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Ongoing Trial May Lead to Better Understanding of Oral Mucositis, a Debilitating Side Effect Affecting Many Cancer Patients

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Trending Stories Report for 22 April 2015

Trending news releases with the most views in a single day. Topics include: diet supplements and cancer, pancreatic cancer, bird flu, parenting, respiratory health, physics from the DOE office of science, breast cancer awareness, and childhood cancer survivors.

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New Drug Combination Shows Promise for Breaking Breast Cancer Resistance

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Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.

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New Model to Predict Pharmacodynamic Activity May Improve Drug Discovery

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A new mathematical model that uses drug-target kinetics to predict how drugs work in vivo may provide a foundation to improve drug discovery, which is frequently hampered by the inability to predict effective doses of drugs. The discovery by Peter Tonge, a Professor of Chemistry and Radiology, and Director of Infectious Disease Research at the Institute for Chemical Biology and Drug Discovery (ICB & DD) at Stony Brook University, along with collaborators at Stony Brook University and AstraZeneca, will be published advanced online on April 20 in Nature Chemical Biology.

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Immunotherapy Drug Pembrolizumab Shows Early Promise for Mesothelioma Patients

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The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Patients diagnosed with the disease, which is tied to exposure to asbestos, have a median survival rate of about one year.

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Trending Stories Report for 17 April 2015

Trending news releases with the most views in a single day. Topics include: neurology, environment, crowdfunding, engineering, smoking, pharmaceuticals, medical research, cardiology and diabetes

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Study Identifies Factors Linked to Greater Adherence to Use of Anticoagulant

Among patients with atrial fibrillation who filled prescriptions for the anticoagulant dabigatran at Veterans Health Administration sites, there was variability in patient medication adherence across sites, with appropriate patient selection and pharmacist-led monitoring associated with greater adherence to the medication, according to a study in the April 14 issue of JAMA.

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Trending Stories Report for 14 April 2015

Trending news releases with the most views in a single day. Topics include: organic chemistry, cybercrime, pancreatic cancer research from Mayo Clinic, diabetes, pediatrics, new cancer treatment in development at Beth Israel Deaconess Medical Center, pain medicine research from the Ohio State University, marijuana in the workplace, and stem cells

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Medical Marijuana Liquid Extract May Bring Hope for Children with Severe Epilepsy

A medicinal liquid form of marijuana may show promise as a treatment for children with severe epilepsy that is not responding to other treatments, according to a study released today that will be presented at the American Academy of Neurology’s 67th Annual Meeting in Washington, DC, April 18 to 25, 2015.

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Researchers Identify Drug Target for ATRA, the First Precision Cancer Therapy

Cancerous tumors have the ability to evade targeted therapies by activating alternative pathways. Tumors also contain cancer stem cells, believed responsible for metastasis and drug resistance. Now scientists in the Cancer Research Institute at Beth Israel Deaconess Medical Center have identified a drug target that addresses both of these challenges.