Holly Kramer, MD, MPH, a kidney specialist and nationally known kidney disease researcher at Loyola University Chicago and Loyola Medicine, has been named president-elect of the National Kidney Foundation, Inc.
• Among working-aged adults who started dialysis between 1996 and 2013, employment was low throughout the study period at 23-24%, and 38% of patients who were employed 6 months prior to being diagnosed with kidney failure stopped working by the time they initiated dialysis. After accounting for differences in patients over time, the probability of employment in kidney failure patients increased slightly over time.
Female kidney donors who are overweight may be at a greater risk for preeclampsia during pregnancy than those with normal body weight, according to a new study. The increased risk is due to a reduction in a type of kidney function called renal functional reserve (RFR).
Kidney specialists face increasing work demands, high rates of burnout, and declining interest in nephrology as a career. A group of articles publishing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN) sheds light on how that these factors threaten to reduce job satisfaction and impair the delivery of high-quality care to patients with kidney diseases.
The most common type of tumor found in the kidney is generally quite small (less than 1.5 in). These tumors are usually found by accident when CAT scans are performed for other reasons and the serendipitous finding poses a problem for doctors.
Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Structural and Molecular Biology, researchers revealed atomic-level details of the protein that serves as a passageway for calcium across kidney cell membranes.
The proteasome inhibitor carfilzomib has taken on an increasing role in the treatment of multiple myeloma, but new research from the Abramson Cancer Center of the University of Pennsylvania shows the therapy comes with the risk of cardiovascular problems in a higher than expected percentage of patients.
Tyler Williamson went to TEDx Birmingham’s 2017 event in March expecting to be inspired and to network and make new connections with fellow attendees. What the 27-year-old did not anticipate was that inspiration would lead him to volunteer to become a living kidney donor just seven months later.
Three months after receiving a kidney transplant, Holly Miyagawa was back on the beach playing volleyball. That was 17 years ago. Since then, the Hermosa Beach, CA, resident has gone on to medal in volleyball at the World Transplant Games and the Transplant Games of America. This New Year's Day, she'll accompany the Donate Life float in the Tournament of Roses Parade, representing Cedars-Sinai, where she received her transplant.
In an effort to provide patients the opportunity to share practical health consumer perspectives, the Clinical Journal of the American Society of Nephrology (CJASN) is including Patient Voice editorials that will accompany certain journal articles. In the first editorial, Paul T. Conway, a past recipient of the ASN President’s medal, highlights 2 CJASN articles that focus on patient comprehension of how treatments align with their individual interests.
A study published in the Journal of Clinical Oncology reports initial findings with a novel drug belonging to a new class of medicines called HIF-2a inhibitors that show promise in treating metastatic kidney cancer.
An interdisciplinary research team led by the National University of Singapore (NUS) has recently discovered a unique panel of urine biomarkers that could accurately diagnose nephrolithiasis, also commonly known as kidney stone.
Researchers have demonstrated for the first time that extracellular vesicles – tiny protein-filled structures – isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease.
• In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury. • Bortezomib treatment was also linked with gastrointestinal and hematologic toxicity.
• In the United States, the excess risk of kidney failure–related death decreased by 12% to 27% over any 5-year interval between 1995 and 2013. • Decreases in excess mortality over time were observed for all ages and both during treatment with dialysis and during time with a functioning kidney transplant.
Around 17% of American adults have chronic kidney disease (CKD), and the rate of prevalence is higher for US Veterans. CKD, if not treated appropriately, can ultimately lead to kidney failure requiring either dialysis or a transplant.
Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The findings are significant because urea levels can be lowered through medication and diet, thereby allowing for improved treatment and possible prevention of diabetes.
The hope given from a deceased donor, and a sibling, give two kidney transplant recipients a chance to live
• New research indicates that the role of dendritic cells in kidney inflammation is more complex than previously thought. Different types of dendritic cells communicate with each other to control the magnitude of the immune response. • The findings may lead to a better understanding of various types of kidney disease.
• In an analysis of pairs of kidneys from the same donor in which 1 kidney was used but the other was discarded, the kidneys that were used tended to perform well. • The majority of discarded kidneys could have potentially been transplanted with good outcomes.
Sunitinib (marketed as Sutent) a drug that has already proven highly effective as first-line treatment for people with metastatic renal cell carcinoma, was recently approved by the U.S. Food and Drug Administration to also treat patients with the disease who are at high risk for tumor recurrence.
Stress in early life may change the immune response in the kidneys, increasing the risk of heart disease later in life, according to a new study.
