Curated News: Nature (journal)

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Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.

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Scientists have captured the first detailed microscopy images of ultra-small bacteria that are believed to be about as small as life can get. The research was led by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory and the University of California, Berkeley. The existence of ultra-small bacteria has been debated for two decades, but there hasn’t been a comprehensive electron microscopy and DNA-based description of the microbes until now.

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A Scripps Institution of Oceanography-led study on how natural and man-made sources of nitrogen are recycled through the Lake Tahoe ecosystem provides new information on how global change may affect the iconic blue lake.

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Evolution is change, and not always for the better. Evolution, in fact, is at the core of many of the diseases that are hardest to treat. Pathogens such as bacteria and parasites evade their host’s defenses or antimicrobial drugs through evolution. Cancer itself in an evolutionary process, whereby “rogue” cells evolve to grow beyond their normal barriers, migrate to distant locations in the body, and ultimately evade chemotherapy.

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Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation that promotes the development of inflammatory bowel disease and metabolic syndrome, new research shows.

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Scientists have observed an increase in carbon dioxide’s greenhouse effect at the Earth’s surface for the first time. They measured atmospheric carbon dioxide’s increasing capacity to absorb thermal radiation emitted from the Earth’s surface over an eleven-year period at two locations in North America. They attributed this upward trend to rising CO2 levels from fossil fuel emissions.

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Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.

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The new zinc-polyiodide redox flow battery uses an electrolyte that has more than two times the energy density of the next-best flow battery used to store renewable energy and support the power grid. It’s high energy density, and resulting lower cost, make it ideal for large cities where space is at a premium.

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A new electrolyte allows rechargeable batteries to operate well without growing dendrites, tiny pin-like fibers that short-circuit rechargeable batteries.

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Researchers have pinpointed a region in the human genome associated with peanut allergy in U.S. children, offering strong evidence that genes can play a role in the development of food allergies.

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In Nature Genetics, DOE JGI researchers and longtime collaborators at the French National Institute for Agricultural Research and Clark University conducted the first broad, comparative phylogenomic analysis of mycorrhizal fungi to understand the basis for fungal symbiotic relationships with plants.

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Researchers at University of California, San Diego School of Medicine have discovered that the inflammatory molecule LTB4 promotes insulin resistance, a first step in developing type 2 diabetes. What’s more, the team found that genetically removing the cell receptor that responds to LTB4, or blocking it with a drug, improves insulin sensitivity in obese mice. The study is published Feb. 23 by Nature Medicine.

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Studying zebrafish embryos, researchers at Washington University School of Medicine in St. Louis have shown that the epigenome plays a significant part in guiding development in the first 24 hours after fertilization. The research may deepen understanding of congenital defects and miscarriage.

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A team of scientists from Vanderbilt and Stanford universities have created the first comprehensive map of the topsy-turvy climate in the western U.S, 21,000 years ago when Southwest was wet and the Northwest was dry and are using it to test and improve the global climate models that have been developed to predict how precipitation patterns will change in the future.

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A new study has found that La Niña-like conditions in the Pacific Ocean off the coast of Panamá were closely associated with an abrupt shutdown in coral reef growth that lasted 2,500 years. The study suggests that future changes in climate similar to those in the study could cause coral reefs to collapse in the future.

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MIT chemical engineers have designed a new type of self-healing hydrogel that could be injected through a syringe. Such gels, which can carry one or two drugs at a time, could be useful for treating cancer, macular degeneration, or heart disease, among other diseases, the researchers say.

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A research team led by investigators from Mayo Clinic’s campus in Jacksonville, Florida, and the University of Oslo, Norway, have identified a molecule that pushes normal pancreatic cells to transform their shape, laying the groundwork for development of pancreatic cancer — one of the most difficult tumors to treat.

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A recent study involving Kansas State University researchers finds that in the coming decades at least one-quarter of the world's wheat production will be lost to extreme weather from climate change if no adaptation measures are taken.

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Researchers from Canada, the UK, Sweden and the US have discovered more than 30 genes that strongly affect an antibody involved in allergies and asthma. Some of the genes could provide targets for drugs to treat those conditions, according to the international team’s study, published online in Nature.

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Researchers at the U.S. Department of Energy’s Argonne National Laboratory have revealed previously unobserved behaviors in nanrods that suggest new rules for the behavior of nanorod ensembles and new insights into how to increase heat-transfer efficiency in a nanoscale system.

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Researchers at Albert Einstein College of Medicine of Yeshiva University have found a possible clue to why older mothers face a higher risk for having babies born with conditions such as Down syndrome that are characterized by abnormal chromosome numbers.

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Research of Africa's Lake Bosumtwi sediments provides insights into abrupt climate change

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The genome is the instruction book for life. But reading that instruction book and carrying out its directives are controlled by the epigenome, which attaches chemical markers to DNA to activate or silence genes. For the first time, researchers at Washington University School of Medicine and elsewhere have assembled a comprehensive map of the human epigenome.

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Much like mapping the human genome laid the foundations for understanding the genetic basis of human health, new maps of the human epigenome may further unravel the complex links between DNA and disease. The epigenome is part of the machinery that helps direct how genes are turned off and on in different types of cells.

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The human genome project captured the public imagination when its first draft was published 14 years ago this week in the international science journal Nature, but the epigenome may hold the real promise for conquering disease.

