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What Malignant Hyperthermia Association Says About Ryanodex

The discovery and subsequent introduction of dantrolene in 1979 was a major breakthrough in the treatment of malignant hyperthermia (MH) that is responsible for saving hundreds, if not thousands, of lives. However, one of the major challenges in the successful treatment of MH is the need for rapid mixing, suspension, and administration of dantrolene during a crisis.

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Dosage of HIV Drug May Be Ineffective for Half of African-Americans

Many African-Americans may not be getting effective doses of the HIV drug maraviroc because they are more likely than European-Americans to inherit functional copies of a protein that speeds the removal of the drug from the body.

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Drug for Rare Blood Disorder Developed at Penn Receives Orphan Drug Status from EU

A Penn Medicine-developed drug has received orphan status in Europe this week for the treatment of paroxysmal nocturnal hemoglobinuria, a rare, life-threatening disease that causes anemia due to destruction of red blood cells and thrombosis.

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Some Anti-Inflammatory Drugs Affect More Than Their Targets

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Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved doses and/or for long periods of time, these prescription-level NSAIDs and other drugs that affect the membrane may produce wide-ranging and unwanted side effects.

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UW Spinoff Aims to Hit the Mark Precisely with Brain-Scanning Tool

As brain surgeons test new procedures and drugs to treat conditions ranging from psychiatric disorders to brain cancer, accuracy is becoming an ever-greater issue. In treating the brain, the state of the art today starts with images from a magnetic resonance (MR) scanner, usually made a few days before surgery. To bring the full promise of MR into the operating room, UW-Madison professor Walter Block has formed a company called InseRT MRI to develop software that allows surgeons to observe the brain in real time on an MR machine during surgery.

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Early Bottlenecks in Developing Biopharmaceutical Products Delay Commercialization

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An analysis of patented university inventions licensed to biotechnology firms has revealed early bottlenecks on the path to commercialization. To open these roadblocks, the researchers suggest that better communication of basic research results during the discovery stage could lead to faster commercialization down the road.

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Aspirin, Take Two

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In a new paper, published this week in the online early edition of PNAS, researchers at the University of California, San Diego School of Medicine conclude that aspirin has a second effect: Not only does it kill cyclooxygenase, thus preventing production of the prostaglandins that cause inflammation and pain, it also prompts the enzyme to generate another compound that hastens the end of inflammation, returning the affected cells to homeostatic health.

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‘Shape-Shifting’ Material Could Help Reconstruct Faces

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Injuries, birth defects or surgery to remove a tumor can create large gaps in bone. And when they occur in the head, face or jaw, these defects can dramatically alter a person’s appearance. Researchers will report at the 248th National Meeting & Exposition of the American Chemical Society that they have developed a “self-fitting” material that expands with warm salt water to precisely fill bone defects, and also acts as a scaffold for bone growth.

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Bone Drugs May Not Protect Osteoporotic Women From Breast Cancer

Osteoporosis drugs known as bisphosphonates may not protect women from breast cancer as had been thought, according to a new study led by researchers at UC San Francisco (UCSF).

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Novel Drug Action Against Solid Tumors Explained

Researchers at UC Davis, City of Hope, Taipai Medical University and National Health Research Institutes in Taiwan have discovered how a drug that deprives the cells of a key amino acid specifically kills cancer cells.

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