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Age Matters: Discovering Why Antidepressants Don’t Work Well For Kids

Nathan Mitchell, a graduate student at the University of Texas Health Science Center in San Antonio wanted to know why the therapeutic benefit afforded by SSRIs was so limited in children and teenagers. If researchers can uncover the biological mechanisms preventing available treatments from producing antidepressant effects, scientists can then target those mechanisms to develop new antidepressants that will treat childhood and adolescent depression more effectively.

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Researchers Develop New Potential Drug for Rare Leukemia

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Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug that shows potential in laboratory studies against a rare type of acute leukemia. And additional studies suggest the same compound could play a role in prostate cancer treatment as well.

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New Therapeutic Target May Improve Treatment for Brain Cancer

These data indicate that TG2 is a possible chemotherapeutic target for Glioblastoma Multiforme (GBM) treatment.

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Roseroot Herb Shows Promise as Potential Depression Treatment Option

Rhodiola rosea (R. rosea), or roseroot, may be a beneficial treatment option for major depressive disorder (MDD), according to results of a study in the journal Phytomedicine led by Jun J. Mao, MD, MSCE, associate professor of Family Medicine, Community Health and Epidemiology and colleagues at the Perelman School of Medicine of University of Pennsylvania.

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Common Bacteria on Verge of Becoming Antibiotic-Resistant Superbugs

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Antibiotic resistance is poised to spread globally among bacteria frequently implicated in respiratory and urinary infections in hospital settings, according to new research at Washington University School of Medicine in St. Louis.

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Nanorobotic Agents Open the Blood-Brain Barrier, Offering Hope for New Brain Treatments

Magnetic nanoparticles can open the blood-brain barrier and deliver molecules directly to the brain, say researchers from the University of Montreal, Polytechnique Montréal, and CHU Sainte-Justine. This barrier runs inside almost all vessels in the brain and protects it from elements circulating in the blood that may be toxic to the brain. The research is important as currently 98% of therapeutic molecules are also unable to cross the blood-brain barrier.

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National Alert Issued: Look-Alike Packaging May Cause Confusion between Neostigmine and Phenylephrine

A National Alert for Serious Medication Errors has been issued by ASHP and the Institute for Safe Medication Practices (ISMP), warning of potentially dangerous mix-ups between two relatively new presentations of older medications, neostigmine injection and phenylephrine injection.

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How to Get Smarter on Pills for Seniors

Cancer patients over the age of 65 often take multiple drugs, which can interfere with cancer treatment. A new study shows that currently used tools to prevent over-medicating senior cancer patients need improvement

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Anti-Diabetic Drug Metformin and Vitamin D3 Show Impressive Promise in Preventing Colorectal Cancer

The concept was simple: If two compounds individually show promise in preventing colon cancer, it’s worth trying the two together. Metformin and Vitamin D3 proved dramatically better than either option alone. Their findings served as the cover feature for the February Cancer Prevention Research.

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Researchers Discover Why Drug For Severe COPD Becomes Less Effective

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Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing a tolerance to the drug after repeated use and makes the drug less effective, according to researchers at Georgia State University, Kumamoto University and the University of Rochester Medical Center.