Diabetes is caused by damaged or non-existing insulin cells inability to produce insulin, a hormone that is necessary in regulating blood sugar levels. Many diabetes patients take insulin supplements to regulate these levels.
Diabetes is caused by damaged or non-existing insulin cells inability to produce insulin, a hormone that is necessary in regulating blood sugar levels. Many diabetes patients take insulin supplements to regulate these levels.
Myths about gluten are hard to bust. Intolerance, allergy, sensitivity, hypersensitivity. What is what? Celiac disease is none of these things. It is an autoimmune disorder, where gluten triggers the immune system to attack the gut. It is common, lifelong, and can seriously harm health - but nobody knows for sure what causes it. Now a review in Frontiers in Pediatrics says a common food additive could both cause and trigger these autoimmune attacks, and calls for warnings on food labels pending further tests.
You’ve heard of “in vitro” (the study of things in test tubes) and “in vivo” (the study of things in a living system). Now meet “in fimo,” a new scientific term coined by researchers at the UNC School of Medicine and Notre Dame University to mean “excrement examined experimentally.”
Mayo Clinic researchers and collaborators have shown in mice that obesity increases the level of "zombie" or senescent cells in the brain, and that those cells, in turn, are linked to anxiety. When senolytic drugs are used to clear those cells, the anxious behaviors in the mice dissipate. These findings appear in Cell Metabolism.
The GI Quality Improvement Consortium, Ltd. (GIQuIC) Registry has been approved as a Qualified Clinical Data Registry (QCDR) for reporting to the Merit-based Incentive Payment System (MIPS) for the 2019 reporting year. GIQuIC will host an informational webinar on reporting via the GIQuIC 2019 QCDR in February 2019.
Are you a Real Housewives fan? If so, you probably know that the show has recently brought colorectal cancer to the spotlight … again. If not, we’ll catch you up quickly.
Experts and research on important topics in the healthcare system
Traditionally, treatment for muscle-invasive bladder cancer is chemotherapy followed by the removal of the bladder. However, researchers have data suggesting that treatment consisting of limited surgery followed by chemotherapy and radiation is just as effective.
A new USC study provides new insight on how dietary fat and cholesterol drive the development of non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease
A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries.
The pancreas is an organ located behind the stomach that produces enzymes and hormones that help with digestion and blood-sugar regulation. Both heavy drinking and gallstones can cause an inflamed pancreas, called pancreatitis, which is associated with significant illness and, in about 10% of cases, death. The recent use of cannabis to manage the development of pancreatitis and its progression has yielded conflicting results. This study assessed the impact of cannabis use on both acute (sudden onset) and chronic (persistent) pancreatitis.
La Jolla Institute for Immunology (LJI) and Kyowa Kirin Pharmaceutical Research, Inc. (KKR), a wholly-owned subsidiary of Kyowa Hakko Kirin Co., Ltd. (KHK), a global specialty pharmaceutical company, today announced the signing of a new agreement. The agreement extends the longest industry-academic collaboration in the world for another three-year term, through until the end of 2021.
Mindfulness training may improve the effectiveness of intensive weight management programs, according to a small study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, demonstrating a possible pathway for treatment of people with pancreatic cancers whose response to standard immunotherapy is poor.
Researchers at Queen’s University Belfast have discovered a new way to analyse bowel cancer tumours, which could lead to more personalised treatments and better prognosis for patients.
Results of a medical records study of children with Crohn’s disease by Johns Hopkins researchers have added substantial evidence for a strong and direct link between malnutrition and increased risk of surgical complications and poor outcomes.
Diseases of the Colon and Rectum Journal Jan 2019 Video Abstracts and Editor Picks
In a new study published in Nature Communications, a team of scientists from UChicago demonstrated the application of tRNA sequencing to gut microbiome samples from mice that were fed either a low-fat or high-fat diet.
BIDMC researchers demonstrated that the lack of claudin 18 prompts the development of precancerous, abnormal cells and polyps in the engineered mouse model.
The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist. One factor in this hunger response is a hormone found in the stomach that makes us more vulnerable to tasty food smells, encouraging overeating and obesity.
Children and young adults without psychosis who are prescribed high-dose antipsychotic medications are at increased risk of unexpected death, despite the availability of other medications to treat their conditions, according to a Vanderbilt University Medical Center study published today in JAMA Psychiatry.
New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.
Why do orally-administered drugs for diabetes work for some people but not others? According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with clinicians from Scripps Clinic, have identified that the loss of two genes drives the formation of serrated colorectal cancer—yielding potential biomarkers. The research has also identified a combination treatment that has treated the cancer in mice. The study published today in Immunity.
Announcement of 2019 Harrington Scholar-Innovator Award recipients by the Harrington Discovery Institute at University Hospitals in Cleveland.
Advocates, patients, providers, and other experts examine disparities and explore solution at the NCCN Patient Advocacy Summit on Equity in Cancer Care
An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The results were published this week in the journal Genetics in Medicine.
