Feature Channels: Stem Cells

• share
• favorite_border

• share
• favorite_border

As research involving the transplantation of human “mini-brains”—known as brain organoids—into animals to study disease continues to expand, so do the ethical debates around the practice. A new paper published in Cell Stem Cell by researchers from Penn Medicine and the Department of Veterans Affairs sought to clarify the abilities of brain organoids and suggests an ethical framework that better defines and contextualizes these organoids and establishes thresholds for their use.

• share
• favorite_border

MedStar Heart & Vascular Institute has enrolled its first patient to a clinical trial to determine whether cardiac stem cells reduce inflammation enough to improve heart function in patients with heart failure severe enough to require a left ventricular assist device, or LVAD.

• share
• favorite_border

Scientists show that the location of stem cells is essential in determining tapeworms’ ability to regenerate.

• share
• favorite_border

In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.

• share
• favorite_border

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis.

• share
• favorite_border

An interdisciplinary team has found a solution to a problem plaguing developmental biology -- long-term cell tracking and manipulation. Researchers painstakingly developed an automated microfluidic device for the stable imaging of mice embryonic stem cells over a three-day period.

• share
• favorite_border

Researchers led by Sean I. Savitz, MD, of UTHealth Houston reported today in the journal Stem Cells that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.

• share
• favorite_border

In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.

• share
• favorite_border

UNM Cancer Center’s Bone Marrow Transplant program is the first in the state to achieve FACT accreditation, enabling many more New Mexicans with blood disorders to stay home

• share
• favorite_border

On the day he was born, Patrick Davey saved a woman's life. His parents donated his umbilical cord blood, which was used in a stem cell transplant that saved the life of cancer patient Holly Becker.

• share
• favorite_border

Nine-month-old brains-in-a-dish and the brains of premature newborn babies generate similar electrical patterns, as captured by electroencephalogram (EEG) — the first time such brain activity has been achieved in a cell-based laboratory model.

• share
• favorite_border

Scientists at the Morgridge Institute for Research have created a new way to study early human developmental timing through a stem cell-based “clock in a dish."

• share
• favorite_border

Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation.

• share
• favorite_border

The project is focused on identifying the role of hypoxia or lack of oxygen to the cells and tissues in the body, and oxygen on the formation of the eye lens.

• share
• favorite_border

The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.

• share
• favorite_border

Using an unbiased labelling technique, mathematical modelling, and single cell profiling to trace the footsteps of stem cells and their daughters, researchers at the University of Cambridge (UK), DGIST (S.Korea), and IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria) have confirmed that two populations of adult stem cells with distinct roles and characteristics reside in the glands of the stomach.

• share
• favorite_border

A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.

• share
• favorite_border

Nanotechnology developed at Rutgers University–New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer’s disease, Parkinson’s disease, other neurodegenerative diseases, and central nervous system injuries.

• share
• favorite_border

UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.

• share
• favorite_border

Stem cells hold the key to wound healing, as they develop into specialised cell types throughout the body - including in teeth.

• share
• favorite_border

The heart cannot regenerate muscle after a heart attack. Injecting heart muscle cells grown in vitro could help the failing heart, but engraftment rates are low. A new and simple method to improve the quality of the delivered cells has now been tested in mice, and it doubles the engraftment rate.

• share
• favorite_border

In a proof-of-concept paper, Pitt researchers chronicle how they transformed genetically engineered human cells into functional, 3D liver tissue that mimics non-alcoholic fatty liver disease (NAFLD) – a condition involving fat buildup in the liver, which can lead to cirrhosis or even liver failure.

• share
• favorite_border

• share
• favorite_border

Mount Sinai researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin’s lymphomas for the first time by combining them with stem cell transplantation, an approach that also dramatically increased the success of the drugs in melanoma and lung cancer, according to a study published in Cancer Discovery in July.

• share
• favorite_border

Convelo Therapeutics Inc., a Cleveland company based on the research findings of Paul Tesar and Drew Adams at the Case Western Reserve University School of Medicine, has entered into a strategic partnership with Genentech to develop new therapeutic drugs to repair damaged myelin insulation on nerve cells for patients suffering from neurological disorders such as multiple sclerosis.

• share
• favorite_border

一项I期临床试验表明，通过采集和处理婴儿自体干细胞并在手术时直接将其注入心脏，有望对左心发育不良综合征(HLHS)进行再生治疗。该研究是美国食品药品监督管理局监测的首项同类研究。The Journal of Thoracic and Cardiovascular Surgery（《胸心血管外科杂志》）上发表了一篇详细介绍该临床试验的论文。

• share
• favorite_border

Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells — fat cells (adipocytes), bone-making cells (osteoblasts) and cartilage-making cells (chondrocytes).

