Those who were enrolled in both Medicare and Medicaid were sicker, had more cognitive impairments and difficulty functioning, and needed more social support than those who were not enrolled in both government programs, Saint Louis University research found. These patients also had significantly higher healthcare costs.
Mary Jo Gilmer studies the impact animals can have on children with life-threatening conditions. She recently received a grant from nonprofit Human Animal Bond Research Institute (HABRI) for a pilot program investigating the health benefits of human-animal interactions (HAIs) in reducing suffering of children with cancer undergoing debilitating treatments.
A new report by researchers at La Jolla Institute found that a genetic deletion, or mutation, of TET2 and TET3 in mouse B cells damps down the generation of functional IgG antibodies, decreasing the effectiveness of immune responses.
A computational model of flatworm regeneration starts to answer the question – what signals determine the rebuilding of specific anatomical structures in regeneration? The model predicts and confirms factors determining body pattern formation, and the critical role nerve fibers play in determining polarity in regeneration.
NIBIB-funded researchers have designed a new class of two-dimensional (2D) nanomaterials that are disc-shaped and flat on the surface, similar to a coin, to aid in treatments for cartilage repair.
Scientists have taken one of the most in-depth looks ever at the riot of protein activity that underlies colon cancer and have identified potential new molecular targets to try to stop the disease.
A Michigan Tech engineer has created a method to fill in the gaps of available connected vehicle data, which will give transportation planners a more accurate picture of traffic in their cities. It is also a more cost-effective data gathering system than what is currently available.
Arsenic-based therapy can reverse drug tolerance in acute myeloid leukemia, Cancer Center researchers at BIDMC show.
A new chemical synthesis strategy to harvest rich information found in natural products has led to identifying simpler derivatives with potential to selectively protect neurons -- important for such diseases as Alzheimer’s -- or to prevent the immune system from rejecting organ transplants.
Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical “messengers” that transmit impulses from neurons to other target cells.
A new study suggests that Oncotype DX-guided treatment could reduce the cost for the first year of breast cancer care in the U.S. by about $50 million (about 2 percent of the overall costs in the first year). The study by Georgetown Lombardi Comprehensive Cancer Center and National Cancer Institute researchers was published April 24, in JNCI.
Rutgers Cancer Institute of New Jersey, the state’s only Comprehensive Cancer Center as recognized by the National Cancer Institute (NCI), has been awarded a $15.1 million grant (P30CA072720) as part of its successful 2019 redesignation.
People over the millennia have reported having deeply moving religious experiences either spontaneously or while under the influence of psychedelic substances such as psilocybin-containing mushrooms or the Amazonian brew ayahuasca, and a portion of those experiences have been encounters with what the person regards as “God” or “ultimate reality.” In a survey of thousands of people who reported having experienced personal encounters with God, Johns Hopkins researchers report that more than two-thirds of self-identified atheists shed that label after their encounter, regardless of whether it was spontaneous or while taking a psychedelic.
A mutation in the ORAI1 gene—studied in a human patient and mice—leads to a loss of calcium in enamel cells and results in defective dental enamel mineralization, finds a study led by researchers at NYU College of Dentistry.
Atomic beams conjure fantasies of gigantic Space Force canons. But there are real tiny atomic beams that shoot out of newly engineered collimators, a kind of tiny silicon peashooter, that could land in handheld devices. The beams streaming out of them create precise inertia much better than a gyroscope's that could help spacecraft navigate the solar system. The atomic beams from the new collimators could also let physicist cheaply and easily produce exotic quantum mechanical states.
A new study reveals the surprising way that family quarrels in seeds drive rapid evolution. Researchers in Arts & Sciences discovered that conflict over the amount of resources an offspring receives from its parent seems to play a special role in the development of certain seed tissues. The study is published the week of April 22 in the Proceedings of the National Academy of Sciences.
The immune system occasionally makes mistakes that require correction. For example, in autoimmunity, T-cells lose "immune tolerance" of self and can destroy one's very own tissues. Conversely, in cancer, the immune system can rapidly exhaust itself in the face of tumor antigens and become unresponsive, allowing tumors to thrive.
Nursing, medical, and dental students can work as a team to improve their knowledge of pediatric oral health—and how to work with their fellow health professionals, finds new research led by NYU Rory Meyers College of Nursing.
A team of researchers from Vanderbilt University’s schools of law, medicine and management has received a five-year research grant from the Agency for Healthcare Research and Quality of the Department of Health and Human Services to develop and test “safe harbor” standards of care based on scientific evidence.
Now research conducted in mice offers new hope that neonatal herpes infections might eventually be avoidable by stimulating an immune response in mothers.
In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells. The work puts scientists a step closer, they say, to injecting such artificial lymph nodes into people and sparking T-cells to fight disease.
Whether a wound—such as a diabetic foot ulcer—heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
A new study led by researchers from the University of California, Irvine finds exercising in the morning, rather than at night, may yield better results.
