Researchers at Johns Hopkins have added to evidence that rising and chronic inflammation as measured by a biomarker in the blood in middle and late age are linked to visible structural changes in the brains of people with poor cognition and dementia.
Deep brain stimulation (DBS) may slow the progression of tremor for early-stage Parkinson’s disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology®, the medical journal of the American Academy of Neurology.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer’s disease. In addition, researchers discovered that certain areas of the brain respond differently to risk factors associated with Alzheimer’s. The study is published in Physiological Reports.
Researchers at Indiana University have found early evidence that tiny snippets of genetic material called microRNA may help with early of conditions such as Alzheimer's disease.
Researchers from Queen’s University Belfast have shown that the eye could be a surrogate for brain degeneration like Alzheimer’s disease (AD).
Two strains of human herpesvirus—human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) —are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those without Alzheimer’s, researchers from the Icahn School of Medicine at Mount Sinai report.
Alzheimer’s disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition, by an international research collaboration including the University of Warwick.Dr Joanna Collingwood, from Warwick’s School of Engineering, was part of a research team which characterised iron species associated with the formation of amyloid protein plaques in the human brain – abnormal clusters of proteins in the brain.
An age group analysis of data from the ADvance trial has shown that participants over the age of 65 continue to derive the most benefit from Deep Brain Stimulation of the fornix (DBS-f), as observed in the data from the phase 2 findings (12 – 24 months) of the Phase II trial.
When seniors experience memory problems, they may start worrying that they have Alzheimer’s disease. Indeed, Alzheimer’s is the most common cause of memory loss in the elderly – but sometimes an entirely different diagnosis is to blame.
A research team at Wayne State University hopes to give clinicians tools for identifying the early signs of impending disease by measuring subtle deviations in the way the brain modulates its chemistry during the formation of new memories. Their research project, “Task-related modulation of hippocampal glutamate, subfield volumes and associative memory in younger and older adults: a longitudinal ¹H FMRS study,” was recently awarded a two-year, $423,500 grant from the National Institute on Aging of the National Institutes of Health.
The Alzheimer’s Foundation of America (AFA) is awarding $206,184 over the next three years to Stony Brook Medicine to support an innovative Positron Emission Tomography (PET) imaging research project that will compare neurons from healthy controls and those with Alzheimer’s disease in an effort to improve drug development.
Copper exposure’s link Alzheimer’s disease, the effects of consumer microbials on the colon, a potential prostate-based activation of a carcinogen in cooked meat, and the impact of hydraulic fracturing mixtures on the immune system featured in latest issue of Toxicological Sciences.
Research from the University of Illinois at Chicago has found that some of the genes affected by alcohol and inflammation are also implicated in processes that clear amyloid beta — the protein that forms globs of plaques in the brain and which contributes to neuronal damage and the cognitive impairment associated with Alzheimer’s disease.
Approximately 47 million people worldwide are living with Alzheimer’s disease (AD) and other dementias. One of the most prominent neuroscientists in the country has developed eight myths and truths about AD to shed light on this form of dementia that causes problems with memory, thinking and behavior.
The latest research and features in cell biology in the Cell Biology News Source
The UCLA Alzheimer’s and Dementia Care Program has been producing a series of online videos aimed at helping caregivers understand how to care for persons with dementia. They utilize actors who portray both dementia patients and their caregivers and cover a wide range of issues facing caregivers.
Recently published research from Iowa State University plant scientists maps the stress response detected by the endoplasmic reticulum, an organelle in cells of corn seedlings. The study shows how cells transition from adaptation to death when faced with persistent stress and could help plant breeders develop stress-resistant crop varieties.
In a paper to be published in the June 1 issue of the Journal of Biological Chemistry, researchers at Washington University in St. Louis provide the first report of an enzyme that breaks down plasmalogens, a breakthrough in understanding the molecular processes that occur during Alzheimer’s and other diseases.
Researchers look at the promising role played by the BMI1 gene, which could someday help mitigate or even reverse the disease.
In the ongoing quest for a successful treatment for Alzheimer’s disease, a team of scientists from several leading research institutions have created a map of the molecular network in the aging brain.
New research from The Ohio State University has found that young people with subtle hearing loss – the kind they aren’t even aware of – are putting demands on their brains that typically wouldn’t be seen until later in life.
UCLA researchers lay out the probabilities that a person will develop Alzheimer’s disease dementia based on age, gender and the results of biomarker tests, which can detect the presence of certain protein fragments in brain and spinal fluid or for brain cell changes linked with the disease.
Wichita State graduate Abdul-Mannaan Giles was selected out of 400 national entries to present his research to members of Congress on Capitol Hill.
