Chinese gay men who were offered a free STD test and then asked to donate to the testing of another man were 48 percent more likely to get tested than men offered the standard of care, UNC researchers found. Learn how this approach could be applied for testing of other diseases.
Researchers used NMR to detail how the matrix domain of the Avian Sarcoma Virus Gag protein binds to certain phospholipids. These phospholipids are vital for Gag protein binding to the plasma membrane of a cell, as the virus replicates and takes its first step toward virus formation and budding.
Recent study finds text-based counseling may help decrease HIV risk among stigmatized European community.
Of the 34 million people worldwide with HIV, and the 200 million with schistosomiasis, the majority live in Africa— where millions of people are simultaneously infected with both diseases. Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that schistosomiasis infections are associated with increased HIV onward transmission, HIV acquisition in HIV negative women with urogenital schistosomiasis, and progression to death in HIV positive women.
A team led by Duke Human Vaccine Institute researchers, publishing online Dec. 11 in the journal Immunity, reported that they have filled in a portion of the roadmap toward effective neutralization of HIV, identifying the steps that a critical HIV antibody takes to develop and maintain its ability to neutralize the virus.
Summaries of recent Fred Hutch research with links for additional background and media contacts.
AIDS patients suffer higher rates of cancer because they have fewer T-cells in their bodies to fight disease. But new research examines why HIV-infected patients have higher rates of cancer—among the leading causes of death among that population—than the general population.
UC San Diego Medical Center in Hillcrest was named a Top Teaching Hospital by The Leapfrog Group. The award is widely acknowledged as one of the most competitive honors that a U.S. hospital can receive.
CINCINNATI--A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from potentially fatal liver scarring, says a University of Cincinnati (UC) College of Medicine physician-scientist.
Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.
New UC San Diego campaign promotes sexual health and has a quick test to prove it. “Good to Go” offers combined testing for HIV and five sexually transmitted diseases, providing some results in as little as 60 seconds and access to free treatment, if needed. Updated clinic opening Dec. 10.
Researchers have found that genetic mutations affecting the capsid, the structure surrounding the HIV genome, make it possible for a protein called TRIM5α to trigger the immune system of elite controllers.
In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren’t likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy (ART). ART is a regimen containing combinations of HIV-targeting drugs that prevents the growth of the virus but does not eradicate it.
Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission might be possible for more people.
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains. The study, published today in Nature, reveals for the first time how the Alzheimer’s-linked gene, APP, is recombined by using the same type of enzyme found in HIV.
The abundance of personal smartphones in southern African countries got University of Washington professor Sarah Gimbel thinking: What if these phones were used by front-line health workers — namely nurses — to collect and analyze data on patients living with HIV or AIDS to improve their care?
A new study by researchers of disease transmission in bats has broad implications for understanding hidden connections that can spread diseases between species and lead to large-scale outbreaks.
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure
Project LifeSkills, a behavioral intervention to prevent HIV in young transgender women, was designated by the HIV/AIDS Prevention Research Synthesis (PRS) project at the U.S. Centers for Disease Control and Prevention (CDC) as showing the best evidence of efficacy.
The MidAtlantic AIDS Education and Training Center (MAAETC) will collaborate with UPMC and local HIV stakeholders to host an all-day educational forum to celebrate the 30th Anniversary of World AIDS Day and the 30th Anniversary of the MAAETC.
This month's Fred Hutch tip sheet includes story ideas about understanding how skin stops tumor growth, advances in studying Kasposi sarcoma, and forecasting the flu. To pursue any of these stories ideas, contact the person listed.
“Think globally, act locally” is a popular global health idea that encourages people to consider the health of the entire planet while taking actions in their own cities and communities. And it’s an idea that inspired a group of students in the Perelman School of Medicine to join with other medical schools in Philadelphia and start a group dedicated to the growing field of global surgery. Until recently, surgery has been largely omitted from global health efforts, taking a back seat to infectious diseases like HIV/AIDS, tuberculosis, and malaria. But as progress is made to treat and prevent these diseases, it has become clear that there is a significant need to focus on treating people in resource-limited settings who are in need of surgical care. And this need touches almost every aspect of health care from cancer to obstetrics to orthopedics. In fact, according to the Lancet Commission on Global Surgery, more than 18 million people die each year from lack of surgical care.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
Biologists have discovered a new way of re-sensitizing drug-resistant tumor cells to DNA-damaging agents, the most widely used group of cancer drugs. Researchers describe how a gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs. Their research may pave the way to new strategies to overcome chemotherapeutic drug resistance.
