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Roche Receives FDA Approval for Novel PD-L1 Biomarker Assay

Roche today announced approval of the VENTANA PD-L1 (SP142) Assay1 by the US Food and Drug Administration (FDA) as a complementary diagnostic to provide PD-L1 status on patients who are considering treatment with the FDA approved Roche immunotherapy TECENTRIQ™ (atezolizumab) for metastatic urothelial cancer (mUC). This test is the first to evaluate patient PD-L1 status using immune cell staining and scoring within the tumor microenvironment, providing clinicians with information that may guide immunotherapy decisions2.

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Medicine Is the One Item You Should Never Buy Online, Says UB Pharmacy Practice Expert

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The convenience of purchasing medicine online does not outweigh the risks, says Karl Fiebelkorn, University at Buffalo pharmacy practice expert.

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'Pain Paradox' Discovery Provides Route to New Pain Control Drugs

A natural substance known to activate pain in the central nervous system has been found to have the opposite effect in other parts of the body, potentially paving the way to new methods of pain control.

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Study Shows Distress Intolerance Associated with Opioid Misuse

Inability to manage negative emotional and somatic stress is associated with opioid misuse in adults with chronic pain, according to new research reported in The Journal of Pain, published by the American Pain Society,

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Research Tackles Problem of Antibiotic Resistance

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Sam Sanderson, Ph.D., a research associate professor in the UNMC College of Pharmacy, recently secured an R01 grant from the National Institutes of Health to find a workable solution to the problem of antibiotic resistance.

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Antibodies Identified That Thwart Zika Virus Infection

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Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, a significant step toward developing a vaccine, better diagnostic tests and possibly new antibody-based therapies.

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More Evidence in Quest to Repurpose Cancer Drugs for Alzheimer’s Disease

An FDA approved drug to treat renal cell carcinoma appears to reduce levels of a toxic brain protein linked to dementia in Alzheimer’s and Parkinson’s diseases when given to animals. This finding is the latest from Georgetown University Medical Center’s Translational Neurotherapeutics Program (TNP) examining tyrosine kinase inhibitors in the treatment of neurodegenerative diseases.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 1-Aug-2016 5:00 PM EDT

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Treating Pain Without Feeding Addiction: Study Shows Promise of Non-Drug Pain Management

A new study shows the potential for patients who have both addiction issues and chronic pain to be helped by an approach that combines behavioral therapy and social support to help them manage their pain without medications that themselves pose an addiction risk.

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New Treatment for Low Back Pain: Minimally Invasive Procedure Receives FDA Clearance

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It’s the most common reason people go to their doctors – back pain. Eighty percent of adults will experience low back pain some time in their lives. In fact, chronic low back pain affects nearly one-third of the nation’s population. Now a minimally invasive, nerve ablating procedure, recently cleared by the FDA, might give some people with chronic low back pain a new treatment option.

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Promising New Drug Could Help Treat Spinal Muscular Atrophy

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According to studies, approximately one out of every 40 individuals in the United States is a carrier of the gene responsible for spinal muscular atrophy (SMA), a neurodegenerative disease that causes muscles to weaken over time. Researchers at the University of Missouri developed a new molecule in April 2014 that was found to be highly effective in animal models exhibiting SMA. Now, testing of that compound is leading to a better prognosis for mice with the disease and the possibility of potential drugs that will improve outcomes for patients with SMA.

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New Surgical Tool for Mitral Valve Repair, Global Study Shows Stroke Largely Preventable, New Study Shows Differences in Blood Pressure Variation Across Ethnicity, and More in the Cardiovascular Health News Source

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Combining New and Old Drugs Improves Survival for Soft-Tissue Cancer Patients

Adding a novel monoclonal antibody therapy called olaratumab to traditional chemotherapy increased median survival by nearly a year in patients with advanced sarcoma, according to a multicenter clinical trial led by researchers at Columbia University Medical Center and NewYork-Presbyterian.

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New UW-Madison Center Offers Ultra-Speed Protein Analysis

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Three University of Wisconsin-Madison researchers have won a prestigious, five-year grant to establish the National Center for Quantitative Biology of Complex Systems, which will develop next-generation protein measurement technologies and offer them to biologists nationwide.

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Novel Compounds Arrested Epilepsy Development in Mice

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy. The findings will be published online in Scientific Reports, a Nature journal, on July 22, 2016.

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Scientists Use Already-Approved Drugs to Force Cancer Cell Death, How to Decide if Watchful Waiting Is the Right Choice, Some Adolescent Cancer Survivors May Require More Comprehensive Mental Health Screening, and MORE in the Cancer News Source

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Researchers ID Cancer Gene-Drug Combinations Ripe for Precision Medicine

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In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. The study, published July 21 in Molecular Cell, uncovered 172 new combinations that could form the basis for future cancer therapies.

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Duke to Participate in Early Clinical Trials for Emerging Neurological Therapies

Duke University could receive up to $19 million to lead early-stage clinical trials for new drugs to treat neurological conditions such as Alzheimer’s disease and neuropathy.

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Chronic Low Back Pain Linked to Higher Rates of Illicit Drug Use

People living with chronic low back pain (cLBP) are more likely to use illicit drugs—including marijuana, cocaine, heroin, and methamphetamine—compared to those without back pain, reports a study in Spine, published by Wolters Kluwer.

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Advanced Instruments Receives FDA Clearance for GloCyte® Automated Cell Counter System

Advanced Instruments, Inc., a leader in laboratory instrumentation, announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its GloCyte Automated Cell Counter System and GloCyte Low and High Level Controls.