Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop
Our study comprehensively reveals the spatiotemporal dynamics of regional specification and state transition in the microglia of the developing human brain. By comparing microglia from mice and humans, we assess the conservation of state transitions
Du et al. discover a chemical cocktail of five small molecules (5SM) promoting adult mammalian CM proliferation and heart regeneration after myocardial infarction. 5SM potentially targets α1 adrenergic receptor, JAK1, DYRKs, PTEN, and MCT1 and make
Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the
Kong et al. present Capybara, a computational pipeline to classify discrete cell identity and intermediate “hybrid” cell states. They apply Capybara to identify hybrid states in cardiac reprogramming, off-target neural identities in motor neuron
In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs,
Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19+ CAR-T cells that mimi
Recent advances and current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application are discussed.
Abnormal nuclear morphology is a hallmark of cancerous cells. Here, Reilly et al. demonstrate that deletion of lamin B1, which is common in myeloid malignancies, causes acquired Pelger-Huët nuclear anomaly and links aberrant nuclear morphology with
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o
(Cell Stem Cell 29, 386–399.e1–e7; March 3, 2022)
Sun et al. discover that myogenic progenitors derived from hPSCs could engraft and mature to become local satellite cells in vivo after transplantation. These engrafted MPCs not only function as satellite cells in muscle regeneration but could also
Blood vessels adapt to the requirements of each organ. In the liver, this adaptation is a progressive specialized transition from fetal to postnatal development, which is facilitated by the transcription factor c-Maf. In vitro c-Maf induces a liver-
This study led by Prof. Qiuyu Zhang (Northwestern Polytechnical University), Prof. Ki-Bum Lee (Rutgers University), and Prof. Liang Kong (School of Stomatology, The Fourth Military Medical University).
Muhammad Ameen, Sadia Khan, Ali Al-Ahmari, Muhab Ayas, Aya Kattih, Amani Alkofide, Mohamad Walid Ballourah, Muheeb Al-Awami
Julia Bruno, Vitor Heidrich, Franciele H. Knebel, Vinícius Campos de Molla, Claudia Joffily Parahyba, Wanessa Miranda-Silva, Paula Fontes Asprino, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Eduardo Rodrigues Fregnani
Ji-Lin Chen, Na Li, Wen-Qiang Liu, Zhong-Fu Zuo, Ting-Hua Wang
Weisheng Hu, Yuan Jing, Qingqian Yu, Ning Huang
Mohammad Tolooei, Hassan Ehteram, Hamed Haddad Kashani
Thulaj Meharwade, Loick Joumier, Maxime Parisotto, Vivian Huynh, Edroaldo Lummertz da Rocha, Mohan Malleshaiah
Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry
Pauliina Auvinen, Jussi Vehviläinen, Heidi Marjonen, Vijayachitra Modhukur, Joonas Sokka, Essi Wallén, Karita Rämö, Laura Ahola, Andres Salumets, Timo Otonkoski, Heli Skottman, Miina Ollikainen, Ras Trokovic, Hanna Kahila, Nina Kaminen-Ahola
Kana Fujimoto, Akira Nakajima, Shohei Hori, Yumiko Tanaka, Yoshitaka Shirasaki, Sotaro Uemura, Naoki Irie
Zhaoping Gan, Liyi Chen, Meiqing Wu, Lianjin Liu, Lingling Shi, Qiaochuan Li, Zhongming Zhang, Yongrong Lai
Qiuying Liu, Mariah K Novak, Rachel Pepin, Katharine Maschhoff, Xiaoli Chen, Shaojie Zhang, Wenqian Hu
Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Michael Gigl, Karin Kleigrewe, Julius Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Daniela Weber, Daniel Wolff, Matthias Edinger, Dirk Busch, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Xian Wu, Hao Gou, Huijun Qiu, Hanmin Liu, Zhou Fu, Lina Chen
Zhi-Na Wang, Hong-Ming Ma, Zi-Yi Chen, Jia-Wen Chen, Xu-Wen Yang, Nan Zhang, Fanjie Meng
Chi Yang, Kai Shi, Jie Wang, Lianqi Yan
Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto
… Despite ongoing attempts since the 1990s, no stably defined pig epiblast-derived stem cell line has been established. Here, guided by … in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 …
Haiting Ma, Rudolph Jaenisch
Yuxuan Li, Xiaofei Wang, Jing Lu
Jie Huang, Haiyan Chen, Shujue Lan, Le Qin, Zixuan Xun, Shuai Han, Hongwei Zhao, Yunqing Ci, Chen Xu, Wenjia Zhu, Xinya Lu, Jiaxin Chen, Qiuyi Zheng, Ermin Li, Xinyun Chen, Chao Lu, Ruizhe Qian, Sifeng Chen, Xiaobo Li, Ning Sun
One way in which scientists are studying how the human body grows and ages is by creating artificial organs in the laboratory.
Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu
Allen Hodge, Patricia Sheean, Paula O’Connor, Kiley Tyler, Abigail Kerschner, Alexis Williams, Kathleen Jensik, Alexis Visotcky, Anita D’Souza, Parameswaran Hari, Binod Dhakal, Saurabh Chhabra, Kathryn E. Flynn, Patrick Hagen, Melinda Stolley
Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-… of stem cell-based therapy …
… and cell types and correlate interfacial mechanical properties with stem cell expansion. Correlations suggest an impact of … stem cell proliferation, we determined the interfacial shear moduli of corresponding interfaces and correlated …
Shunrong Sun, Wulipan Fulati, Lin Shen, Min Wu, Zilan Huang, Wensi Qian, Pingping Chen, Yingwei Hu, Mingyue Chen, Yu Xu, Hongdi Zhang, Jiexian Ma, Yanhui Xie
Huiming Ma, Na Hu, Shasha Xing, Shudan Liu, Songlin Guo, Feiyan Zhang, Xiaona Ma, Xueyun Liang, Dongmei Chen
Hongorzul Davaapil, Madeline McNamara, Alessandra Granata, Robyn G. C. Macrae, Mei Hirano, Martina Fitzek, Jose Antonio Aragon-Martin, Anne Child, David M. Smith, Sanjay Sinha
Shiying Niu, Changsheng Cong, Zhaopeng Wang, Meili Sun, Yueying Zhang
Nicolette M Johnson, Louis R Parham, Jeeyoon Na, Keara E Monaghan, Hannah M Kolev, Alena Klochkova, Melissa S Kim, Charles H Danan, Zvi Cramer, Lauren A Simon, Kaitlyn E Naughton, Stephanie Adams-Tzivelekidis, Yuhua Tian, Patrick A Williams, Nicolae A Leu, Simone Sidoli, Kelly A Whelan, Ning Li, Christopher J Lengner, Kathryn E Hamilton
Mirko Hh Schmidt, Verica Vasic, Kathrin Barth, Frank Bicker, Ulrike Schumann, Christine Maurer, Nora Heinig, Cora Roehlecke, Ute Nimtschke, Lana Schumann, Matthias Meinhardt, Thomas Mittmann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Irmgard Tegeder
Researchers from The University of Texas MD Anderson Cancer Center showed that natural killer (NK) cells derived from donated umbilical cord blood, combined with a novel bispecific antibody known as AFM13 that targets CD16A and CD30, achieved effective responses in patients with pretreated and refractory CD30+ lymphoma. The study was presented today at the American Association for Cancer Research (AACR) Annual Meeting 2022.
Shue Wang, Yuwen Zhao, Rui Yang, Zoe Bousraou, Kiarra Richardson
James W Simpkins, Deborah Corbin, Saumuendra N Sarkar
The neural-crest derived enteric nervous system (ENS) is the intrinsic nervous system of the gastrointestinal (GI) tract and controls all gut functions, including motility.
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