Northwestern Medicine scientists have discovered two ways to preserve diseased upper motor neurons that would normally be destroyed in ALS, based on a study in mice. Upper motor neurons initiate movement, and they degenerate in ALS.
New research from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of the death of certain inhibitory neurons in the brain shortly after birth may be at least partly to blame for infantile spasms syndrome (ISS), a rare but devastating form of epilepsy that develops most frequently between four and eight months of age but can emerge within weeks of birth until ages 4 or 5.
During the past 17 years, there has been a remarkable increase in scientific research concerning chronic traumatic encephalopathy (CTE) with researchers at the BU CTE Center at the forefront.
St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse
Even in people with complete paralysis after spinal cord injury, some nerves fibers are preserved. A Columbia physician-scientist is developing a new way to salvage those fibers and restore movement.
University of Maryland School of Medicine’s researchers have discovered that a certain type of cell that sits on top of the brain’s smallest blood vessels senses when their brain region needs energy. When glucose levels are low, these cells signal blood vessels to dilate, increasing the blood flow regionally and allowing more energy to fuel that part of the brain.
High blood pressure and diabetes are known risk factors for stroke, but now a new study shows that the amount of risk may decrease as people age. The study is published in the January 18, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A new study by Stony Brook University researchers showed there is indeed a strong relationship between what we eat early in life and food preferences in adults. This relationship depends the effects of our early experience with food has on the brain. The work is published in Science Advances.
Investigators at Albert Einstein College of Medicine, Montefiore Health System, Regenstrief Institute, and Indiana University School of Medicine have received an $11 million grant from the National Institutes of Health (NIH) to evaluate an Einstein-developed test for assessing cognitive impairment and dementia.
Researchers have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy.
A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.
In 2015, published findings from the landmark Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure management reduced cardiovascular disease and lowered the risk of death. In 2019, results of the SPRINT MIND trial showed that lowering blood pressure also reduced the risk of mild cognitive impairment in older adults. Now, researchers from Wake Forest University School of Medicine have shown that while intensive blood pressure control was beneficial to SPRINT participants’ health during the trial, the benefits for cardiovascular mortality went away after approximately two years when protocols for blood pressure management were no longer being followed.
Researchers at Washington University School of Medicine in St. Louis have identified a pathway in the brains of mice that is activated when the animals see other mice scratching, but that pathway does not run through the visual cortex.
High blood pressure means faster slide into signs of dementia or Alzheimer’s, but does not explain the overall disparity between Hispanic/Latino people and non-Hispanic people in dementia risk.
Researchers at Albert Einstein College of Medicine have now received a five-year, $3.4 million grant from the National Institutes of Health (NIH) to assess the tradeoffs between soccer’s aerobic brain benefits and the adverse effects from heading in a study employing neuroimaging, exercise testing, and cognitive testing.
In patients with post-stroke cognitive impairment, the risk factors that contribute to stroke recurrence or death in certain populations is still unknown. A better understanding of who is at risk for a stroke recurrence or death would allow clinicians to better identify, monitor and treat stroke patients at a higher risk, which could potentially prevent stroke recurrence and save lives.
Ismael Seáñez will lead an interdisciplinary team of Washington University researchers and physicians to understand the changes in the neural circuits that may result in motor function improvements through using spinal cord stimulation.
Scientists at Tufts University have discovered a pathway through which communications are regulated in the brain, and a misfire in the messaging can result in overeating, slower burning of calories, and other metabolic problems linked to obesity.
Penn State College of Medicine received a $1.6 million grant from the National Institutes of Health will support research into whether COVID-19 contributes to the development of cognitive decline.
A team of Florida State University College of Medicine researchers has found a link between a specific protein in the brain and increased vulnerability to neurodegeneration for individuals with temporal lobe epilepsy (TLE).
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