ATR activity controls stem cell quiescence via the cyclin F–SCF complex
Proceedings of the National Academy of Sciences (PNAS)… Stem cell quiescence is regulated by multiple factors including p53, Rb, cyclin-dependent kinase inhibitors, such as p21 and p27, and Notch signaling (5–10). How these pathways may integrate to maintain stem cell … Dysregulation or loss of quiescence …