With $3.8 million in support from the National Institute on Aging, University of California, Irvine neurobiologists are working to identify the early indicators of dementia in older adults as disease-related brain plaques accumulate but before symptoms can be observed.
Penn Medicine study illuminates how seniors cope with Alzheimer’s-risk biomarker results
October Tips Include: A noninvasive eye scan for detecting Alzheimer’s disease; a first-of-its-kind heart device for babies born with a congenital heart defect; research that could lead to a vaccine for antibiotic-resistant “superbugs” and heart research suggesting that stem cells from young hearts could rejuvenate older ones. To pursue any of these story ideas, please contact the contact listed for each.
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.
A new study published online this week in the American Journal of Human Genetics from Penn researchers uncovers the mechanisms of the genetic mutations, or variants, associated with the TMEM106B gene.
People who have a healthier diet throughout their adult lives are more likely to be stronger and fitter in older age than those who don’t, according to a new study led by the University of Southampton.
University of Iowa researchers report that a roundworm can learn to put on alert a defense system important for protecting cells from damage. The finding could lead to a new approach for treating neurodegenerative diseases in humans caused by damaged cells.
Scientists now believe that the Fountain of Youth flows from our genes, or at least from the genes of people who live healthy lives to age 100 or later. To discover what’s special about the genes of centenarians—and apply that knowledge to extend the healthy lives of the rest of us—the NIH has awarded researchers at Albert Einstein College of Medicine and The Scripps Research Institute (TSRI) a five-year, $9 million grant.
Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals. In a Nature Communications study published today, researchers showed that worms with excess levels of certain proteins lived longer and healthier than normal worms. In addition, mice with excess levels of these proteins demonstrated a delay in blood vessel dysfunction associated with aging. The study has major implications for our understanding of aging and age-associated disorders.
A proposal to humanize several mouse genes for research into Alzheimer’s disease has spurred the National Institute on Aging to award $11.35 million to the University of California, Irvine.
Scientists drilling down to the molecular roots of Alzheimer’s disease have encountered a good news/bad news scenario. The bad news is that in the early stages of the disease, high-risk TREM2 variants can hobble the immune system’s ability to protect the brain from amyloid beta. The good news, according to researchers at Washington University School of Medicine in St. Louis, is that later in the disease, the absence of TREM2 protein seems to protect the brain from damage.
Indiana University has been awarded a one-year, $7.6 million grant from the National Institute on Aging (NIA) to establish a network of sites to study early-onset Alzheimer’s disease.
A researcher at the University of Kentucky is exploring whether low doses of Rapamycin, a drug commonly used as an immunosuppressant for organ transplant recipients, can restore brain function before the disease changes in the brain affect a person's memory.
Gulf War veterans with low-level exposure to chemical weapons show lasting adverse effects on brain structure and memory function, reports a study in the October Journal of Occupational and Environmental Medicine.
Women who develop high blood pressure in their 40s may be more likely to develop dementia years later, according to a study published in the October 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
While the social and economic cost of Alzheimer’s is well documented, a new study shows that frontotemporal degeneration (FTD)—the most common dementia for people under age 60—inflicts a significantly higher economic burden on both patients and their caregivers. It found that the average annual costs associated with FTD to total $119,654, nearly two times the reported annual cost of Alzheimer’s.
According to a new study, frontotemporal degeneration (FTD), the most common dementia for people under age 60, inflicts a much more severe economic burden on patients and their caregivers than Alzheimer’s disease, as well as other forms of dementia that typically show their first symptoms later in life.
Cross-Sector Collaboration Aimed at Speeding the Development of Potential Therapies That May Protect Brain Cells
A long-term study of nearly 3,000 older adults found that those who could not identify at least 4 out of 5 common odors were more than twice as likely as those with a normal sense of smell to develop dementia within five years. About 14% could name just 3, 5% percent could identify only 2, and 2% could name just 1. One percent of the study subjects were not able to identify a single scent.
A new zinc sensor has been developed by researchers, which will allow for a deeper understanding of the dynamic roles that metal ions play in regulating health and disease in the living body.
Many people with schizophrenia have trouble with learning and memory. A new study has found intriguing links between sleep, cognition and a compound called kynurenine. These links could illuminate the mechanism that causes cognitive problems among those with the disease, and could point the way to new treatments to reduce some of the disease’s symptoms.
Contrary to previous research, caffeine may not relieve movement symptoms for people with Parkinson’s disease, according to a study published in the September 27, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
National Institutes of Health supports education in Alzheimer’s disease at Rensselaer Polytechnic Institute
Leading Parkinson’s experts and advocates from around the world will gather at Van Andel Research Institute in Grand Rapids, Michigan, this month for Grand Challenges in Parkinson’s Disease, a scientific event highlighting the latest breakthroughs in Parkinson’s research and treatment. The 6th annual symposium will include talks from 19 scientific speakers, a poster session and extensive networking opportunities.
A study to be published in the September 29 issue of the Journal of Biological Chemistry reports the use of an emerging method to identify proteins that allows two organelles, the mitochondria and the endoplasmic reticulum, to attach to each other.
With disease-modifying treatment trials for Alzheimer’s disease (AD) currently unsuccessful and only medications to treat symptoms available, what now? A leading neuroscientist has developed the “Dementia Prevention Initiative,” which abandons generalized ways to research and treat AD. His secret weapon: a novel “N-of-1 design” that tailors medicine down to a single patient. Instead of conducting a conventional trial of 100 people all getting the same treatment, he has switched it around and is conducting 100 single personalized trials.
