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“Dramatic” Early Phase 1 Results for AG-120 in IDH1 Mutated AML

University of Colorado Cancer Center study shows "extremely promising” early phase 1 clinical trial results for the investigational drug AG-120 against the subset of patients with acute myeloid leukemia (AML) harboring mutations in the gene IDH.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 1-Dec-2014 12:05 AM EST

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Life's Extremists May Be an Untapped Source of Antibacterial Drugs

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Life's extremists, a family of microbes called Archaea, may be an untapped source of new antibacterial drugs. That conclusion arises from the discovery of the first antibacterial gene in this ancient lineage.

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First-In-Class Nasal Spray Demonstrates Promise for Migraine Pain Relief

Researchers are developing a novel prochlorperazine nasal spray formulation as a potential new treatment for migraines.

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Nasal Spray Vaccine Has Potential for Long-Lasting Protection from Ebola Virus

A nasal vaccine in development by researchers at The University of Texas at Austin has been shown to provide long-term protection for non-human primates against the deadly Ebola virus.

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Common Blood Pressure Medication Does Not Increase Risk of Breast Cancer, New Study Finds

Women who take a common type of medication to control their blood pressure are not at increased risk of developing breast cancer due to the drug, according to new study by researchers at the Intermountain Medical Center Heart Institute in Murray, Utah.

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Investigational Drug May Offer Another Option to Treat Marfan Syndrome

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The investigational drug Losartan, which worked better in an animal model, was equally effective to a high dose of the beta blocker, atenolol in treating Marfan syndrome, a rare genetic disease.

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Big Data Study Identifies New Potential Target Coating for Drug-Eluting Stents

A new study has identified an FDA approved cancer drug, crizotinib, as a possible new coating for drug-eluting stents. Researchers found that crizotinib in mice helped prevent the narrowing of blood vessels after stenting without affecting the blood vessel lining. Results of this study were published today in The Journal of Clinical Investigation.

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Anti-Leukemia Drug May Also Work Against Ovarian Cancer

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An antibody therapy already in clinical trials to treat chronic lymphocytic leukemia may also prove effective against ovarian cancer – and likely other cancers as well, report researchers at the University of California, San Diego School of Medicine.

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Chemical Disguise Transforms RNAi Drug Delivery

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Researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery converts these disguised drug precursors — called siRNNs — into active RNAi drugs.

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