Recent animal experiments showed that LEAPS COVID 19 conjugates induced faster and much higher than expected antibody responses against a non-mutating region of the virus that causes COVID 19, after only one injection.
At La Jolla Institute for Immunology (LJI) researchers are dedicated to finding a way to stop plaques from forming in the first place. In a new study, LJI scientists show that certain T lymphocytes, a type of white blood cell, that start out trying to fight the disease can end up increasing inflammation and making atherosclerosis cases even worse.
Behavioral scientist will lead St. Jude community outreach and research programs focused on the prevention of HPV-associated cancers through vaccination
Texas Biomedical Research Institute (Texas Biomed) scientists have added another tool to the COVID-19 toolbelt, validating a new small animal model for studying SARS-CoV-2, the virus that causes COVID-19.
Study results documenting parental hesitancy to begin and complete their child's HPV vaccine series were published in The Lancet Public Health by researchers at The University of Texas Health Science Center at Houston (UTHealth).
A study by UCLA researchers shows that in people with mild cases of COVID-19, antibodies against SARS-CoV-2 — the virus that causes the disease — drop sharply over the first three months after infection, decreasing by roughly half every 36 days on average. If sustained at that rate, the antibodies would disappear within about a year.
Researchers at The Rockefeller University in New York have developed new tools to rapidly test the ability of antibodies to neutralize SARS-CoV-2, the novel coronavirus responsible for the COVID-19 pandemic. The approach, described today in the Journal of Experimental Medicine (JEM), will help researchers understand whether patients are susceptible to reinfection by SARS-CoV-2 and assess the effectiveness of experimental vaccines, as well as develop antibody-based therapies against the disease.
Scientists and historians working at McMaster University, the Mütter Museum and the University of Sydney have pieced together the genomes of old viruses that were used as vaccination strains during and after the American Civil War ultimately leading to the eradication of smallpox.
The University of Miami Miller School of Medicine has been selected to be part of the National Institutes of Health COVID-19 Prevention Trials Network (CoVPN) to launch clinical trials to test investigational COVID-19 vaccines.
A prominent Australian pharmacologist has called for a new approach to treating COVID-19 as hopes fade of finding an effective vaccine or antiviral before the end of the year.
From mRNA vaccines entering clinical trials, to peptide-based vaccines and using molecular farming to scale vaccine production, the COVID-19 pandemic is pushing new and emerging nanotechnologies into the frontlines and the headlines. Nanoengineers at UC San Diego detail the current approaches to COVID-19 vaccine development, and highlight how nanotechnology has enabled these advances, in a review article in Nature Nanotechnology published July 15.
A team led by scientists at Scripps Research has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19.
Strains of a common subtype of influenza virus, H3N2, have almost universally acquired a mutation that effectively blocks antibodies from binding to a key viral protein, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.
Researchers at the Francis Crick Institute have characterised the structure of the SARS-CoV-2 spike protein as well as its most similar relative in a bat coronavirus.
Fueling transformative research through collaboration, the San Antonio Partnership for Precision Therapeutics (SAPPT) announces the funding of three more collaborative COVID-19 research efforts in San Antonio. SAPPT has awarded more than $600,000 to fund these projects, following the funding of a SARS CoV-2 vaccine project announced in April of this year.
Announcement of the Harrington Discovery Institute and Morgan Stanley raising funds for furthering COVID-19 research.
The race to find a vaccine for the new coronavirus is well underway. Governments and researchers are aiming to provide billions of people with immunity in eighteen months or less, which would be unprecedented.
University of Wisconsin–Madison researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination — including a COVID-19 vaccine from Moderna Therapeutics that has advanced to clinical trials with humans.
Experiments in mice have shown early success in vaccinating them against potentially deadly bacterial infections, such as methicillin-resistant Staphylococcal aureus, or MRSA, the strain resistant to most drug treatments.
A UCLA-led study has found that in 2 of 3 states and jurisdictions with policies that require students entering school to receive the human papillomavirus vaccine, vaccination rates among 13-to-17-year-olds were significantly higher than in surrounding states without such policies.
SHAREInternational collaboration provides important piece of COVID-19 puzzleLA JOLLA—A new study from researchers at La Jolla Institute for Immunology (LJI) and Erasmus University Medical Center (Erasmus MC) shows that even the sickest COVID-19 patients produce T cells that help fight the virus. The study offers further evidence that a COVID-19 vaccine will need to elicit T cells to work alongside antibodies.
While the latest findings on long-term efficacy of the HPV vaccine are cause for celebration, vaccinations should be coupled with preventive screening to better protect women from cervical cancer, two University of Michigan experts argue in an invited commentary in The Lancet’s EClinicalMedicine journal.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
Administering the MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say a team of experts in this week's mBio, a journal of the American Society for Microbiology.
Like a scene out of “Invasion of the Body Snatchers,” a virus infects a host and converts it into a factory for making more copies of itself.