In this issue, find research on infant sugary drink consumption, China's top 20 health challenges, aging and healthy years in the Netherlands, and increasing opioid use in Massachusetts
Audio from the American Neurological Association’s 143rd Annual Meeting media roundtable, held October 22, 2018, is now available. At the roundtable, presenters of the meeting’s six principal symposia presented highlights, discussed the relevance of the work, and answered questions.
The Midwest AIDS Training and Education Center (MATEC) at the University of Illinois at Chicago has received $4.4 million in funding from the federal government to advance its work improving HIV/AIDS care, prevention and education in Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, Ohio and Wisconsin.
FINDINGS Infants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection. The researchers found that 23 percent of the infants who became infected with HIV during the mother’s pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.
Fear never works. Or does it? Fear can be a powerful tool in public health efforts, although graphic, emotionally evocative campaigns have been the source of controversy over the past half-century.
Researchers at the UNC School of Medicine have been awarded a 5-year, $3.8 million grant from the National Institute of Allergy and Infectious Diseases to develop next generation, ultra-long-acting antiretroviral formulations for HIV treatment and prevention that have the potential to dramatically improve adherence.
Currently, a once-daily pill to prevent HIV infection is available. However, adherence to a once-daily regimen can be difficult for some people. Researchers from the UNC School of Medicine and the Centers for Disease Control and Prevention published a study today in Nature Communications that reports a potentially promising remedy for this problem.
A team of nurses and physicians has received a four-year, $3 million grant from the National Heart, Lung, and Blood Institute to extend traditional HIV treatment protocols to improve the cardiovascular health of people living with HIV.
Scientists from the Cancer Science Institute of Singaporeat the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.
The University of Illinois at Chicago is one of eight universities awarded funding by the National Institutes of Health to prevent and treat sexually transmitted infections, including HIV, among adolescents and young adults in Africa and Brazil. Collectively, the international projects are known as Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H).
he Sorenson Impact Center’s University Venture Fund - Impact Investing (UVF II) closed its first investment in a seed round into Salt Lake City-based Navigen, Inc.
A new study, focusing on a small molecule called IP6 and the role it plays in the HIV life cycle, "opens a door for development of new treatments."
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
Providers in states that expanded Medicaid were more likely to believe that the law would improve HIV outcomes, the study found. However, providers in all states agreed that the law would improve healthcare outcomes in general for their HIV patients.
Nigerian youth are at the epicenter of an expanding HIV crisis in Sub-Saharan Africa. HIV testing is an important early entry point to accessing preventive education, care and treatment. Yet fewer than one in five Nigerian youth have been tested. A Saint Louis University study seeks to change this by developing and implementing Innovative Tools to Expand HIV Self-Testing (I-TEST) for at-risk youth ages 14-24.
Joyce Anastasi, PhD, DrNP, FAAN, Independence Foundation Professor at NYU Rory Meyers College of Nursing, was awarded a $3.5 million grant by the National Institutes of Health (NIH) to study whether stimulating acupuncture points can help manage HIV-related neuropathic pain.
Nearly 2.3 million times last year, Americans learned they had a sexually transmitted disease. But despite these record-high infection rates for chlamydia and gonorrhea, most patients only receive treatment for their own infection – when they probably could get antibiotics or a prescription for their partner at the same time. A team of physicians examines the barriers that stand in the way of getting expedited partner therapy to more people.
The NIH has awarded the UNC HIV Cure Center and Cell Microsystems a Small Business Innovation and Research contract to develop an automated platform to quantify the latent HIV reservoir, a key step in finding a cure for the virus.
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