Feature Channels: Diabetes

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Ten years after undergoing bariatric surgery as teens, over half of study participants demonstrated not only sustained weight loss, but also resolution of obesity-related conditions, such as type 2 diabetes, high blood pressure and high cholesterol, according to the report published in the New England Journal of Medicine.

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Most patients should continue taking their glucagon-like peptide-1 (GLP-1) receptor agonists before elective surgery, suggests new clinical guidance released by the American Society of Anesthesiologists (ASA), American Gastroenterological Association, American Society for Metabolic and Bariatric Surgery, International Society of Perioperative Care of Patients with Obesity, and the Society of American Gastrointestinal and Endoscopic Surgeons. Patients at the highest risk for significant gastrointestinal (GI) side effects should follow a liquid diet for 24 hours before the procedure or other measures, depending on the specific circumstances.

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Adults aged 35 to 60 are drinking at unprecedented rates, with those who binge drank in high school reporting more past 30-day high-risk drinking in midlife. And this link may be especially strong for women, according to a study just published in Alcohol: Clinical and Experimental Research Health. These trends are particularly concerning as health conditions, and biological processes common with aging put adults in midlife at greater health risk from alcohol use.

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Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA–associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA–associated AKI among patients on anti-cancer drugs is unclear. Surprisingly, new research suggests that taking GLP-1RA is not associated with an increased risk of AKI in patients receiving anti-cancer therapies. The findings will be presented at ASN Kidney Week 2024 October 23– 27.

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Prior efforts to identify novel kidney biomarkers as risk factors for chronic kidney disease (CKD) progression have typically evaluated proteins individually, which limits their prognostic power. The National Institute of Diabetes and Digestive and Kidney Diseases’ (NIDDK’s) CKD Biomarkers Consortium of investigators recently developed and tested novel dimensions of kidney health by combining a set of 17 urine and plasma biomarkers that had been individually associated with CKD progression. The research will be presented at ASN Kidney Week 2024 October 23– 27.

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Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients’ age. A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings will be presented at ASN Kidney Week 2024 October 23 – 27.

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The results of numerous high-impact phase 3 clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2024 October 23–27.

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A new research study co-led by Jennifer Raymond, MD, MCR, Chief of the Center for Endocrinology, Diabetes and Metabolism at CHLA, is launching at 12 U.S. sites to explore how Type 1 diabetes affects the development of children’s brains during key growth periods. The five-year study is funded by a $2.7 million National Institutes of Health (NIH) grant.

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Physician scientists at the UNC School of Medicine played a pivotal role in getting this therapy to the bedside, from assisting with clinical trials to the infusion of the first pediatric patient in North Carolina at UNC Children’s.

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Researchers at UT Southwestern Medical Center have developed a machine learning model that can identify patients with diabetic cardiomyopathy, a heart condition characterized by abnormal changes in the heart’s structure and function that predisposes them to increased risk of heart failure. The findings, published in the European Journal of Heart Failure, offer a data-driven method to detect a high-risk diabetic cardiomyopathy phenotype, enabling early interventions that could help prevent heart failure in this vulnerable population.

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Adults with type 2 diabetes on a low-carbohydrate diet may see benefits to their beta-cell function allowing them to better manage their disease and possibly discontinue medication, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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New research from the University of Washington investigated responses to sweetened beverage taxes using the purchasing behavior of approximately 400 households in Seattle, San Francisco, Oakland and Philadelphia.

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Carlos L. Arteaga, M.D., Director of the Harold C. Simmons Comprehensive Cancer Center and Associate Dean of Oncology Programs at UT Southwestern Medical Center, and David Mangelsdorf, Ph.D., Chair and Professor of Pharmacology and Professor of Biochemistry, have been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine.

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The Endocrine Society, a global organization that promotes endocrinology research and clinical practice, and Keystone Symposia, a nonprofit host of conferences and symposia on a range of life science and biomedical topics, will jointly host a series of three conferences to advance endocrine research.

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A recent study highlights the increased risks faced by elderly patients with type 2 diabetes mellitus (T2DM) who also suffer from sarcopenia, a condition of age-related muscle loss. The findings indicate that these patients are significantly more likely to experience severe disability, rehospitalization, and even death compared to those without sarcopenia. This research underscores the importance of early detection and intervention in managing sarcopenia, aiming to improve health outcomes and quality of life for elderly diabetics. It provides crucial insights into the growing challenge of sarcopenia within this population.

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New research by Stony Brook Medicine nephrology specialists that centers on targeting key cellular signaling between two types of kidney cells, and inducing a certain gene within those processes, may help prevent or reduce the progression of diabetic kidney disease (DKD), the leading cause of chronic kidney disease worldwide.

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What do online grocery shopping, venomous snails, and foot biomechanics have in common? All three were research subjects under investigation at the 2024 DMRC retreat, the largest in the history of the event.

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Nationwide Children’s Hospital has been named to U.S. News & World Report’s Best Children’s Hospitals Honor Roll for the 11th consecutive year. The Honor Roll is a top distinction awarded to only 10 children’s hospitals nationwide. Nationwide Children’s also is ranked in the top 10 in seven of the 10 specialties.