Scientists at The Scripps Research Institute (TSRI) have found a new approach to the “reprogramming” of ordinary adult cells into stem cells.
In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state. The technique makes it possible to study motor neurons of the human central nervous system in the lab. Unlike commonly studied mouse motor neurons, human motor neurons growing in the lab would be a new tool since researchers can’t take samples of these neurons from living people but can easily take skin samples.
Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for treatment. In a study published today online in Stem Cell Reports, researchers found that stem cells in the muscles of muscular dystrophy patients may, at an early age, lose their ability to regenerate new muscle, due to shortened telomeres
Researchers in Germany have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying. The approach, which is described in a paper to be published September 7 in The Journal of Experimental Medicine, could allow those in need of such transplants, including leukemia and lymphoma patients, to be treated with fewer donor stem cells while limiting potential adverse side effects.
In a mouse study designed to understand how chronic inflammation in sinusitis damages the sense of smell, scientists at Johns Hopkins say they were surprised to learn that the regeneration of olfactory tissue requires some of the same inflammatory processes and chemicals that create injury and loss of smell in the first place.
A new biomedical tool using nanoparticles that deliver transient gene changes to targeted cells could make therapies for a variety of diseases — including cancer, diabetes and HIV — faster and cheaper to develop, and more customizable.
Researchers at the University of Georgia’s Regenerative Bioscience Center have developed Brain Glue, a substance that could one day serve as a treatment for traumatic brain injuries, or TBIs.
More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the San Diego Veterans Administration Medical Center report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical trial of a novel combination drug therapy for B-cell cancers.
Not much is known about stem cell metabolism, but a new study from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.
The University of New Mexico Comprehensive Cancer Center began helping New Mexicans with blood disorders a little more than one year ago. It is the state’s only bone marrow transplant program. The program offers treatment choices for people with lymphoma and myeloma and will expand to help people with other blood disorders.
UCLA researchers have discovered a new way to activate the stem cells in the hair follicle to make hair grow. The research, led by scientists Heather Christofk and William Lowry, may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss associated with such factors as hormonal imbalance, stress, aging or chemotherapy treatment.
Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart Institute.
An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.
The first few weeks after sperm meets egg still hold many mysteries. Among them: what causes the process to fail, leading to many cases of infertility. But scientists haven’t had a good way to explore the biology behind this phenomenon. Now, a new achievement using human stem cells could give researchers a chance to see what they couldn’t before, while avoiding ethical issues associated with studying actual embryos.
A research team has overcome challenges that have limited gene therapy. They demonstrate how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat human diseases. The researchers provide “proof-of-concept,” treating mice with two common related human ailments: type-2 diabetes and obesity.
Researchers from UNC and NC State are developing a potential stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis – often-fatal conditions that affect tens of millions of Americans.
Researchers at Baylor Scott & White Research Institute reveal curcumin has potential to overcome chemoresistance in pancreatic ductal adenocarcinoma, a common but aggressive form of cancer in the pancreas.
Research teams at the Virginia Tech Carilion Research Institute from three colleges — Engineering, Science, and Veterinary Medicine — are developing new approaches to treat glioblastoma, the aggressive form of brain cancer diagnosed in U.S. Sen. John McCain.
A stem cell-based method created by University of California, Irvine scientists can selectively target and kill cancerous tissue while preventing some of the toxic side effects of chemotherapy by treating the disease in a more localized way.
Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The paper was published online today in Nature.
University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining failure of retinoic acid trials against breast cancer and offers a possible strategy for their use.
Stem cell centers claim to offer effective treatment to patients with heart failure, despite the fact that the treatment is not approved for such use by the U.S. Food and Drug Administration (FDA), says the author of research letter in the current issue of JAMA Internal Medicine.
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) today unanimously approved a $5.8 million award to University of California San Diego School of Medicine researchers to develop a new immunotherapy in which patients’ cells would be equipped with a special receptor that recognizes and targets cancer stem cells, whose survival abilities often render standard therapies ineffective or short-term.
UW-Madison researchers have invented an all-chemical replacement for the confusing, even dangerous materials, now used to grow stem cells.
Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia
Dr. Zea Borok of the Keck School of Medicine of USC has received a $6.9 million, seven-year NIH grant that could lead to new therapies for common lung diseases
Recent strides toward understanding dry eye are leading to better and longer-lasting therapies for the millions of people in the U.S. who are affected by the condition.
Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy begins.
Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed.
A discovery, described in a recent study by researchers at Beaumont Health, revealed ACL tears send a signal to stem cells throughout our body. This could lead to future breakthroughs to enable stem cells to repair injuries and reduce development of conditions like osteoarthritis.
A new study from the Monell Center and collaborating institutions advances understanding of how stem cells on the tongue grow into the different types of mature taste cells that detect either sweet, salty, sour, bitter, or umami. The findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine-tune a person’s taste perception to encourage healthier eating.
At present, the only FDA approved method of treating glaucoma is to lower eye pressure; this slows the progression of glaucomatous optic nerve damage but does not completely halt it, and certainly does not regenerate damaged nerve tissue.
Researchers believe this is the first study of its kind to reveal the body’s systemic stem cell response to an ACL injury. Osteoarthritis affects more than 30 million adults in the United States. Many cases occur after trauma to a joint. It’s also a leading cause of disability.
University of Colorado Cancer Center study pinpoints promising link in the chain of hedgehog signaling that, when broken, could reduce the metastatic potential of breast cancer.
The University of Illinois at Chicago College of Medicine will launch a new center that will focus on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.
A team led by Igor Slukvin, a University of Wisconsin-Madison professor of pathology and laboratory medicine, and cell and regenerative biology, describes the developmental pathway that gives rise to the different types of cells that make up human vasculature.
A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones.
Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome. The findings point to a path for treating this syndrome and hold promise for analyzing other neurological diseases.
A team of scientists from the University of Wisconsin-Madison and Cedars-Sinai in Los Angeles have used the cells of AHDS patients to recreate not only the disease, but a mimic of the patient’s blood-brain barrier in the laboratory dish using induced pluripotent stem cell technology.
Researchers examined the mechanisms of B cell immune reconstitution in pediatric patients who had undergone bone marrow transplantation and discovered a disruption in the maturation of B cells – critical to the immune system – preventing the production of antibodies that fight infection.
A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
Patients with double hit lymphoma (DHL) who undergo autologous stem-cell transplantation (autoSCT) after achieving remission are not more likely to remain in remission or live longer than patients who do not undergo autoSCT, according to a new analysis from the Perelman School of Medicine and the Abramson Cancer Center of the University of Pennsylvania.
New lung “organoids”—tiny 3-D structures that mimic features of a full-sized lung—have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.
Researchers at the University of Cincinnati (UC) have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.
Twenty years after undergoing a life-saving treatment at Loyola University Medical Center, cancer survivor Carolyn Gatenby returned to Loyola to donate 20 handmade quilts. “I wanted to give back,” Mrs. Gatenby said. “I’ve had 20 good years that I didn’t think I’d have.”
Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.
Scientists at The Scripps Research Institute (TSRI) have discovered why some cancers may reoccur after years in remission.
Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells—a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.
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