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Cellular Recycling Complexes May Hold Key to Chemotherapy Resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.

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Top Stories 25 August 2015

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Scripps Florida Scientists’ Structural Discoveries Could Aid in Better Drug Design

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Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output, findings that could aid future drug design.

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Antidepressants Fine-Tune Brain Reward Pathway to Lessen Neuropathic Pain

Commonly used antidepressant drugs change levels of a key signaling protein in the brain region that processes both pain and mood, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published August 24 in the Proceedings of the National Academy of Sciences (PNAS).

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Promising Class of New Cancer Drugs Might Cause Memory Loss in Mice

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New research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss.

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Study Finds Tests Used to Measure Internal Bleeding For Patients Taking Two Popular Drugs May Not Be Reliable

A recently-published study found that while internal bleeding may be uncommon as a result of taking blood thinners such as Xarelto® (rivaroxaban) and Eliquis® (apixaban), the normal coagulation tests physicians use to check for the side effect of bleeding may not be reliable.

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New Compounds Could Reduce Alcoholics’ Impulse to Drink

Alcoholism inflicts a heavy physical, emotional and financial toll on individuals and society. Now new discoveries and promising animal studies are offering a glimmer of hope that a new class of drugs could treat the disease without many of the unwanted side effects caused by current therapies. The scientists are presenting their work today at the 250th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.

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Scientists Report Success Using Zebrafish Embryos to Identify Potential New Diabetes Drugs

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In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

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Study Compares Heparin to Warfarin for Treatment of Blood Clots in Patients with Cancer

Among patients with active cancer and acute symptomatic venous thromboembolism (VTE; blood clots in the deep veins), the use of the low molecular-weight heparin tinzaparin daily for 6 months compared with warfarin did not significantly reduce recurrent VTE and was not associated with reductions in overall death or major bleeding, but was associated with a lower rate of clinically relevant nonmajor bleeding, according to a study in the August 18 issue of JAMA.

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Lice in at Least 25 States Show Resistance to Common Treatments

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The start of the school year means new classes, new friends, homework and sports. It also brings the threat of head lice. Scientists report today that lice populations in at least 25 states have developed resistance to over-the-counter treatments still widely recommended by doctors and schools. The researchers are presenting their work today at the 250th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.