To understand why some patients with appendix cancer respond to standard treatment while others do not, University of California San Diego School of Medicine and Moores Cancer Center researchers, in collaboration with Foundation Medicine, performed genetic profiling on 703 appendiceal tumors — the largest such study of this disease to date — to compare mutations present in both cancer types.
A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.
The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $4.7 million grant to Cleveland Clinic to study the prevention of life-threatening, cancer-associated blood clots. The new funding will support a Cleveland Clinic-led research consortium, which will focus on developing strategies to prevent cancer-associated thrombosis (blood clot formation), a potential side effect of cancer treatment.
Stony Brook University, iCell Gene Therapeutics and University of Louisville collaborate to offer a new CAR T immunotherapy to treat patients.
Seattle Children’s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.
The University of Texas MD Anderson Cancer Center and Jazz Pharmaceuticals plc today announced a five-year collaboration agreement with a goal of evaluating therapies for multiple hematologic malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes.
Rutgers University–New Brunswick engineers have created a smart wristband with a wireless connection to smartphones that will enable a new wave of personal health and environmental monitoring devices. Their technology, which could be added to watches and other wearable devices that monitor heart rates and physical activity, is detailed in a study published online in Microsystems & Nanoengineering.
A one-year, $100,000 grant awarded to a Rutgers Cancer Institute of New Jersey researcher from the Leukemia Research Foundation will support exploration into an aggressive blood cancer that impacts both children and adults – T-cell acute lymphoblastic leukemia (T-ALL).
A new study finds that long-term heat therapy may increase mitochondrial function in the muscles. The discovery could lead to new treatments for people with chronic illness or disease. The study—the first of its kind in humans—is published ahead of print in the Journal of Applied Physiology.
Responding to customer requirements to handle increased volumes in decentralized clinical testing, MedTest Dx today announced the introduction of its BA-800M Clinical Analyzer for general chemistry with a full line of reagents and the launch of its BC-5390 5-Part Differential Hematology Analyzer at the 2018 American Association for Clinical Chemistry (AACC) Annual Scientific Meeting.
Clinical trials at CU Cancer Center and elsewhere result in FDA approval of the drug ivosidenib for the treatment of adult patients with IDH1+ AML.
While blood and marrow transplants can save the life of a pediatric cancer patient, research out of the University of Alabama at Birmingham found that those patients may be at an increased risk of premature death even years or decades after the procedure as compared with the general population.
UCSF Benioff Children’s Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease (SCD). The results of the 48-week, phase 3 clinical trial are published in the July 19, 2018, issue of New England Journal of Medicine (NEJM).
This is an announcement about Dr. Linda Brady winning the 2018 V-RED Award from the Vasculitis Foundation. She was nominated by her patient for making a critical, early diagnosis of autoimmune vasculitis.
More than one in 10 children hospitalized with sepsis die, but when a series of clinical treatments and tests is completed within an hour of its detection, the chances of survival increase considerably.
A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.
Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease. Tests in human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name.
Drinking artificially-sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and cancer death, a team of investigators led by a Yale Cancer Center scientist has found. The study was published today in the journal The Public Library of Science One.
Shape Memory Medical recently announced FDA clearance for U.S. marketing of their IMPEDE Embolization Plug, a technology funded by NIBIB and created to block irregular blood vessels.
A research team led by Duke Cancer Institute scientists has found that this blood cancer infiltrates the central nervous system not by breaching the blood-brain barrier, but by evading the barrier altogether.
By some estimates, 18 million people die each year from sepsis triggered by endotoxins – fragments of the outer membranes of bacteria. A biochemical engineer at Missouri University of Science and Technology has patented a method of removing these harmful elements from water and also from pharmaceutical formulations.Her goal: improve drug safety and increase access to clean drinking water in the developing world.
EKF Diagnostics, the global in vitro diagnostics company, announces U.S. Food and Drug Administration 510(k) clearance and CLIA waiver for the Company’s hand-held, reagent-free hemoglobin analyzer, the DiaSpect Tm. The device is cleared for use in point of care (POC) and Certificate of Waiver settings, such as physicians’ offices, clinics and other non-traditional laboratory locations.
Bloodstream infections can be life-threatening to individuals undergoing kidney dialysis. Following infection control procedures is critical, yet best practices may not always occur at busy dialysis facilities.
If a hepatitis C vaccine were successfully developed, it would dramatically reduce transmission of hepatitis C among drug users. even if the vaccine did not provide complete immunity, according to a study published in Science Translational Medicine.
Researchers discover new clues about a recently identified blood cell condition known as clonal hematopoiesis, implicated in hematologic cancers, cardiovascular illness Surprisingly, the study reveals that inherited genetic variants can drive the condition by fueling additional mutations later in life The findings can help inform ways to gauge disease risk based on specific mutations, develop strategies to avert disease Clonal hematopoiesis is estimated to affect more than 1 in 10 people older than 65
XaTek Inc., a Cleveland-based company developing a portable sensing system that can quickly assess the clotting ability of a person’s blood, recently raised $9.1 million in Series A capital to further advance and test the device, called ClotChip.
