Novel gene editing technique reveals cancer weakness in the immune system and opens possibilities to identify disease-causing genes and new drug targets
new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors.
Recurrent lupus nephritis, a severe complication for patients with systemic lupus erythematosus (SLE) with end-stage renal disease who undergo kidney transplant, is happening less often now compared to the past. This positive trend is likely due to improvements in the immunosuppression regimen these patients now receive, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
The 2018 American College of Rheumatology/American Rheumatology Health Professionals Annual Meeting.
Progression free survival in triple-negative breast cancer increased when immunotherapy-chemotherapy treatment combination is used as the first treatment option.
The Cancer Research Institute has updated its analysis of the global immuno-oncology landscape, published today in Nature Reviews Drug Discovery.
Researchers from Australia and Japan have discovered a new human immunodeficiency syndrome in two patients on separate continents. The study, which will be published October 18 in the Journal of Experimental Medicine, reveals that a mutation in a gene called IKBKB disrupts the immune system, leading to excessive inflammation and the loss of both T and B white blood cells.
UT Southwestern biochemist Dr. Zhijian “James” Chen today was named winner of the prestigious 2019 Breakthrough Prize in Life Sciences for his discovery of the cGAS enzyme that launches the body’s immune defense against infections and cancers. That enzyme patrols the cell’s interior and triggers the immune system in response to DNA.
Robust environmental monitoring should be used as the world approaches global eradication of polio, say University of Michigan researchers who recently studied the epidemiology of the 2013 silent polio outbreak in Rahat, Israel.
The American Association of Pharmaceutical Scientists (AAPS) is pleased to announce the elevation of six recipients to AAPS Fellow (FAAPS), one of the highest honors given to members of the association. Each year
Wistar researchers have characterized the function of neutrophils, a type of white blood cells, during early stages of tumor progression, showing that they migrate from the bone marrow to distant sites and facilitate tumor cell seeding and establishment of metastasis.
The steps cells take in response to challenges are more complex than previously thought, finds new research. The study investigates a system relevant to cancer, viral infection, and diabetes.
Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Researchers are investigating whether infants born into poverty have stronger inflammatory responses, predisposing them to chronic disease during their lives.
In a UCI-led study, researchers found evidence that mast cells, an important group of immune cells typically associated with allergies, actually enable the body to survive fasting or intense exercise. The study was published today in Cell Metabolism.
A new Lassa fever and rabies vaccine shows lasting immunity and suggests a new way to test for protection.
An emerging treatment known as adoptive T-cell therapy has proven effective in a Phase II clinical trial for treating progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection sometimes observed in patients with cancer and other diseases in which the immune system is compromised. The study, led by Katy Rezvani, M.D., Ph.D., professor, Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center, showed marked improvement in three PML patients infused with donor T cells targeting the BK virus. Findings were published in the Oct. 11 online issue of the New England Journal of Medicine.
Experts say it's always better to get the flu vaccine than not.
Description: Papers on carcinogenesis; organophosphate flame retardants and zebrafish behavior; AHR gene targeting and hepatotoxicity; nontoxic substructures; and genistein and type 1 diabetes featured in latest issue of Toxicological Sciences.
For decades, scientists have been trying to develop a vaccine that prevents mosquitoes from spreading malaria among humans. This unique approach — in which immunized humans transfer anti-malarial proteins to mosquitoes when bitten — is called a transmission-blocking vaccine (TBV). A new biotech advancement moves us closer to this goal. If successful, it could help reduce the spread of the disease, which kills more than 400,000 people annually.
A Rutgers University–New Brunswick-led team of researchers is calling for the creation of a global microbiota vault to protect the long-term health of humanity. Such a Noah’s Ark of beneficial germs would be gathered from human populations whose microbiomes are uncompromised by antibiotics, processed diets and other ill effects of modern society, which have contributed to a massive loss of microbial diversity and an accompanying rise in health problems. The human microbiome includes the trillions of microscopic organisms that live in and on our bodies, contributing to our health in a myriad of ways.
Scientists at Scripps Research have discovered the role of an immune system double agent. This molecule, called USP18, can help curtail immune responses, but it can also open the door to bacterial infections, such as harmful listeria and staph infections.
