Wistar has received a grant of approximately $4.6 million from the National Institutes of Health in support of innovative research to tackle antibiotic resistance.
In this newly published paper authors Hui Li, Ph.D., and Pak King Wong, Ph.D., (The Pennsylvania State University, PA, USA), Michael Morowitz, Ph.D., (University of Pittsburgh, PA, USA) and Neal Thomas, Ph.D., (Penn State University, PA, USA) describe their development of a novel technology approach designed to help clinicians better manage bacterial infection diagnosis and treatment, reduce the improper use of antibiotics and limit the spread of drug-resistant organisms.
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
A team of researchers led by the University of South Australia has discovered a way to find and beat superbugs, providing a critical breakthrough against many deadly infectious diseases.
In small, community hospitals that don’t have resources for a dedicated staff to oversee the proper use of antibiotics, turning to staff pharmacists showed promise in a model study conducted by Duke Health.
Staphylococcus aureus bacteria are a major cause of serious infections that often persist despite antibiotic treatment, but scientists at the UNC School of Medicine have now discovered a way to make these bacteria much more susceptible to some common antibiotics.
The study is the first to put antibiotic biosynthesis and resistance into an evolutionary context. The findings will help to guide the future discovery of new antibiotics and antibiotic alternatives which are medicines that are vitally needed given the current global threat of antimicrobial resistance.
Resistance to two critical antibiotic types, one a “drug of last resort” when all others fail against some “superbugs,” are widely distributed in Southeast Asia, raising the risk of untreatable infections, say a team of investigators led by Georgetown University Medical Center.
OS-MRSA has created confusion in clinical laboratories for the past decade because of its difficulty to diagnose. Findings of a new study identified a way to detect what an important gene has been hiding that could be critical for the successful treatment of the superbug.
The Centers for Medicare and Medicaid Services Inpatient Prospective Payment System rule for the coming fiscal year will raise reimbursements for novel antibiotics, a meaningful step in confronting the threat of infections resistant to older medicines. At the same time, the rule does not require or support antibiotic stewardship in healthcare settings, also an essential measure to protect the effectiveness of existing infection-fighting medicines.
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health examined independent charity prescription drug assistance programs in the U.S. and found that nearly all—97 percent—did not provide coverage for uninsured patients.
A new study by researchers at Intermountain Healthcare has found that administering broad-spectrum antibiotics, which act against a wide range of disease-causing bacteria, to treat patients with pneumonia often does more harm than good.
Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to draw natural killer immune cells to cancer cells.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
Over one billion people, including 880 million children, are infected with intestinal nematode worms, such as roundworms, hookworms and tapeworms, according to the World Health Organization.
Scientists in recent years have hypothesized that cell-cell differences aides the emergence of drug resistance. A new study published online in Nature Communications has tested this theory and yielded findings that may provide a path to reduce chemotherapy resistance.
New research from Cornell University offers a new pathway for targeting pathogens in the fight against antibiotic resistant bacteria.
Drug-resistant malaria is prevalent in Southeast Asia and may spread. Doctors currently can tell whether powerful malaria drugs will work through or a DNA duplication method that allows for optical detection of a disease’s biomarkers, but it's tough to use in low-resource areas.
The introduction of the Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms -- DISARM -- Act -- by United States Senators Johnny Isakson (R-GA) and Bob Casey (D-PA) Tuesday represents an essential step toward addressing the growing threat of infections that are increasingly resistant to existing treatments. By improving critical Medicare reimbursement for antibiotics and promoting their appropriate use, the legislation has the potential to stabilize the antibiotics market, spur the development of new infection-fighting drugs, and preserve the effectiveness of existing medicines.
Preschool children with community-acquired pneumonia often receive unnecessary tests and treatment at outpatient clinics and emergency departments, according to a nationally representative study led by Todd Florin, MD, MSCE, from Ann & Robert H. Lurie Children’s Hospital of Chicago.
Tuberculosis is the most lethal infectious disease in the world. Researchers at Washington University School of Medicine in St. Louis and Umea University in Sweden have found a compound that can prevent and even reverse antibiotic resistance in TB bacteria.
A study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed a close association between liposarcoma (LPS), a type of cancer that develops from fat cells, and the bromodomain and extraterminal (BET) protein family.
A new study found that 81% of antibiotics prescribed by dentists to prevent infections prior to dental visits are unnecessary.
A new compound which visualises and kills antibiotic resistant superbugs has been discovered by scientists at the University of Sheffield and Rutherford Appleton Laboratory (RAL).