NIBIB-funded researchers at the University of Minnesota (UMN) created a new, dynamic 3D bioprinted tumor model in a laboratory dish to screen anticancer drugs and study the spread of cancer and primary site tumor growth.
UC San Diego researchers have improved their recycling process that regenerates degraded cathodes from spent lithium-ion batteries. The new process is safer and uses less energy than their previous method in restoring cathodes to their original capacity and cycle performance.
Researchers at the Georgia Institute of Technology have created a new type of origami that can morph from one pattern into a different one, or even a hybrid of two patterns, instantly altering many of its structural characteristics.
Researchers used CRISPR gene editing to thwart a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.
Using CRISPR gene editing, a research team has thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.
Artificial intelligence approach predicts the 3D structure of proteins based on its amino acid sequence
Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
Two proteins that bind to stress hormones work together to maintain a healthy heart in mice, according to scientists at the National Institutes of Health and their collaborators. These proteins, stress hormone receptors known as the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), act in concert to help support heart health.
Researchers at the McKelvey School of Engineering have received funding to to engineer microbes that create an underwater adhesive based on, but stickier than, the natural adhesive made by mussels.
A novel type of body awareness training helps women recover from drug addiction, according to new research from the University of Washington. People in the study made marked improvement, and many improvements lasted for a year.
In a new article in JNCI reporting the first known prognostic marker for triple-negative breast cancer, researchers provide evidence that a widely used breast cancer drug, tamoxifen, may be effective against this notoriously aggressive disease subtype.
First major multisite randomized controlled trial of a workplace wellness program shows mixed results at 18 months Program led employees to increase exercise and improve weight-management habits, but it had no effect on health outcomes Program did not improve worker absenteeism, tenure or job performance Program did not reduce employees’ use of health care services or health care spending in the short term
Using liquid in a solid-state NMR experiment, UC San Diego researchers show which parts of a protein are involved in the formation of the jelly-like state and that other nuclear components can modulate the jelly state, providing a way to regulate how and where it forms.
Hematology researchers have further refined how a treatment currently used urgently to control bleeding in hemophilia patients holds promise for prevention as well. A study in animals may lead to a new therapy for patients who now develop antibodies to the standard maintenance treatment.
Reactive neurostimulation reduces seizure frequency by remodeling the brain, and early electrical signatures of this process could be used to accelerate and personalize treatment.
Largest study to date uncovers the reality of young doctors’ lives in the hospital.
New algorithm successfully identifies patients with a tumor-fueling DNA repair defect found in multiple cancers and treatable with a common cancer drug.
A gene that dictates which of three sexes a papaya tree will become could spur a leap in the ultra-nutritious crop’s production.
Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became “misregulated” by the disease.
For decades, hospitals have worked to get staff to wash their hands and prevent the spread of germs. But a new study suggests they may want to expand those efforts to their patients, too. Fourteen percent of 399 hospital patients had “superbug” antibiotic-resistant bacteria on their hands or nostrils early in their hospital stay, and nearly a third of tests for such bacteria on objects that patients commonly touch came back positive.
University of California San Diego Department of Philosophy professor Manuel Vargas and Santiago Amaya of the Universidad de los Andes in Bogotá, Colombia have been awarded a $1.2 million grant from the John Templeton Foundation to advance understanding of agency, free will and responsibility — three interrelated concepts at the core of everyday life.
Gold atoms ski along boron nitride nanotubes and stabilize in metallic monolayers. The resulting gold quantum dots could be a promising material for future electronics and quantum computing.
A million Americans with injury or age-related disabilities need someone to help them eat. Now engineers have taught a robot to pick up food with a fork and gingerly deliver it to a person’s mouth.
Johns Hopkins Kimmel Cancer Center researchers say a new study of clusters of mouse cells known as “organoids” has significantly strengthened evidence that epigenetic changes, common to aging, play a essential role in colon cancer initiation. The findings show that epigenetic changes are the spark that pushes colon-cancer driving gene mutations into action, the researchers say.
In a recent University of California, Irvine-led study published in Nucleic Acids Research, a team of scientists described a catalog of 4489 putative mitochondrial DNA (mtDNA) deletions, including their frequency and relative read rate. This catalog comprises the first comprehensive database of mitochondrial deletions derived from human brain.
Nurse practitioners and nursing students can use local, real-time maps of opioid overdoses to inform their clinical work with adolescents in community health settings, finds new research from NYU Rory Meyers College of Nursing.
For decades, articles in research journals and the popular press alike have reported that being a family caregiver takes a toll on a person’s health, boosting levels of inflammation and weakening the function of the immune system. Now, after analyzing 30 papers on the levels of immune and inflammatory molecules in caregivers, Johns Hopkins researchers say the link has been overstated and the association is extremely small. Caregiver stress explains less than 1 percent of the variability in immune and inflammation biomarkers, they report. Their new meta-analysis was published March 10 in The Gerontologist.
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