The connection between slowed walking speed and declining mental acuity appears to arise in the right hippocampus, a finger-shaped region buried deep in the brain at ear-level, according to a 14-year study conducted by scientists at the University of Pittsburgh Graduate School of Public Health.
Faculty, staff and graduate students are taking on one of society’s most vexing health challenges: how to prevent or slow the onset of dementia through changes in diet and exercise. And what sets the Lifestyle Interventions Group apart is its inclusion of disciplines beyond the typical confines of brain science.
Patients can engage with the Ambient Activity Technology device any time to view family photos, hear their favorite music, and play games.
Mount Sinai researchers find this network central to Alzheimer’s disease susceptibility
In a recent feasibility study, BIDMC tested an anti-epileptic drug for its potential impact on the brain activity of patients with mild Alzheimer’s disease. The team documented changes in patients’ EEGs that suggest the drug could have a beneficial effect.
Going for a walk outside, reading, listening to music—these and other enjoyable activities can reduce blood pressure for elderly caregivers of spouses with Alzheimer’s disease, suggests a study in Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society. The journal is published by Wolters Kluwer.
Study shows seniors with dementia are on the rise. Dr. Yves Joanette is available to speak about the disease.
Is it possible to prevent dementia from happening in the first place? That’s what a leading FAU neuroscientist plans to prove using an innovative approach that defies the idea that “one-size-fits-all” when it comes to battling Alzheimer’s disease, Lewy Body Dementia, Parkinson’s disease and other related disorders. Using a personalized approach and precision medicine to reduce risk, this center is one of only a handful of centers in the world that focuses on dementia prevention.
The Mediterranean diet, rich in plant-based foods, is associated with a variety of health benefits, including a lower incidence of dementia.
The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.
Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute (TSRI), together with scientists from Mayo Clinic’s Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).
A new study shows that people with a protective Aβ mutation have less of the peptide in their blood all through their lives, likely explaining why they do not get Alzheimer's. It suggests ways to prevent the disease in the vast majority of people who don’t have the mutation.
Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.
A new, high-resolution view of the structure of Hsp104 (heat shock protein 104), a natural yeast protein nanomachine with six subunits, may show news ways to dismantle harmful protein clumps in disease.
Duke University researchers have identified a potential new mechanism for Parkinson's disease in both mice and human endocrine cells that populate the small intestines.
The rate of death from Alzheimer’s disease in the United States increased by more than 50 percent in the past 15 years. In part, it’s because Americans are living longer – age is one of the biggest risk factors for developing Alzheimer’s. But it’s also because medical professionals can identify risk factors.
At a glance: Most frequent genetic cause of ALS and a form of dementia (FTD) is known to produce toxic peptides that interfere with RNA splicing—an intermediary step in generating functional proteins from genes. New Harvard Medical School study finds these toxic peptides block assembly of the cellular machinery responsible for RNA splicing. This blockage leads to splicing errors for genes that regulate the workings of mitochondria and neurons and the expression of other genes. Restoring normal splicing function may be a therapeutic strategy for averting or treating the development of ALS, FTD or both.
Profs. Michal Schwartz and Ido Amit at the Weizmann Institute of Science have discovered a unique immune cell type whose regulated activation may form the foundation of a future treatment for Alzheimer’s disease
According to research reported online today in Neurology, the international Dementia with Lewy Bodies Consortium issued new guidelines about diagnosing and treating the disease and called for more clinical trials into the illness.
The milestone Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) Study is working with government and academic researchers to launch three add-on studies to expand the impact of the core study where more than 18,000 people with cognitive decline but an unclear diagnosis will receive an amyloid PET scan.
/PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF), the only public charity solely focused on funding the development of drugs for Alzheimer's, and Science Exchange today announced the launch of ADDF ACCESS, a first-of-its-kind online platform designed to match scientists working on central nervous system (CNS) diseases with a vetted network of contract research organizations (CROs).
Memory loss, language problems and other symptoms of cognitive decline are strongly associated with diseases of the small blood vessels in the brain, according to a study published in the International Journal of Geriatric Psychiatry.
A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain.
At a meeting in Leuven, Belgium, a coherent picture began to emerge for how fluid pockets of proteins and RNAs contribute to health and disease.
Mayo Clinic Monthly News Tips — May 2017
Cognitive tests can detect early Alzheimer’s disease in older adults without symptoms according to a new Keck School of Medicine of USC study.
A study has found that abnormal proteins found in Alzheimer’s, Parkinson’s and Huntington’s diseases share a similar ability to cause damage when they invade brain cells. The finding suggests that an effective treatment for one neurodegenerative disease might work for other neurodegenerative diseases as well.
A new Iowa State University study may have identified the link that explains years of conflicting research over a mitochondrial gene and the risk for Alzheimer’s disease.
