UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.
New research from Cornell University details how two highly lethal viruses have greater pathogenic potential when their proteins are combined.
Hui Yang, Harold and Inge Marcus Career Associate Professor of Industrial and Manufacturing Engineering at Penn State, was awarded a $320,625 grant from the National Science Foundation (NSF) to study exactly how a process called glycosylation can cause proteins to disrupt the harmony of cell activity.
UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.
The human heart’s energy needs and functions are difficult to reproduce in other animals; one new system looks to circumvent these issues and provide a functional view of how different treatments can help ailing cells in the heart following oxygen and nutrient deprivations. Researchers have unveiled a new silicon chip that holds human lab-grown heart muscle cells for assessing the effectiveness of new drugs. They discuss their work in this week’s APL Bioengineering.
Mice scurry around while foraging for food, but genetics may be the unseen hand controlling these meandering movements. Researchers at University of Utah Health are using machine learning to draw links between genetic controls that shape incremental steps of instinctive and learned behaviors. The results are available online in Cell Reports on August 13.
Accumulation of unusual RNA-DNA hybrids, known as R-loops, are often associated with cancers. Xiaoyu Xue, assistant professor in the Department of Chemistry and Biochemistry at Texas State University, is heading a research study examining the role of the human motor protein Aquarius (AQR) in resolving R-loops to gain insight into possible avenues of cancer prevention.
The study is the first to put antibiotic biosynthesis and resistance into an evolutionary context. The findings will help to guide the future discovery of new antibiotics and antibiotic alternatives which are medicines that are vitally needed given the current global threat of antimicrobial resistance.
Scientists have discovered that the building blocks of proteins can stabilize cell membranes. This finding may explain how the first cells emerged from the primordial soup billions of years ago: Protein building blocks could have stabilized membranes against salt and ions present in ancient oceans.
Stem cells hold the key to wound healing, as they develop into specialised cell types throughout the body - including in teeth.
Conhecido por seu prognóstico precário, o adenocarcinoma de pulmão é o tipo de câncer de pulmão mais comum, responsável por aproximadamente 4 de 10 diagnósticos, de acordo com o National Institute of Cancer. Os pesquisadores do campus da Flórida da Mayo Clinic agora podem distinguir entre duas vias onde esse câncer fatal pode se desenvolver.
Das Lungenadenokarzinom ist bekannt für seine schlechte Prognose und laut National Cancer Institute mit etwa 4 von 10 Diagnosen die häufigste Form von Lungenkrebs. Forscher auf dem Mayo Clinic Campus in Florida können nun zwischen zwei Signalwegen unterscheiden, auf denen sich dieser tödliche Krebs entwickeln kann.
美国国家癌症研究所的研究表明，肺腺癌是最常见的肺癌类型，且公认预后较差，每10例肺癌诊断中约有4例为肺腺癌。Mayo Clinic佛罗里达院所的研究人员现在可以区分这种致命癌症的两种可能发生途径。他们表示其发现可以帮助未来的患者。研究结果发表在Cancer Cell（《癌细胞》）期刊上。
Connu pour son pronostic défavorable, l'adénocarcinome pulmonaire est le type le plus commun de cancer du poumon, responsable d'environ 4 diagnostics sur 10, selon l'Institut national du cancer. Des chercheurs du campus de Floride de la Mayo Clinic peuvent désormais distinguer deux voies de développement de ce cancer mortel.
The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.
Brian Walker, Ph.D., with the Myeloma Center at the University of Arkansas for Medical Sciences (UAMS) has received a $542,486, three-year grant from the Leukemia & Lymphoma Society to look at changes in the DNA sequence that effects the development and advancement of multiple myeloma, a cancer of plasma cells in the blood.
A crucial signaling pathway that can tell the immune system to fight off cancer can also be co-opted by cancer cells to put the brakes on the immune system.
A team of biologists has discovered how cells become different from each other during embryogenesis, a finding that offers new insights into genetic activity and has implications for better understanding the onset of disease and birth defects.
A new study, led by researchers at La Jolla Institute for Immunology (LJI), identified and then reverse engineered the molecular properties shared by antibodies that are particularly efficient at inactivating or “neutralizing” Lassa virus providing a map for rational vaccine design.
Study in mice reveals several distinct molecular mechanisms underlying abnormal touch sensitivity in autism spectrum disorders
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