Saint Louis University researcher Daniel Hoft, M.D., Ph.D., has been named to the National Vaccine Advisory Committee. Hoft was named a voting member of the group on June 8.
A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient’s own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment. The study, which will be published June 19 in the Journal of Experimental Medicine (JEM), reveals that the vaccines are a safe and effective way to induce the body’s immune system to attack any tumor cells that could cause disease relapse.
The University of Illinois at Chicago will soon test a vaccine for COVID-19. Expected to launch July 9, the trial — a phase 3 clinical study — will test the efficacy of a vaccine developed by biotech company Moderna.
Parents have been wondering whether they should keep their child’s health care appointments during the coronavirus crisis. Pediatrician Mona Patel, MD, has a simple answer: Yes. Don't delay your child's healthcare.
Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
In a new study, Johns Hopkins researchers found that testing people for SARS-CoV-2 — the virus that causes COVID-19 — too early in the course of infection is likely to result in a false negative test, even though they may eventually test positive for the virus.
Cancer researchers at Children’s Hospital of Philadelphia (CHOP) have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus. Using this strategy, the researchers believe a resulting vaccine would provide protection across the human population and drive a long-term immune response.
In a new study, published June 5, 2020, in the Journal of Experimental Medicine, scientists at La Jolla Institute for Immunology (LJI) shows that antibodies against JEV are “cross-reactive” and can also recognize Zika virus. Unfortunately, these antibodies can actually make Zika cases more severe.
The COVID Research Program is rapidly enrolling patients from New Jersey, which has one of the world’s highest concentrations of COVID-19 patients. Atlantic Health System offers a study sponsored by TScan Therapeutics, Inc., a leading T cell therapeutics company in Waltham, Massachusetts, focused on identifying the precise way the human immune system recognizes and responds to infections like COVID-19 or other diseases, like cancers. TScan has developed a novel technology that enables them to identify the natural targets of T cells.
A monthly media tip sheet of recent Fred Hutch research findings and other news.
A $1M gift from the John and Mary Tu Foundation is accelerating the efforts of UC San Diego translational research virologist Davey Smith to increase the number of people tested for COVID-19, as well as develop new ways to track and treat the virus. Smith and his team are studying how the disease spreads to better inform contact tracing, as well as leading clinical trials to test new drugs for treatment of COVID-19.
Medical school and healthcare industry leaders warn that a drastic decline in pediatric vaccinations in the United States, poses a great risk of serious illnesses in the midst of the COVID-19 pandemic
Notre Dame researchers create online tool to track development of coronavirus vaccines.
The internationally-renowned Gene Therapy Program at the University of Pennsylvania is joining the AAVCOVID vaccine program led by Massachusetts Eye and Ear and Massachusetts General Hospital (MGH), members of Mass General Brigham. AAVCOVID is a unique gene-based vaccine candidate designed to protect against SARS-CoV-2, the virus that causes COVID-19.
AveXis, will lead the manufacturing efforts of the new AAVCOVID vaccine, utilizing its cutting-edge AAV technology for treatment of rare and life-threatening neurological genetic diseases. AveXis has the option to manufacture the AAV vaccine for additional clinical development, registration and/or commercial activities.
The AAVCOVID vaccine program at Massachusetts Eye and Ear and Massachusetts General Hospital has entered into manufacturing agreements with Viralgen, Aldevron and Catalent in order to support manufacturing of the experimental vaccine for clinical studies in the second half of 2020.
While scientists around the world search for a coronavirus vaccine, an equivalent effort should be made to develop drugs that would mitigate the virus’s effects on patients, says Johns Hopkins Carey Business School Senior Lecturer Bonnie Robeson, who previously served as a principal investigator in drug discovery and development at the National Cancer Institute.
Researchers have received funding from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to screen and evaluate certain molecules known as adjuvants that may improve the ability of coronavirus vaccines to stimulate the immune system and generate appropriate responses necessary to protect the general population against the virus.
The first COVID-19 vaccine to reach phase 1 clinical trial has been found to be safe, well-tolerated, and able to generate an immune response against SARS-CoV-2 in humans, according to new research published in The Lancet.
Seventeen years ago, another viral outbreak was in the news. People wore masks, many were nervous to fly. This outbreak, known as SARS, was caused by a type of coronavirus we now call SARS-CoV-1. The difference was that SARS-CoV-1 was controlled and the virus is all but extinct. The newspaper headlines became a distant memory.
Therapies to change people’s sexual preference cause suicidal ideation, Georgia law effective at reducing late-term abortions and more
In response to the COVID-19 pandemic, researchers from the Massachusetts Institute of Technology have published a pair of studies in a COVID-19 special issue of the Harvard Data Science Review, freely available via open access, describing new methods for accelerating drug approvals during pandemics and for providing more accurate measures of the probabilities of success for clinical trials of vaccines and other anti-infective therapies.
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