A new study finds 29 percent of veterans who underwent recommended screening colonoscopies were uncomfortable with the idea of stopping these screenings when the benefit was expected to be low for them personally.
Cardiovascular patients at risk for gastrointestinal bleeding from taking oral anticoagulants like warfarin reduce that risk by 34 percent when taking a proton pump inhibitor (PPI) in combination, according to a Vanderbilt University Medical Center study published in JAMA.
Combining low doses of a toxic herbicide with sugar-binding proteins called lectins may trigger Parkinsonism -- including symptoms like body tremors and slowing of body motions -- after the toxin travels from the stomach to the brain.
Large-scale genomic study discovers 40 new genetic variants associated with colorectal cancer risk
Baltimore, MD--The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work from a team led by Carnegie's Will Ludington. Their findings are published this week in the Proceedings of the National Academy of Sciences.
A new study from UT Southwestern Medical Center shows neurons in mice that influence metabolism are active for up to two days after a single workout.
Researchers at Moffitt Cancer Center are trying to devise alternative mechanisms to block KRas. Their recent study demonstrates that the protein GSK3 is an important mediator of KRas-dependent tumor viability. Their research was published today in Nature Communications.
In a new study published in the Journal of Clinical Oncology, Manuel Hidalgo, MD, PhD, and colleagues conducted a phase I/II trial designed to evaluate the efficacy and safety of nab-paclitaxel given in combination with gemcitabine in patients with pancreatic cancer and reduced health status. The team – based at the Centro Nacional de Investigaciones Oncologicas (Spanish National Cancer Center), where Hidalgo previously served as Director of the Clinical Research Program and Vice Director of Translational Research – reported that the combination of therapies significantly improved survival even in less robust patients with metastatic pancreatic ductal adenocarcinoma (PDAC) compared to gemcitabine alone.
A research team has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features of cancerous cells found in patients’ urine by developing a nanoscale resolution map of the cells’ surface.
Patients diagnosed with pancreatic cancer face a poor prognosis because the tumor forms dense scar-like tissue that is difficult for chemotherapy drugs to penetrate, but a new model may help researchers develop new therapies.
NEW YORK, NY — December 3, 2018 — MDCalc, the global leader in online evidence-based medical calculators, has launched its new guideline summaries in a public beta. The first set of 11 summaries debuted at the annual scientific meeting of the American College of Gastroenterology (ACG) in Philadelphia in early October 2018.
You may remember a loved one making you a bowl of chicken noodle soup whenever you were feeling under the weather as a child. Just how healthy is this culinary cure-all? BIDMC clinical dietitian Sandy Allonen, RD, weighs in.
A team that includes researchers from the Bridge Institute at the University of Southern California (USC) and the Department of Energy’s SLAC National Accelerator Laboratory used X-rays to map the shape of a receptor in the body as it binds with misoprostol. This research, published in Nature Chemical Biology, could help in the quest to design low-cost drugs that can tackle postpartum bleeding without affecting other tissues.
The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in areas of great importance: Alzheimer’s Disease, Melanoma, Parkinson’s Disease, Schizophrenia, Breast Cancer, Lung Cancer, Leukemia, Ulcerative Colitis, Vascular Disease, and Colorectal Cancer. This year the Foundation also funded two Centers of Excellence in Value Assessment.
Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother's gut are passed on to the baby and stimulate the baby's immune responses. This transmission is impacted in children born by caesarean section.
Moores Cancer Center at UC San Diego Health launched the Pancreatic Cancer Prevention and Screening Clinic in an attempt to reduce the number of people who develop the disease and improve survival for those who do. Every day in the U.S., 145 people are diagnosed and every 12 minutes someone dies.
Former MLB player Frank Baker says his experience at UAB’s Pancreatobiliary Disease Center was a home run.
Richard Goldberg, who directs the West Virginia University Cancer Institute, is searching for new ways to slow colorectal cancer’s progression. In a recent study, he and an international team of scientists investigated a new drug combination for treating metastatic colorectal cancer in patients who had no—or only temporary—success with conventional chemotherapy treatments.
An undergraduate researcher is identifying bacteria that can potentially help improve gut health by colonizing the gut mucosal layer and stimulating the immune system.
Millions of Americans have no idea that they have fatty liver disease. This growing problem will soon be the number one reason for liver transplantation, overtaking hepatitis C. Holiday overindulgence in alcohol and food could make the problem dramatically worse.
Are there changes that affect genes and fuel a person’s propensity to develop obesity? That’s a question under study at Texas Biomedical Research Institute. Associate Scientist Melanie Carless, Ph.D., is Principal Investigator of a $3 million, four-year grant from the National Institute of Diabetes, Digestive and Kidney Diseases to research this hypothesis.
While probiotics are often used to treat acute gastroenteritis (also known as infectious diarrhea) in children, the latest evidence shows no significant differences in outcomes, compared to a placebo.
• $1 million in initial funding to evaluate DNA repair inhibitors in pancreatic cancer • Aim to accelerate pancreatic cancer research and improve patient outcomes for pancreatic cancer