Researchers at Wake Forest Institute for Regenerative Medicine have reached important milestones in their quest to engineer replacement tissue in the lab to treat digestive system conditions – from infants born with too-short bowels to adults with inflammatory bowel disease, colon cancer, or fecal incontinence.
Virginia Tech Carilion Research Institute scientist works to develop new treatments for wound healing and cancer.
At a glance: BioPlex network identifies protein interaction partners for more than 5,800 protein-coding genes, representing more than a quarter of the human genome. The network maps over 56,000 unique protein-to-protein interactions among nearly 11,000 proteins, significantly expanding coverage of the human interactome. 87 percent of identified interactions were previously undescribed. BioPlex serves as “social network,” providing functional insights into protein communities involving many areas of biology, from development to disease.
Cell therapy company jCyte has received Regenerative Medicine Advanced Therapy designation from the FDA for their developmental retinitis pigmentosa therapy.
Leading biologists and bioethicists from the Institute for Regenerative Medicine at the University of Pennsylvania, and other institutions, will come together to discuss these topics in a day-long symposium entitled, “Managing Cell and Human Identity.”
St. Jude Children’s Research Hospital scientists have regenerated immature auditory hair cells in adult mice by manipulating two genes. The research offers clues for better treatment of hearing loss.
Researchers from the University of Illinois at Chicago have identified a molecular switch that converts skin cells into cells that make up blood vessels, which could ultimately be used to repair damaged vessels in patients with heart disease or to engineer new vasculature in the lab.
A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain.
Blind tadpoles were able to process visual information from eyes grafted onto their tails after being treated with a small molecule neurotransmitter drug that augmented innervation, integration, and function of the transplanted organs. The work, which used a pharmacological reagent already approved for use in humans, provides a potential road map for promoting innervation – the supply of nerves to a body part – in regenerative medicine.
Applications by the IMP, the Research Institute of Molecular Pathology in Vienna, were 100% successful in the latest call of the European Research Council ERC. Over the coming five years, projects by Senior Scientists Meinrad Busslinger and Elly Tanaka will be funded with 4.8 million euros.
Connecting pieces of information by finding a common thread often takes glaucoma researchers in unexpected directions. Zinc is one such thread that joined together different experts at Boston Children’s Hospital and Harvard Medical School.
Scientists at the University of Wisconsin-Madison are using the decellularized husks of plants such as parsley, vanilla and orchids to form three-dimensional scaffolds that can then be primed and seeded with human stem cells to optimize their growth in the lab dish and, ultimately, create novel biomedical implants.
The University of Texas Health Science Center at Houston (UTHealth), in collaboration with the Human Genome Sequencing Center at Baylor College of Medicine (HGSC), is a participant in a $500 million program of the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program to bring whole genome sequencing and other “omic” technologies that monitor the expression of the genome in response to the environment to the forefront of clinical research.
Mayo Clinic’s Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Children’s Hospital of Philadelphia are collaborating to delay and prevent heart failure for hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of a child's heart is severely underdeveloped.
Researchers from Memorial Sloan Kettering Cancer Center (MSK) today published a seminal review of the rapidly evolving field of precision oncology, which allows doctors to recommend therapies based on a genetic understanding of a person’s cancer. Appearing in the special cancer-focused February 9 issue of Cell, the article — “Implementing Genome-Driven Oncology” — presents a critically self-reflective but solutions-focused perspective on this approach to cancer treatment.
Do you know what makes a "plastic surgeon" different from a "cosmetic surgeon"? If you're considering surgery to improve your appearance, the answer has important implications for choosing an appropriately qualified physician, according to a report in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
An anticancer agent in development promotes regeneration of damaged heart muscle – an unexpected research finding that may help prevent congestive heart failure in the future.
In a new study, Yale Cancer Center researchers identified a novel genetic defect that prevents brain tumor cells from repairing damaged DNA.
Regenerative medicine has much to offer the cardiovascular field, although there is still a way to go before it is ready for routine clinical application, according to Andre Terzic, MD, PhD, director of the Mayo Clinic Center for Regenerative Medicine and a professor in Cardiovascular Diseases Research at the Mayo Clinic, in Rochester, Minn.
Denis Evseenko, MD, PhD, of Keck Medicine of USC receives a $2.5 million grant from CIRM to develop an off-the-shelf therapy for osteoarthritis. Osteoarthritis affects tens of millions of Americans, with that number expected to grow exponentially due to obesity and longer lifespans.