Bronx residents impacted by diabetes, led by Health People, will protest the city's complete failure to implement effective diabetes prevention at Mayor de Blasio's Bronx visit at 9am at the Bronx County Courthouse at 161 Street and Grand Concourse.
A new DNA vaccine when delivered to the skin prompts an immune response that produces antibodies to protect against toxic proteins associated with Alzheimer’s disease – without triggering severe brain swelling that earlier antibody treatments caused in some patients.
Beaumont Research Institute investigators are hopeful that their study involving small molecules in saliva will help identify those at risk of developing Alzheimer’s disease.
Faced with a serious disease, patients want to know the answer to a difficult question: “How long will I live?”
Penn Medicine’s Alzheimer’s disease genetics data repository has received a five-year funding renewal from the National Institute on Aging (NIA) of the National Institutes of Health. The award is expected to total $7.7 million over five years.
A new study has found that dementia rates increase when anticoagulation treatment is delayed for patients with atrial fibrillation, the most common heart arrhythmia in the world that affects more than 2.7 million American adults.
Combining the Intermountain Mortality Risk Score (IMRS), developed by clinicians at Intermountain Healthcare, with the traditional CHA2DS2-VASc risk score, was more accurate in identifying at-risk patients than using the traditional score alone.
All is not lost according to the first study to look at and measure communication outcomes in both the caregiver spouse and the patient with dementia. In fact, researchers have found that “practice makes perfect” with the right intervention and a tool that can accurately measure couples’ communication.
Studies have shown that loss of the sense of smell can be among the first warning signs of diseases such as Alzheimer’s and Parkinson’s. Now a researcher at the Perelman School of Medicine at the University of Pennsylvania wants to shift the search for clues about this process back even further, to find out if there is a common factor responsible for the loss of smell that may also serve as an early warning signal for a number of neurodegenerative diseases.
A new large-scale genetic study found that low body mass index (BMI) is likely not a causal risk factor for Alzheimer’s disease, as earlier research had suggested, according to a study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
"Unprevented Diabetes Means Unnecessary Alzheimer's", a report by Health People: Community Preventive Health Institute projects that without prevention for New York City's estimated 1.3 million pre-diabetics and for New York State's 5.4 million pre-diabetics, city diabetes cases will rise by 325,000 cases in five years and overall state diabetes cases by 1.35 million cases; based on reach research, these new cohort of diabetics are at a 40% increased risk for developing Alzheimer's over time.
With diabetes raising the risk for Alzheimer’s Disease by 40%, New Yorkers are facing an escalating Alzheimer's epidemic fueled by failures of New York City and State to undertake effective diabetes prevention.
Much is known about flu viruses, but little is understood about how they reproduce inside human host cells, spreading infection. Now, a research team headed by investigators from the Icahn School of Medicine at Mount Sinai is the first to identify a mechanism by which influenza A, a family of pathogens that includes the most deadly strains of flu worldwide, hijacks cellular machinery to replicate.
Texas A&M researchers are working to develop drugs to enhance the function of these receptors in the brain, which could have three very different applications: easing pain, slowing the cognitive decline associated with Alzheimer’s and making it easier for people to stop smoking.
A gene mutation may accelerate the loss of memory and thinking skills in people who are at risk for Alzheimer’s disease, according to a study published in the May 3, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. The gene mutation is called the BDNF Val66Met allele, or just the Met allele.
Researchers at Sunnybrook Health Sciences Centre in Toronto have begun the world’s first clinical trial evaluating the feasibility and safety of opening the blood-brain barrier (BBB) in patients with Alzheimer’s disease (AD) utilizing focused ultrasound.
The lack of easily accessible, culturally proficient, and gerontology-trained providers creates a unique challenge for older adults in rural communities. Providing earlier cognitive assessment to facilitate earlier management of cognitive decline issues can assist with aging-in-place and decreased health care costs.
Researchers have discovered two genes, known as UNC5C and ENC1, that are associated with aging individuals having better memory and brain function than would be expected, given the amount of pathologies that accumulated in their brains.
This discovery, described online in the April 25 edition of eLife, will lead to important research and may one day help experts develop new and better therapies for Alzheimer's and other forms of cognitive decline.
Using human skin cells, University of California, Irvine neurobiologists and their colleagues have created a method to generate one of the principle cell types of the brain called microglia, which play a key role in preserving the function of neural networks and responding to injury and disease.
New discoveries tied to how food affects our body and why we make certain food choices could help inform nutrition plans and policies that encourage healthy food choices. The Experimental Biology 2017 meeting will showcase groundbreaking research in food policy, nutrition and the biochemistry of food.
ASU production breaks new ground for science communication
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