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Medicine

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Precision Medicine, personalized medicine, White House Precision Medicine intitiative, genome medicine, Personalized Therapies, Undiagnosed Diseases

White House Strategist to Lead UAB’s Personalized Medicine Institute

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Matthew Might, Ph.D., a renowned computer scientist and strategic leader appointed to the White House Precision Medicine Initiative by former President Barack Obama, has been named the inaugural director of the Hugh Kaul Personalized Medicine Institute at UAB.

Medicine

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Pneumonia, Influenza, viral pneumonia, Viruses, Disease Prevention, Asthma, Allergies, Drugs, asthma drugs, Accolate, Singulair, repurposing drugs, University Of Virginia, University of Virginia School of Medicine, UVA, UVA School of Medicine, Carter Immunology Center, Beirne B. Carter, Virology, Geriatrics, Infectious Diseases, Thomas J. Braciale, Amber Cardan

Asthma Drugs Could Prevent Deadly Form of Pneumonia, Research Suggests

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Two drugs used to treat asthma and allergies may offer a way to prevent a form of pneumonia that can kill up to 40 percent of people who contract it, researchers at the University of Virginia School of Medicine have found.

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Popular Heartburn Drugs Linked to Gradual Yet ‘Silent’ Kidney Damage

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Taking popular heartburn medication for prolonged periods may lead to serious kidney damage, even in people who show no signs of kidney problems, according to researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care System. The drugs are sold under brand names such as Prevacid, Prilosec, Nexium and Protonix.

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TSRI-Invented Compound Ozanimod Shows Positive Results in Late-Stage Clinical Trial for Relapsing Multiple Sclerosis

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Results from a new Phase 3 study conducted by the Celgene Corporation demonstrate that ozanimod, a drug candidate originally discovered and optimized at The Scripps Research Institute (TSRI), can reduce the frequency of multiple sclerosis relapse.

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Drugs That Alter Inhibitory Targets Offer Therapeutic Strategies for Autism, Schizophrenia

Researchers at SUNY Downstate recently discovered that an inhibitory brain receptor triggers synaptic pruning in adolescence. Drugs that selectively target these receptors, when administered during adolescence, can alter synapse number, with possible implications for the treatment of autism and schizophrenia.

Medicine

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Medication Adherence, medication research, Medication, Congestive Heart Failure, cardiovascuar disease

Interventions Improve Medication Adherence, Decrease Risk of Hospitalizations

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Poor adherence to medication regimens is a common problem among patients with cardiovascular diseases like high blood pressure, heart disease, and heart failure. Poor adherence is one reason mortality rates among those patients remain high. Todd Ruppar, associate professor in the Sinclair School of Nursing at the University of Missouri, has found that a variety of interventions aimed at increasing medication adherence can help people with cardiovascular disease avoid the hospital. Ruppar will address the barriers to medication adherence during the Public Health Grand Rounds offered by the Centers for Disease Control and Prevention (CDC) on Tuesday, Feb. 21 in Atlanta.

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Science

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An Alternative to Opioids? Compound From Marine Snail Is Potent Pain Reliever

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A tiny snail may offer an alternative to opioids for pain relief. Scientists at the University of Utah have found a compound that blocks pain by targeting a pathway not associated with opioids. Research in rodents indicates that the benefits continue long after the compound have cleared the body.

Science

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Biological and Environmental Research, biological and environmental sciences, Advanced Scientific Computing Research, Nature, Nature (magazine), Peptides, Proteins, Protein, protein analysis, Drug Design, drug, Drugs, hyperstable constrained peptides, Peptide, peptide drugs, Computational Methods, custom drugs, Seattle Structural Genomics Center for Infect

Unlocking Peptide Potential

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Powerful new computational methods now enable scientists to design a virtually unlimited variety of hyperstable peptide structures not found in nature. This research opens a new frontier in drug discovery.

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Micro-RNA May Amplify Effectiveness of Sorafenib in Difficult Liver Cancer Cases

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Only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.

Science

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Placenta, Autism, UC Davis MIND Institute, DLL1, Methylation, epigentics

Placenta Provides Time Capsule for Autism Studies

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In two recent studies, researchers at UC Davis have shown that placental tissue can provide critical information about the epigenetic landscape that influences fetal development.