In a live webcast December 7, Molly Shoichet will discuss new research that holds the potential to stop diseases – including cancer, blindness, and strokes – and reverse their effects.
Dr. Eric Olson, Director of the Hamon Center and Chairman of Molecular Biology at UT Southwestern Medical Center, was recognized nationally and locally for his academic mentoring prowess, along with his pioneering research into tissue regeneration and gene editing.
What causes vision loss in glaucoma? There are two common answers that at first may seem disparate: the first is pressure, as in elevated ocular pressure, and the second is damage to the optic nerve, which is the structure that sends visual information to the brain. Both answers are correct.
Cardiovascular diseases are the leading cause of death in the U.S. With one in every four deaths occurring each year, the five-year survival rate after a heart attack is worse than most cancers. A big part of the problem is the inability of the human heart to effectively repair itself after injury. A team of University of Houston researchers is trying to change that.
With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists at Washington University School of Medicine in St. Louis have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis.
Nerves in the central nervous system of adult mammals do not usually regenerate when injured. The granule cell, a nerve cell located in the cerebellum, is different. When its fibres, called parallel fibres, are cut, rapid regeneration ensues and junctions with other neurons called "synapses" are rebuilt. The precise mechanism for this was unclear.
For the first time in human application, Mayo Clinic researchers successfully closed an open wound on the upper chest caused by postoperative complications of lung removal. The protocol and approach were based on an ongoing trial investigating this method to treat anal fistulas in Crohn’s disease.
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Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source
Writing in Nature Medicine, researchers at University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, with colleagues in Japan and Wisconsin, report that they have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats, resulting in functional benefit.
Neuroscientists document some of the first steps in the process by which a stem cell transforms into different cell types.
Kejin Hu, Ph.D., has found a robust reprogramming factor that increases the efficiency of creating human induced pluripotent stem cells (HiPSCs) from skin fibroblasts more than 20-fold, speeds the reprogramming time by several days and enhances the quality of reprogramming.
Get the latest news on heart disease, the leading cause of death for people of most ethnicities in the U.S., in the Newswise Heart Disease news source.
A new study led by scientists at The Scripps Research Institute (TSRI) and the J. Craig Venter Institute (JCVI) shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.
SBP researchers have identified specific ways in which fetal muscle stem cells remodel their environment to support their enhanced capacity for regeneration, which could lead to targets for therapies to improve adult stem cells’ ability to replace injured or degenerated muscle.
Findings clear path to devise new treatments for muscular injuries and dystrophies
Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.
Research suggests we do not yet have the whole story about how fertilised eggs produce the many different types of cell that make up our adult bodies.
Case Western Reserve University School of Medicine scientists demonstrate in lab animals the regenerative dynamics of a specific signaling protein, C-C class chemokine 2 (CCL2). CCL2 sends inflammatory immune cells (macrophages) to peripheral nerve cell clusters to promote repair and to trigger gene expression that leads to new growth in nerve cells.
Ghosts are not your typical cell biology research subjects but scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human Development (NICHD) who developed a technique to observe muscle stem/progenitor cells migrating within injury sites in live mice, report that “ghost fibers,” remnants of the old extracellular matrix left by dying muscle fibers, guide the cells into position for healing to begin.
UofL scientists demonstrate that the protein kinase TAK1 (transforming growth factor-ß-activated kinase 1), is vital in regulating the survival and proliferation of satellite stem cells, responsible for regenerating adult skeletal muscles.
The vitamin D receptor (VDR) promotes the differentiation of oligodendrocyte progenitor cells (OPCs) and boosts myelin sheath regeneration, according to a study in The Journal of Cell Biology. The research suggests potential new ways to treat multiple sclerosis patients.
St. Jude Children’s Research Hospital scientists capitalize on technological advances to lay the groundwork for drug development against “disordered” proteins that play key roles in human health and disease
Researchers at the University of Louisville have identified the role of TNF receptor-associated factor 6 (TRAF6), an adaptor protein and E3 ubiquitin ligase, in ensuring the vitality of stem cells that regenerate muscle tissue.
New drug found to heal eyes in two days after corneal surgery. Originally created in France for chronic diabetic skin wounds, the heparin sulfate mimetic Cacicol (or RGTA) helps eyes heal faster by stimulating collagen production.
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