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New Clues About a Brain Protein with High Affinity for Valium

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Valium, one of the best known antianxiety drugs, produces its calming effects by binding with a particular protein in the brain. But the drug has an almost equally strong affinity for a completely different protein. New studies revealing atomic level details of this secondary interaction might offer clues about Valium's side effects and point the way to more effective drugs.

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Does Getting “Expensive” Drug Affect How Much Patient Benefits?

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People’s perceptions of the cost of a drug may affect how much they benefit from the drug, even when they are receiving only a placebo, according to a new study of people with Parkinson’s disease published in the January 28, 2015 online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Analysis Rejects Linkage Between Testosterone Therapy And Cardiovascular Risk

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Fears of a link between testosterone replacement therapy and cardiovascular risk are misplaced, according to a review published in this month’s Mayo Clinic Proceedings. The therapy has come under widespread scrutiny in recent months, including by a federal Food and Drug Administration (FDA) panel convened last fall.

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Pictured Together for the First Time: A Chemokine and Its Receptor

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Researchers at University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and the Bridge Institute at the University of Southern California report the first crystal structure of the cellular receptor CXCR4 bound to an immune signaling protein called a chemokine. The structure answers longstanding questions about a molecular interaction that plays an important role in human development, immune responses, cancer metastasis and HIV infections.

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Classic Psychedelic Use Found to Be Protective with Regard to Psychological Distress and Suicidality, Study Finds

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Classic psychedelic drugs include LSD, psilocybin and mescaline. This new School of Public Health research is published in the Journal of Psychopharmacology.

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Century-Old Drug Reverses Autism-Like Symptoms in Fragile X Mouse Model

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Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice. Now, a new study published in this week’s online issue of Molecular Autism, suggests that a genetic form of autism-like symptoms in mice are also corrected with the drug, even when treatment was started in young adult mice.

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New Research Unlocks How Melanoma Can Resist Newly Approved Drug Combo Therapy

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In a new study researchers at the UCLA Jonsson Comprehensive Cancer Center have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage.

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Researchers Discover New “Trick” Steroids Use To Suppress Inflammation

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A new “trick” steroids use to suppress inflammation, which could be used to make new anti-inflammatory drugs without the harmful side effects of steroids, has been discovered by researchers at Georgia State University.

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Cone Snail Venom Holds Promise for Medical Treatments for Cancer and Addiction

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While considered a delicacy in some parts of the world, snails have found a more intriguing use to scientists and the medical profession offering a plethora of research possibilities.

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Possible Treatments Identified for Highly Contagious Stomach Virus

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Antibiotics aren’t supposed to be effective against viruses. But new evidence in mice suggests antibiotics may help fight norovirus, a highly contagious gastrointestinal virus, report scientists at Washington University School of Medicine in St. Louis.