Scientists have identified a gene that helps prevent the harmful buildup of proteins that can lead to neurological disorders such as Alzheimer’s and Parkinson’s disease. As published in Nature, the researchers found that the “Ankrd16” gene acts like a failsafe in proofreading and correcting errors to avoid the abnormal production of improper proteins.
People who eat a diet rich in vegetables, fruit, nuts and fish may have bigger brains, according to a study published in the May 16, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The UCLA Division of Geriatrics has received a five-year, $13.6 million award from the Patient-Centered Outcomes Research Institute (PCORI) to compare Alzheimer’s disease care delivered through a health system with care that occurs in a community-based setting.
Atrial fibrillation patients who are diagnosed with carotid artery disease face higher risks for developing dementia, according to new research from the Intermountain Medical Center Heart Institute in Salt Lake City.
Are abnormal intestinal microorganisms a risk factor for developing cognitive impairment? Researchers at Rush University Medical Center are trying to answer that question with a new study that will explore how the intestinal microbiota – the bacteria in the intestine –influence the progression of cognitive decline and the development of Alzheimer’s disease.
Researchers describe changes in hippocampal neurons early after pathogenic alpha-synuclein aggregates begin to appear. This understanding could point to novel therapeutic treatments to prevent or reverse neuronal defects and halt development of dementia.
Structural model of physiological tau-microtubule interactions sheds light on neurological diseases that correlate with their disruption
The ability to test human types of memory in animals will strengthen the search for drugs to treat Alzheimer's disease.
Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections, like what is seen in people with macular degeneration or who’ve had too much exposure to the glare of electronic screens.
The new research opens the door to studying common brain conditions such as autism, schizophrenia, addiction and Alzheimer’s disease under reproducible conditions in a dish.
An international research team has come up with a new method with potential for revealing the structure of individual amyloid fibrils with powerful beams of X-ray laser light.
The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, may play a more prominent role in disease development among women than men, according to new research from the Vanderbilt Memory and Alzheimer’s Center.
The new 122,000-square-foot, three-story Neurosciences Center provides a highly collaborative environment for clinical care, research and academic services related to neurological disorders and diseases.
Researchers at the UCLA School of Nursing and the department of neurology at the David Geffen School of Medicine at UCLA have reported a promising drug strategy that blocks tau transmission. The study was published online in the journal Biochemical and Biophysical Research Communications.
NeuroVision Imaging Inc. has announced a Series C financing round of $15 million with an initial close of $11.2 million. The round is led by Wildcat Capital Management with funding from several new investment groups. The financing provides support for NeuroVision as it seeks validation and regulatory approval for its breakthrough, low-cost, noninvasive, eye imaging system for measuring retinal autofluorescence that can detect amyloid beta (Aβ) plaque in the eye.
A new research study by scientists in Australia and the US provides an explanation for why clinical trials of drugs reducing proteins in the brain that were thought to cause dementia and Alzheimer’s have failed. The study has opened the way for potential new treatments with existing drugs.
A new study published in JMIR Medical Informatics describes how a “smart home” prototype may help people with dementia dress themselves through automated assistance, enabling them to maintain independence and dignity and providing their caregivers with a much-needed respite.
Researchers at the University of Utah Health are looking to the salience network of the brain to develop music-based treatments to help alleviate anxiety in patients with dementia. Their research will appear in the April online issue of The Journal of Prevention of Alzheimer's Disease.
People with restless legs syndrome may have changes in a portion of the brain that processes sensory information, according to a study published in the April 25, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
For most people, it’s better to start taking drugs for multiple sclerosis (MS) early on rather than letting the disease run its course, according to a new guideline for treating MS from the American Academy of Neurology. The guideline is published in the April 23, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology, and presented at the 70th AAN Annual Meeting in Los Angeles, April 21 to April 27, 2018. The guideline is endorsed by the Multiple Sclerosis Association of America and the National Multiple Sclerosis Society.
A coalition of brain scientists and civic leaders, including Mayor Kevin Faulconer and county Supervisors Dianne Jacob and Kristin Gaspar, announced that the federal government has awarded a $1.3 million grant to Sanford Burnham Prebys Medical Discovery Institute to advance the local search for a cure for Alzheimer's.
People with tremors in their hands from a condition called essential tremor may find some relief from a new, non-invasive type of nerve stimulation, according to a preliminary scientific abstract released today that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.
A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.
People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
People who have tried unsuccessfully to prevent migraine with other treatments may find relief with a drug called erenumab, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.
Researchers announce new definition of Alzheimer’s disease.
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