Feature Channels: Clinical Trials

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In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding

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UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

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Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types—the most commonly used viral vectors for in vivo gene therapy.

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Both simple and advanced computed tomography (CT) were effective in accurately predicting which stroke patients would benefit from endovascular thrombectomy to remove a large cerebral clot, but together they were even better, reported researchers at UTHealth in Houston.

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A University of Washington-led clinical trial involving more than 600 children in Kenya and Tanzania, in which community members were trained to deliver mental health treatment, showed improvement in participants’ trauma-related symptoms up to a year after receiving therapy.

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The Cutaneous Oncology Program at the GW Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma. The study, sponsored by Regeneron, will examine outcomes for patients treated with Libtayo® (cemiplimab) — an immunotherapy treatment — prior to surgery and radiation therapy.

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Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a new clinical trial.

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Team members from eight Hackensack Meridian Health medical centers raised nearly $330,000 for Giving Heals, Meridian Health Foundation’s comprehensive fundraising campaign, which supports four important initiatives: strengthening oncology services, improving clinical outcomes, enhancing the patient experience and broadening clinical research and academic programs. To date, nearly $110 million has been raised toward a goal of $150 million to support Hackensack Meridian Health medical centers in Monmouth, Ocean and Middlesex counties.

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In diseases like cancer, atherosclerosis, and sickle cell anemia, cathepsins promote their propagation. Drug trials to inhibit these enzymes have failed due to baffling side effects. Now a new study examines cathepsins in systems to remove some of the bafflement.

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A variety of existing drugs for treating conditions such as diabetes, inflammation, alcohol abuse, and arthritis in dogs can also kill cancer cells in the lab, according to a study by scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

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Mice given a new drug targeting a key gene involved in lipid and glucose metabolism could tolerate a high-fat diet regimen (composed of 60% fat from lard) without developing significant liver damage, becoming obese, or disrupting their body’s glucose balance.

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Patient enrollment in clinical trials as the first course of treatment after cancer diagnosis is low, despite the fact that enrollment may increase life expectancy, according to researchers at Penn State.

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Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors’ memory and concentration.

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The Jan. 17 issue of the Journal of the American Medical Association (JAMA) features an important study about sepsis with an accompanying editorial by a University of Nebraska Medical Center expert. The study and editorial sets the record straight on an unproven therapy some physicians use to treat sepsis, a deadly infectious disease. The editorial, written by Andre Kalil, M.D., M.P.H., professor of infectious diseases in the UNMC Department of Internal Medicine, writes in support of the new and rigorous international study based on a randomized clinical trial in Australia, published in the same issue. The editorial appears in the Jan. 17 online issue and also will appear in the Feb. 4 print edition.

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A Mayo Clinic está criando uma biblioteca de dados de sequenciamento genômico de 100.000 participantes consentidos da Mayo Clinic para avançar na pesquisa e no atendimento ao paciente.

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Mayo Clinic正在着手创建一个基因组测序数据库以促进研究和改善患者治疗。该数据库将包含10万名参与者的基因组测序数据，Mayo Clinic已取得上述参与者的知情权。

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Researchers from St. Jude Children’s Research Hospital and the Chinese Children’s Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute lymphoblastic leukemia (ALL) driven by the Philadelphia chromosome. Results showed that the drug dasatinib provides more benefit than the standard of care, which led to changes in the way this leukemia is treated. The findings were reported today in JAMA Oncology.

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A virtual system for in-home physical therapy (PT) provides good outcomes for patients undergoing rehabilitation following total knee arthroplasty (TKA) – with lower costs than traditional in-person PT, reports a study in the January 15, 2020 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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CenExel Clinical Research recently strengthened its psychiatric team with the recruitment of Mark N. Lerman, MD, to serve as a principal investigator for phase I-IV studies at the Atlanta Center for Medical Research (ACMR), a CenExel Center of Excellence.

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Many liver cancer tumors contain a highly diverse set of cells, a phenomenon known as intra-tumor heterogeneity that can significantly affect the rate at which the cancer grows, Mount Sinai researchers report. The immune system’s contribution to this heterogeneity can have major clinical implications.

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The Society has released a statement regarding the controversy over recently published studies on coronary bypass grafting surgery and percutaneous coronary interventions in patients with left main disease.

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Scientists present brain-imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe stroke.

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University of California San Diego School of Medicine researchers report that patients with prostate cancer assigned to eat seven or more servings of vegetables and fruits daily saw no extra protection from the increased consumption of micronutrients, running contrary to current thought.

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Investigators at John Theurer Cancer Center at Hackensack University Medical Center in New Jersey were part of the CANDOR global phase III clinical trial for patients with refractory (persistent) multiple myeloma. The study was selected as the prestigious plenary presentation at the 61st American Society of Hematology (ASH) Annual Meeting, the world's leading conference for hematologic cancers and blood disorders, held in Orlando in December.

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UPMC is the first center in the U.S. to implant a wireless retinal device to treat advanced age-related macular degeneration.

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Personalised cancer treatment is one step closer to becoming a reality for more patients, thanks to a Cancer Council Beat Cancer Project grant awarded to University of South Australia researcher Dr Stephanie Reuter Lange to explore how computer-based modelling can optimise cancer treatment and remove the need for expensive clinical trials.

