c), an important biomarker for blood glucose levels and diabetes. The association was even stronger in obese individuals with a higher Body Mass Index (BMI). The results, which suggest the bacteria may play a role in the development of diabetes in adults, are available online in The Journal of Infectious Diseases.
A new research survey conducted by the Center for the Study of Asian American Health at NYU Langone Medical Center shows the Bangladeshi community in New York City experiences numerous barriers to diabetes care because of limited English proficiency and lack of diabetes awareness.
A study by Columbia researchers suggests that cells in the patient’s intestine could be coaxed into making insulin, circumventing the need for a stem cell transplant. Until now, stem cell transplants have been seen by many researchers as the ideal way to replace cells lost in type I diabetes and to free patients from insulin injections. The research—conducted in mice—was published 11 March 2012 in the journal Nature Genetics.
A small clinical trial led by researchers at UC San Diego School of Medicine and VA San Diego Healthcare System (VASDHS) found that patients with advanced heart failure and type 2 diabetes showed improved mitochondrial structure after three months of treatment with epicatechin-enriched cocoa. Epicatechin is a flavonoid found in dark chocolate.
UT Southwestern Medical Center cardiologists have uncovered how a specific protein’s previously unsuspected role contributes to the deterioration of heart muscle in patients with diabetes. Investigators in the mouse study also have found a way to reverse the damage caused by this protein.
Too high? Too low? Only about half of those with type 2 diabetes have their blood sugar levels on target, but a new drug, studied by the University of Michigan shows promise in managing glucose levels. TAK-875 works by boosting the release of insulin from pancreatic B cells, but only when diabetics need it most – such as when glucose and fatty acids rise in the blood after a meal.
Researchers have combined bioactive peptides to stimulate wound healing. The peptides act by stimulating the growth of new blood vessels and promoting re-growth of tissue. Further development of these peptides could lead to a treatment for chronic and acute wounds. The study was published in PLoS ONE.
In a reversal of two decades of medical reports, a Mayo Clinic study finds the frequency of nerve damage called diabetic polyneuropathy is similar in prediabetic patients and healthy people. Physicians should seek explanations other than prediabetes for patients who have painful small fiber polyneuropathy, the researchers say. The study was published in the February issue of Diabetes Care.
Diabetes expert Terri Lipman of Penn Nursing encourages a neighborhood community to "Dance for Health."
Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines. The new study, in mice, may upend long-held theories about the causes of the disease.
The largest genetics study to date of type 2 diabetes (T2D) has identified new gene variants associated with risk for the common metabolic disease. The variants are common to multiple ethnic populations.
A specific goal to eat a set number of daily servings of low-glycemic-index foods can improve dietary habits of people with Type 2 diabetes, according to new research.
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests that hyperglycemia (high blood sugar) injures the heart, even in patients without a history of heart disease or diabetes. The high-sensitivity test they used detected levels of cTnT tenfold lower than those found in patients diagnosed with a heart attack.
Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
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