Concentrations of antibiotics found in some of the world's rivers exceed 'safe' levels by up to 300 times, the first ever global study has discovered.
To treat Candida albicans, a common yeast that can cause illness in those with weakened immune systems, University at Buffalo researchers limited the fungus’ access to iron, an element crucial to the organism’s survival.
New drug also may increase effectiveness of oral chemotherapy for these tumors, known for their resistance to treatment.
Those same antibiotics driving antibiotic resistance could also help defeat it if used with the right strategy. Making it work would require companion health strategies like staying home from work when carrying resistant bacteria.
With more targeted therapies being approved each year for cancer, the development of drug resistance to these agents is a growing concern. It has often been assumed that drug resistance is due to the presence or development of additional genetic alterations; however, it is now clear that resistance mechanisms are more complicated. Researchers from Moffitt Cancer Center and Dana-Farber Cancer Institute have discovered a mechanism of drug resistance to Venetoclax®, also known as ABT-199, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and acute myeloid leukemia. Their findings, published in the journal Cancer Cell, also suggest a possible co-treatment strategy to overcome this resistance.
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health finds that the spread of carbapenem-resistant Enterobacteriaceae (CRE)—bacteria that have high levels of resistance to most antibiotics—could be reduced if only 25 percent of the largest health care facilities in a region used a patient registry, a database that can track which patients are carrying CRE.
While sifting through the bacterial genome of salmonella, Cornell University food scientists discovered mcr-9, a new stealthy, jumping gene so diabolical and robust that it resists one of the world’s few last-resort antibiotics.
Diana Aga's research examines how sewage treatment systems help — or don’t help — to eliminate antimicrobial drugs and their remnants, called residues, from wastewater before it’s discharged into rivers and lakes.
Harvard Medical School, MIT receive $9 million to study neurobiology, physiologic effects of cannabinoids
Researchers at Washington University School of Medicine in St. Louis have found that treating mice with an antibiotic reduces the size of lesions caused by endometriosis. The researchers are planning a clinical trial to test the strategy in women who have the painful condition.
Creating a defect in tRNA molecules could weaken bacteria’s two-pronged defense and help make faster-acting antibiotics.
Although penicillin was discovered nearly a century ago, scientists are still learning how the drug makes bacterial cells pop like overfilled balloons.
Researchers at the Cancer Center at Beth Israel Deaconess Medical Center revealed an unexpected relationship between levels of the amino acid leucine and the growth of tamoxifen resistance in estrogen-receptor positive breast cancer
A new study led by a research team from Massachusetts Eye and Ear and Harvard Medical School describes how bacteria adapted to the modern hospital environment and repeatedly cause antibiotic-resistant bloodstream infections. This study examined one of the first sustained hospital outbreaks of a multidrug-resistant bacterium, Enterococcus faecalis, which occurred from the early through the mid-1980s, causing over 60 outbreak strains.
New research from Washington University in St. Louis suggests that many "redundant" enzymes are actually specialists that ensure maximal growth across different environments. Further, these enzymes were found to increase E. coli’s resistance to antibiotics at low pH conditions, such as those found in the GI tract or urinary tract — raising concerns that current antibiotic susceptibility tests are inadequate.
A UW team tested how well current water and wastewater disinfecting methods affect antibiotic resistance genes in bacterial DNA. While these methods work well to deter bacterial growth, they had varied success in either degrading or deactivating a representative antibiotic resistance gene.
Fighting antibiotic resistance is a never-ending struggle. By the time a new antibiotic is tested and proven effective, the bacteria it’s meant to fight are often already developing resistance to it.
As current antibiotics dwindle in effectiveness against multidrug-resistant pathogens, researchers are seeking potential replacements in some unlikely places. Now a team has identified bacteria with promising antibiotic activity against known pathogens.
The April cover article of SLAS Discovery features “Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies,” by Monika I. Konaklieva, Ph.D., an online ahead-of-print article first published in December 2018.
Mayo Clinic researchers and their collaborators have shown that when senescent cells — also known as “zombie cells” — are removed from fat tissue in obese mice, severity of diabetes and a range of its causes or consequences decline or disappear.
Bacteria may travel thousands of miles through the air worldwide instead of hitching rides with people and animals, according to Rutgers and other scientists. Their “air bridge” hypothesis could shed light on how harmful bacteria share antibiotic resistance genes.
Infections caused by drug-resistant bacteria are a global public health threat causing serious illness and even death. Strains of the bacterium Enterococcus faecium (E. faecium) are generally harmless in healthy people, but can be pathogenic in immunocompromised or severely ill patients.
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