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Due in part to advanced surgical techniques, more effective medicines, and a multidisciplinary approach to treating the disease, University of Colorado Cancer Center is able to operate on 30+ percent of pancreatic cancer patients, nearly double the national average.

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Cancer patients may one day be able to get their entire course of radiation therapy in less than a second rather than coming in for treatment over the course of several weeks, and researchers in the Abramson Cancer Center of the University of Pennsylvania have taken the first steps toward making it a reality

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Zinc and folic acid, a pair of dietary supplements long touted as an effective treatment for male infertility, failed to improve pregnancy rates, sperm counts, and sperm potency in a new study conducted at University of Utah Health and other medical centers in conjunction with the National Institutes of Health. According to the researchers, the finding presents the most definitive evidence to date that so-called fertility supplements do not live up expectations.

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Dana-Farber Cancer Institute will create the Chen-Huang Center for EGFR (epidermal growth factor receptor) Mutant Lung Cancers to stimulate research, promote clinical trials, and strengthen the Institute’s capabilities for studying and treating lung cancer.

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Physicians and scientists at Rush University Medical Center have found that injecting tumors with influenza vaccines, including some FDA-approved seasonal flu shots, turns cold tumors to hot, a discovery that could lead to an immunotherapy to treat cancer. The study results were published December 30th in the Proceedings of the National Academy of Sciences.

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In response to continued discussion on the validity of the conclusions of the EXCEL trial, The American Association for Thoracic Surgery (AATS) has released a statement calling for the release of all trial data.

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The five-year, $5 million Atlas of Retinal Imaging in Alzheimer’s Study (ARIAS) is sponsored by BayCare Health System’s Morton Plant Hospital and St. Anthony’s Hospital and funded largely by Morton Plant Mease Health Care Foundation and St. Anthony’s Hospital Foundation in Pinellas County, Florida.

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In a special brain health collection, AACC’s The Journal of Applied Laboratory Medicine highlights the innovative clinical tests that laboratory medicine experts are developing to improve care for concussions.

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Children who undergo expansive genetic sequencing may not be getting the thorough DNA analysis their parents were expecting, say experts at UT Southwestern Medical Center.

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Ein Studie von Mayo Clinic an 5540 Patienten mit metastasiertem kolorektalem Karzinom hat ergeben, dass für Patienten, deren Krankheit unter Kontrolle ist, eine Erhaltungs-Chemotherapie nach der Erstbehandlung nützlicher als eine aggressivere Behandlung ist.

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项在5,540名转移性结直肠癌患者中进行的Mayo Clinic研究发现，对于病情得到控制的患者而言，在初始治疗后进行维持化疗比激进治疗更有益。

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Une étude de Mayo Clinic portant sur 5 540 patients atteints d'un cancer colorectal métastatique révèle que la chimiothérapie d’entretien réalisée après le traitement initial est plus bénéfique pour les patients dont la maladie est sous contrôle, par rapport à un traitement plus agressif.

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Um estudo da Mayo Clinic que envolveu 5.540 pacientes com câncer colorretal metastático revelou que a quimioterapia de manutenção após o tratamento inicial é mais benéfica para pacientes cuja doença está sob controle, em contraste com um tratamento mais agressivo.

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Un estudio de Mayo Clinic que abarcó a 5540 pacientes con cáncer colorrectal metastásico descubre que la quimioterapia de mantenimiento después del tratamiento inicial es más beneficiosa para los pacientes cuya enfermedad está bajo control que el tratamiento más agresivo.

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A worldwide research effort is underway for finding a treatment option for hyperphagia, the most common genetic cause of life-threatening childhood obesity.

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Brain imaging of pathological tau-protein "tangles" reliably predicts the location of future brain atrophy in Alzheimer's patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center.

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For sick or prematurely born babies spending their first days of life in a hospital’s neonatal intensive care unit (NICU), the soothing voice and gentle touch of a loving parent can have a tremendous impact toward a positive outcome — that is, unless mom or dad’s visit leaves the infant with something extra: a dangerous bacterial infection.

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Yale Cancer Center (YCC) announces the launch of the Center for Community Engagement and Health Equity (CEHE). Building on YCC’s longstanding commitment to high-quality, expert, and patient-centered cancer care, screening, and prevention across the state of Connecticut, the new Center is dedicated to ensuring cancer health equity and improving outcomes with an emphasis on traditionally underserved neighborhoods.

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An innovative approach to analyzing the medical scans of patients in clinical trials could help ensure the accuracy of trial results while reducing the workload for busy oncologists, according to a new study by researchers at the University of Michigan Rogel Cancer Center.

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Proton therapy leads to significantly lower risk of side effects severe enough to lead to unplanned hospitalizations for cancer patients when compared with traditional radiation, while cure rates between the two groups are almost identical

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Pregnant women living with HIV don’t always receive antiretroviral medications recommended for use in pregnancy, according to a recent study published in Jama Network Open this week. Ann & Robert H. Lurie Children's Hospital of Chicago’s researchers collaborated in the multi-site Surveillance Monitoring for ART Toxicities (SMARTT) study of the Pediatric HIV/AIDS Cohort Study (PHACS) network.