DNA sequences between mitochondria within a single cell are vastly different, found researchers. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific therapies.
In a new study of kidney disease patients, researchers used DNA sequencing to identify the underlying genetic cause of disease, improving diagnosis and treatment.
Iowa State's Robbyn Annand is studying how a hybrid of electrochemical and microfluidic technologies could be used to improve the dialysis equipment that cleans salt, waste and water from blood. That technology could enable a wearable, artificial kidney.
• In tissue samples from patients who received kidney transplants without the need for chronic immunosuppression, researchers found increased expression of many genes associated with the regulation of certain immune cells. • The findings provide an improved understanding of transplant organ acceptance and rejection.
Social media is a powerful tool that can help people facing health challenges, such as Native Americans on kidney dialysis.
Three Loyola Medicine kidney transplant patients received kidneys from three living donors on the same day in a transplant chain.
Los investigadores de Mayo Clinic demostraron una vinculación entre el tipo de anticoagulante que toma el paciente para evitar un accidente cerebrovascular y más riesgo de deterioro de la función renal o de insuficiencia renal.
Mayo Clinic researchers have shown a link between which type of oral anticoagulant (blood-thinning medication) a patient takes to prevent a stroke and increased risks of kidney function decline or failure.
Slight changes to the system for allocating deceased-donor kidneys could result in higher rates of organ procurement and lead to more kidney transplants across the country, according to new research co-authored by an Indiana University Kelley School of Business professor.
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
Michigan Medicine enters drug discovery collaboration with AstraZeneca in Chronic Kidney Disease
Rural counties continue to rank lowest among counties across the U.S., in terms of health outcomes. A group of national organizations including the Robert Wood Johnson Foundation and the National 4-H Council are leading the way to close the rural health gap.
HIV patients and their doctors are urged to be more aware of the additional health risks associated with treated HIV infection. This follows new research that shows HIV patients at high risk for a heart attack or stroke are also at substantially greater risk for chronic kidney disease and vice versa.
High protein diets may lead to long-term kidney damage among those suffering from chronic chronic kidney disease, according to research led by nephrologist Kamyar Kalantar-Zadeh, MD, MPH, PhD, of the University of California, Irvine.
• In young women, a history of kidney stones was associated with metabolic and hypertensive complications. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• From 2004 to 2016, VA patients had lower rates of transplantation compared with patients with Medicare or private insurance. • VA patients also had a higher rate of mortality on the waiting list compared with privately insured patients. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• The estimated global burden of chronic kidney disease attributable to fine particulate matter is more than 10.7 million cases per year. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• A new study demonstrated that TRC101, a hydrochloric acid binder for the treatment of metabolic acidosis associated with chronic kidney disease, provided a rapid and sustained average increase in serum bicarbonate. • All adverse effects were mild or moderate.
A phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form of polycystic kidney disease, a condition with no cure.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2017, October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• In white patients with chronic kidney disease, those with depressive symptoms had a higher risk of early death than those without depressive symptoms. This risk was much lower after accounting for use of anti-depressants, however. • In black patients, the presence of depressive symptoms was not linked to risk of death. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• In an analysis of published studies, individuals who used proton pump inhibitors had a 33% increased relative risk of developing chronic kidney disease or kidney failure when compared with non-users. • Results from the analysis will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• The American Society of Nephrology (ASN), the world’s largest organization of kidney health professionals, has elected Mark D. Okusa, MD, FASN, as the next ASN President. • Dr. Okusa officially assumes his role as ASN President during the society’s annual meeting, ASN Kidney Week 2017, the largest gathering of kidney care specialists in the world, and will begin his term on January 1, 2018.
• In patients treated for hypertension, greater reductions in mean blood pressure were linked with reduced kidney function. • Results from the analysis will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
A clinical trial involving hundreds of participants has shown that one of the most frequently prescribed antidepressants may not benefit millions of patients who also have chronic kidney disease.
• Insomnia was linked with increased risks of early death, rapid kidney function decline, and kidney failure in a group of US veterans. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• Among children with impaired kidney function, those with high blood pressure at night experienced a faster time to kidney failure than children with normal blood pressure. This decline was even more pronounced in patients with high blood pressure during both day and night when compared with children with normal blood pressure. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• In a recent analysis, African American patients were less likely to be wait-listed than White patients. This difference was influenced by factors including age, comorbidities, socio-economic status, being on dialysis, having a living donor, transplant knowledge, and social support. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
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