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Two international teams of researchers led by Ludwig San Diego’s Bing Ren have published in the current issue of Nature two papers that analyze in unprecedented detail the variability and regulation of gene expression across the entire human genome, and their correspondence with the physical structure of chromosomes.

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In a remarkable new advance against the virus that causes AIDS, scientists from The Scripps Research Institute have announced the creation of a novel drug candidate so potent and universally effective, it might work as part of an unconventional vaccine.

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Researchers have long sought alternatives to morphine – a powerful and widely used painkiller – that curb its side effects, including dependency, nausea and dizziness. Now, an experiment at the Department of Energy’s SLAC National Accelerator Laboratory has supplied the most complete atomic-scale map of such a compound docked with a cellular receptor that regulates the body’s pain response and tolerance.

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Researchers in the laboratory of Rugang Zhang have discovered a target for ovarian clear cell carcinoma, a very difficult-to-treat form of the disease.

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For decades, theories on the genetic advantage of sexual reproduction had been put forward, but none had ever been proven in humans, until now. Researchers at the University of Montreal and the Sainte-Justine University Hospital Research Centre in Montreal, Canada have just shown how humanity’s predispositions to disease gradually decrease the more we mix our genetic material together. This discovery was finally made possible by the availability in recent years of repositories of biological samples and genetic data from different populations around the globe.

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While diet and exercise are important, new findings sharpen the role genetics play in people’s tendency to gain weight and where the fat is stored. This work is the first step toward finding individual genes that play key roles in body shape and size.

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Silicon nanomaterials used for localized delivery of chemotherapy drugs behave differently in cancerous tumors than in healthy tissues. The new findings could help scientists improve materials for the controlled release of the chemotherapy drugs.

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Researchers working at the Department of Energy’s SLAC National Accelerator Laboratory have captured the first X-ray portraits of living bacteria. This milestone, reported in the Feb. 11 issue of Nature Communications, is a first step toward possible X-ray explorations of the molecular machinery at work in viral infections, cell division, photosynthesis and other processes that are important to biology, human health and our environment.

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A first of its kind genetic study confirms the history of the Druze community: The community began to form genetically in the 11th century AD, and there has since been no genetic impact of other ethnic groups on the community

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Researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in the spread of ovarian cancer. This has enabled them to identify small molecules that can inhibit adhesion and invasion, hallmarks of metastasis.

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Researchers at the University of Illinois at Chicago College of Medicine report in Nature Communications that an enzyme called MnSOD causes cells, as they become cancerous, to switch from aerobic metabolism — using oxygen to break down sugars for energy — to a type of fermentation called glycolysis, which does not require oxygen.

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The U.S. Midwest and surrounding states have endured increasingly more frequent flood episodes over the past half-century, according to a study from the University of Iowa.

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St. Jude Children’s Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin. The research appears in the current online issue of the scientific journal Nature Genetics.

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A protein called YAP, which drives the growth of organs during development and regulates their size in adulthood, plays a key role in the emergence of resistance to targeted cancer therapies, according to a new study led by UC San Francisco researchers.

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An international team of scientists, including Minghua Zhang, Dean and Director of Stony Brook University’s School of Marine and Atmospheric Sciences (SoMAS), has found that man-made aerosol emissions from industrial processes have changed the relationship between temperature and precipitation in the northing tropics. The findings, published early online in Nature Geoscience, may help to indicate the shifts in seasonal rainfall in Central America, which is critical for agriculture in the region.

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NIBIB-funded researchers have developed a novel 3D vaccine that could provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful immune response. The vaccine was recently found to be effective in delaying tumor growth in mice.

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Applying lessons learned from autism to brain cancer, researchers have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.

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A collaborative study led by scientists from the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) has revealed the mechanical forces that drive epithelial wound healing in the absence of cell supporting environment. This research was published in Nature Communications in January 2015.

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For at least 40 years, scientists who study how the body metabolizes sugar have accepted one point: there are four enzymes that kick-start the body’s process of getting energy from food. But this biochemical foursome may not deserve all of the credit. According to research by scientists at Duke and Northwestern universities, the hexokinase team actually has a fifth player.

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Head and neck squamous cell cancer (HNSCC) ranks among the top ten most prevalent cancers in the United States. Despite its prevalence, little is known about how this cancer develops and spreads. However, in a paper published in the January 29, 2015 edition of Nature, researchers offer critical new information about head and neck cancers.

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Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to researchers at NYU Langone Medical Center.

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A team of Vanderbilt University biologists have found a way to use a laser and an optical fiber to reset an animal's master biological clock: A discovery that could in principle be used therapeutically to treat conditions like seasonal affect disorder, reduce the adverse health effects of night shift work and possibly even cure jet lag.

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A team of Vanderbilt University biologists have found a way to use a laser and an optical fiber to reset an animal's master biological clock: A discovery that could in principle be used therapeutically to treat conditions like seasonal affect disorder, reduce the adverse health effects of night shift work and possibly even cure jet lag.

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A three-dimensional seismic image of the mantle beneath the Lau Basin in the South Pacific just published in Nature has an intriguing anomaly. The image showed the least magma where the scientists expected to find the most. After considerable debate they concluded that magma with a high water content was flushed so rapidly that it wasn't showing up in the images.

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A new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune “memory” to improve, an important step toward the development of more effective, longer-lasting vaccines.