Using the drug darapladib, researchers have inhibited a cholesterol-and immune system-associated protein, thereby reducing the development of heart-disease plaques that may cause death, heart attacks, and strokes in a pig model of atherosclerosis and diabetes.
The Lipid Sciences Research Program at Wake Forest University School of Medicine has been awarded a grant renewal of more than $9 million to define aspects of blood lipoproteins, such as cholesterol, that may be critical in prevention of coronary heart disease "“ the leading cause of death across the civilized world.
In the face of a growing obesity epidemic in the United States, researchers at Wake Forest University Baptist Medical Center have new study results that indicate that how much fat a person has is not as important as where that fat is located when assessing risk for cardiovascular events and metabolic disease.
Multidetector CT (MDCT) is just as accurate as MRI in assessing myocardial infarct size--an important predictor of clinical outcome-- in an emergency setting according to a recent study conducted by researchers in collaboration between the VA Medical Center in San Francisco, CA and the University Claude Bernard in Lyon, France.
People coping with rheumatoid arthritis or lupus already have a lot to deal with. Even so, paying attention to heart health may be especially important for this group. The August 2008 issue of the Harvard Heart Letter reports that rheumatoid arthritis doubles a person's risk of heart attack or cardiac arrest. Heart disease risk is even higher with lupus, and a new study suggests that gout, another common kind of arthritis, is also linked to cardiovascular disease.
A professor and engineering students at Rowan University are working to develop a mock circulatory system the will test a catheter that can potentially cool the hearts of coronary victims 10 times faster than today's technology. Their goal: to save heart tissue and save lives.
Race by itself is not a factor in heart failure when white and non-white patients are evenly matched on baseline variables such as age, weight, medical history and cardiac function, according to new research from UAB (University of Alabama at Birmingham. The findings, published in the June issue of the Journal of Cardiac Failure, are the first to use a propensity-matched technique to look at racial disparities in heart failure.
Farm-raised tilapia, one of the most highly consumed fish in America, has very low levels of beneficial omega-3 fatty acids and, perhaps worse, very high levels of omega-6 fatty acids. The combination could be potentially dangerous for some patients with heart disease, arthritis, asthma and other allergic and auto-immune diseases that are particularly vulnerable to an "exaggerated inflammatory response."
Quickly ascending to a high altitude can challenge the healthiest people, but it can spell extra trouble for individuals with a heart problem, according to the July 2008 Harvard Heart Letter. How your heart will respond to the challenges of high altitude depends on how high you are going, what you plan to do there, the state of your heart, and your overall fitness.
Women may respond less favorably than men to cardiovascular disease (CV) drug-treatments for enlarged heart, according to NewYork-Presbyterian Hospital/Weill Cornell Medical Center physician-scientists.
An analysis of previous studies indicates that among men and high-risk women with a certain type of heart attack or angina an invasive treatment strategy (such as cardiac catheterization) is associated with reduced risk of rehospitalization, heart attack or death, whereas low-risk women may have an increased risk of heart attack or death with this treatment, according to an article in the July 2 issue of JAMA.
Thanks to George Carlin we know there are seven words you can never say on TV. There are also seven dirty words about heart disease that everyone should know.
If more states introduce tobacco control programs for their residents who are regular smokers, the number of U.S. deaths due to coronary heart disease might drop, finds a new study that looks at an ongoing Massachusetts initiative.
High blood pressure in childhood is associated with higher blood pressure or hypertension in adulthood, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health.
Lower levels of high-density lipoprotein (HDL) cholesterol due to a gene mutation is not associated with an increased risk of ischemic heart disease, according to a study in the June 4 issue of JAMA.
Nearly half of patients with a history of heart disease have poor knowledge about the symptoms of a heart attack and do not perceive themselves to have an elevated cardiovascular risk, according to a report in the May 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Adding noninvasive imaging to current risk-assessment protocols may identify more people who are at risk of developing heart disease, UT Southwestern Medical Center researchers have found.
At the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium "“ the cell layer surrounding the outside of the heart "“ give rise to three important types of cells with potential for cardiac repair.
Physicians can now close certain types of leaky heart valves through a tiny puncture in the groin, using live 3D imaging for precise guidance, rather than performing open heart surgery.
Despite widespread use of cholesterol-lowering drugs, a significant number of cardiac patients continue to suffer heart attacks and stroke. Researchers theorize that high levels of an enzyme found in coronary plaques may be to blame, by making plaques more likely to rupture and block blood flow. The drug darapladib may offer a way to fight that risk, according to new research led by the University of Pennsylvania School of Medicine.
The gender gap is alive and well in heart disease, a new study finds, with women differing from men on everything from symptoms to treatment. One of the most striking findings: women were twice as likely as men to have "normal" or "mild" results on an exam of the heart's blood vessels, with no single blockage taking up more than 50 percent of any one blood vessel.
An aortic aneurysm can be a surprising, serious and unsettling diagnosis.
If heart attack symptoms such as chest or neck pain or shortness of breath persist for five minutes, call 911 or seek emergency medical care, recommends the American Heart Association.
Schoolchildren who required surgery as infants for congenital heart disease run a significant risk of having problems with inattention and hyperactivity, and often require remedial services in school. "These children are at risk for academic and behavior problems, and our findings reinforce how important it is to provide them with ongoing follow-up and neurodevelopmental screening," said the study leader.