Medicine

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Experimental Biology 2017, Faseb, Anatomy, Physiological, Biochemistry, Molecular Biology, Pathology, Nutrition, Pharmacology

Speakers Announced for 2017 Experimental Biology Meeting

World-renowned scientists will present pioneering research and discuss key issues affecting the life sciences at the 2017 Experimental Biology meeting (EB 2017), the premier annual meeting of six scientific societies in Chicago to be held April 22–26.

Medicine

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Insomnia Medication, Insomnia Meds, Insomnia, Physician Education, Pharmacology, Prescribing Patterns, Clinical Decision Making, Treatment Choices, Habits, Decision Influences

Mental Shortcuts

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Clinical decision-making and treatment choice is a complex cognitive process influenced by multiple variables.

Medicine

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Cancer, Awards, Roth Award, Genetech, Roche, Lymphoma, Drug Development

Cancer Survivor and Noted Physician-Scientist Sandra Horning to Receive Roth Award

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Sandra Horning, MD, Chief Medical Officer and executive vice president of global development for Roche and Genentech, a member of the Roche Group, has been named the 2017 recipient of the Duane Roth Memorial Award, which will be presented February 16 at the annual Industry/Academia Translational Oncology Symposium at UC San Diego Moores Cancer Center.

Science

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Targeted Drug Delivery, Vesicles, mechanical deformation, mechanoporation, fluid flow, membrane mechanics, microfluidic devices

Putting the 'Squeeze' on Drug Delivery

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One big challenge targeted drug delivery faces today is efficiently “loading” a drug into a carrier without compromising the carrier’s structural integrity. A promising method is to deform a carrier by squeezing it through a narrow, microscale constriction. This mechanical deformation creates transient pores in the carrier membrane to enhance the membrane’s permeability to macromolecules and promote the efficient uptake of drugs. During the Society of Rheology meeting, being held Feb. 12-16, Joseph Barakat will present his work to develop a model for vesicle squeezing that can be used to predict and optimize drug loading procedures.

Medicine

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Opioid, Antidepressant, Antipsychotic Drugs, Benzodiazepine, Elderly, Senior Health, Central Nervous System (CNS)

Use of Multiple Brain-Affecting Drugs Is Rising Among Seniors, Despite Risks, U-M Research Finds

The number of older Americans who take three or more medicines that affect their brains has more than doubled in just a decade, a new study finds. The sharpest rise occurred in seniors living in rural areas.

Medicine

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Cancer Treatment, Pharmaceutical Sciences, Drug Delivery, Targeted Drug Delivery, Pancreatic Cancer, chemotherapy delivery, Ndsu

NDSU Student Studying Cancer Treatment Wins Three Minute Thesis Competition

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NDSU students have many opportunities to practice skills they will use in their professional lives. The NDSU Graduate School hosted a Three Minute Thesis Competition to challenge graduate students to effectively communicate complex research to a general audience.

Medicine

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Children's Medicine, Zein, Nanoparticles, milk protein, Antiretrovirals, Neuroblastoma, Tranzderm Solutions, South Dakota State University

Corn, Milk Proteins Make Medicine Easier to Swallow

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It’s all about the layers! Encapsulating a drug in corn protein nanoparticles and then covering with them milk protein can make children’s medications better tasting and safer.

Medicine

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Back Pain, Nsaids, Pain Killers, spinal pain, Chiropractic, Chiropractors, Analgesic, Opioids, pain, Back Injury

Chiropractors Offer Alternative to NSAIDs for Back Pain

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People suffering from back pain should consider first trying chiropractic services and other non-drug therapies in light of a new research review that found common over-the-counter and prescription pain medications have limited effectiveness for back pain and raise the risk of side-effects, according to the American Chiropractic Association (ACA).

Science

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Constant Challenge for Discovery Propels Harvinder Gill

The Texas Tech researcher has shown how vaccines can be administered more effectively through the use of creative methods of drug delivery.

Medicine

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An Alternative Theory on How Aspirin May Thwart Cancer

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Studies abound that point to a role for plain old aspirin in keeping deadly cancers at bay. While aspirin is not yet part of mainstream treatment for any cancer, it is recommended by the U.S. Preventive Services Task Force for certain adults to help prevent colorectal cancer.







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