Two years after inventing a microfluidic chip believed to help detect a life-threatening blood infection, researchers in the Texas Tech University Department of Chemistry & Biochemistry and the Texas Tech University Health Sciences Center are finally seeing their product work successfully for human patients.
Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. This finding could lead to a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors—drugs that are commonly used to combat high cholesterol.
An international team of leukemia scientists has discovered how to predict healthy individuals at risk of developing acute myeloid leukemia (AML), an aggressive and often deadly blood cancer.
Research led by Washington University School of Medicine in St. Louis has shown, in mice, that genetic material can be delivered to damaged cells in the kidneys, a key step toward developing gene therapy to treat chronic kidney disease. The potentially fatal condition affects 30 million Americans, most of whom don’t realize they have chronic kidney disease.
Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have found that the cost for the 10 “highest spend” medications in Medicare Part D — the U.S. federal government’s primary prescription drug benefit for older citizens — rose almost one-third between 2011 and 2015, even as the number of persons using these drugs dropped by the same amount.
A study in the American Journal of Critical Care finds that a scoring system based on the PIRO concept was useful in predicting mortality in surgical intensive care patients with severe sepsis or septic shock due to an intra-abdominal source.
Researchers develop a simple and efficient method to induce human pluripotent stem cells to become blood, which could be key in future treatments for blood disorders, immune deficiencies and cancer
Infection with the hepatitis C virus (HCV) is a contagious liver disease with symptoms that range from mild illness for a few weeks to serious, lifelong liver problems. Veterans with HCV infection are almost three times as likely to have an alcohol use disorder (AUD) than veterans without HCV. It is not well understood how the dual occurrence of HCV infection and an AUD impacts a person’s immune system, mood, and brain function. This study investigated how a co-existing AUD contributes to inflammation and psychiatric problems in adults with HCV.
Loyola Medicine neurologist José Biller, MD, is co-editor of an authoritative new textbook on uncommon causes of stroke. "Uncommon Causes of Stroke" is a comprehensive guide for healthcare professionals diagnosing, treating and assessing complex causes of strokes and other cerebrovascular disorders.
For women, even mild sleep problems can raise blood pressure, finds study.
Actinium-225 is a promising isotope for cancer treatment. Only a few places in the world can produce an extremely limited supply of it. Recently, researchers at the Department of Energy’s national laboratories have collaborated to use particle accelerators to expand this isotope’s availability.
National Comprehensive Cancer Network releases new patient guidelines for liver, gallbladder, and bile duct (hepatobiliary) cancers, sponsored by the Global Liver Institute.
BIDMC researchers led a retrospective analysis of four randomized clinical trials focused on the effects of DAA therapies in patients with HCV-associated liver failure and developed a new means of predicting improvement in liver function in response to DAA treatment.
A study led by The University of Texas MD Anderson Cancer Center revealed that the investigational drug quizartinib prolonged overall survival for patients with a deadly form of acute myeloid leukemia (AML) linked to a genetic mutation called FMS-like internal tandem duplications (FLT3-ITD).
Scientists have developed an algorithm that predicts potentially dangerous low blood pressure, or hypotension, that can occur during surgery. The algorithm identifies hypotension 15 minutes before it occurs in 84 percent of cases, the researchers report in a new study published in the Online First edition of Anesthesiology.
A drug discovered and advanced by The University of Texas MD Anderson Cancer Center’s Institute for Applied Cancer Science (IACS) and the Center for Co-Clinical Trials (CCCT) inhibits a vital metabolic process required for cancer cells’ growth and survival.
Researchers have demonstrated that a program aimed at helping people modify lifestyle factors such as diet and exercise is as effective as medication at reducing blood pressure.
By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs' effectiveness and convenience
The number of insurance denials for life-saving hepatitis C drugs among patients with both private and public insurers remains high across the United States. Private insurers had the highest denial rates, with 52.4 percent of patients denied coverage, while Medicaid denied 34.5 percent of patients and Medicare denied 14.7 percent.
By screening 250 user reviews and comments for a once popular -- but proven inaccurate -- mobile app claiming to change your iPhone into a blood pressure monitor, Johns Hopkins researchers have added to evidence that a high “star rating” doesn’t necessarily reflect medical accuracy or value.
Embolization -- the use of various techniques to cut off the blood vessels that feed tissue growth -- has gained traction over the past few decades to treat cancerous tumors, and one specific version is gas embolotherapy. During this process, the blood supply is cut off using acoustic droplet vaporization, which uses microscopic gas bubbles induced by exposure to ultrasonic waves. Researchers have discovered that these bubbles could also be used as potential drug delivery systems. The researchers report their findings this week in Applied Physics Letters.
Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
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