Young children who lead inactive lifestyles are five-to-six times more likely to be at serious risk of heart disease, with that degree of danger emerging as early as their teenage years, according to a new study by researchers at the University of North Carolina at Chapel Hill.
New research shows that an aggressive statin regimen can reduce the dangerous plaque that clogs arteries, causing heart attacks. Results were presented today at the American College of Cardiology Scientific Session in Chicago and were published today in Circulation, a journal of the American Heart Association.
An international blood pressure study comparing two single-pill drug combinations has yielded results so significant that the study has been stopped early "“ and the researchers say their findings might alter the way high blood pressure is treated worldwide.
Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem.
The gene for the HDL-associated protein paraoxonase 1 (PON1) appears to be associated with coronary artery disease and with the risk of developing adverse cardiac events, and variations in both the PON1 gene and its related enzyme activity may increase the risk for cardiovascular disease events, according to a study in the March 19 issue of JAMA, a theme issue on Genetics and Genomics.
Low-fat diets are more effective in preserving and promoting a healthy cardiovascular system than low-carbohydrate, Atkins'-like diets, according to a new study by researchers at the Medical College of Wisconsin in Milwaukee. The study, is published in the February edition of the scientific journal Hypertension.
A review of previously published research suggests that stem cells harvested from an adult's blood or marrow may provide treatment benefit to select patients for some autoimmune diseases and cardiovascular disorders, according to an article in the February 27 issue of JAMA.
The number of elderly individuals newly diagnosed with heart failure has declined during the past ten years, but the number of those living with the condition has increased, according to a report in the February 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Americans who live with spinal cord injury do not appear to be at greater risk of developing carbohydrate and lipid disorders such as insulin resistance, diabetes, impaired glucose tolerance, and high or low blood cholesterol levels "“ risk factors for heart disease "“ than able-bodied persons.
While advances have been made in understanding how genetics, metabolism of HDL and LDL cholesterol, the inflammatory process, blood clots, and blood pressure regulation all play a part in the atherosclerosis disease process, a solution is likely many years away and will require huge--but worthwhile--investments of time, money and collaboration across fields of study.
Loyola pediatric, adult cardiologists set up clinic for patients who may not be getting the highly specialized care they need.
If you are in love this Valentine's Day, you have more than one reason to celebrate. Being involved in a healthy, loving relationship is good for the heart, says Vanderbilt Heart and Vascular Institute cardiologist, Julie Damp, M.D.
We teach our children how to walk, talk and go to the bathroom, but do we teach them how to eat right? National statistics show that many of us do not. According to the American Obesity Association, an alarming 15.5 percent of children between the ages of six and 11 are considered obese, putting them on a collision course with the nation's biggest killer: heart disease.
A Mayo Clinic analysis of two decades of autopsy results shows a long-term decline in the prevalence of coronary disease has ended and the disease may be on the upswing. The findings appear in today's issue of Archives of Internal Medicine.
Statin drugs are helping many people lower their cholesterol, but a new study in the February Journal of Lipid Research reveals that statins actually increase the production of another protein that limits their benefit.
Psychosocial interventions "” like counseling, telephone support and self-help materials "” can assist heart disease patients who are trying to give up cigarettes, but the most successful cessation treatments last a month or more, according to a new review of studies.
An estimated one in 20 patients undergoing a common operation to boost blood supply to the heart and to ward off repeat heart attacks may do better if their surgeons also remold the heart to a near normal size, by cutting and suturing together stretched muscle and scar tissue resulting from the initial attack, according to cardiac surgeons at Johns Hopkins.
An anti-inflammatory drug similar to aspirin may provide an inexpensive means of treating and/or reducing the risk for diabetes in obese young adults by reducing glycemia and lowering inflammation, a study being published in the February issue of Diabetes Care finds.
Overweight people have a higher risk of heart attacks, strokes and other problems that arise from clogged, hardened arteries. Now, a new study in mice gives the first direct evidence of why this link might exist "“ and a tantalizing look at how it might be broken.
A new academic study led by UCLA revealed that the smallest particles from vehicle emissions may be the most damaging components of air pollution in triggering plaque build-up in the arteries that can lead to heart attack and stroke. The scientists also identified a way in which pollutant particles may promote hardening of the arteries "“ by inactivating the protective qualities of HDL cholesterol, known as the "good cholesterol."
Using new techniques for rapidly scanning the human genome, researchers have associated levels of cholesterol and triglycerides, two fats in the blood, to 18 genetic variants, six of which represent new DNA regions never before associated with the traits. The findings help explain some of the variability in cholesterol and triglyceride levels that arises from genes.
Dr. Blanchard of the UCSD Medical Center, and Susan Iliff, a retired nurse discuss the symptoms of heart attack in women.
Mount Sinai Cardiac Experts Available for Heart Month Interviews
Josh Bristow, 51, is one of a very few patients in the nation with AIDS and late-stage heart failure to have a left ventricular assist device (LVAD) implanted as "destination therapy." He needed a heart transplant, but the immune-compromising nature of AIDS virtually excluded him as a candidate for transplantation because of the increased risk of infection and the inability to undergo immunosuppression to prevent organ rejection.
People with restless legs syndrome (RLS) are twice as likely to have a stroke or heart disease compared to people without RLS, and the risk is greatest in those with the most frequent and severe symptoms, according to research published in the January 1, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.
University of Michigan scientists and their colleagues have helped characterize a previously unknown link in the chain of biochemical reactions implicated in some forms of heart disease.
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