There’s no right age to switch to a geriatric specialist, but there are guidelines that can help determine whether a geriatrician – a physician who specializes in the healthcare needs of people who are aging – is the right choice for you or your loved one.
Findings of a new and comprehensive study from FSU College of Medicine Associate Professor Antonio Terracciano and colleagues, published today in the journal JAMA Psychiatry, has found no evidence to support the idea that personality changes begin before the clinical onset of mild cognitive impairment (MCI) or dementia.
A new role has been identified for the major Alzheimer’s risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers at Washington University School of Medicine in St. Louis show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer’s-associated protein: tau. In the absence of ApoE, tau tangles did very little harm to brain cells.
Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.
On Friday, Sept. 22, UCI MIND and Alzheimer’s Orange County will co-host the 28th Annual Southern California Alzheimer’s Disease Research Conference, themed “The Elephant in the Room: Sensitive Subjects in Dementia Care.” It will highlight “taboo” topics that impact the daily lives of Alzheimer’s patients and their relatives, including elder abuse, end-of-life issues, sex and intimacy, and driving risks.
Dr. Brinton Has Pioneered a Promising Neurogenesis Therapy for Alzheimer's
The Keck School of Medicine of USC launches a new study investigating a vaccine and oral medication to stop Alzheimer’s years before it begins
/PRNewswire-USNewswire/ -- Nearly 200 academic and industry researchers came together to share updates on preclinical and clinical-stage Alzheimer's disease research at the 18th Annual Conference on Alzheimer's Drug Discovery. The two-day conference, organized by the Alzheimer's Drug Discovery Foundation (ADDF), is the first and only to focus solely on non-amyloid drug programs in development.
Dementia can potentially be prevented by targeting specific risk factors like education in early life, hearing in midlife, and smoking later in life, according to newly published research by the Lancet Commission on Dementia Prevention, Intervention, and Care. The commission, of which Johns Hopkins School of Nursing(JHSON) faculty member Laura N. Gitlin, PhD, was a member, compiled current research and emerging knowledge about dementia to develop an analysis and plan for moving forward in care.
The simple new technique could offer vastly superior predictions of disease severity in a huge range of conditions with a genetic component, including Alzheimer’s, autism, cancer, cardiovascular disease, diabetes, obesity, schizophrenia and depression.
Frontotemporal degeneration (FTD) is a progressive neurodegenerative condition that is present in tens of thousands of Americans, but is often difficult to diagnose accurately. Now in a study published this week online ahead of print in Neurology, researchers from the Perelman School of Medicine at the University of Pennsylvania have found evidence that a simple eye exam and retinal imaging test may help improve that accuracy.
In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state. The technique makes it possible to study motor neurons of the human central nervous system in the lab. Unlike commonly studied mouse motor neurons, human motor neurons growing in the lab would be a new tool since researchers can’t take samples of these neurons from living people but can easily take skin samples.
A simple scratch-and-sniff test may one day be able to help identify some people at greater risk of developing Parkinson’s disease up to 10 years before the disease could be diagnosed, according to a new study published in the September 6, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Scientists have known that abnormal protein deposits and swarms of activated immune cells accumulate in brains of people with Alzheimer’s. Now researchers have untangled how these proteins and inflammation interact in lab experiments to reveal how therapies might reverse the disease process.
Tools to diagnose Alzheimer’s disease and latent tuberculosis are among the winning projects in the Design by Biomedical Undergraduate Teams (DEBUT) challenge, a biomedical engineering design prize competition for teams of undergraduate students. The teams developed prototypes of devices that advance technology and improve human health.
A study led by Johns Hopkins Bloomberg School of Public Health researchers that tracked activity levels of 646 adults over 30 years found that, contrary to previous research, exercise in mid-life was not linked to cognitive fitness in later years.
Researchers have discovered a clue to the mechanism for neuronal degeneration and possible target for a therapeutic approach to these disorders.
People who get less rapid eye movement (REM) sleep may have a greater risk of developing dementia, according to a new study published in the August 23, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. REM sleep is the sleep stage when dreaming occurs.
A study led by researchers at Cedars-Sinai and NeuroVision Imaging LLC provides the scientific basis for using noninvasive eye imaging to detect the pathological hallmarks of Alzheimer’s. The experimental technology, developed by Cedars-Sinai and NeuroVision, scans the retina using techniques that can identify beta-amyloid protein deposits that mirror those in the brain.
Cedars-Sinai neuroscience investigators have found that Alzheimer’s disease affects the retina – the back of the eye – similarly to the way it affects the brain. The study also revealed that an investigational, noninvasive eye scan could detect the key signs of Alzheimer’s disease years before patients experience symptoms.
A team led by scientists at St. Jude Children’s Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig’s disease. The researchers were led by J. Paul Taylor, M.D., Ph.D., chair of the St. Jude Cell and Molecular Biology Department and a Howard Hughes Medical Institute investigator; and Rosa Rademakers, Ph.D., of the Mayo Clinic in Jacksonville, Florida. The findings appear today in the journal Neuron.
Rutgers and Duke University professors explore how to improve care and reduce the use of antipsychotic medications in nursing homes
In a study looking at brain scans of people with mild loss of thought and memory ability, Johns Hopkins researchers report evidence of lower levels of the serotonin transporter — a natural brain chemical that regulates mood, sleep and appetite.
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