Havran, a professor at Scripps Research and associate dean of the Skaggs Graduate School of Chemical and Biological Sciences, was recently named the 2018 Outstanding Mentor by the Society of Fellows, a postdoctoral organization at Scripps Research.
Wistar scientists and collaborators demonstrate for the first time that through engineering constructs, they can express DNA-encoded monoclonal antibodies (DMAbs) targeting CTLA-4, an important cancer checkpoint molecule that blocks anti-cancer immunity.
Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation).
In a new study, researchers have found that the gut microbiome appears to play a key role in how well the body accepts a transplanted heart. The scientists found a causal relationship between the presence of certain microbes and transplant outcome.
For teens with allergies and asthma, a few extra Halloween precautions need to be put in place to keep them safe from triggers that can send them down a path of sneezing, wheezing or coughing.
Atlantic Health System, an integrated health care delivery system, today announced a partnership with the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and Origin Commercial Ventures to create a new platform to deliver economically viable immunotherapies and other breakthrough cancer treatments to the region through expedited access and novel payment options.
T cell discoveries led to game-changing treatment revolutionizing cancer care
Splitting up and getting back together is always hard to do, but for proteins, it's almost impossible. However, a computer-guided algorithm may help scientists find just the right spot to split a protein and then reassemble it to functionality.
Clinical trial to test potential for blood-based biopsies to identify cancer patients more likely to response to treatment with immunotherapy
Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. They caution in the journal Pediatric Blood & Cancer that expediting HLH treatment may miss underlying malignancies that could end up being fatal to the patient.
In a new study published in the Journal of Biological Chemistry, researchers at Imperial College London and the Francis Crick Institute report some of the details of how Salmonella shuts down an immune pathway after infection.
Wistar scientists have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.
Houston Methodist Cancer Center has expanded its basic cancer research program, cancer prevention and control efforts, and surgical oncology services with the addition of two national recruits.
UCI School of Medicine researchers have been awarded a $3.4 million grant by the National Cancer Institute (NCI) as part of the Beau Biden Cancer Moonshot initiative. The funding will support efforts to provide proof of principal data for an entirely new class of cancer killing immunotherapeutics with the potential to treat highly diverse types of cancer, from leukemia to breast cancer.
Scientists have known that bacteria produce small spherical versions of themselves. Lacking basic materials to function like normal cells, the role of minicells has remained a mystery. Now, researchers at UC San Diego have demonstrated for the first time that minicells play a key function in the survival of bacteria.
Diabetes makes it harder for the immune system to fight off some infections, leaving people with the condition at a higher risk for serious complications from vaccine-preventable diseases, like the flu, pneumonia, hepatitis B, tetanus and shingles.
Governor Andrew M. Cuomo today announced Buffalo-based Roswell Park Comprehensive Cancer Center has formed the Innovative Immunotherapy Alliance S.A., the first-ever biotech venture between the U.S. and Cuba.
Scientists in the UK have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to the study “Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment,” by Wong et al., published today in the Journal of Experimental Medicine.
CU Boulder researchers have identified a family of small molecules that turn off defense mechanisms inside bacteria that enable them to resist antibiotics. The compounds could ultimately be given alongside existing medications to rejuvenate them.
Researchers at the Case Western Reserve University School of Dental Medicine found that smoking also weakens the ability for pulp in teeth to fight illness and disease.
Restricting protein from a cancer patient’s diet may enhance the response to immunotherapy, according to an Indiana University cancer physician researcher.
Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers say their studies demonstrate that use of an experimental drug called CASIN in laboratory mice results in higher efficiency when harvesting blood stem cells from donors and less toxicity in transplant recipients.
Researchers at Mount Sinai have discovered that an antimicrobial protein found in the gut can stave off a common and highly lethal side effect of bone marrow transplants, according to a study published in the Journal of Clinical Investigation in September.
Harnessing the immune system to treat cancer shows great promise in some patients, but for many, the response does not last long-term. In an effort to find out why, Fred Hutchinson Cancer Research Center scientists are using a new technology to look at how cancer cells change under the pressure of immunotherapy treatments.
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