• share
• favorite_border

Um estudo clínico de fase 1 é a primeira pesquisa monitorada pela Food and Drug Administration (Agência Americana de Controle de Alimentos e Medicamentos) que demonstra o potencial da terapia regenerativa para a síndrome da hipoplasia do coração esquerdo (SHCE) por meio de coleta, processamento e introdução das próprias células tronco da criança no coração durante o momento da cirurgia.

• share
• favorite_border

A new biomedical research study finds a transcription factor called Slug contributes to breast cell fitness by promoting efficient repair of DNA damage. The absence of Slug leads to unresolved DNA damage and accelerated aging of breast cells.

• share
• favorite_border

Eye research funders come together to foster research to treat age-related macular degeneration.

• share
• favorite_border

A worldwide coalition of researchers and clinicians has agreed that light therapy is among the most effective interventions for the prevention of oral mucositis, painful ulcers in the mouth resulting from cancer therapy.

• share
• favorite_border

Irvine, Calif., July 8, 2019 — University of California, Irvine researchers have developed and tested on mice a therapeutic treatment that uses engineered stem cells to target and kill cancer bone metastases while preserving the bone.  This new approach, reported in the journal EBioMedicine, equips engineered mesenchymal stem cells with targeting agents that drive them to bone metastatic sites, where they offload therapeutics.

• share
• favorite_border

An interdisciplinary team of UCLA scientists has found that small cell neuroendocrine cancers from a range of tissues have a common molecular signature and share drug sensitivities with blood cancers.

• share
• favorite_border

UC San Diego will launch a payload of stem cell-derived human brain organoids to the International Space Station. Researchers will document how these “mini brains” organize into the beginnings of a functional brain with implications for the future of human life in space.

• share
• favorite_border

Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.

• share
• favorite_border

In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future. Using a series of snapshots, researchers recently captured such so-called “butterfly effects” in heart muscle cell development, and say this new view into the sequence of gene expression activity may lead to better understanding disease risk.

• share
• favorite_border

In a new study, aimed at using stem cells for hair growth, Columbia researchers have created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the way pharmaceutical companies search for new hair growth drugs.

• share
• favorite_border

Researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have found that breast cancer cells that swallow up nearby stem cells take on some of their properties, enhancing their ability to invade other tissues throughout the body and seed secondary tumors, a process known as metastasis.

• share
• favorite_border

Scientists have developed a stem-cell-based modeling system that identifies how some neurons are resistant to ALS—a breakthrough that offers potential for battling neurodegeneration.

• share
• favorite_border

Researchers found that stem cells can commit to a cell fate far more rapidly than anticipated.

• share
• favorite_border

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) discovered in laboratory studies that an experimental drug called selinexor may block a crucial survival pathway exploited by myelofibrosis cells.

• share
• favorite_border

Pregnant women are often advised to avoid certain drugs because of potential risks to their unborn infant's growing brain cells.

• share
• favorite_border

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Ochsner Hospital for Children are collaborating within a consortium to provide solutions for patients with hypoplastic left heart syndrome (HLHS), a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

• share
• favorite_border

A statewide bipartisan initiative is transforming health care from a focus on treating disease to one of tapping the body's ability to heal itself. Regenerative Medicine Minnesota is a legislative initiative aimed at improving health by advancing regenerative medicine in research, technology, education and patient care across the state.

• share
• favorite_border

Dr. Nathan Bryan, one of the nation’s top experts in the health effects of nitric oxide, is pleased to announce that Pneuma Nitric Oxide Activating Skin Serum™, a revolutionary, innovative and patent pending dual chamber technology that delivers nitric oxide gas to the surface of the skin is now available to men and women concerned about combatting the effects of aging skin.Dr. Nathan Bryan, one of the nation’s top experts in the health effects of nitric oxide, is pleased to announce that Pneuma Nitric Oxide Activating Skin Serum™, a revolutionary, innovative and patent pending dual chamber technology that delivers nitric oxide gas to the surface of the skin is now available to men and women concerned about combatting the effects of aging skin.

• share
• favorite_border

To treat large gaps in long bones, like the femur, that often eventually result in amputation, researchers developed a process that partially recreates the bone growth process that occurs before birth.

• share
• favorite_border

Researchers at the University of Illinois at Chicago and the University of Pennsylvania have developed a unique technique that uses stem cells and flexible implantable bone-stabilizing plates to help speed the healing of large breaks or defects. The technique allows the stem cells applied to break sites to experience some mechanical stress, as they do in developing embryos.

• share
• favorite_border

Irvine, Calif., June 5, 2019 — A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers.  “Until now, stem cell therapies for autoimmune and neurodegenerative diseases have produced mixed results in clinical trials, partly because we don’t know how the treatments work,” said corresponding author Weian Zhao, an associate professor of pharmaceutical sciences and biomedical engineering who is affiliated with the Sue & Bill Gross Stem Cell Research Center.

• share
• favorite_border

As people age, their muscle regeneration capacity declines in part because they can no longer make enough muscle stem cells to replace damaged tissue.